MA33569B1 - Ligands sigma pour la prevention ou le traitement de la douleur induite par la chimiotherapie - Google Patents
Ligands sigma pour la prevention ou le traitement de la douleur induite par la chimiotherapieInfo
- Publication number
- MA33569B1 MA33569B1 MA34669A MA34669A MA33569B1 MA 33569 B1 MA33569 B1 MA 33569B1 MA 34669 A MA34669 A MA 34669A MA 34669 A MA34669 A MA 34669A MA 33569 B1 MA33569 B1 MA 33569B1
- Authority
- MA
- Morocco
- Prior art keywords
- prevention
- treatment
- sigma
- ligament
- chemotherapy pain
- Prior art date
Links
- 230000002265 prevention Effects 0.000 title abstract 2
- 238000002512 chemotherapy Methods 0.000 title 1
- 210000003041 ligament Anatomy 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 2
- 229940123237 Taxane Drugs 0.000 abstract 1
- 229940122803 Vinca alkaloid Drugs 0.000 abstract 1
- 229940044683 chemotherapy drug Drugs 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 229910052697 platinum Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA PRÉSENTE INVENTION CONCERNE L'UTILISATION D'UN LIGAND SIGMA DE FORMULE (I) POUR LA PRÉVENTION OU LE TRAITEMENT DE LA DOULEUR INDUITE PAR UN AGENT CHIMIOTHÉRAPEUTIQUE, EN PARTICULIER LA DOULEUR INDUITE PAR DES TAXANES, DES VINCA-ALCALOÏDES OU DES MÉDICAMENTS CHIMIOTHÉRAPEUTIQUES CONTENANT DU PLATINE.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09382144A EP2292236A1 (fr) | 2009-08-14 | 2009-08-14 | Ligands sigma pour la prévention ou le traitement de douleurs induites par la chimiothérapie |
| PCT/EP2010/061720 WO2011018487A1 (fr) | 2009-08-14 | 2010-08-12 | Ligands sigma pour la prévention ou le traitement de la douleur induite par la chimiothérapie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA33569B1 true MA33569B1 (fr) | 2012-09-01 |
Family
ID=41531868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA34669A MA33569B1 (fr) | 2009-08-14 | 2012-03-08 | Ligands sigma pour la prevention ou le traitement de la douleur induite par la chimiotherapie |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US20120141606A1 (fr) |
| EP (2) | EP2292236A1 (fr) |
| JP (1) | JP5922575B2 (fr) |
| KR (3) | KR20150140419A (fr) |
| CN (1) | CN102497864B (fr) |
| AR (1) | AR077876A1 (fr) |
| AU (2) | AU2010283761B2 (fr) |
| BR (1) | BR112012003053A2 (fr) |
| CA (1) | CA2770441C (fr) |
| CO (1) | CO6511240A2 (fr) |
| CY (1) | CY1116697T1 (fr) |
| DK (1) | DK2464356T3 (fr) |
| EC (1) | ECSP12011658A (fr) |
| ES (1) | ES2543645T3 (fr) |
| HR (1) | HRP20150788T1 (fr) |
| HU (1) | HUE025642T2 (fr) |
| IL (1) | IL217911A0 (fr) |
| IN (1) | IN2012DN02149A (fr) |
| MA (1) | MA33569B1 (fr) |
| MX (1) | MX2012001877A (fr) |
| MY (1) | MY157334A (fr) |
| NZ (1) | NZ598213A (fr) |
| PH (1) | PH12012500286A1 (fr) |
| PL (1) | PL2464356T3 (fr) |
| PT (1) | PT2464356E (fr) |
| RU (1) | RU2543382C2 (fr) |
| SG (1) | SG178338A1 (fr) |
| SI (1) | SI2464356T1 (fr) |
| SM (1) | SMT201500189T1 (fr) |
| TN (1) | TN2012000048A1 (fr) |
| TW (1) | TWI529168B (fr) |
| UA (1) | UA108859C2 (fr) |
| WO (1) | WO2011018487A1 (fr) |
| ZA (1) | ZA201200843B (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2116539A1 (fr) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles en tant que ligands améliorant les effets analgésiques des opioïdes et réduisant leur dépendance |
| EP2353598A1 (fr) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour utilisation dans la prévention et/ou le traitement de la douleur post-opératoire |
| EP2353591A1 (fr) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour la potentialisation de l'effet analgésique d'opioïdes et d'opiacés dans la douleur post-opératoire et en atténuant la dépendance |
| EP2388005A1 (fr) * | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Ligands sigma pour la prévention et/ou le traitement du vomissement induit par la chimiothérapie ou la radiothérapie |
| EP2415471A1 (fr) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Utilisation de ligands sigma dans l'hyperalgie induite par opioïdes |
| EP2426111A1 (fr) * | 2010-08-09 | 2012-03-07 | Laboratorios Del. Dr. Esteve, S.A. | Formes cristallines de chlorhydrate de 4-[-2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine |
| EP2524694A1 (fr) * | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Utilisation de ligands sigma dans la douleur liée au diabète de type 2 |
| EP2792352A1 (fr) | 2013-04-16 | 2014-10-22 | Laboratorios Del. Dr. Esteve, S.A. | Combinaisons comprenants un ligand de receptor Sigma et un ligand de réceptor adrénergic-alpha-2 |
| CN105611925A (zh) * | 2013-09-12 | 2016-05-25 | 埃斯蒂维实验室股份有限公司 | NSAID与σ受体配体的组合物 |
| AU2014364644A1 (en) | 2013-12-17 | 2016-06-23 | Laboratorios Del Dr. Esteve, S.A. | Gabapentinoids and Sigma receptor ligands combinations |
| TN2016000228A1 (en) | 2013-12-17 | 2017-10-06 | Esteve Labor Dr | SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS. |
| AR108682A1 (es) * | 2016-06-06 | 2018-09-12 | Esteve Labor Dr | Derivados de pirazol-3-iloxi ligandos del receptor sigma |
| CA3121202A1 (fr) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Composes pyrrole et pyrazole et leurs procedes d'utilisation |
| WO2024105225A1 (fr) * | 2022-11-18 | 2024-05-23 | Universitat De Barcelona | Combinaisons synergiques d'un antagoniste du récepteur sigma 1 (s1r) et d'un inhibiteur d'époxyde hydrolase soluble (sehi) et leur utilisation dans le traitement de la douleur |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU11248A1 (ru) | 1927-03-29 | 1929-09-30 | В.С. Григорьев | Способ очистки антрацена |
| FR2301250A1 (fr) * | 1975-02-21 | 1976-09-17 | Bellon Labor Sa Roger | Nouveaux diaryl-1, 4o-aminoalcoxy-3 pyrazoles et leurs sels |
| EP1634872A1 (fr) * | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Dérivés de pyrazole en tant qu'inhibiteurs des récepteurs sigma |
| CA2576144C (fr) | 2004-08-27 | 2012-12-11 | Laboratorios Del Dr. Esteve, S.A. | Inhibiteurs de recepteur sigma |
| SI1781618T1 (sl) * | 2004-08-27 | 2013-01-31 | Laboratorios Del Dr. Esteve, S.A. | Inhibitorji sigma receptorja |
| JP2009528315A (ja) * | 2006-03-01 | 2009-08-06 | ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ | シグマ受容体阻害剤としてのピラゾール誘導体 |
| CN101395157A (zh) * | 2006-03-01 | 2009-03-25 | 伊斯特芬博士实验室有限公司 | 作为西格玛受体抑制剂的吡唑衍生物 |
-
2009
- 2009-08-14 EP EP09382144A patent/EP2292236A1/fr not_active Withdrawn
-
2010
- 2010-08-10 TW TW099126632A patent/TWI529168B/zh not_active IP Right Cessation
- 2010-08-12 JP JP2012524233A patent/JP5922575B2/ja active Active
- 2010-08-12 NZ NZ598213A patent/NZ598213A/en not_active IP Right Cessation
- 2010-08-12 PL PL10744560T patent/PL2464356T3/pl unknown
- 2010-08-12 AU AU2010283761A patent/AU2010283761B2/en not_active Ceased
- 2010-08-12 RU RU2012109554/04A patent/RU2543382C2/ru not_active IP Right Cessation
- 2010-08-12 EP EP10744560.3A patent/EP2464356B1/fr active Active
- 2010-08-12 PT PT107445603T patent/PT2464356E/pt unknown
- 2010-08-12 MX MX2012001877A patent/MX2012001877A/es active IP Right Grant
- 2010-08-12 US US13/389,733 patent/US20120141606A1/en not_active Abandoned
- 2010-08-12 IN IN2149DEN2012 patent/IN2012DN02149A/en unknown
- 2010-08-12 SG SG2012009098A patent/SG178338A1/en unknown
- 2010-08-12 KR KR1020157034281A patent/KR20150140419A/ko not_active Ceased
- 2010-08-12 CN CN201080036098.6A patent/CN102497864B/zh active Active
- 2010-08-12 WO PCT/EP2010/061720 patent/WO2011018487A1/fr not_active Ceased
- 2010-08-12 BR BR112012003053A patent/BR112012003053A2/pt not_active IP Right Cessation
- 2010-08-12 KR KR1020177028558A patent/KR20170125951A/ko not_active Ceased
- 2010-08-12 MY MYPI2012000561A patent/MY157334A/en unknown
- 2010-08-12 ES ES10744560.3T patent/ES2543645T3/es active Active
- 2010-08-12 DK DK10744560.3T patent/DK2464356T3/en active
- 2010-08-12 PH PH1/2012/500286A patent/PH12012500286A1/en unknown
- 2010-08-12 HR HRP20150788TT patent/HRP20150788T1/hr unknown
- 2010-08-12 HU HUE10744560A patent/HUE025642T2/en unknown
- 2010-08-12 SI SI201030977T patent/SI2464356T1/sl unknown
- 2010-08-12 KR KR1020127006715A patent/KR101605151B1/ko not_active Expired - Fee Related
- 2010-08-12 CA CA2770441A patent/CA2770441C/fr not_active Expired - Fee Related
- 2010-08-13 AR ARP100102983A patent/AR077876A1/es unknown
- 2010-12-08 UA UAA201202969A patent/UA108859C2/ru unknown
-
2012
- 2012-01-31 TN TNP2012000048A patent/TN2012000048A1/en unknown
- 2012-02-02 IL IL217911A patent/IL217911A0/en unknown
- 2012-02-03 ZA ZA2012/00843A patent/ZA201200843B/en unknown
- 2012-02-09 EC ECSP12011658 patent/ECSP12011658A/es unknown
- 2012-03-08 MA MA34669A patent/MA33569B1/fr unknown
- 2012-03-14 CO CO12044528A patent/CO6511240A2/es not_active Application Discontinuation
-
2015
- 2015-07-15 CY CY20151100618T patent/CY1116697T1/el unknown
- 2015-08-05 SM SM201500189T patent/SMT201500189T1/xx unknown
-
2016
- 2016-03-17 US US15/073,460 patent/US20160199380A1/en not_active Abandoned
- 2016-04-07 US US15/093,589 patent/US20160220575A1/en not_active Abandoned
- 2016-09-14 AU AU2016228207A patent/AU2016228207B2/en not_active Ceased
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