CH679639A5 - - Google Patents

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Publication number: CH679639A5
Authority: CH; Switzerland
Prior art keywords: oral care; weight; care product; bactericide; composition according
Prior art date: 1988-12-29

Application number

CH4685/89A

Other languages

German (de)

English (en)

Inventor

Nuran Nabi

Abdul Gaffar

John Afflitto

Orum Stringer

Michael Prencipe

Original Assignee

Colgate Palmolive Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-29

Filing date

1989-12-27

Publication date

1992-03-31

1988-12-29 Priority claimed from US07/291,712 external-priority patent/US4894220A/en

1989-08-25 Priority claimed from US07/398,566 external-priority patent/US5032386A/en

1989-08-25 Priority claimed from US07/398,592 external-priority patent/US5188821A/en

1989-12-27 Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co

1992-03-31 Publication of CH679639A5 publication Critical patent/CH679639A5/de

Links

230000000844 anti-bacterial effect Effects 0.000 claims description 125
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 85
239000003899 bactericide agent Substances 0.000 claims description 82
239000012190 activator Substances 0.000 claims description 62
239000000203 mixture Substances 0.000 claims description 50
230000014759 maintenance of location Effects 0.000 claims description 43
239000000551 dentifrice Substances 0.000 claims description 36
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 36
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 34
239000003795 chemical substances by application Substances 0.000 claims description 34
238000005498 polishing Methods 0.000 claims description 29
210000003296 saliva Anatomy 0.000 claims description 28
229920001577 copolymer Polymers 0.000 claims description 27
VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 24
125000002091 cationic group Chemical group 0.000 claims description 23
125000000129 anionic group Chemical group 0.000 claims description 18
150000001875 compounds Chemical class 0.000 claims description 18
239000002904 solvent Substances 0.000 claims description 18
239000004094 surface-active agent Substances 0.000 claims description 18
PGKQTZHDCHKDQK-UHFFFAOYSA-N 2-phenylethenylphosphonic acid Chemical compound OP(O)(=O)C=CC1=CC=CC=C1 PGKQTZHDCHKDQK-UHFFFAOYSA-N 0.000 claims description 16
239000000178 monomer Substances 0.000 claims description 16
239000007788 liquid Substances 0.000 claims description 15
230000002787 reinforcement Effects 0.000 claims description 12
208000002064 Dental Plaque Diseases 0.000 claims description 11
239000002562 thickening agent Substances 0.000 claims description 11
239000002253 acid Substances 0.000 claims description 10
229910052799 carbon Inorganic materials 0.000 claims description 10
208000006558 Dental Calculus Diseases 0.000 claims description 9
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 9
150000003839 salts Chemical class 0.000 claims description 9
229920000388 Polyphosphate Polymers 0.000 claims description 8
239000010692 aromatic oil Substances 0.000 claims description 8
125000004432 carbon atom Chemical group C* 0.000 claims description 8
239000001205 polyphosphate Substances 0.000 claims description 8
235000011176 polyphosphates Nutrition 0.000 claims description 8
MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 claims description 7
239000003513 alkali Substances 0.000 claims description 7
239000001506 calcium phosphate Substances 0.000 claims description 7
239000002324 mouth wash Substances 0.000 claims description 7
ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims description 7
SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 6
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
150000003863 ammonium salts Chemical class 0.000 claims description 6
RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical group O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims description 6
239000000377 silicon dioxide Substances 0.000 claims description 6
235000019739 Dicalciumphosphate Nutrition 0.000 claims description 5
150000001447 alkali salts Chemical class 0.000 claims description 5
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 5
229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 5
229940038472 dicalcium phosphate Drugs 0.000 claims description 5
USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical class C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims description 5
150000004676 glycans Chemical class 0.000 claims description 5
229940051866 mouthwash Drugs 0.000 claims description 5
150000002989 phenols Chemical class 0.000 claims description 5
229920001282 polysaccharide Polymers 0.000 claims description 5
239000005017 polysaccharide Substances 0.000 claims description 5
GSSDUXHQPXODCN-UHFFFAOYSA-N 1-phenylethenylphosphonic acid Chemical compound OP(O)(=O)C(=C)C1=CC=CC=C1 GSSDUXHQPXODCN-UHFFFAOYSA-N 0.000 claims description 4
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 4
125000004429 atom Chemical group 0.000 claims description 4
SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 claims description 4
230000002209 hydrophobic effect Effects 0.000 claims description 4
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 4
ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 claims description 3
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
230000002378 acidificating effect Effects 0.000 claims description 3
125000002252 acyl group Chemical group 0.000 claims description 3
125000000217 alkyl group Chemical group 0.000 claims description 3
229920006318 anionic polymer Polymers 0.000 claims description 3
239000008365 aqueous carrier Substances 0.000 claims description 3
125000003710 aryl alkyl group Chemical group 0.000 claims description 3
125000003118 aryl group Chemical group 0.000 claims description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 3
239000008103 glucose Substances 0.000 claims description 3
229940051250 hexylene glycol Drugs 0.000 claims description 3
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
239000011976 maleic acid Substances 0.000 claims description 3
XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical group COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 3
231100000252 nontoxic Toxicity 0.000 claims description 3
230000003000 nontoxic effect Effects 0.000 claims description 3
229910052760 oxygen Inorganic materials 0.000 claims description 3
230000003381 solubilizing effect Effects 0.000 claims description 3
239000000126 substance Substances 0.000 claims description 3
YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 claims description 2
125000003342 alkenyl group Chemical group 0.000 claims description 2
125000002877 alkyl aryl group Chemical group 0.000 claims description 2
229940072049 amyl acetate Drugs 0.000 claims description 2
150000008064 anhydrides Chemical class 0.000 claims description 2
PGMYKACGEOXYJE-UHFFFAOYSA-N anhydrous amyl acetate Natural products CCCCCOC(C)=O PGMYKACGEOXYJE-UHFFFAOYSA-N 0.000 claims description 2
239000000440 bentonite Substances 0.000 claims description 2
229910000278 bentonite Inorganic materials 0.000 claims description 2
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
150000001558 benzoic acid derivatives Chemical class 0.000 claims description 2
229960002903 benzyl benzoate Drugs 0.000 claims description 2
JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 2
229940043256 calcium pyrophosphate Drugs 0.000 claims description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
235000019821 dicalcium diphosphate Nutrition 0.000 claims description 2
125000000524 functional group Chemical group 0.000 claims description 2
MNWFXJYAOYHMED-UHFFFAOYSA-M heptanoate Chemical compound CCCCCCC([O-])=O MNWFXJYAOYHMED-UHFFFAOYSA-M 0.000 claims description 2
229910052757 nitrogen Inorganic materials 0.000 claims description 2
125000000962 organic group Chemical group 0.000 claims description 2
229910052698 phosphorus Inorganic materials 0.000 claims description 2
229910052710 silicon Inorganic materials 0.000 claims description 2
150000003460 sulfonic acids Chemical class 0.000 claims description 2
229910052717 sulfur Inorganic materials 0.000 claims description 2
239000000375 suspending agent Substances 0.000 claims description 2
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
229940078499 tricalcium phosphate Drugs 0.000 claims description 2
229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 2
235000019731 tricalcium phosphate Nutrition 0.000 claims description 2
235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
239000008158 vegetable oil Substances 0.000 claims description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims 2
MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 claims 1
LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims 1
BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims 1
229910000400 magnesium phosphate tribasic Inorganic materials 0.000 claims 1
239000012188 paraffin wax Substances 0.000 claims 1
UVGZJJKEELPWRH-JSCKKFHOSA-M potassium (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexanoate Chemical compound [K+].O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C([O-])=O UVGZJJKEELPWRH-JSCKKFHOSA-M 0.000 claims 1
235000019983 sodium metaphosphate Nutrition 0.000 claims 1
XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 83
229960003500 triclosan Drugs 0.000 description 83
-1 2 ' Chemical class 0.000 description 50
229920005646 polycarboxylate Polymers 0.000 description 50
239000000047 product Substances 0.000 description 48
239000000606 toothpaste Substances 0.000 description 33
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 30
235000013772 propylene glycol Nutrition 0.000 description 26
229910052588 hydroxylapatite Inorganic materials 0.000 description 23
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 23
229940034610 toothpaste Drugs 0.000 description 23
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 21
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 21
UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 21
229920000642 polymer Polymers 0.000 description 21
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 20
239000000600 sorbitol Substances 0.000 description 20
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 16
235000019441 ethanol Nutrition 0.000 description 16
235000019333 sodium laurylsulphate Nutrition 0.000 description 16
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
239000000243 solution Substances 0.000 description 15
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 14
235000011187 glycerol Nutrition 0.000 description 14
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 14
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 13
210000002919 epithelial cell Anatomy 0.000 description 10
RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 10
239000000499 gel Substances 0.000 description 10
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 9
WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 9
239000003906 humectant Substances 0.000 description 9
229910052708 sodium Inorganic materials 0.000 description 9
239000011734 sodium Substances 0.000 description 9
229920002125 Sokalan® Polymers 0.000 description 8
238000010521 absorption reaction Methods 0.000 description 8
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 8
210000004400 mucous membrane Anatomy 0.000 description 8
MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 8
XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 7
230000000694 effects Effects 0.000 description 7
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 7
229960003742 phenol Drugs 0.000 description 7
239000011775 sodium fluoride Substances 0.000 description 7
235000013024 sodium fluoride Nutrition 0.000 description 7
229960004711 sodium monofluorophosphate Drugs 0.000 description 7
241001127925 Arracacha virus A Species 0.000 description 6
238000002832 anti-viral assay Methods 0.000 description 6
239000000679 carrageenan Substances 0.000 description 6
229920001525 carrageenan Polymers 0.000 description 6
229940113118 carrageenan Drugs 0.000 description 6
239000003921 oil Substances 0.000 description 6
235000019198 oils Nutrition 0.000 description 6
239000004408 titanium dioxide Substances 0.000 description 6
TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 description 5
NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 5
JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 5
239000005770 Eugenol Substances 0.000 description 5
UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 5
229960002217 eugenol Drugs 0.000 description 5
238000009472 formulation Methods 0.000 description 5
239000003349 gelling agent Substances 0.000 description 5
239000000463 material Substances 0.000 description 5
125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 5
239000002245 particle Substances 0.000 description 5
239000002002 slurry Substances 0.000 description 5
AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 5
ZTWTYVWXUKTLCP-UHFFFAOYSA-N vinylphosphonic acid Chemical compound OP(O)(=O)C=C ZTWTYVWXUKTLCP-UHFFFAOYSA-N 0.000 description 5
229920002134 Carboxymethyl cellulose Polymers 0.000 description 4
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
239000002202 Polyethylene glycol Substances 0.000 description 4
239000005844 Thymol Substances 0.000 description 4
239000000654 additive Substances 0.000 description 4
239000001768 carboxy methyl cellulose Substances 0.000 description 4
229940091249 fluoride supplement Drugs 0.000 description 4
238000011534 incubation Methods 0.000 description 4
239000007791 liquid phase Substances 0.000 description 4
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 4
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 4
239000008375 oral care agent Substances 0.000 description 4
PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 4
239000012071 phase Substances 0.000 description 4
230000007505 plaque formation Effects 0.000 description 4
229920001223 polyethylene glycol Polymers 0.000 description 4
GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 4
235000012239 silicon dioxide Nutrition 0.000 description 4
229960000790 thymol Drugs 0.000 description 4
241000894006 Bacteria Species 0.000 description 3
CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 3
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
150000007513 acids Chemical class 0.000 description 3
BAPJBEWLBFYGME-UHFFFAOYSA-N acrylic acid methyl ester Natural products COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 3
229910052783 alkali metal Inorganic materials 0.000 description 3
230000002882 anti-plaque Effects 0.000 description 3
239000008346 aqueous phase Substances 0.000 description 3
230000008901 benefit Effects 0.000 description 3
IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical class C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 3
150000007942 carboxylates Chemical class 0.000 description 3
210000004027 cell Anatomy 0.000 description 3
238000005119 centrifugation Methods 0.000 description 3
239000007859 condensation product Substances 0.000 description 3
229920006037 cross link polymer Polymers 0.000 description 3
239000003431 cross linking reagent Substances 0.000 description 3
235000014113 dietary fatty acids Nutrition 0.000 description 3
238000004090 dissolution Methods 0.000 description 3
239000000194 fatty acid Substances 0.000 description 3
229930195729 fatty acid Natural products 0.000 description 3
150000004665 fatty acids Chemical class 0.000 description 3
239000004615 ingredient Substances 0.000 description 3
229920000554 ionomer Polymers 0.000 description 3
125000005341 metaphosphate group Chemical group 0.000 description 3
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 3
210000003254 palate Anatomy 0.000 description 3
239000004584 polyacrylic acid Substances 0.000 description 3
239000000843 powder Substances 0.000 description 3
230000002265 prevention Effects 0.000 description 3
150000003254 radicals Chemical class 0.000 description 3
229960004029 silicic acid Drugs 0.000 description 3
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 3
239000004299 sodium benzoate Substances 0.000 description 3
235000010234 sodium benzoate Nutrition 0.000 description 3
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
125000001424 substituent group Chemical group 0.000 description 3
239000006228 supernatant Substances 0.000 description 3
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HLCFGWHYROZGBI-JJKGCWMISA-M Potassium gluconate Chemical compound [K+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O HLCFGWHYROZGBI-JJKGCWMISA-M 0.000 description 1
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CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 description 1
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238000009825 accumulation Methods 0.000 description 1
229940091181 aconitic acid Drugs 0.000 description 1
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229910052910 alkali metal silicate Inorganic materials 0.000 description 1
229910001618 alkaline earth metal fluoride Inorganic materials 0.000 description 1
150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
150000008051 alkyl sulfates Chemical class 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
RREGISFBPQOLTM-UHFFFAOYSA-N alumane;trihydrate Chemical compound O.O.O.[AlH3] RREGISFBPQOLTM-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
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CKGWFZQGEQJZIL-UHFFFAOYSA-N amylmetacresol Chemical compound CCCCCC1=CC=C(C)C=C1O CKGWFZQGEQJZIL-UHFFFAOYSA-N 0.000 description 1
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239000002553 antibacterial enhancer Substances 0.000 description 1
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QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
230000003385 bacteriostatic effect Effects 0.000 description 1
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OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
229960001950 benzethonium chloride Drugs 0.000 description 1
UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
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150000001732 carboxylic acid derivatives Chemical group 0.000 description 1
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HNEGQIOMVPPMNR-IHWYPQMZSA-N citraconic acid Chemical compound OC(=O)C(/C)=C\C(O)=O HNEGQIOMVPPMNR-IHWYPQMZSA-N 0.000 description 1
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MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
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239000000796 flavoring agent Substances 0.000 description 1
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230000002070 germicidal effect Effects 0.000 description 1
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230000005484 gravity Effects 0.000 description 1
150000002357 guanidines Chemical class 0.000 description 1
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KUQWZSZYIQGTHT-UHFFFAOYSA-N hexa-1,5-diene-3,4-diol Chemical compound C=CC(O)C(O)C=C KUQWZSZYIQGTHT-UHFFFAOYSA-N 0.000 description 1
ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
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150000002430 hydrocarbons Chemical class 0.000 description 1
239000000017 hydrogel Substances 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
125000001165 hydrophobic group Chemical group 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
229910001506 inorganic fluoride Inorganic materials 0.000 description 1
230000010354 integration Effects 0.000 description 1
239000002563 ionic surfactant Substances 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000004973 liquid crystal related substance Substances 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
JDSHMPZPIAZGSV-UHFFFAOYSA-N melamine Chemical compound NC1=NC(N)=NC(N)=N1 JDSHMPZPIAZGSV-UHFFFAOYSA-N 0.000 description 1
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HNEGQIOMVPPMNR-NSCUHMNNSA-N mesaconic acid Chemical compound OC(=O)C(/C)=C/C(O)=O HNEGQIOMVPPMNR-NSCUHMNNSA-N 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
125000005395 methacrylic acid group Chemical group 0.000 description 1
238000000034 method Methods 0.000 description 1
WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
HNEGQIOMVPPMNR-UHFFFAOYSA-N methylfumaric acid Natural products OC(=O)C(C)=CC(O)=O HNEGQIOMVPPMNR-UHFFFAOYSA-N 0.000 description 1
239000000693 micelle Substances 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
210000000214 mouth Anatomy 0.000 description 1
210000004877 mucosa Anatomy 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
235000019488 nut oil Nutrition 0.000 description 1
239000010466 nut oil Substances 0.000 description 1
235000010292 orthophenyl phenol Nutrition 0.000 description 1
KZNNRLXBDAAMDZ-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane trihydrate Chemical compound O.O.O.O=[Al]O[Al]=O KZNNRLXBDAAMDZ-UHFFFAOYSA-N 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229920001568 phenolic resin Polymers 0.000 description 1
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical group O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
229920000744 poly(arginines) Polymers 0.000 description 1
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229920000573 polyethylene Polymers 0.000 description 1
229940057847 polyethylene glycol 600 Drugs 0.000 description 1
229920001444 polymaleic acid Polymers 0.000 description 1
229920000193 polymethacrylate Polymers 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920002635 polyurethane Polymers 0.000 description 1
239000004814 polyurethane Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000004224 potassium gluconate Substances 0.000 description 1
235000013926 potassium gluconate Nutrition 0.000 description 1
229960003189 potassium gluconate Drugs 0.000 description 1
229910001414 potassium ion Inorganic materials 0.000 description 1
OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
229940099402 potassium metaphosphate Drugs 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000004076 pyridyl group Chemical group 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
230000005855 radiation Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000011347 resin Substances 0.000 description 1
230000000284 resting effect Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
108700004121 sarkosyl Proteins 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
238000005029 sieve analysis Methods 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
AYMJWVLAMAPVPL-UHFFFAOYSA-M sodium fluorophosphonic acid fluoride Chemical compound [F-].[Na+].OP(O)(F)=O AYMJWVLAMAPVPL-UHFFFAOYSA-M 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
238000005063 solubilization Methods 0.000 description 1
230000007928 solubilization Effects 0.000 description 1
WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 1
239000001587 sorbitan monostearate Substances 0.000 description 1
235000011076 sorbitan monostearate Nutrition 0.000 description 1
229940035048 sorbitan monostearate Drugs 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
125000000542 sulfonic acid group Chemical group 0.000 description 1
239000013589 supplement Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
238000010998 test method Methods 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
125000004862 thiobutyl group Chemical group 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 description 1
238000003828 vacuum filtration Methods 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
238000005406 washing Methods 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
125000005023 xylyl group Chemical group 0.000 description 1
150000003751 zinc Chemical class 0.000 description 1
150000003752 zinc compounds Chemical class 0.000 description 1
GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Birds (AREA)
Epidemiology (AREA)
Oral & Maxillofacial Surgery (AREA)
Emergency Medicine (AREA)
Cosmetics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CH4685/89A 1988-12-29 1989-12-27 CH679639A5 (pl)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US07/291,712 US4894220A (en)	1987-01-30	1988-12-29	Antibacterial antiplaque oral composition
US39860689A	1989-08-25	1989-08-25
US39860589A	1989-08-25	1989-08-25
US39966989A	1989-08-25	1989-08-25
US07/398,566 US5032386A (en)	1988-12-29	1989-08-25	Antiplaque antibacterial oral composition
US07/398,592 US5188821A (en)	1987-01-30	1989-08-25	Antibacterial antiplaque oral composition mouthwash or liquid dentifrice
US41068289A	1989-09-21	1989-09-21

Publications (1)

Publication Number	Publication Date
CH679639A5 true CH679639A5 (pl)	1992-03-31

Family

ID=27569612

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH4685/89A CH679639A5 (pl)	1988-12-29	1989-12-27

Country Status (30)

Country	Link
JP (1)	JP2708134B2 (pl)
CN (1)	CN1048867C (pl)
AT (1)	AT397765B (pl)
AU (1)	AU625379B2 (pl)
BR (1)	BR8906866A (pl)
CH (1)	CH679639A5 (pl)
DE (1)	DE3942643B4 (pl)
DK (1)	DK175071B1 (pl)
DZ (2)	DZ1382A1 (pl)
FI (1)	FI100691B (pl)
FR (2)	FR2641186B1 (pl)
GB (3)	GB2227660B (pl)
GR (1)	GR1004463B (pl)
HK (3)	HK154796A (pl)
HU (1)	HU212183B (pl)
IE (1)	IE65326B1 (pl)
IL (1)	IL92692A0 (pl)
LU (1)	LU87650A1 (pl)
MA (1)	MA21712A1 (pl)
MX (1)	MX173741B (pl)
MY (1)	MY105879A (pl)
NL (1)	NL194716C (pl)
NO (1)	NO179503C (pl)
NZ (1)	NZ231813A (pl)
OA (1)	OA09253A (pl)
PL (1)	PL165470B1 (pl)
PT (1)	PT92734B (pl)
SE (2)	SE507731C2 (pl)
SK (1)	SK751289A3 (pl)
ZW (1)	ZW17289A1 (pl)

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DE10051955A1 (de) *	2000-10-20	2002-05-02	Wella Ag	Haarbehandlungsmittel in Form eines festen und formstabilen Gels
HUP0303048A2 (hu)	2000-12-15	2003-12-29	Unilever N.V.	Orális fogtisztító kompozíció, alkalmazása és ilyen kompozíciót tartalmazó csomagolt áru
PL203187B1 (pl)	2001-01-16	2009-09-30	Unilever Nv	Doustna kompozycja zawierajaca kwas pikolinowy i cząstki nadtlenkowe oraz jej zastosowanie
EP1413589A4 (en) *	2001-07-13	2006-06-07	Kao Corp	ORAL POLYMERS AND ORAL COMPOSITIONS
RU2205625C1 (ru) *	2002-07-12	2003-06-10	Открытое акционерное общество "Косметическое объединение "Свобода"	Лечебно-профилактическая композиция для обработки зубов
US6912826B2 (en)	2002-10-07	2005-07-05	Zoran Momich	Carrier loading cartoner
US7846422B2 (en)	2003-08-04	2010-12-07	Kao Corporation	Method for prevention or treatment of periodontal diseases and composition for an oral cavity
US20060024245A1 (en) *	2004-07-29	2006-02-02	Cadbury Adams, Llc.	Tooth whitening compositions and delivery systems therefor
US8974772B2 (en) *	2004-12-28	2015-03-10	Colgate-Palmolive Company	Two phase toothpaste composition
AU2008349846B2 (en) *	2008-02-08	2012-05-31	Colgate-Palmolive Company	Arginine salts and their uses for the treatment of illnesses in the oral cavity
SG173838A1 (en) *	2009-04-02	2011-09-29	Colgate Palmolive Co	Dentifrice composition
WO2011020684A2 (en)	2009-08-19	2011-02-24	Unilever Plc	Delivery system
WO2011109919A1 (en)	2010-03-09	2011-09-15	Unilever Plc	Stable oral care compositions
SG186944A1 (en) *	2010-07-29	2013-02-28	Colgate Palmolive Co	Phosphate free oral care compositions based on magnolia antibacterial agent
CN107308010A (zh)	2010-09-10	2017-11-03	荷兰联合利华有限公司	复合颗粒活性物及其制造方法
WO2012031786A2 (en)	2010-09-10	2012-03-15	Unilever Plc	Oral care compositions for benefiting teeth
EP2699217B1 (en)	2011-04-18	2018-01-24	Unilever N.V.	Tooth remineralizing oral care compositions
CN107743386A (zh)	2015-06-05	2018-02-27	荷兰联合利华有限公司	口腔护理装置
EA035044B1 (ru)	2015-06-05	2020-04-21	Юнилевер Н.В.	Устройство для доставки системы восстановления эмали на поверхность зубов
EA035881B1 (ru)	2015-06-05	2020-08-26	Юнилевер Н.В.	Способ косметического отбеливания зубов
EP3222326A1 (en)	2016-03-23	2017-09-27	Unilever PLC	Toothpaste composition
EP3295921A1 (en)	2016-09-14	2018-03-21	Unilever PLC	Use of oral care composition
GB201811065D0 (en) *	2018-07-05	2018-08-22	GlaxoSmithKline Consumer Healthcare UK IP Ltd	Novel composition
BR112021002528B1 (pt)	2018-09-12	2023-12-05	Unilever Ip Holdings B.V	Composição de cuidado pessoal não aquosa e uso de um ph 9,45 ou superior
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1989
- 1989-12-12 SE SE8904180A patent/SE507731C2/sv unknown
- 1989-12-13 IL IL92692A patent/IL92692A0/xx not_active IP Right Cessation
- 1989-12-13 AU AU46769/89A patent/AU625379B2/en not_active Expired
- 1989-12-15 NZ NZ231813A patent/NZ231813A/en unknown
- 1989-12-20 MX MX018805A patent/MX173741B/es unknown
- 1989-12-21 GR GR890100853A patent/GR1004463B/el not_active IP Right Cessation
- 1989-12-21 GB GB8928878A patent/GB2227660B/en not_active Expired - Lifetime
- 1989-12-21 ZW ZW172/89A patent/ZW17289A1/xx unknown
- 1989-12-22 DE DE3942643A patent/DE3942643B4/de not_active Expired - Lifetime
- 1989-12-25 DZ DZ890197A patent/DZ1382A1/fr active
- 1989-12-26 MA MA21974A patent/MA21712A1/fr unknown
- 1989-12-27 MY MYPI89001861A patent/MY105879A/en unknown
- 1989-12-27 CH CH4685/89A patent/CH679639A5/de not_active IP Right Cessation
- 1989-12-27 PT PT92734A patent/PT92734B/pt not_active IP Right Cessation
- 1989-12-28 NO NO895310A patent/NO179503C/no not_active IP Right Cessation
- 1989-12-28 FR FR8917373A patent/FR2641186B1/fr not_active Expired - Lifetime
- 1989-12-28 DK DK198906709A patent/DK175071B1/da not_active IP Right Cessation
- 1989-12-28 HU HU896808A patent/HU212183B/hu unknown
- 1989-12-28 IE IE419589A patent/IE65326B1/en not_active IP Right Cessation
- 1989-12-28 CN CN89109648A patent/CN1048867C/zh not_active Expired - Fee Related
- 1989-12-28 FI FI896316A patent/FI100691B/fi active IP Right Grant
- 1989-12-28 SK SK7512-89A patent/SK751289A3/sk not_active IP Right Cessation
- 1989-12-29 NL NL8903187A patent/NL194716C/nl not_active IP Right Cessation
- 1989-12-29 LU LU87650A patent/LU87650A1/fr unknown
- 1989-12-29 OA OA59716A patent/OA09253A/xx unknown
- 1989-12-29 BR BR898906866A patent/BR8906866A/pt not_active Application Discontinuation
- 1989-12-29 AT AT0296889A patent/AT397765B/de not_active IP Right Cessation
- 1989-12-29 PL PL89283117A patent/PL165470B1/pl unknown
1990
- 1990-01-04 JP JP2000211A patent/JP2708134B2/ja not_active Expired - Lifetime
1992
- 1992-08-07 GB GB9216778A patent/GB2257362B/en not_active Expired - Lifetime
- 1992-10-13 FR FR9212240A patent/FR2681529B1/fr not_active Expired - Lifetime
- 1992-12-03 GB GB9225278A patent/GB2259856B/en not_active Expired - Lifetime
1993
- 1993-06-23 DZ DZ930077A patent/DZ1699A1/fr active
1996
- 1996-08-15 HK HK154796A patent/HK154796A/xx not_active IP Right Cessation
- 1996-08-15 HK HK154996A patent/HK154996A/xx not_active IP Right Cessation
- 1996-08-15 HK HK154896A patent/HK154896A/xx not_active IP Right Cessation
1997
- 1997-10-09 SE SE9703681A patent/SE510832C2/sv unknown

Also Published As

Publication number	Publication date
LU87650A1 (fr)	1990-07-10
FR2641186A1 (fr)	1990-07-06
GB2257362B (en)	1993-09-01
IE894195L (en)	1990-06-29
GB8928878D0 (en)	1990-02-28
JP2708134B2 (ja)	1998-02-04
GR890100853A (el)	1991-03-15
SE8904180D0 (sv)	1989-12-12
GB9225278D0 (en)	1993-01-27
HU896808D0 (en)	1990-03-28
JPH02288819A (ja)	1990-11-28
FI896316A0 (fi)	1989-12-28
MY105879A (en)	1995-02-28
PT92734A (pt)	1990-06-29
GB2227660B (en)	1993-09-01
FI100691B (fi)	1998-02-13
NZ231813A (en)	1992-05-26
FR2681529B1 (fr)	1994-07-22
HK154996A (en)	1996-08-23
AT397765B (de)	1994-06-27
DK670989D0 (da)	1989-12-28
GB9216778D0 (en)	1992-09-23
NO179503C (no)	1996-10-23
IL92692A0 (en)	1990-09-17
MA21712A1 (fr)	1990-07-01
GR1004463B (el)	2004-02-27
DK670989A (da)	1990-06-30
OA09253A (fr)	1992-06-30
GB2259856B (en)	1993-09-01
CN1048867C (zh)	2000-02-02
CN1044047A (zh)	1990-07-25
NL194716B (nl)	2002-09-02
SE8904180L (sv)	1990-06-30
DZ1699A1 (fr)	2002-02-17
AU4676989A (en)	1990-07-05
SE510832C2 (sv)	1999-06-28
FR2681529A1 (fr)	1993-03-26
DK175071B1 (da)	2004-05-24
NL8903187A (nl)	1990-07-16
NO895310D0 (no)	1989-12-28
HK154896A (en)	1996-08-23
SE507731C2 (sv)	1998-07-06
HK154796A (en)	1996-08-23
GB2259856A (en)	1993-03-31
NO895310L (no)	1990-07-02
MX173741B (es)	1994-03-25
SK280567B6 (sk)	2000-03-13
SE9703681D0 (sv)	1997-10-09
PL165470B1 (pl)	1994-12-30
GB2257362A (en)	1993-01-13
NL194716C (nl)	2003-01-07
IE65326B1 (en)	1995-10-18
ATA296889A (de)	1993-11-15
HU212183B (en)	1996-03-28
PT92734B (pt)	1996-06-28
PL283117A1 (en)	1991-02-11
SK751289A3 (en)	2000-03-13
DE3942643A1 (de)	1990-07-05
BR8906866A (pt)	1990-10-09
FR2641186B1 (fr)	1994-12-23
NO179503B (no)	1996-07-15
SE9703681L (sv)	1997-10-09
GB2227660A (en)	1990-08-08
AU625379B2 (en)	1992-07-09
DZ1382A1 (fr)	2004-09-13
ZW17289A1 (en)	1992-01-01
DE3942643B4 (de)	2008-03-27

Legal Events

Date

Code

Title

Description

2007-10-30

PFA

Name/firm changed

Owner name: COLGATE-PALMOLIVE COMPANY

Free format text: COLGATE-PALMOLIVE COMPANY#300 PARK AVENUE#NEW YORK/NY (US) -TRANSFER TO- COLGATE-PALMOLIVE COMPANY#300 PARK AVENUE#NEW YORK/NY (US)

2009-12-31

PL

Patent ceased

Publication	Publication Date	Title
DE3942643B4 (de)	2008-03-27	Mundpflegemittel
DE3942644B4 (de)	2007-09-06	Antibakteriell zahnbelagverhinderndes und zahnsteinverhinderndes Mundpflegemittel
DD291246A5 (de)	1991-06-27	Mundpflegemittel
AT395109B (de)	1992-09-25	Mundpflegemittel
US5344641A (en)	1994-09-06	Antibacterial antiplaque oral composition
DE69625122T2 (de)	2003-09-11	Orale antibakterielle Zusammensetzung zum Aufbringen auf Zahnimplantatoberflächen
DE60014144T2 (de)	2005-09-29	Verbesserte zweikomponente orale zusammensetzungen die zinn-derivate enthalten
US5800803A (en)	1998-09-01	Oral composition exhibiting enhanced uptake by dental tissue of noncationic antibacterial agents
US5296214A (en)	1994-03-22	Anticalculus composition
DE2922664A1 (de)	1980-12-11	Gegen zahnsteinbildung wirksame orale zusammensetzung
DE3017417A1 (de)	1980-11-27	Antibakterielle zusammensetzung fuer die mundhygiene
DE69328903T2 (de)	2000-12-07	Gegen zahnbelag, gingivitis und karies wirkende orale zusammensetzung
DE69415515T2 (de)	1999-07-29	Orale präparate zur behandlung von plaque und gingivitis, die einen nicht-kationischen antibakteriellen wirkstoff und ein bikarbonatsalz enthalten
CH661440A5 (de)	1987-07-31	Mittel zur oral-dentalen anwendung gegen plaque und gingivitis.
DE3151217A1 (de)	1982-08-05	Mittel zur foerderung der mundhygiene
DE3645147C2 (de)	2000-11-09	Zahnpflegemittel
DE69934402T2 (de)	2007-09-27	Klare mundpflegemitteln
DE2842182A1 (de)	1980-02-14	Mundpflegemittel
DE3029921A1 (de)	1981-03-12	Gegen zahnsteinbildung wirksame zusammensetzung.
CA2006703C (en)	1997-02-04	Antibacterial anti-plaque oral composition
EP3883529A1 (en)	2021-09-29	Oral care compositions
CH654202A5 (en)	1986-02-14	Process for the production of an oral composition with antitartar activity
IE65678B1 (en)	1995-11-15	Antiplaque antibacterial oral composition