CA2937417C - Procede ameliore pour la preparation de trazodone et son sel de chlorhydrate - Google Patents

Procede ameliore pour la preparation de trazodone et son sel de chlorhydrate Download PDF

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Publication number
CA2937417C
CA2937417C CA2937417A CA2937417A CA2937417C CA 2937417 C CA2937417 C CA 2937417C CA 2937417 A CA2937417 A CA 2937417A CA 2937417 A CA2937417 A CA 2937417A CA 2937417 C CA2937417 C CA 2937417C
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CA
Canada
Prior art keywords
compound
trazodone
alcohol
hydrochloride
free base
Prior art date
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Active
Application number
CA2937417A
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English (en)
Other versions
CA2937417A1 (fr
Inventor
Shashikant KADAM
Narender Rao SOMISETTI
Srinivas ASHILI
Narsimulu RAIGONI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Piramal Pharma Ltd
Original Assignee
Piramal Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Piramal Pharma Ltd filed Critical Piramal Pharma Ltd
Publication of CA2937417A1 publication Critical patent/CA2937417A1/fr
Application granted granted Critical
Publication of CA2937417C publication Critical patent/CA2937417C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La présente invention concerne un procédé amélioré pour la préparation de trazodone et son sel de chlorhydrate sensiblement pur. Le procédé comprend la réaction du composé II (comme décrit) avec le composé III (comme décrit) facultativement en présence d'une base inorganique, et d'un catalyseur ; dans lequel, dans ledit procédé la trazodone base libre et/ou son sel de chlorhydrate sont isolés par précipitation à une température plus basse. Le procédé amélioré pour la préparation de chlorhydrate de trazodone (composé I) permet d'obtenir le produit avec une quantité totale de substances alkylantes (comme spécifié dans la description) en tant qu'impureté inférieure à 10 ppm. Le procédé amélioré pour la préparation de chlorhydrate de trazodone (composé I) permet d'obtenir le produit avec une quantité totale de 1-(3-chlorophényl)-4-(3-chloropropyl)pipérazine en tant qu'impureté inférieure à 2,5 ppm.
CA2937417A 2014-01-21 2014-12-12 Procede ameliore pour la preparation de trazodone et son sel de chlorhydrate Active CA2937417C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN203/MUM/2014 2014-01-21
IN203MU2014 IN2014MU00203A (fr) 2014-01-21 2014-12-12
PCT/IB2014/066841 WO2015110883A1 (fr) 2014-01-21 2014-12-12 Procédé amélioré pour la préparation de trazodone et son sel de chlorhydrate

Publications (2)

Publication Number Publication Date
CA2937417A1 CA2937417A1 (fr) 2015-07-30
CA2937417C true CA2937417C (fr) 2022-04-12

Family

ID=53680891

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2937417A Active CA2937417C (fr) 2014-01-21 2014-12-12 Procede ameliore pour la preparation de trazodone et son sel de chlorhydrate

Country Status (6)

Country Link
EP (1) EP3097099A4 (fr)
JP (1) JP2017505302A (fr)
CA (1) CA2937417C (fr)
IL (1) IL246835A0 (fr)
IN (1) IN2014MU00203A (fr)
WO (1) WO2015110883A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL234822B1 (pl) 2017-03-14 2020-04-30 Politechnika Krakowska Im Tadeusza Kosciuszki Sposób otrzymywania trazodonu
CN117517545A (zh) * 2023-12-08 2024-02-06 重庆锐恩医药有限公司 一种盐酸曲唑酮有关物质检测方法
WO2025220036A1 (fr) * 2024-04-16 2025-10-23 Medilux Laboratories Pvt. Ltd. Nouveau procédé de préparation de chlorhydrate de trazodone

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1066857B (it) * 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
US4252806A (en) * 1979-09-24 1981-02-24 Mead Johnson & Company Triazoloquinolones
HU201324B (en) * 1988-07-29 1990-10-28 Egyt Gyogyszervegyeszeti Gyar New process for production of substituated 1,2,4-triasole (4,3-a)-piridin-2 (2h)-on
ITMI20071603A1 (it) * 2007-08-03 2009-02-04 Acraf Trazodone e trazodone cloridrato in forma purificata
WO2009105604A1 (fr) * 2008-02-20 2009-08-27 Auspex Pharmaceuticals, Inc. Triazolopyridines substituées

Also Published As

Publication number Publication date
EP3097099A1 (fr) 2016-11-30
JP2017505302A (ja) 2017-02-16
EP3097099A4 (fr) 2017-08-23
WO2015110883A1 (fr) 2015-07-30
CA2937417A1 (fr) 2015-07-30
IL246835A0 (en) 2016-08-31
IN2014MU00203A (fr) 2015-09-25

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