CH536836A - Verfahren zur Herstellung neuer Benzolsulfonyl-semicarbazide - Google Patents

Verfahren zur Herstellung neuer Benzolsulfonyl-semicarbazide

Info

Publication number: CH536836A
Authority: CH; Switzerland
Prior art keywords: pentamethylene; benzenesulfonyl; sodium hydroxide; converted; hydroxide solution
Prior art date: 1961-09-02

Application number

CH604066A

Other languages

German (de)

English (en)

Inventor

Adolf Dr Hagedorn

Ruth Dr Heerdt

Johann Daniel Prof Dr Achelis

Walter Dr Aumueller

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1961-09-02

Filing date

1962-08-08

Publication date

1973-06-29

1962-08-08 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1962-08-08 Priority to CH470573A priority Critical patent/CH536838A/de

1973-06-29 Publication of CH536836A publication Critical patent/CH536836A/de

Links

HTJPCEFRNUKJKU-UHFFFAOYSA-N benzene;(sulfonylamino)urea Chemical class C1=CC=CC=C1.NC(=O)NN=S(=O)=O HTJPCEFRNUKJKU-UHFFFAOYSA-N 0.000 title 1
230000002218 hypoglycaemic effect Effects 0.000 title 1
125000002947 alkylene group Chemical group 0.000 claims abstract description 5
LSNDGFYQJRXEAR-UHFFFAOYSA-N benzenesulfonamidourea Chemical class NC(=O)NNS(=O)(=O)C1=CC=CC=C1 LSNDGFYQJRXEAR-UHFFFAOYSA-N 0.000 claims abstract description 5
229910052736 halogen Inorganic materials 0.000 claims abstract description 5
230000007062 hydrolysis Effects 0.000 claims abstract description 5
238000006460 hydrolysis reaction Methods 0.000 claims abstract description 5
150000003839 salts Chemical class 0.000 claims abstract description 5
238000006243 chemical reaction Methods 0.000 claims abstract description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
238000000034 method Methods 0.000 claims description 10
-1 p-chlorobenzenesulfonyl Chemical group 0.000 claims description 8
125000004432 carbon atom Chemical group C* 0.000 claims description 6
229910000474 mercury oxide Inorganic materials 0.000 claims description 6
UKWHYYKOEPRTIC-UHFFFAOYSA-N mercury(ii) oxide Chemical compound [Hg]=O UKWHYYKOEPRTIC-UHFFFAOYSA-N 0.000 claims description 6
238000002360 preparation method Methods 0.000 claims description 6
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
150000001875 compounds Chemical class 0.000 claims description 4
206010012601 diabetes mellitus Diseases 0.000 claims description 4
239000000706 filtrate Substances 0.000 claims description 4
150000002367 halogens Chemical group 0.000 claims description 4
239000000047 product Substances 0.000 claims description 4
QXKXDIKCIPXUPL-UHFFFAOYSA-N sulfanylidenemercury Chemical compound [Hg]=S QXKXDIKCIPXUPL-UHFFFAOYSA-N 0.000 claims description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 claims description 2
230000003178 anti-diabetic effect Effects 0.000 claims description 2
239000003472 antidiabetic agent Substances 0.000 claims description 2
JWPWVPPTDSULMI-UHFFFAOYSA-N benzenesulfonamidothiourea Chemical class NC(=S)NNS(=O)(=O)C1=CC=CC=C1 JWPWVPPTDSULMI-UHFFFAOYSA-N 0.000 claims description 2
239000008280 blood Substances 0.000 claims description 2
210000004369 blood Anatomy 0.000 claims description 2
239000004202 carbamide Substances 0.000 claims description 2
230000004069 differentiation Effects 0.000 claims description 2
230000000694 effects Effects 0.000 claims description 2
239000000155 melt Substances 0.000 claims description 2
LWJROJCJINYWOX-UHFFFAOYSA-L mercury dichloride Chemical compound Cl[Hg]Cl LWJROJCJINYWOX-UHFFFAOYSA-L 0.000 claims description 2
239000000203 mixture Substances 0.000 claims description 2
229910052757 nitrogen Inorganic materials 0.000 claims description 2
125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
229940127017 oral antidiabetic Drugs 0.000 claims description 2
239000003538 oral antidiabetic agent Substances 0.000 claims description 2
238000006400 oxidative hydrolysis reaction Methods 0.000 claims description 2
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims description 2
LWMPFIOTEAXAGV-UHFFFAOYSA-N piperidin-1-amine Chemical compound NN1CCCCC1 LWMPFIOTEAXAGV-UHFFFAOYSA-N 0.000 claims description 2
238000001953 recrystallisation Methods 0.000 claims description 2
238000007127 saponification reaction Methods 0.000 claims description 2
238000003756 stirring Methods 0.000 claims description 2
239000000725 suspension Substances 0.000 claims description 2
238000002560 therapeutic procedure Methods 0.000 claims description 2
150000003568 thioethers Chemical class 0.000 claims description 2
229910006080 SO2X Inorganic materials 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/28—Nitrogen atoms
- C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06L—DRY-CLEANING, WASHING OR BLEACHING FIBRES, FILAMENTS, THREADS, YARNS, FABRICS, FEATHERS OR MADE-UP FIBROUS GOODS; BLEACHING LEATHER OR FURS
- D06L4/00—Bleaching fibres, filaments, threads, yarns, fabrics, feathers or made-up fibrous goods; Bleaching leather or furs
- D06L4/10—Bleaching fibres, filaments, threads, yarns, fabrics, feathers or made-up fibrous goods; Bleaching leather or furs using agents which develop oxygen
- D06L4/15—Bleaching fibres, filaments, threads, yarns, fabrics, feathers or made-up fibrous goods; Bleaching leather or furs using agents which develop oxygen using organic agents
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/184—Carboxylic acids; Anhydrides, halides or salts thereof
- D06M13/196—Percarboxylic acids; Anhydrides, halides or salts thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Textile Engineering (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CH604066A 1961-09-02 1962-08-08 Verfahren zur Herstellung neuer Benzolsulfonyl-semicarbazide CH536836A (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CH470573A CH536838A (de)	1961-09-02	1962-08-08	Verfahren zur Herstellung neuer Benzolsulfonyl-semicarbazide

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DEB63889A DE1233872B (de)	1961-09-02	1961-09-02	Verfahren zur Herstellung von Benzolsulfonyl-semicarbaziden

Publications (1)

Publication Number	Publication Date
CH536836A true CH536836A (de)	1973-06-29

Family

ID=6974180

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
CH604066A CH536836A (de)	1961-09-02	1962-08-08	Verfahren zur Herstellung neuer Benzolsulfonyl-semicarbazide
CH954262A CH414632A (de)	1961-09-02	1962-08-08	Verfahren zur Herstellung neuer Benzolsulfonylsemicarbazide
CH470473A CH536837A (de)	1961-09-02	1962-08-08	Verfahren zur Herstellung neuer Benzolsulfonyl-semicarbazide

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
CH954262A CH414632A (de)	1961-09-02	1962-08-08	Verfahren zur Herstellung neuer Benzolsulfonylsemicarbazide
CH470473A CH536837A (de)	1961-09-02	1962-08-08	Verfahren zur Herstellung neuer Benzolsulfonyl-semicarbazide

Country Status (9)

Country	Link
AT (1)	AT239249B (fr)
CH (3)	CH536836A (fr)
CY (1)	CY310A (fr)
DE (1)	DE1233872B (fr)
DK (1)	DK102864C (fr)
FR (1)	FR2222M (fr)
GB (1)	GB951029A (fr)
MY (1)	MY6500064A (fr)
OA (1)	OA00405A (fr)

1961
- 1961-09-02 DE DEB63889A patent/DE1233872B/de active Pending
1962
- 1962-07-31 GB GB29360/62A patent/GB951029A/en not_active Expired
- 1962-08-08 CH CH604066A patent/CH536836A/de not_active IP Right Cessation
- 1962-08-08 CH CH954262A patent/CH414632A/de unknown
- 1962-08-08 CH CH470473A patent/CH536837A/de not_active IP Right Cessation
- 1962-08-30 DK DK183463AA patent/DK102864C/da active
- 1962-08-31 AT AT288463A patent/AT239249B/de active
- 1962-11-30 FR FR917201A patent/FR2222M/fr not_active Expired
1964
- 1964-10-15 OA OA50459A patent/OA00405A/fr unknown
1965
- 1965-02-25 CY CY31065A patent/CY310A/xx unknown
- 1965-12-31 MY MY196564A patent/MY6500064A/xx unknown

Also Published As

Publication number	Publication date
GB951029A (en)	1964-03-04
CH954262A4 (fr)	1966-12-30
MY6500064A (en)	1965-12-31
DE1233872B (de)	1967-02-09
OA00405A (fr)	1966-05-15
CH414632A (de)	1966-12-30
FR2222M (fr)	1963-12-23
DK102864C (da)	1965-10-18
CH536837A (de)	1973-06-29
AT239249B (de)	1965-03-25
CY310A (en)	1965-02-25

Legal Events

Date	Code	Title	Description
1978-03-15	PL	Patent ceased

Publication	Publication Date	Title
CH392498A (de)	1965-05-31	Verfahren zur Herstellung von neuen Benzolsulfonyl-cyclohexyl-harnstoffen
CH474490A (de)	1969-06-30	Verfahren zur Herstellung neuer Benzolsulfonylharnstoffe
AT236410B (de)	1964-10-26	Verfahren zur Herstellung von neuen Benzolsulfonyl-alkylen-semicarbaziden
AT219039B (de)	1962-01-10	Verfahren zur Herstellung von neuen Isoindolinderivaten
AT236976B (de)	1964-11-25	Verfahren zur Herstellung von neuen Benzolsulfonylharnstoffen
AT236974B (de)	1964-11-25	Verfahren zur Herstellung von neuen Benzolsulfonylharnstoffen
AT233009B (de)	1964-04-25	Verfahren zur Herstellung neuer Sulfonylsemicarbazide
CH509991A (de)	1971-07-15	Verfahren zur Herstellung von Sulfonamiden
AT214937B (de)	1961-05-10	Verfahren zur Herstellung von neuen N-Arylsulfonyl-N'-tetramethylenharnstoffen
AT219038B (de)	1962-01-10	Verfahren zur Herstellung von neuen Isoindolinderivaten
DE1164398B (de)	1964-03-05	Verfahren zur Herstellung von antidiabetisch wirksamen Derivaten des N-Benzolsulfonyl-N-cyclohexylharnstoffs
AT226728B (de)	1963-04-10	Verfahren zur Herstellung von neuen Benzolsulfonyl-cyclohexyl-harnstoffen
AT236408B (de)	1964-10-26	Verfahren zur Herstellung von neuen Benzolsulfonyl-alkylen-semicarbaziden
AT234114B (de)	1964-06-10	Verfahren zur Herstellung von neuen Benzolsulfonylharnstoffen
AT235845B (de)	1964-09-25	Verfahren zur Herstellung von neuen Benzolsulfonylsemicarbaziden
AT236396B (de)	1964-10-26	Verfahren zur Herstellung von neuen Benzolsulfonylharnstoffen
AT236411B (de)	1964-10-26	Verfahren zur Herstellung von neuen Benzolsulfonyl-semicarbaziden
AT236409B (de)	1964-10-26	Verfahren zur Herstellung von neuen Benzolsulfonyl-semicarbaziden
AT233584B (de)	1964-05-11	Verfahren zur Herstellung von neuen Hydrindensulfonylharnstoffen
AT236402B (de)	1964-10-26	Verfahren zur Herstellung von neuen Benzolsulfonyl-semicarbaziden
DE1206914B (de)	1965-12-16	Verfahren zur Herstellung von Benzolsulfonylharnstoffen
AT212302B (de)	1960-12-12	Verfahren zur Herstellung von neuen Benzophenonsulfonamiden
AT310750B (de)	1973-10-10	Verfahren zur Herstellung von neuen Thiolactamverbindungen und deren Salzen
AT216486B (de)	1961-07-25	Verfahren zur Herstellung von neuen Mercaptoacylamiden
AT268288B (de)	1969-02-10	Verfahren zur Herstellung von neuen antidiabetisch wirksamen Sulfonamiden