CH656801A5 - Medicaments contenant un derive du psoralene. - Google Patents

Medicaments contenant un derive du psoralene. Download PDF

Info

Publication number: CH656801A5
Authority: CH; Switzerland
Prior art keywords: methoxypsoralen; medicines; active substance; cells; contain
Prior art date: 1982-04-09

Application number

CH2751/83A

Other languages

English (en)

French (fr)

Inventor

Jean-Jacques Goupil

Original Assignee

Goupil Jean Jacques

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-04-09

Filing date

1983-05-19

Publication date

1986-07-31

1983-05-19 Application filed by Goupil Jean Jacques filed Critical Goupil Jean Jacques

1986-07-31 Publication of CH656801A5 publication Critical patent/CH656801A5/fr

Links

229940126601 medicinal product Drugs 0.000 title 1
150000003194 psoralenes Chemical class 0.000 title 1
BGEBZHIAGXMEMV-UHFFFAOYSA-N 5-methoxypsoralen Chemical compound O1C(=O)C=CC2=C1C=C1OC=CC1=C2OC BGEBZHIAGXMEMV-UHFFFAOYSA-N 0.000 claims description 42
206010028980 Neoplasm Diseases 0.000 claims description 23
SQBBOVROCFXYBN-UHFFFAOYSA-N methoxypsoralen Natural products C1=C2OC(=O)C(OC)=CC2=CC2=C1OC=C2 SQBBOVROCFXYBN-UHFFFAOYSA-N 0.000 claims description 21
229960002045 bergapten Drugs 0.000 claims description 20
KGZDKFWCIPZMRK-UHFFFAOYSA-N bergapten Natural products COC1C2=C(Cc3ccoc13)C=CC(=O)O2 KGZDKFWCIPZMRK-UHFFFAOYSA-N 0.000 claims description 20
238000011282 treatment Methods 0.000 claims description 13
229940079593 drug Drugs 0.000 claims description 9
239000003814 drug Substances 0.000 claims description 9
230000035755 proliferation Effects 0.000 claims description 9
239000013543 active substance Substances 0.000 claims description 6
235000019271 petrolatum Nutrition 0.000 claims description 6
230000000699 topical effect Effects 0.000 claims description 5
IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 4
239000003795 chemical substances by application Substances 0.000 claims description 3
230000035515 penetration Effects 0.000 claims description 3
230000001476 alcoholic effect Effects 0.000 claims description 2
239000000839 emulsion Substances 0.000 claims description 2
239000002480 mineral oil Substances 0.000 claims description 2
230000000149 penetrating effect Effects 0.000 claims description 2
235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
239000008158 vegetable oil Substances 0.000 claims description 2
229910052500 inorganic mineral Inorganic materials 0.000 claims 1
235000010755 mineral Nutrition 0.000 claims 1
210000004027 cell Anatomy 0.000 description 16
201000011510 cancer Diseases 0.000 description 8
238000002360 preparation method Methods 0.000 description 6
108020004414 DNA Proteins 0.000 description 5
208000000453 Skin Neoplasms Diseases 0.000 description 5
230000005855 radiation Effects 0.000 description 5
239000004264 Petrolatum Substances 0.000 description 4
229940066842 petrolatum Drugs 0.000 description 4
238000011200 topical administration Methods 0.000 description 4
201000004681 Psoriasis Diseases 0.000 description 3
230000003902 lesion Effects 0.000 description 3
201000000849 skin cancer Diseases 0.000 description 3
206010004146 Basal cell carcinoma Diseases 0.000 description 2
201000009030 Carcinoma Diseases 0.000 description 2
102000053602 DNA Human genes 0.000 description 2
206010014970 Ephelides Diseases 0.000 description 2
206010017533 Fungal infection Diseases 0.000 description 2
206010020648 Hyperkeratoses Diseases 0.000 description 2
206010025323 Lymphomas Diseases 0.000 description 2
208000003351 Melanosis Diseases 0.000 description 2
241000699670 Mus sp. Species 0.000 description 2
238000001574 biopsy Methods 0.000 description 2
210000004207 dermis Anatomy 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
210000003722 extracellular fluid Anatomy 0.000 description 2
208000024386 fungal infectious disease Diseases 0.000 description 2
231100000053 low toxicity Toxicity 0.000 description 2
210000002751 lymph Anatomy 0.000 description 2
230000017074 necrotic cell death Effects 0.000 description 2
239000002547 new drug Substances 0.000 description 2
239000000546 pharmaceutical excipient Substances 0.000 description 2
231100000760 phototoxic Toxicity 0.000 description 2
ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 2
230000036555 skin type Effects 0.000 description 2
VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 1
BUNGCZLFHHXKBX-UHFFFAOYSA-N 8-methoxypsoralen Natural products C1=CC(=O)OC2=C1C=C1CCOC1=C2OC BUNGCZLFHHXKBX-UHFFFAOYSA-N 0.000 description 1
201000004624 Dermatitis Diseases 0.000 description 1
206010015150 Erythema Diseases 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
241000233866 Fungi Species 0.000 description 1
239000004166 Lanolin Substances 0.000 description 1
QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 description 1
206010038111 Recurrent cancer Diseases 0.000 description 1
206010047642 Vitiligo Diseases 0.000 description 1
238000002679 ablation Methods 0.000 description 1
208000010668 atopic eczema Diseases 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
230000002146 bilateral effect Effects 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
208000030381 cutaneous melanoma Diseases 0.000 description 1
210000001339 epidermal cell Anatomy 0.000 description 1
210000002615 epidermis Anatomy 0.000 description 1
208000010932 epithelial neoplasm Diseases 0.000 description 1
231100000321 erythema Toxicity 0.000 description 1
230000002538 fungal effect Effects 0.000 description 1
238000011835 investigation Methods 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
229940039717 lanolin Drugs 0.000 description 1
235000019388 lanolin Nutrition 0.000 description 1
231100001231 less toxic Toxicity 0.000 description 1
210000004698 lymphocyte Anatomy 0.000 description 1
201000001441 melanoma Diseases 0.000 description 1
229960004469 methoxsalen Drugs 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
201000005962 mycosis fungoides Diseases 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
230000002062 proliferating effect Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000001243 protein synthesis Methods 0.000 description 1
230000001185 psoriatic effect Effects 0.000 description 1
230000000306 recurrent effect Effects 0.000 description 1
230000001373 regressive effect Effects 0.000 description 1
230000010076 replication Effects 0.000 description 1
230000037390 scarring Effects 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
210000003491 skin Anatomy 0.000 description 1
210000004927 skin cell Anatomy 0.000 description 1
201000003708 skin melanoma Diseases 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
231100001274 therapeutic index Toxicity 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000008719 thickening Effects 0.000 description 1
QGHREAKMXXNCOA-UHFFFAOYSA-N thiophanate-methyl Chemical compound COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC QGHREAKMXXNCOA-UHFFFAOYSA-N 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
230000014616 translation Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Dermatology (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CH2751/83A 1982-04-09 1983-05-19 Medicaments contenant un derive du psoralene. CH656801A5 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8206262A FR2524801B1 (fr)	1982-04-09	1982-04-09	Medicaments contenant un derive du psoralene
BE0/210731A BE896700A (fr)	1982-04-09	1983-05-09	Medicaments contenant un derive du psoralene.

Publications (1)

Publication Number	Publication Date
CH656801A5 true CH656801A5 (fr)	1986-07-31

Family

ID=36782343

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH2751/83A CH656801A5 (fr)	1982-04-09	1983-05-19	Medicaments contenant un derive du psoralene.

Country Status (7)

Country	Link
JP (1)	JPH0653664B2 (ja)
AU (1)	AU559029B2 (ja)
BE (1)	BE896700A (ja)
CA (1)	CA1205386A (ja)
CH (1)	CH656801A5 (ja)
FR (1)	FR2524801B1 (ja)
GB (1)	GB2140686B (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9106365D0 (en) *	1991-03-26	1991-05-15	Bioglan Lab Ltd	An emollient for use with ultraviolet light
FR2695036B1 (fr) *	1992-09-03	1994-10-28	Goupil Jean Jacques	Huile contenant du 5-méthoxypsoralène à une concentration de 60 à 100 PPM et son utilisation pour le traitement du psoriasis.
US5556612A (en) *	1994-03-15	1996-09-17	The General Hospital Corporation	Methods for phototherapeutic treatment of proliferative skin diseases
CN116102713A (zh) *	2022-09-07	2023-05-12	江苏三木化工股份有限公司	一种多臂结构胺类环氧固化剂及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2406444A1 (fr) *	1977-10-21	1979-05-18	Goupil Jean Jacques	Nouveau medicament contenant un derive du psoralene
LU80347A1 (fr) *	1977-10-21	1979-03-16	Goupil J	5-methoxy-psoralene comme nouveau medicament et procede de synthese

1982
- 1982-04-09 FR FR8206262A patent/FR2524801B1/fr not_active Expired
1983
- 1983-05-09 BE BE0/210731A patent/BE896700A/fr not_active IP Right Cessation
- 1983-05-19 CH CH2751/83A patent/CH656801A5/fr not_active IP Right Cessation
- 1983-05-24 AU AU14905/83A patent/AU559029B2/en not_active Ceased
- 1983-05-26 CA CA000428960A patent/CA1205386A/en not_active Expired
- 1983-06-01 JP JP58097768A patent/JPH0653664B2/ja not_active Expired - Lifetime
- 1983-06-01 GB GB08315070A patent/GB2140686B/en not_active Expired

Also Published As

Publication number	Publication date
AU1490583A (en)	1984-11-29
JPH0653664B2 (ja)	1994-07-20
JPS59222413A (ja)	1984-12-14
GB8315070D0 (en)	1983-07-06
AU559029B2 (en)	1987-02-19
FR2524801B1 (fr)	1985-08-30
GB2140686A (en)	1984-12-05
CA1205386A (en)	1986-06-03
FR2524801A1 (fr)	1983-10-14
BE896700A (fr)	1983-09-01
GB2140686B (en)	1986-09-17

Legal Events

Date	Code	Title	Description
1996-01-31	PL	Patent ceased

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CN1352546A (zh)	2002-06-05	皮肤增白剂
EP1297832A2 (en)	2003-04-02	Composition and methods for treating psoriasis
FR3031900A1 (fr)	2016-07-29	Triptolide et ses derives dans le traitement des tumeurs et pathologies pre-cancereuses cutanees
US20030083324A1 (en)	2003-05-01	Photosensitizing ointment
JP2006514072A (ja)	2006-04-27	光線療法における適用のための、並びに皮膚及び／又は関節疾患の処置のためのポルフィリン合成の物質の使用
US20220218826A1 (en)	2022-07-14	Composition for topical use for photodynamic therapy
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