CH623848A5 - - Google Patents

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Info

Publication number: CH623848A5
Authority: CH; Switzerland
Prior art keywords: lipase; acetone; minutes; activity; mixture
Prior art date: 1974-02-21

Application number

CH212475A

Other languages

German (de)

English (en)

Inventor

Hans Dr Betzing

Dac Dr Lekim

Original Assignee

Nattermann A & Cie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-02-21

Filing date

1975-02-20

Publication date

1981-06-30

1974-02-21 Priority claimed from DE19742408379 external-priority patent/DE2408379C3/de

1975-01-30 Priority claimed from DE19752505887 external-priority patent/DE2505887C3/de

1975-02-20 Application filed by Nattermann A & Cie filed Critical Nattermann A & Cie

1981-06-30 Publication of CH623848A5 publication Critical patent/CH623848A5/de

Links

238000002360 preparation method Methods 0.000 claims description 23
108090001060 Lipase Proteins 0.000 claims description 18
239000004367 Lipase Substances 0.000 claims description 18
102000004882 Lipase Human genes 0.000 claims description 18
235000019421 lipase Nutrition 0.000 claims description 18
102000004190 Enzymes Human genes 0.000 claims description 16
108090000790 Enzymes Proteins 0.000 claims description 16
229940088598 enzyme Drugs 0.000 claims description 16
238000000034 method Methods 0.000 claims description 15
235000019626 lipase activity Nutrition 0.000 claims description 13
108010019160 Pancreatin Proteins 0.000 claims description 9
230000000694 effects Effects 0.000 claims description 9
229940055695 pancreatin Drugs 0.000 claims description 9
210000000496 pancreas Anatomy 0.000 claims description 5
239000004382 Amylase Substances 0.000 claims description 4
102000013142 Amylases Human genes 0.000 claims description 4
108010065511 Amylases Proteins 0.000 claims description 4
235000019418 amylase Nutrition 0.000 claims description 4
229940079919 digestives enzyme preparation Drugs 0.000 claims description 4
239000004006 olive oil Substances 0.000 claims description 4
235000008390 olive oil Nutrition 0.000 claims description 4
229920002472 Starch Polymers 0.000 claims description 2
235000019698 starch Nutrition 0.000 claims description 2
239000008107 starch Substances 0.000 claims description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 36
239000000203 mixture Substances 0.000 claims 12
208000035404 Autolysis Diseases 0.000 claims 10
206010057248 Cell death Diseases 0.000 claims 10
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 10
230000028043 self proteolysis Effects 0.000 claims 10
239000000243 solution Substances 0.000 claims 10
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 9
239000000463 material Substances 0.000 claims 9
210000001519 tissue Anatomy 0.000 claims 9
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 8
239000000284 extract Substances 0.000 claims 8
IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims 7
210000000056 organ Anatomy 0.000 claims 7
239000002904 solvent Substances 0.000 claims 7
239000000047 product Substances 0.000 claims 6
OAABHEHWRQAHEJ-UHFFFAOYSA-N butan-1-ol;chloroform Chemical compound ClC(Cl)Cl.CCCCO OAABHEHWRQAHEJ-UHFFFAOYSA-N 0.000 claims 5
238000005238 degreasing Methods 0.000 claims 5
239000000843 powder Substances 0.000 claims 5
239000002244 precipitate Substances 0.000 claims 5
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
230000000875 corresponding effect Effects 0.000 claims 4
210000004923 pancreatic tissue Anatomy 0.000 claims 4
239000000469 ethanolic extract Substances 0.000 claims 3
235000013372 meat Nutrition 0.000 claims 3
235000015277 pork Nutrition 0.000 claims 3
238000001556 precipitation Methods 0.000 claims 3
238000003756 stirring Methods 0.000 claims 3
230000001476 alcoholic effect Effects 0.000 claims 2
238000003776 cleavage reaction Methods 0.000 claims 2
238000001035 drying Methods 0.000 claims 2
239000003925 fat Substances 0.000 claims 2
238000004108 freeze drying Methods 0.000 claims 2
238000002955 isolation Methods 0.000 claims 2
239000007791 liquid phase Substances 0.000 claims 2
238000004519 manufacturing process Methods 0.000 claims 2
230000007017 scission Effects 0.000 claims 2
239000010414 supernatant solution Substances 0.000 claims 2
238000010257 thawing Methods 0.000 claims 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 claims 1
108010058846 Ovalbumin Proteins 0.000 claims 1
BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 claims 1
LDKDGDIWEUUXSH-UHFFFAOYSA-N Thymophthalein Chemical compound C1=C(O)C(C(C)C)=CC(C2(C3=CC=CC=C3C(=O)O2)C=2C(=CC(O)=C(C(C)C)C=2)C)=C1C LDKDGDIWEUUXSH-UHFFFAOYSA-N 0.000 claims 1
239000002253 acid Substances 0.000 claims 1
150000007513 acids Chemical class 0.000 claims 1
239000006286 aqueous extract Substances 0.000 claims 1
238000011088 calibration curve Methods 0.000 claims 1
239000005018 casein Substances 0.000 claims 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 1
235000021240 caseins Nutrition 0.000 claims 1
238000005119 centrifugation Methods 0.000 claims 1
230000007812 deficiency Effects 0.000 claims 1
230000018044 dehydration Effects 0.000 claims 1
238000006297 dehydration reaction Methods 0.000 claims 1
230000001079 digestive effect Effects 0.000 claims 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
208000035475 disorder Diseases 0.000 claims 1
238000002474 experimental method Methods 0.000 claims 1
238000000605 extraction Methods 0.000 claims 1
238000001914 filtration Methods 0.000 claims 1
238000005187 foaming Methods 0.000 claims 1
210000004907 gland Anatomy 0.000 claims 1
229910052751 metal Inorganic materials 0.000 claims 1
239000002184 metal Substances 0.000 claims 1
230000004048 modification Effects 0.000 claims 1
238000012986 modification Methods 0.000 claims 1
239000003921 oil Substances 0.000 claims 1
235000019198 oils Nutrition 0.000 claims 1
239000003960 organic solvent Substances 0.000 claims 1
239000011148 porous material Substances 0.000 claims 1
230000001376 precipitating effect Effects 0.000 claims 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
238000011084 recovery Methods 0.000 claims 1
230000028327 secretion Effects 0.000 claims 1
239000011877 solvent mixture Substances 0.000 claims 1
239000000725 suspension Substances 0.000 claims 1
230000001225 therapeutic effect Effects 0.000 claims 1
238000004448 titration Methods 0.000 claims 1
238000010626 work up procedure Methods 0.000 claims 1
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
108091005804 Peptidases Proteins 0.000 description 3
239000004365 Protease Substances 0.000 description 3
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 3
108090000371 Esterases Proteins 0.000 description 2
KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
241000283690 Bos taurus Species 0.000 description 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
108010067035 Pancrelipase Proteins 0.000 description 1
210000000941 bile Anatomy 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
239000001087 glyceryl triacetate Substances 0.000 description 1
235000013773 glyceryl triacetate Nutrition 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
230000002366 lipolytic effect Effects 0.000 description 1
230000020477 pH reduction Effects 0.000 description 1
239000000758 substrate Substances 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

CH212475A 1974-02-21 1975-02-20 CH623848A5 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19742408379 DE2408379C3 (de)		1974-02-21	Verfahren zur Herstellung eines lipasereichen Enzympräparates aus Pankreasgewebe
DE19752505887 DE2505887C3 (de)	1975-01-30	1975-01-30	Verfahren zur Herstellung eines lipasereichen Enzympraparates

Publications (1)

Publication Number	Publication Date
CH623848A5 true CH623848A5 (fr)	1981-06-30

Family

ID=25766672

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH212475A CH623848A5 (fr)	1974-02-21	1975-02-20

Country Status (12)

Country	Link
US (1)	US3925158A (fr)
JP (1)	JPS5328514B2 (fr)
AT (1)	AT338415B (fr)
CA (1)	CA1047422A (fr)
CH (1)	CH623848A5 (fr)
DK (1)	DK136728C (fr)
ES (1)	ES434840A1 (fr)
FR (1)	FR2262045B1 (fr)
GB (1)	GB1454983A (fr)
NL (1)	NL7501945A (fr)
PH (1)	PH11983A (fr)
SE (1)	SE424086B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4088539A (en) *	1976-05-07	1978-05-09	A. Nattermann & Cie Gmbh	Process of manufacturing enzyme preparation rich in lipase
SE454566B (sv) *	1984-04-24	1988-05-16	Lars G I Hellgren	Farmaceutisk komposition innehallande en verksam mengd av vattenlosliga proteinaser som extraherats fran ett vattenlevande djur valt av ordningen euphausiaceae eller slektet mallotus
US5288619A (en) *	1989-12-18	1994-02-22	Kraft General Foods, Inc.	Enzymatic method for preparing transesterified oils
GB2404885B (en) *	2003-08-12	2006-03-01	Mi Llc	Electrical treatment for oil based drilling or completion fluids
TWI764208B (zh) *	2020-07-22	2022-05-11	台灣中油股份有限公司	清潔組合物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1328202A (en) *	1969-06-17	1973-08-30	Union International Co Ltd	Manufacture of pancreatin

1975
- 1975-02-12 CA CA219,898A patent/CA1047422A/fr not_active Expired
- 1975-02-18 US US550641A patent/US3925158A/en not_active Expired - Lifetime
- 1975-02-19 FR FR7505115A patent/FR2262045B1/fr not_active Expired
- 1975-02-19 NL NL7501945A patent/NL7501945A/xx not_active Application Discontinuation
- 1975-02-19 SE SE7501873A patent/SE424086B/xx unknown
- 1975-02-19 ES ES434840A patent/ES434840A1/es not_active Expired
- 1975-02-20 GB GB724675A patent/GB1454983A/en not_active Expired
- 1975-02-20 CH CH212475A patent/CH623848A5/de not_active IP Right Cessation
- 1975-02-21 DK DK68275A patent/DK136728C/da active
- 1975-02-21 JP JP2107575A patent/JPS5328514B2/ja not_active Expired
- 1975-02-21 PH PH16828A patent/PH11983A/en unknown
- 1975-02-21 AT AT136075A patent/AT338415B/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATA136075A (de)	1976-12-15
FR2262045A1 (fr)	1975-09-19
GB1454983A (en)	1976-11-10
JPS50123872A (fr)	1975-09-29
DK136728C (da)	1978-04-24
PH11983A (en)	1978-10-04
ES434840A1 (es)	1976-12-16
FR2262045B1 (fr)	1978-08-18
SE7501873L (fr)	1975-08-22
DK68275A (fr)	1975-10-13
DK136728B (da)	1977-11-14
CA1047422A (fr)	1979-01-30
AT338415B (de)	1977-08-25
NL7501945A (nl)	1975-08-25
JPS5328514B2 (fr)	1978-08-15
US3925158A (en)	1975-12-09
SE424086B (sv)	1982-06-28

Legal Events

Date	Code	Title	Description
1988-10-31	PL	Patent ceased
2024-10-31	PL	Patent ceased

Publication	Publication Date	Title
DE69615105T2 (de)	2002-01-24	Enzymatische Behandlung von Kakao
EP0475451B1 (fr)	1994-01-26	Procédé pour préparer du jaune d'oeuf à faible teneur en cholestérol
DE3026193A1 (de)	1981-01-29	Verfahren zur herstellung von sojaproteinhydrolysat aus fetthaltigem sojabohnenmaterial
DE2600060A1 (de)	1976-07-08	Verfahren zur gewinnung von protein aus pflanzenmaterial
CH623848A5 (fr)	1981-06-30
US1922484A (en)	1933-08-15	Extracting oil from animal tissue and the lipoid substances by papain digestion
DE2460334C3 (de)	1979-09-06	Verfahren zur Gewinnung von Insulin und Pankreatin aus Schweinepankreas
EP0065246B1 (fr)	1985-08-21	Procédé de production de substances actives anaboliques favorisant la respiration et de faible poids moléculaire pour des fins prophylactiques, thérapeutiques et pour des techniques de culture de cellules et de tissus
DE2408379C3 (de)	1976-07-29	Verfahren zur Herstellung eines lipasereichen Enzympräparates aus Pankreasgewebe
DE2408379B2 (de)	1975-12-18	Verfahren zur Herstellung eines lipasereichen Enzympräparates aus Pankreasgewebe
DE2106706B2 (de)	1973-05-10	Verfahren zur herstellung von pankreatin als trockenes pulver mit hoher proteolytischer, amylolytischer und lipolytischer aktivitaet
DE1089630B (de)	1960-09-22	Verfahren zur Herstellung geruch- und geschmackloser Proteinabbauprodukte aus Blut
DE69112236T2 (de)	1996-01-25	Verfahren zur mikrobiologischen Herstellung von Ironen.
DE617463C (de)	1935-08-20	Verfahren zur Herstellung eines entbitterten Getreidekeimproduktes
AT151781B (de)	1937-12-10	Verfahren zur Herstellung eines aktiven Trockenpräparates aus Papain und ähnlichen pflanzlichen Enzymen.
DE2831338A1 (de)	1980-01-31	Eiweissprodukt und verfahren zu dessen herstellung
AT378472B (de)	1985-08-12	Verfahren zur gewinnung von wasserunloeslichen getreidebestandteilen
DE750119C (de)	1945-01-09	Verfahren zur Herstellung von Eiweissstoffen aus Muskelfasern tierischer Herkunft
DE2945970A1 (de)	1980-06-04	Fermentpraeparat zur beschleunigung der reifung von fleischprodukten und verfahren zu dessen herstellung
DE711242C (de)	1941-09-29	Verfahren zur Herstellung von Bleichmitteln fuer Teig, Fette u. dgl.
DE1517749C3 (de)	1975-02-27	Verfahren zur Herstellung von bei Raumtemperatur lange haltbaren Trockenpräparaten der Phosphotransacetylase aus Escherichia coli
DE735692C (de)	1943-05-24	Verfahren zur Darstellung von Pankreas-Lipase-Praeparaten
US565329A (en)	1896-08-04	Digestive compound
DE359878C (de)	1922-09-28	Verfahren zur Darstellung von hochwirksamen, von Ballaststoffen weitgehend befreiten Vitaminpraeparaten
US1113021A (en)	1914-10-06	Manufacture of food preparations or extracts.