CA2770441C - Sigma ligands for the prevention or treatment of pain induced by chemotherapy - Google Patents

Sigma ligands for the prevention or treatment of pain induced by chemotherapy Download PDF

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Publication number
CA2770441C
CA2770441C CA2770441A CA2770441A CA2770441C CA 2770441 C CA2770441 C CA 2770441C CA 2770441 A CA2770441 A CA 2770441A CA 2770441 A CA2770441 A CA 2770441A CA 2770441 C CA2770441 C CA 2770441C
Authority
CA
Canada
Prior art keywords
substituted
unsubstituted
paclitaxel
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2770441A
Other languages
English (en)
French (fr)
Other versions
CA2770441A1 (en
Inventor
Jose Manuel Baeyens-Cabrera
Helmut Heinrich Buschmann
Jose Miguel Vela Hernandez
Daniel Zamanillo-Castanedo
Francisco-Rafael Nieto-Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of CA2770441A1 publication Critical patent/CA2770441A1/en
Application granted granted Critical
Publication of CA2770441C publication Critical patent/CA2770441C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2770441A 2009-08-14 2010-08-12 Sigma ligands for the prevention or treatment of pain induced by chemotherapy Expired - Fee Related CA2770441C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09382144A EP2292236A1 (de) 2009-08-14 2009-08-14 Sigma-Liganden zur Vorbeugung oder Behandlung von Schmerzen infolge von Chemotherapie
EP09382144.5 2009-08-14
PCT/EP2010/061720 WO2011018487A1 (en) 2009-08-14 2010-08-12 Sigma ligands for the prevention or treatment of pain induced by chemotherapy

Publications (2)

Publication Number Publication Date
CA2770441A1 CA2770441A1 (en) 2011-02-17
CA2770441C true CA2770441C (en) 2017-12-12

Family

ID=41531868

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2770441A Expired - Fee Related CA2770441C (en) 2009-08-14 2010-08-12 Sigma ligands for the prevention or treatment of pain induced by chemotherapy

Country Status (34)

Country Link
US (3) US20120141606A1 (de)
EP (2) EP2292236A1 (de)
JP (1) JP5922575B2 (de)
KR (3) KR20150140419A (de)
CN (1) CN102497864B (de)
AR (1) AR077876A1 (de)
AU (2) AU2010283761B2 (de)
BR (1) BR112012003053A2 (de)
CA (1) CA2770441C (de)
CO (1) CO6511240A2 (de)
CY (1) CY1116697T1 (de)
DK (1) DK2464356T3 (de)
EC (1) ECSP12011658A (de)
ES (1) ES2543645T3 (de)
HR (1) HRP20150788T1 (de)
HU (1) HUE025642T2 (de)
IL (1) IL217911A0 (de)
IN (1) IN2012DN02149A (de)
MA (1) MA33569B1 (de)
MX (1) MX2012001877A (de)
MY (1) MY157334A (de)
NZ (1) NZ598213A (de)
PH (1) PH12012500286A1 (de)
PL (1) PL2464356T3 (de)
PT (1) PT2464356E (de)
RU (1) RU2543382C2 (de)
SG (1) SG178338A1 (de)
SI (1) SI2464356T1 (de)
SM (1) SMT201500189T1 (de)
TN (1) TN2012000048A1 (de)
TW (1) TWI529168B (de)
UA (1) UA108859C2 (de)
WO (1) WO2011018487A1 (de)
ZA (1) ZA201200843B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2116539A1 (de) 2008-04-25 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. 1-Aryl-3-Amino-alkoxy-pyrazole als Sigma-Liganden zur Verbesserung der analgetischen Wirkung von Opioiden und zur Schwächung der Abhängigkeit davon
EP2353598A1 (de) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma-Liganden zur Anwendung in der Vorbeugung und/oder Behandlung von postoperativem Schmerz
EP2353591A1 (de) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma-Liganden zur Verstärkung der analgesischen Wirkung von Opioden und Opiaten bei postoperativem Schmerz und zur Schwächung der Abhängigkeit davon
EP2388005A1 (de) * 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma-Liganden zur Vorbeugung und/oder Behandlung von Erbrechen infolge von Chemotherapie oder Strahlentherapie
EP2415471A1 (de) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Verwendung von Sigmaliganden bei opioidinduzierter Hyperalgesie
EP2426111A1 (de) * 2010-08-09 2012-03-07 Laboratorios Del. Dr. Esteve, S.A. Feste 4-[-2-[[5-Methyl-1-(2-naphthalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholinhydrochlorid-Formen
EP2524694A1 (de) * 2011-05-19 2012-11-21 Laboratorios Del. Dr. Esteve, S.A. Verwendung von Sigmaliganden bei Schmerz im Zusammenhang mit Typ-2-Diabetes
EP2792352A1 (de) 2013-04-16 2014-10-22 Laboratorios Del. Dr. Esteve, S.A. Alpha-2-Adrenorezeptor und Sigmarezeptor-Ligande enthaltenden Kombinationen
CN105611925A (zh) * 2013-09-12 2016-05-25 埃斯蒂维实验室股份有限公司 NSAID与σ受体配体的组合物
AU2014364644A1 (en) 2013-12-17 2016-06-23 Laboratorios Del Dr. Esteve, S.A. Gabapentinoids and Sigma receptor ligands combinations
TN2016000228A1 (en) 2013-12-17 2017-10-06 Esteve Labor Dr SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS.
AR108682A1 (es) * 2016-06-06 2018-09-12 Esteve Labor Dr Derivados de pirazol-3-iloxi ligandos del receptor sigma
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
WO2024105225A1 (en) * 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU11248A1 (ru) 1927-03-29 1929-09-30 В.С. Григорьев Способ очистки антрацена
FR2301250A1 (fr) * 1975-02-21 1976-09-17 Bellon Labor Sa Roger Nouveaux diaryl-1, 4o-aminoalcoxy-3 pyrazoles et leurs sels
EP1634872A1 (de) * 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Pyrazolderivate als Inhibitoren von Sigmarezeptoren
CA2576144C (en) 2004-08-27 2012-12-11 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
SI1781618T1 (sl) * 2004-08-27 2013-01-31 Laboratorios Del Dr. Esteve, S.A. Inhibitorji sigma receptorja
JP2009528315A (ja) * 2006-03-01 2009-08-06 ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ シグマ受容体阻害剤としてのピラゾール誘導体
CN101395157A (zh) * 2006-03-01 2009-03-25 伊斯特芬博士实验室有限公司 作为西格玛受体抑制剂的吡唑衍生物

Also Published As

Publication number Publication date
HRP20150788T1 (hr) 2015-08-28
AU2016228207A1 (en) 2016-11-03
ZA201200843B (en) 2012-10-31
US20160220575A1 (en) 2016-08-04
PH12012500286A1 (en) 2015-06-26
IL217911A0 (en) 2012-03-29
EP2464356B1 (de) 2015-05-06
JP2013501754A (ja) 2013-01-17
CN102497864A (zh) 2012-06-13
KR101605151B1 (ko) 2016-03-21
PL2464356T3 (pl) 2015-10-30
CY1116697T1 (el) 2017-03-15
PT2464356E (pt) 2015-08-31
BR112012003053A2 (pt) 2016-08-02
ECSP12011658A (es) 2012-03-30
KR20150140419A (ko) 2015-12-15
TN2012000048A1 (en) 2013-09-19
SI2464356T1 (sl) 2015-08-31
AU2010283761A1 (en) 2012-03-08
AU2010283761B2 (en) 2016-10-13
KR20170125951A (ko) 2017-11-15
DK2464356T3 (en) 2015-07-13
RU2012109554A (ru) 2013-09-20
HUE025642T2 (en) 2016-04-28
CN102497864B (zh) 2015-07-22
HK1171945A1 (en) 2013-04-12
TWI529168B (zh) 2016-04-11
NZ598213A (en) 2014-05-30
CA2770441A1 (en) 2011-02-17
WO2011018487A1 (en) 2011-02-17
IN2012DN02149A (de) 2015-08-07
JP5922575B2 (ja) 2016-05-24
ES2543645T3 (es) 2015-08-20
MY157334A (en) 2016-05-31
UA108859C2 (uk) 2015-06-25
EP2464356A1 (de) 2012-06-20
RU2543382C2 (ru) 2015-02-27
US20160199380A1 (en) 2016-07-14
SMT201500189T1 (it) 2015-09-07
MX2012001877A (es) 2012-04-11
KR20120055692A (ko) 2012-05-31
US20120141606A1 (en) 2012-06-07
AR077876A1 (es) 2011-09-28
MA33569B1 (fr) 2012-09-01
TW201121959A (en) 2011-07-01
CO6511240A2 (es) 2012-08-31
EP2292236A1 (de) 2011-03-09
SG178338A1 (en) 2012-03-29
AU2016228207B2 (en) 2017-09-07

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Legal Events

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EEER Examination request

Effective date: 20150703

MKLA Lapsed

Effective date: 20200831