CH149014A - Process for the preparation of an N-substituted compound of the pyridone series. - Google Patents

Process for the preparation of an N-substituted compound of the pyridone series.

Info

Publication number
CH149014A
CH149014A CH149014DA CH149014A CH 149014 A CH149014 A CH 149014A CH 149014D A CH149014D A CH 149014DA CH 149014 A CH149014 A CH 149014A
Authority
CH
Switzerland
Prior art keywords
preparation
substituted compound
pyridone
pyridone series
series
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH149014A publication Critical patent/CH149014A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Darstellung einer N-substituierten Verbindung der Pyridonreihe.    Es wurde gefunden, dass man     zu    einer  N-substituierten Verbindung der     Pyridon-          reihe    gelangen kann, wenn man     2-Di-          äthylaminoäthoxypyridin-    3 -     carbonsäureani-          lid    durch Erwärmen umlagert.  



  Das entstandene     N-Diätliylaminoäthyl-2-          pyridon-3-carbonsäureanilid    siedet bei 250    unter 0,03 mm Druck. Es ist in organischen  Lösungsmitteln, sowie in Säuren löslich. Das  farblose Monochlorhydrat schmilzt bei 195  .  



  Die neue Base soll für therapeutische  Zwecke Verwendung finden.  



  Beispiel:  2 - Diäthylaminoäthoxypyridin - 3 -     carbon-          säureanilid    wird durch Erhitzen auf etwa  2 M bis 270' umgelagert.



  Process for the preparation of an N-substituted compound of the pyridone series. It has been found that an N-substituted compound of the pyridone series can be obtained if 2-diethylaminoethoxypyridine-3-carboxylic acid anilide is rearranged by heating.



  The resulting N-dietliylaminoethyl-2-pyridone-3-carboxylic acid anilide boils at 250 under 0.03 mm pressure. It is soluble in organic solvents as well as acids. The colorless monochlorohydrate melts at 195.



  The new base will be used for therapeutic purposes.



  Example: 2 - diethylaminoethoxypyridine - 3 - carboxylic acid anilide is rearranged by heating to about 2M up to 270 '.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung einer N-sub- stituierten Verbindung der Pyridonreihe, da durch gekennzeichnet, dass man 2-Di- äthylaminoäthoxypyridin-3 - carbonsäureani- lid durch Erwärmen umlagert. Das entstandene N-Diäthylaminoäthyl-2- pyridon-3-carbonsäureanilid siedet bei 205 " unter 0,03 mm Druck. Es ist in organischen Lösungsmitteln, sowie in Säuren löslich. Das farblose Monochlorhydrat schmilzt bei<B>195</B> . Die neue Base soll für therapeutische Zwecke Verwendung finden. PATENT CLAIM: Process for the preparation of an N-substituted compound of the pyridone series, characterized in that 2-diethylaminoethoxypyridine-3-carboxylic acid anilide is rearranged by heating. The resulting N-diethylaminoethyl-2-pyridone-3-carboxylic acid anilide boils at 205 "under 0.03 mm pressure. It is soluble in organic solvents and acids. The colorless monochlorohydrate melts at 195. The new base should be used for therapeutic purposes.
CH149014D 1929-08-10 1929-08-10 Process for the preparation of an N-substituted compound of the pyridone series. CH149014A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH146709T 1929-08-10
CH149014T 1929-08-10

Publications (1)

Publication Number Publication Date
CH149014A true CH149014A (en) 1931-08-15

Family

ID=25714917

Family Applications (1)

Application Number Title Priority Date Filing Date
CH149014D CH149014A (en) 1929-08-10 1929-08-10 Process for the preparation of an N-substituted compound of the pyridone series.

Country Status (1)

Country Link
CH (1) CH149014A (en)

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