CH646414A5 - Purified pancreatic spasmolytic polypeptide, process for its isolation, and pharmaceutical composition - Google Patents

Purified pancreatic spasmolytic polypeptide, process for its isolation, and pharmaceutical composition Download PDF

Info

Publication number: CH646414A5
Authority: CH; Switzerland
Prior art keywords: cys; pro; ser; psp; polypeptide
Prior art date: 1979-09-11

Application number

CH681480A

Other languages

German (de)

English (en)

Inventor

Klavs Holger Jorgensen

Karin Damm Jorgensen

Lars Thim

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-09-11

Filing date

1980-09-10

Publication date

1984-11-30

1980-09-10 Application filed by Novo Industri As filed Critical Novo Industri As

1984-11-30 Publication of CH646414A5 publication Critical patent/CH646414A5/de

Links

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239000008194 pharmaceutical composition Substances 0.000 title claims 4
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239000000243 solution Substances 0.000 claims description 25
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HOBWAPHTEJGALG-JKCMADFCSA-N [(1r,5s)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;sulfate Chemical compound [O-]S([O-])(=O)=O.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1 HOBWAPHTEJGALG-JKCMADFCSA-N 0.000 description 1
230000009858 acid secretion Effects 0.000 description 1
238000010306 acid treatment Methods 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
239000000783 alginic acid Substances 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
229960001126 alginic acid Drugs 0.000 description 1
150000004781 alginic acids Chemical class 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
235000012538 ammonium bicarbonate Nutrition 0.000 description 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
235000011130 ammonium sulphate Nutrition 0.000 description 1
239000003708 ampul Substances 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
229960002028 atropine sulfate Drugs 0.000 description 1
235000013405 beer Nutrition 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000036772 blood pressure Effects 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000011575 calcium Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
238000005341 cation exchange Methods 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000003610 charcoal Substances 0.000 description 1
229960002376 chymotrypsin Drugs 0.000 description 1
230000008602 contraction Effects 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
229960003624 creatine Drugs 0.000 description 1
239000006046 creatine Substances 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
238000001839 endoscopy Methods 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
239000006167 equilibration buffer Substances 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
210000003608 fece Anatomy 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
210000004211 gastric acid Anatomy 0.000 description 1
210000004051 gastric juice Anatomy 0.000 description 1
238000001502 gel electrophoresis Methods 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
230000000762 glandular Effects 0.000 description 1
239000008103 glucose Substances 0.000 description 1
201000000079 gynecomastia Diseases 0.000 description 1
238000003306 harvesting Methods 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
230000028993 immune response Effects 0.000 description 1
238000002649 immunization Methods 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
238000001802 infusion Methods 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
239000002198 insoluble material Substances 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
239000011630 iodine Substances 0.000 description 1
229940057428 lactoperoxidase Drugs 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
229910021645 metal ion Inorganic materials 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
229960004127 naloxone Drugs 0.000 description 1
UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
210000004923 pancreatic tissue Anatomy 0.000 description 1
229940055695 pancreatin Drugs 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
230000008855 peristalsis Effects 0.000 description 1
230000002572 peristaltic effect Effects 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
235000015277 pork Nutrition 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000005086 pumping Methods 0.000 description 1
229940043131 pyroglutamate Drugs 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
229960003147 reserpine Drugs 0.000 description 1
230000004043 responsiveness Effects 0.000 description 1
MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
230000028327 secretion Effects 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
230000036269 ulceration Effects 0.000 description 1
230000002792 vascular Effects 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Reinforced Plastic Materials (AREA)

CH681480A 1979-09-11 1980-09-10 Purified pancreatic spasmolytic polypeptide, process for its isolation, and pharmaceutical composition CH646414A5 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7931518		1979-09-11

Publications (1)

Publication Number	Publication Date
CH646414A5 true CH646414A5 (en)	1984-11-30

Family

ID=10507754

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH681480A CH646414A5 (en)	1979-09-11	1980-09-10	Purified pancreatic spasmolytic polypeptide, process for its isolation, and pharmaceutical composition

Country Status (15)

Country	Link
JP (1)	JPS609760B2 (fr)
AT (1)	AT373149B (fr)
AU (1)	AU537523B2 (fr)
BE (1)	BE885199A (fr)
CA (1)	CA1160624A (fr)
CH (1)	CH646414A5 (fr)
DE (1)	DE3034198A1 (fr)
DK (1)	DK380880A (fr)
ES (1)	ES494917A0 (fr)
FI (1)	FI802828A7 (fr)
FR (1)	FR2464942A1 (fr)
IT (1)	IT1195032B (fr)
NL (1)	NL8005084A (fr)
NO (1)	NO802683L (fr)
SE (1)	SE8006333L (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB924815A (en) *	1959-12-24	1963-05-01	Maurice Roux	Improvements in methods of preparation of polypeptides of spasmolytic activity

1980
- 1980-09-08 DK DK380880A patent/DK380880A/da not_active Application Discontinuation
- 1980-09-09 NL NL8005084A patent/NL8005084A/nl not_active Application Discontinuation
- 1980-09-10 FR FR8019545A patent/FR2464942A1/fr active Granted
- 1980-09-10 NO NO802683A patent/NO802683L/no unknown
- 1980-09-10 CH CH681480A patent/CH646414A5/de not_active IP Right Cessation
- 1980-09-10 AT AT0455180A patent/AT373149B/de not_active IP Right Cessation
- 1980-09-10 ES ES494917A patent/ES494917A0/es active Granted
- 1980-09-10 FI FI802828A patent/FI802828A7/fi not_active Application Discontinuation
- 1980-09-10 SE SE8006333A patent/SE8006333L/xx not_active Application Discontinuation
- 1980-09-11 IT IT24588/80A patent/IT1195032B/it active
- 1980-09-11 BE BE6/47265A patent/BE885199A/fr not_active IP Right Cessation
- 1980-09-11 AU AU62317/80A patent/AU537523B2/en not_active Ceased
- 1980-09-11 JP JP55125375A patent/JPS609760B2/ja not_active Expired
- 1980-09-11 CA CA000360561A patent/CA1160624A/fr not_active Expired
- 1980-09-11 DE DE19803034198 patent/DE3034198A1/de not_active Withdrawn

Also Published As

Publication number	Publication date
ES8105699A1 (es)	1981-06-16
DK380880A (da)	1981-05-12
AT373149B (de)	1983-12-27
IT8024588A0 (it)	1980-09-11
NL8005084A (nl)	1981-03-13
FR2464942B1 (fr)	1984-10-26
JPS56123996A (en)	1981-09-29
ATA455180A (de)	1983-05-15
NO802683L (no)	1981-05-07
ES494917A0 (es)	1981-06-16
JPS609760B2 (ja)	1985-03-12
SE8006333L (sv)	1981-03-12
DE3034198A1 (de)	1981-04-09
AU6231780A (en)	1981-03-19
IT1195032B (it)	1988-09-28
FR2464942A1 (fr)	1981-03-20
BE885199A (fr)	1981-03-11
AU537523B2 (en)	1984-06-28
CA1160624A (fr)	1984-01-17
FI802828A7 (fi)	1981-03-11

Legal Events

Date	Code	Title	Description
1988-05-31	PL	Patent ceased
2024-10-31	PL	Patent ceased

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US4948785A (en)	1990-08-14	Plant polysaccharide fractions inducing prolactin in mammals
EP0158986B1 (fr)	1993-09-15	Peptides à activité anticoagulante, leur procédé de préparation, leur isolement, leur emploi et les agents les contenant
DE3855970T2 (de)	1998-01-29	Verwendung von Amylin oder CGRP zur Behandlung des Diabetes mellitus
EP0167575B1 (fr)	1993-05-26	Cardiodilatine, une nouvelle hormone peptidique et son procede de fabrication
US4370317A (en)	1983-01-25	Pancreatic spasmolytic polypeptide
EP0209061A2 (fr)	1987-01-21	Peptides à activité anticoagulante, leur procédé de préparation, d'obtention, leur application et les agents les contenant
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DE2734150B2 (de)	1979-04-05	Verfahren zur Herstellung von Human-Lysozympräparaten
DE2558537C2 (de)	1984-07-19	Verfahren zum Isolieren von Substanzen mit insulinähnlicher Wirksamkeit aus Blut oder Blutbestandteilen von Kälbern oder Schweinen
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CH646414A5 (en)	1984-11-30	Purified pancreatic spasmolytic polypeptide, process for its isolation, and pharmaceutical composition
SU871721A3 (ru)	1981-10-07	Способ получени биологически активного вещества,обладающего способностью усиливать секрецию инсулина и улучшать глюкозную толерантность
LU83206A1 (de)	1981-06-24	Gereinigtes polypeptid,verfahren zum isolieren und verwendung desselben sowie pharmazeutische zusammensetzung und waessrige sterile loesung
DE2159923C3 (de)	1974-05-22	Verfahren zur Gewinnung eines Stoffes mit insulinähnlicher Wirkung und diese Stoffe enthaltende Arzneipräparate
US3475534A (en)	1969-10-28	Methods of treating hyperinsulinism