CH542218A - Procédé pour préparer des aryl-hydroxy-pyrimidines - Google Patents

Procédé pour préparer des aryl-hydroxy-pyrimidines

Info

Publication number
CH542218A
CH542218A CH772973A CH772973A CH542218A CH 542218 A CH542218 A CH 542218A CH 772973 A CH772973 A CH 772973A CH 772973 A CH772973 A CH 772973A CH 542218 A CH542218 A CH 542218A
Authority
CH
Switzerland
Prior art keywords
pyrimidines
hydroxy
preparing aryl
aryl
preparing
Prior art date
Application number
CH772973A
Other languages
English (en)
French (fr)
Inventor
George De Angelis Gerald
Ernst Hess Hans-Jurgen
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CH542218A publication Critical patent/CH542218A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CH772973A 1970-10-05 1971-10-05 Procédé pour préparer des aryl-hydroxy-pyrimidines CH542218A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7821670A 1970-10-05 1970-10-05

Publications (1)

Publication Number Publication Date
CH542218A true CH542218A (fr) 1973-11-15

Family

ID=22142671

Family Applications (4)

Application Number Title Priority Date Filing Date
CH772973A CH542218A (fr) 1970-10-05 1971-10-05 Procédé pour préparer des aryl-hydroxy-pyrimidines
CH1452971A CH554876A (fr) 1970-10-05 1971-10-05 Procede pour preparer des arylpyrimidines.
CH1532172A CH554346A (fr) 1970-10-05 1971-10-05 Procede pour preparer des arylpyrimidines.
CH1521472A CH554875A (fr) 1970-10-05 1971-10-05 Procede pour preparer des aryl-hydroxy-pyrimidines.

Family Applications After (3)

Application Number Title Priority Date Filing Date
CH1452971A CH554876A (fr) 1970-10-05 1971-10-05 Procede pour preparer des arylpyrimidines.
CH1532172A CH554346A (fr) 1970-10-05 1971-10-05 Procede pour preparer des arylpyrimidines.
CH1521472A CH554875A (fr) 1970-10-05 1971-10-05 Procede pour preparer des aryl-hydroxy-pyrimidines.

Country Status (16)

Country Link
US (1) US3707560A (2)
JP (2) JPS5648511B1 (2)
AT (4) AT316563B (2)
AU (1) AU465734B2 (2)
BE (1) BE773484A (2)
CA (1) CA988519A (2)
CH (4) CH542218A (2)
DE (2) DE2165962C2 (2)
DK (1) DK131858C (2)
ES (4) ES395676A1 (2)
FI (1) FI55502C (2)
FR (1) FR2110227B1 (2)
GB (2) GB1373535A (2)
NL (1) NL168511C (2)
SE (2) SE390304B (2)
ZA (1) ZA716615B (2)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859288A (en) * 1970-10-05 1975-01-07 Pfizer Arylpyrimidines - inhibitors of platelet aggregation and bronchodilators
US3908012A (en) * 1970-10-05 1975-09-23 Pfizer Arylpyrimidines-inhibitors of platelet aggregation and bronchodilators
US3895112A (en) * 1970-10-05 1975-07-15 Pfizer Arylpyrimidines in the relaxation of smooth muscle
US3835132A (en) * 1972-02-01 1974-09-10 Shell Oil Co Morpholino-piperazinyl pyrimidines
US3950525A (en) * 1973-06-19 1976-04-13 Pfizer Inc. Relaxation of smooth muscle in a mammal
DE2343419A1 (de) * 1973-08-29 1975-03-13 Gruenenthal Chemie Verfahren zur herstellung von pyrimidinderivaten
US4725600A (en) * 1984-07-13 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
US4935516A (en) * 1988-01-29 1990-06-19 Ube Industries, Ltd. Process for preparing 4-hydroxypyrimidine
JPH0625157B2 (ja) * 1988-01-29 1994-04-06 宇部興産株式会社 ４―ヒドロキシピリミジン類の製造方法
DE3825647A1 (de) * 1988-07-28 1990-02-01 Geyer Gmbh & Co Christian Vorrichtung zur befestigung eines elektrischen schaltgeraetes
DE3905364A1 (de) * 1989-02-22 1990-08-23 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool
AU777735B2 (en) * 1999-07-15 2004-10-28 Pharmacopeia, Inc. Bradykinin B1 receptor antagonists
US7731985B2 (en) * 2002-03-15 2010-06-08 Ciba Specialty Chemicals Corporation 4-aminopyrimidines and their use for the antimicrobial treatment of surfaces
MXPA04011472A (es) * 2002-05-22 2005-02-14 Amgen Inc Derivados de amino-piridina, piridina y piridazina para usarse como ligandos del receptor vaniloide para el tratamiento del dolor.
WO2004085433A2 (en) * 2003-03-28 2004-10-07 Pharmacia & Upjohn Company Llc Positive allosteric modulators of the nicotinic acetylcholine receptor
WO2006113769A1 (en) * 2005-04-15 2006-10-26 Amgen Inc. Vanilloid receptor ligands and their use in treatments
JP2009164373A (ja) * 2008-01-08 2009-07-23 Toshiba Corp 半導体装置
CA2787365A1 (en) * 2010-01-25 2011-07-28 Chdi Foundation, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
KR20140072037A (ko) 2011-08-30 2014-06-12 씨에이치디아이 파운데이션, 인코포레이티드 키뉴레닌-3-모노옥시게나제 억제제, 약학적 조성물 및 이의 사용 방법
SI2750677T1 (sl) 2011-08-30 2017-10-30 Chdi Foundation, Inc. Inhibitorji kinurenin-3-monooksigenaze, farmacevtski sestavki in postopki njihove uporabe
AU2015289492B2 (en) 2014-07-17 2020-02-20 Chdi Foundation, Inc. Methods and compositions for treating HIV-related disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3047462A (en) * 1959-03-06 1962-07-31 Lab Jacques Logeais Soc D Expl Quinazolone anti-inflammatory composition

Also Published As

Publication number Publication date
SE385885B (sv) 1976-07-26
FR2110227B1 (2) 1975-02-07
US3707560A (en) 1972-12-26
SE390304B (sv) 1976-12-13
ES420211A1 (es) 1976-03-16
BE773484A (fr) 1972-04-05
NL168511B (nl) 1981-11-16
DK131858B (da) 1975-09-15
FI55502B (fi) 1979-04-30
AU465734B2 (en) 1975-10-09
AT315856B (de) 1974-05-15
AT317229B (de) 1974-08-26
CA988519A (en) 1976-05-04
ES395676A1 (es) 1974-10-16
DE2165962C2 (de) 1982-05-13
FI55502C (fi) 1979-08-10
CH554876A (fr) 1974-10-15
GB1373535A (en) 1974-11-13
ES420209A1 (es) 1976-06-01
DE2149249B2 (de) 1974-11-07
JPS5636468A (en) 1981-04-09
AT316563B (de) 1974-06-15
ZA716615B (en) 1972-06-28
GB1373536A (en) 1974-11-13
NL7113670A (2) 1972-04-07
NL168511C (nl) 1982-04-16
AU3425971A (en) 1973-04-12
DK131858C (da) 1976-02-16
AT314540B (de) 1974-04-10
SE7410488L (2) 1974-08-16
FR2110227A1 (2) 1972-06-02
CH554346A (fr) 1974-09-30
DE2149249A1 (de) 1972-04-13
JPS5648511B1 (2) 1981-11-16
JPS578107B2 (2) 1982-02-15
DE2165962A1 (de) 1972-08-31
ES420210A1 (es) 1976-06-01
DE2149249C3 (de) 1975-07-03
CH554875A (fr) 1974-10-15

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Legal Events

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