CH149010A - Process for the preparation of an N-substituted compound of the pyridone series. - Google Patents
Process for the preparation of an N-substituted compound of the pyridone series.Info
- Publication number
- CH149010A CH149010A CH149010DA CH149010A CH 149010 A CH149010 A CH 149010A CH 149010D A CH149010D A CH 149010DA CH 149010 A CH149010 A CH 149010A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- substituted compound
- pyridone
- pyridone series
- series
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims description 4
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 3
- 238000002360 preparation method Methods 0.000 title claims description 3
- 239000000155 melt Substances 0.000 claims description 4
- NQKOVVLSDQFPQP-UHFFFAOYSA-N 2-[2-(dimethylamino)ethoxy]-N-phenylpyridine-3-carboxamide Chemical compound CN(CCOC1=NC=CC=C1C(=O)NC1=CC=CC=C1)C NQKOVVLSDQFPQP-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 150000003931 anilides Chemical class 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Darstellung einer N-substituierten Verbindung der Pyridonreihe. Es wurde gefunden, dass man zu einer N-substituierten Verbindung der Pyridonreihe gelangen kann, wenn man 2-Dimethylamino- äthoxypyridin-3-carbonsäureanilid durch Er wärmen umlagert.
Das entstandene N-Dimethylaminoäthyl- 2-pyridon-3-carborisäureanilid schmilzt bei 88 . Es ist in organischen Lösungsmitteln, sowie in Säuren löslich. Das farblose Monochlor hydrat schmilzt bei<B>2180.</B>
Die neue Base soll für therapeutische Zwecke Verwendung finden.
<I>Beispiel:</I> 2-Dimethylaminoäthoxypyridin - 3 - carbon- säureanilid wird durch Erhitzen auf etwa 220<B>0</B> bis 270 umgelagert.
Process for the preparation of an N-substituted compound of the pyridone series. It has been found that an N-substituted compound of the pyridone series can be obtained if 2-dimethylamino ethoxypyridine-3-carboxylic acid anilide is rearranged by warming it.
The resulting N-dimethylaminoethyl-2-pyridone-3-carboric anilide melts at 88. It is soluble in organic solvents as well as acids. The colorless monochlorohydrate melts at <B> 2180. </B>
The new base will be used for therapeutic purposes.
<I> Example: </I> 2-Dimethylaminoethoxypyridine - 3 - carboxylic acid anilide is rearranged by heating to around 220 <B> 0 </B> to 270.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH149010T | 1929-08-10 | ||
| CH146709T | 1929-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH149010A true CH149010A (en) | 1931-08-15 |
Family
ID=25714913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH149010D CH149010A (en) | 1929-08-10 | 1929-08-10 | Process for the preparation of an N-substituted compound of the pyridone series. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH149010A (en) |
-
1929
- 1929-08-10 CH CH149010D patent/CH149010A/en unknown
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