CH84832A - Process for the preparation of a complex silver compound of glycocolla - Google Patents
Process for the preparation of a complex silver compound of glycocollaInfo
- Publication number
- CH84832A CH84832A CH84832DA CH84832A CH 84832 A CH84832 A CH 84832A CH 84832D A CH84832D A CH 84832DA CH 84832 A CH84832 A CH 84832A
- Authority
- CH
- Switzerland
- Prior art keywords
- silver compound
- complex
- glycocolla
- complex silver
- preparation
- Prior art date
Links
- 229940100890 silver compound Drugs 0.000 title claims description 12
- 150000003379 silver compounds Chemical class 0.000 title claims description 12
- 238000000034 method Methods 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title claims description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 229910001923 silver oxide Inorganic materials 0.000 claims description 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 125000003827 glycol group Chemical group 0.000 claims description 2
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- 150000001450 anions Chemical class 0.000 description 3
- 150000003378 silver Chemical class 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000013905 glycine and its sodium salt Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- 150000001371 alpha-amino acids Chemical class 0.000 description 1
- 235000008206 alpha-amino acids Nutrition 0.000 description 1
- -1 amine compounds Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 229910000069 nitrogen hydride Inorganic materials 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 229940054334 silver cation Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 1
- 150000004764 thiosulfuric acid derivatives Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic Table without C-Metal linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
Description
Verfahren zur Darstellung einer komplexen Silberverbindung des Glykokolls. Komplexe Silberverbindungen von α-Amino- säuren sind noch nicht bekannt. Bei Zusatz voll Ammoniak und Aminen, wie zum Bei spiel Methylamin, Äthylamin oder Äthylen diamin, sowie von Cyaniden, Thiosulfaten, Rhodaniden zu organischen und anorganischen Silbersalzen entstehen bekanntlich komplexe Silbersalze, welche das Silber nicht oder nur zum geringen Teil in der Form des elektrisch dissoziierten einwertigen Silberkationsbesitzen.
Die Ammoniak- und Aminverbindungen ent halten nach den Untersuchungen von Bod- länder (Berichte der deutschen chemischen Gesellschaft 36, 1903, S. 2878), Bodländer und Fittig (Zeitschrift für physiologische Che mie, 39, 1902, S. 605), sowie von Euler (Be richte der deutschen chemischen Gesellschaft 36, 1903, S. 1854) das komplexe Kation [Ag(Am)2]', wo Am NH3, CH3 ³ NH2 usw. be deutet. Die Cyaniddoppelsalze weisen das komplexe Anion [Ag(CN)2]', die Rhodaniddop- pelsalze das Anion [Ag(SCN)2]', die Thiosulfat- doppelsalze das Anion [Ag(S203)2]''' und [Ag(S2Os)3]''''' auf.
Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Darstellung einer kom- plexen Silberverbindung des Glykokolls, wel- ehes darauf beruht, dass man auf Glykokoll- silber einen Überschuss voll Glykokoll zur Einwirkung bringt.
Die komplexe Silberverbindung des Gly- kokolls bildet ein farbloses, in weissen Täfel chen kristallisierendes Salz, welches sich ziemlich leicht in Wasser löst. Die Löslich keit wird durch Zusatz einer Aminosäure noch erhöht. Die wässerige Lösung reagiert lackmus- alkalisch. Sie zeichnet sich. gegenüber den wässerigen Lösungen der einfachen Silber salze durch eine bedeutend grössere Haltbar keit aus. Auf Zusatz von Natronlauge oder Soda trübt sie sich erst nach längerem Stehen. Die komplexe Silberverbindung des Glykokolls soll zu therapeutischen Zwecken verwendet werden.
<I>Beispiel 1:</I> In eine kaltgesättigte wässerige Lösung von vier Teilen Glykokoll wird ein Teil Gly- kokollsilber eingetragen. Die Flüssigkeit wird, wenn notwendig, filtriert und in eine Kälte mischung gestellt. Die komplexe Silberver bindung des (Trlykokolls scheidet sich als farbloses Salz aus. Nach Abtrennung der Kristalle kann man die Mutterlauge neuer dings mit Glykokoll sättigen und durch Ein tragen von Glykokollsilber weitere Mengen der komplexen Silberverbindung erhalten.
Beispiel 2: 15,2 Teile Glykokollsilber werden in einer konzentrierten Lösung von 67,5 Teilen Gly- kokoll gelöst und die Flüssigkeit unter Aus- sehluf von Licht bei niedriger Temperatur irn Vakuum zur Trockne gedampft.
Beispiel 3: An Stelle von fertiggebildetem Glykokoll- silber kann man auch in eine kaltgesättigte Lösung von S Teilen Glykokoll 1 Teil frisch gefälltes Silberoxyd eintragen. Es entsteht dann beim Erwärmen in der Lösung Gly- kokollsilber, welches mit dem Überschuss an Glykokoll die komplexe Silberverbindung bildet. Zur Gewinnung der Komplexverbindung wird die durch Filtrieren vom ungelösten Silberoxyd befreite Lösung in eine Kälte mischung gestellt. Es scheiden sich dann die farblosen Tafelehen der Komplexverbindung ab.
Process for the preparation of a complex silver compound of glycocolla Complex silver compounds of α-amino acids are not yet known. When adding full ammonia and amines, such as methylamine, ethylamine or ethylene diamine, as well as cyanides, thiosulphates, rhodanides to organic and inorganic silver salts, complex silver salts are known to form, which do not or only partially dissociate the silver in the form of the electrically monovalent silver cation possessions.
The ammonia and amine compounds contain according to the investigations by Bodlander (reports of the German chemical society 36, 1903, p. 2878), Bodländer and Fittig (Zeitschrift für Physiologische Chemie, 39, 1902, p. 605), and by Euler (Be richte der Deutschenchemische Gesellschaft 36, 1903, S. 1854) the complex cation [Ag (Am) 2] ', where Am NH3, CH3 ³ NH2 etc. mean. The cyanide double salts have the complex anion [Ag (CN) 2] ', the rhodanide double salts the anion [Ag (SCN) 2]', the thiosulphate double salts the anion [Ag (S203) 2] '' 'and [Ag ( S2Os) 3] '' '' 'on.
The subject matter of the present invention is a method for the preparation of a complex silver compound of glycocollar, which is based on the fact that an excess of glycocollar is brought into action on glycocollilil.
The complex silver compound of the glycol forms a colorless salt that crystallizes in white tablets and dissolves fairly easily in water. The solubility is increased by adding an amino acid. The aqueous solution has a litmus alkaline reaction. She stands out. Compared to the aqueous solutions of the simple silver salts, they have a significantly longer shelf life. With the addition of caustic soda or soda, it only becomes cloudy after standing for a long time. The complex silver compound of glycocolla is said to be used for therapeutic purposes.
<I> Example 1: </I> One part of glycollsilver is added to a cold, saturated aqueous solution of four parts of glycocoll. If necessary, the liquid is filtered and placed in a cold mixture. The complex silver compound of the (trlycol separates out as a colorless salt. After the crystals have been separated off, the mother liquor can again be saturated with glycocoll and additional amounts of the complex silver compound can be obtained by adding glycocollsilver.
Example 2: 15.2 parts of glycocollsilver are dissolved in a concentrated solution of 67.5 parts of glycocolla and the liquid is evaporated to dryness with the exclusion of light at low temperature in a vacuum.
Example 3: Instead of fully formed glycocollil silver, 1 part of freshly precipitated silver oxide can also be added to a cold-saturated solution of 5 parts of glycocolla. When the solution is warmed up, glycocollsilver is formed, which forms the complex silver compound with the excess of glycocolla. To obtain the complex compound, the solution freed from undissolved silver oxide by filtration is placed in a cold mixture. The colorless tablets of the complex compound then separate out.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH84832T | 1918-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH84832A true CH84832A (en) | 1920-04-16 |
Family
ID=4341033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH84832D CH84832A (en) | 1918-12-23 | 1918-12-23 | Process for the preparation of a complex silver compound of glycocolla |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH84832A (en) |
-
1918
- 1918-12-23 CH CH84832D patent/CH84832A/en unknown
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