DK2049501T3 - Hydroxyleret og methoxyleret cyclopenta [D]-pyrimidiner som AKT-proteinkinase-inhibitorer - Google Patents

Hydroxyleret og methoxyleret cyclopenta [D]-pyrimidiner som AKT-proteinkinase-inhibitorer

Info

Publication number
DK2049501T3
DK2049501T3 DK07799337.6T DK07799337T DK2049501T3 DK 2049501 T3 DK2049501 T3 DK 2049501T3 DK 07799337 T DK07799337 T DK 07799337T DK 2049501 T3 DK2049501 T3 DK 2049501T3
Authority
DK
Denmark
Prior art keywords
pyrimidines
hydroxylated
protein kinase
kinase inhibitors
akt protein
Prior art date
Application number
DK07799337.6T
Other languages
Danish (da)
English (en)
Inventor
Eli W Wallace
Anna L Banka
Stephen T Schlachter
Ian S Mitchell
James F Blake
Rui Xu
Nicholas C Kallan
Dengming Xiao
Keith Lee Spencer
Josef R Bencsik
Jun Liang
Brian Safina
Birong Zhang
Christine Chabot
Steven Do
Original Assignee
Array Biopharma Inc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38686743&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2049501(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma Inc, Genentech Inc filed Critical Array Biopharma Inc
Application granted granted Critical
Publication of DK2049501T3 publication Critical patent/DK2049501T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
DK07799337.6T 2006-07-06 2007-07-05 Hydroxyleret og methoxyleret cyclopenta [D]-pyrimidiner som AKT-proteinkinase-inhibitorer DK2049501T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81871806P 2006-07-06 2006-07-06
PCT/US2007/072885 WO2008006040A1 (en) 2006-07-06 2007-07-05 Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors

Publications (1)

Publication Number Publication Date
DK2049501T3 true DK2049501T3 (da) 2011-12-12

Family

ID=38686743

Family Applications (2)

Application Number Title Priority Date Filing Date
DK07799337.6T DK2049501T3 (da) 2006-07-06 2007-07-05 Hydroxyleret og methoxyleret cyclopenta [D]-pyrimidiner som AKT-proteinkinase-inhibitorer
DK11166125.2T DK2402325T3 (en) 2006-07-06 2007-07-05 Hydroxylerede cyclopenta[d]pyrimidiner som AKT-proteinkinaseinhibitorer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK11166125.2T DK2402325T3 (en) 2006-07-06 2007-07-05 Hydroxylerede cyclopenta[d]pyrimidiner som AKT-proteinkinaseinhibitorer

Country Status (34)

Country Link
EP (4) EP2402325B1 (2)
JP (4) JP5266216B2 (2)
KR (5) KR20140093291A (2)
CN (2) CN101578273B (2)
AR (3) AR061842A1 (2)
AT (1) ATE524447T1 (2)
AU (1) AU2007269060B2 (2)
BR (3) BR122013028005B8 (2)
CA (2) CA2656622C (2)
CL (1) CL2007001993A1 (2)
CO (1) CO6150161A2 (2)
CR (1) CR10600A (2)
CY (1) CY1112117T1 (2)
DK (2) DK2049501T3 (2)
ES (3) ES2372774T3 (2)
HR (1) HRP20110908T1 (2)
HU (1) HUE026237T2 (2)
IL (2) IL196028A (2)
IN (1) IN2014KN02886A (2)
MA (1) MA31655B1 (2)
MX (4) MX366319B (2)
MY (1) MY147364A (2)
NO (1) NO342346B1 (2)
NZ (3) NZ610633A (2)
PL (2) PL2402325T3 (2)
PT (1) PT2049501E (2)
RS (1) RS52212B (2)
RU (2) RU2478632C2 (2)
SG (4) SG188905A1 (2)
SI (2) SI2049501T1 (2)
TW (2) TWI402266B (2)
UA (1) UA95641C2 (2)
WO (1) WO2008006040A1 (2)
ZA (1) ZA200900070B (2)

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ATE532789T1 (de) 2006-07-06 2011-11-15 Array Biopharma Inc Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
UA95641C2 (xx) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
CA2656566C (en) 2006-07-06 2014-06-17 Array Biopharma Inc. Dihydrofuro pyrimidines as akt protein kinase inhibitors
ATE523499T1 (de) 2006-07-06 2011-09-15 Array Biopharma Inc Cyclopenta [d]-pyrimidine als akt-proteinkinasehemmer
US20110135569A1 (en) 2007-03-20 2011-06-09 Peak Biosciences Inc. Method for therapeutic administration of radionucleosides
WO2009006567A2 (en) 2007-07-05 2009-01-08 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN101918373B (zh) 2007-07-05 2013-06-05 阵列生物制药公司 作为akt蛋白激酶抑制剂的嘧啶基环戊烷
EP2240455B1 (en) 2008-01-09 2012-12-26 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
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