CH235236A - Process for the preparation of 2 ', 3', 5'-trimethyl-cyclopentane-1 ', 5-spiro-1-methyl-2,4,6-triketo-hexahydropyrimidine. - Google Patents
Process for the preparation of 2 ', 3', 5'-trimethyl-cyclopentane-1 ', 5-spiro-1-methyl-2,4,6-triketo-hexahydropyrimidine.Info
- Publication number
- CH235236A CH235236A CH235236DA CH235236A CH 235236 A CH235236 A CH 235236A CH 235236D A CH235236D A CH 235236DA CH 235236 A CH235236 A CH 235236A
- Authority
- CH
- Switzerland
- Prior art keywords
- sep
- methyl
- spiro
- hexahydropyrimidine
- triketo
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title description 2
- 230000000694 effects Effects 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 230000003533 narcotic effect Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Description
Verfahren zur Herstellung von 2',3',5'-Trimethyl-eyelopentan-1',5-spiro-l-methyl- 2,4,6-tr iketo-hegahydropyr imidin.
EMI0001.0005
Gegenstand <SEP> vorliegenden <SEP> Zusatzpatentes
<tb> iGt <SEP> :ein <SEP> Verfahren <SEP> zur <SEP> Herstellung <SEP> von
<tb> 2',3', <SEP> 5' <SEP> - <SEP> Trilmethyl <SEP> - <SEP> cyelloipentan@-, <SEP> 1', <SEP> 5 <SEP> - <SEP> sl)iro,-1 methyl <SEP> - <SEP> 2,4,6 <SEP> - <SEP> triketo <SEP> - <SEP> hexahydropyrimi-diin,
<tb> welzhea <SEP> dadurch <SEP> gekennzeichnet <SEP> ist, <SEP> dass <SEP> man
<tb> 2, <SEP> 3, <SEP> 5-Tri@m!ethyl <SEP> - <SEP> cyclopentan-l-cyan-1-oarbon sä.ureester <SEP> mit <SEP> Methyiha:
rnstoff <SEP> kondensiert
<tb> und <SEP> das <SEP> erhaltene <SEP> Produkt <SEP> anschliessend <SEP> der
<tb> Hydfrolyse <SEP> unterwirft.
<tb>
Die <SEP> neue <SEP> Verbindung <SEP> ist <SEP> ein <SEP> ho:ch.visk <SEP> oses,
<tb> schwach <SEP> gelblich <SEP> gefärbtes <SEP> 01, <SEP> Kp.,)" <SEP> 139 <SEP> bis
<tb> 141 . <SEP> Sie <SEP> beeitzt <SEP> na-rkotisehe <SEP> Wirkung.
<tb>
<I>Bespiel:</I>
<tb> Zu <SEP> einer <SEP> Lösung <SEP> von <SEP> 4,6 <SEP> Teilen <SEP> Natrium
<tb> in <SEP> 70 <SEP> T'ei,len <SEP> ab@solutern <SEP> Alkohol <SEP> fügt <SEP> man
<tb> 20,9 <SEP> Teile <SEP> 2,3,5-Trimethyl-cyclopentan-l cyan-1-carbans@äureäthyleisteir <SEP> und <SEP> 7 <SEP> Teile
<tb> Meithylbfarnstoff <SEP> und <SEP> erhitzt <SEP> 10 <SEP> Stunden <SEP> lang
<tb> untrer <SEP> Rückflussikühlung. <SEP> Hierauf <SEP> destilliert
<tb> mann <SEP> den <SEP> Alkohol <SEP> ab <SEP> und <SEP> erhitzt <SEP> den <SEP> Rück-
EMI0001.0006
,stand <SEP> mit <SEP> der <SEP> 66:e:
chsfachen <SEP> Menge <SEP> Schwefel säure <SEP> (25%ig) <SEP> 8 <SEP> .Stunden, <SEP> lang <SEP> zum <SEP> Sieden.
<tb> Die <SEP> neue <SEP> Verbindung <SEP> lä@sst <SEP> ,sich <SEP> nicht <SEP> im. <SEP> kri stallisiemter <SEP> Form <SEP> erhalten, <SEP> sie <SEP> wird <SEP> durch
<tb> Ausäthern <SEP> isoliert <SEP> und <SEP> nach <SEP> dem <SEP> Trocknen
<tb> über <SEP> entwässertem <SEP> Natriumsulfat <SEP> und <SEP> Ver jagen <SEP> des <SEP> Äthers <SEP> im <SEP> Vakuum <SEP> destilliert.
Process for the preparation of 2 ', 3', 5'-trimethyl-eyelopentan-1 ', 5-spiro-1-methyl-2,4,6-triketo-hegahydropyrimidine.
EMI0001.0005
Subject <SEP> of the present <SEP> additional patent
<tb> iGt <SEP>: a <SEP> process <SEP> for <SEP> production <SEP> of
<tb> 2 ', 3', <SEP> 5 '<SEP> - <SEP> Trilmethyl <SEP> - <SEP> cyelloipentan @ -, <SEP> 1', <SEP> 5 <SEP> - <SEP> sl) iro, -1 methyl <SEP> - <SEP> 2,4,6 <SEP> - <SEP> triketo <SEP> - <SEP> hexahydropyrimi-diyne,
<tb> welzhea <SEP> characterized by <SEP> <SEP>, <SEP> that <SEP> man
<tb> 2, <SEP> 3, <SEP> 5-Tri @ m! ethyl <SEP> - <SEP> cyclopentane-1-cyano-1-carbonic acid ester <SEP> with <SEP> Methyiha:
substance <SEP> condensed
<tb> and <SEP> the <SEP> received <SEP> product <SEP> then <SEP> the
<tb> Subject to hydrolysis <SEP>.
<tb>
The <SEP> new <SEP> connection <SEP> is <SEP> a <SEP> ho: ch.visk <SEP> oses,
<tb> weak <SEP> yellowish <SEP> colored <SEP> 01, <SEP> Kp.,) "<SEP> 139 <SEP> to
<tb> 141. <SEP> You <SEP> mitzt <SEP> na-rkotisehe <SEP> effect.
<tb>
<I> Example: </I>
<tb> To <SEP> a <SEP> solution <SEP> of <SEP> 4.6 <SEP> parts <SEP> sodium
<tb> in <SEP> 70 <SEP> parts <SEP> from @ solutern <SEP> alcohol <SEP> adds <SEP> man
<tb> 20.9 <SEP> parts <SEP> 2,3,5-trimethyl-cyclopentane-1 cyan-1-carbans @ äureäthyleisteir <SEP> and <SEP> 7 <SEP> parts
<tb> Meithylbfarnstoff <SEP> and <SEP> heated <SEP> for 10 <SEP> hours <SEP>
<tb> under <SEP> reflux cooling. <SEP> Then <SEP> distilled
<tb> man <SEP> heats <SEP> alcohol <SEP> from <SEP> and <SEP> <SEP> the <SEP> return
EMI0001.0006
, stood <SEP> with <SEP> the <SEP> 66: e:
xfold <SEP> amount <SEP> sulfuric acid <SEP> (25%) <SEP> 8 <SEP>. hours, <SEP> long <SEP> for <SEP> boiling.
<tb> The <SEP> new <SEP> connection <SEP> leaves <SEP>, <SEP> not <SEP> in. <SEP> crystallized <SEP> form <SEP> received, <SEP> it <SEP> becomes <SEP>
<tb> Ethering <SEP> isolates <SEP> and <SEP> after <SEP> the <SEP> drying
<tb> over <SEP> dehydrated <SEP> sodium sulfate <SEP> and <SEP> expelling <SEP> the <SEP> ether <SEP> distilled in the <SEP> vacuum <SEP>.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH235236T | 1942-07-29 | ||
| CH230367T | 1942-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH235236A true CH235236A (en) | 1944-11-15 |
Family
ID=25727475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH235236D CH235236A (en) | 1942-07-29 | 1942-07-29 | Process for the preparation of 2 ', 3', 5'-trimethyl-cyclopentane-1 ', 5-spiro-1-methyl-2,4,6-triketo-hexahydropyrimidine. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH235236A (en) |
-
1942
- 1942-07-29 CH CH235236D patent/CH235236A/en unknown
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