CH307559A - Process for the preparation of a diammonium compound. - Google Patents
Process for the preparation of a diammonium compound.Info
- Publication number
- CH307559A CH307559A CH307559DA CH307559A CH 307559 A CH307559 A CH 307559A CH 307559D A CH307559D A CH 307559DA CH 307559 A CH307559 A CH 307559A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- diammonium compound
- ethoxy
- bis
- octane
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 5
- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 claims description 3
- 229940073608 benzyl chloride Drugs 0.000 claims description 3
- XXBDWLFCJWSEKW-UHFFFAOYSA-N dimethylbenzylamine Chemical compound CN(C)CC1=CC=CC=C1 XXBDWLFCJWSEKW-UHFFFAOYSA-N 0.000 claims description 3
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000155 melt Substances 0.000 claims description 2
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 229940126601 medicinal product Drugs 0.000 description 2
- 238000001816 cooling Methods 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 150000003839 salts Chemical group 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
<B>verfahren</B> zur <B>Herstellung einer</B> Diammoniumverhindung. Gegenstand des vorliegenden Patentes ist ein Verfahren zur Herstellung einer Diammo- niumverbindung. Das Verfahren ist dadurch gekennzeichnet, da.ss man auf 1 Mol 1,8-Bis- (ss-dimethylamino-äthoxy)-oktan 2 Mol Ben- zylehlorid einwirken lässt.
Die erhaltene neue Verbindung, das 1,8- Bis- [ss- (benzyl-dimethyl-ammonium) - äthoxy ] - oktan-dichlorid, sehmilzt bei 135 . Sie soll als Arzneimittel und als Zwischenprodukt für Arzneimittel Verwendung finden.
<I>Beispiel:</I> 2,88 Teile 1.,8-Bis-(ss-dimethylamino-äth- oxy)-oktan und 3 Teile Benzylchlorid werden in 20 Teilen Butanon etwa 14 Stunden unter Rüekfluss gekocht.
Nach Kühlen wird das ab- geschiedene rohe quartäre Salz abgetrennt und aus Butanon unter Zugabe von wenig Isopro- panol oder Methanol umkristallisiert. Hierauf trocknet man bei 50-60 im Hochvakuum. Das 1,8-Bis-[ss-(benzyl-dimethyl-ammonium)- äthoxy]-oktan-diehlorid sehmilzt bei 135 .
<B> Process </B> for <B> producing </B> a diammonium compound. The present patent is a process for the production of a diammonium compound. The process is characterized in that 2 moles of benzyl chloride are allowed to act on 1 mole of 1,8-bis (ss-dimethylamino-ethoxy) octane.
The new compound obtained, 1,8-bis- [ss- (benzyl-dimethyl-ammonium) -ethoxy] -octane dichloride, sehmelt at 135. It should be used as a medicinal product and as an intermediate product for medicinal products.
<I> Example: </I> 2.88 parts of 1., 8-bis (ss-dimethylamino-ethoxy) octane and 3 parts of benzyl chloride are refluxed in 20 parts of butanone for about 14 hours.
After cooling, the precipitated crude quaternary salt is separated off and recrystallized from butanone with the addition of a little isopropanol or methanol. It is then dried at 50-60 in a high vacuum. The 1,8-bis- [ss- (benzyl-dimethyl-ammonium) -ethoxy] -octane-dichloride melts at 135.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH305890T | 1952-04-21 | ||
| CH307559T | 1952-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH307559A true CH307559A (en) | 1955-05-31 |
Family
ID=25735024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH307559D CH307559A (en) | 1952-04-21 | 1952-04-21 | Process for the preparation of a diammonium compound. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH307559A (en) |
-
1952
- 1952-04-21 CH CH307559D patent/CH307559A/en unknown
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