CL2004000926A1 - Cristal de la fosfodiesterasa 5 (pde5) modificada; usos y procedimientos para identificar compuestos que se unen a pde5. - Google Patents

Cristal de la fosfodiesterasa 5 (pde5) modificada; usos y procedimientos para identificar compuestos que se unen a pde5.

Info

Publication number
CL2004000926A1
CL2004000926A1 CL200400926A CL2004000926A CL2004000926A1 CL 2004000926 A1 CL2004000926 A1 CL 2004000926A1 CL 200400926 A CL200400926 A CL 200400926A CL 2004000926 A CL2004000926 A CL 2004000926A CL 2004000926 A1 CL2004000926 A1 CL 2004000926A1
Authority
CL
Chile
Prior art keywords
pde5
phosphodesterase
join
procedures
crystal
Prior art date
Application number
CL200400926A
Other languages
English (en)
Spanish (es)
Inventor
Graham Brown Colin Roger David
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CL2004000926A1 publication Critical patent/CL2004000926A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CL200400926A 2003-05-01 2004-04-30 Cristal de la fosfodiesterasa 5 (pde5) modificada; usos y procedimientos para identificar compuestos que se unen a pde5. CL2004000926A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0310058 2003-05-01

Publications (1)

Publication Number Publication Date
CL2004000926A1 true CL2004000926A1 (es) 2005-04-22

Family

ID=33397043

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200400926A CL2004000926A1 (es) 2003-05-01 2004-04-30 Cristal de la fosfodiesterasa 5 (pde5) modificada; usos y procedimientos para identificar compuestos que se unen a pde5.

Country Status (10)

Country Link
EP (1) EP1623026A1 (pt)
JP (1) JP2006525801A (pt)
AR (1) AR044133A1 (pt)
BR (1) BRPI0409931A (pt)
CA (1) CA2522472A1 (pt)
CL (1) CL2004000926A1 (pt)
MX (1) MXPA05011769A (pt)
RU (1) RU2005133628A (pt)
TW (1) TW200510540A (pt)
WO (1) WO2004097010A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2152876A2 (en) * 2007-05-02 2010-02-17 Sirna Therapeutics Inc. Rna interference mediated inhibition of cyclic nucleotide type 4 phosphodiesterase (pde4b) gene expression using short interfering nucleic acid (sina)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE199569T1 (de) * 1993-05-27 2001-03-15 Univ Washington Cyclisch gmp bindende cyclisch gmp spezifische phosphodiesterase materialien und verfahren.
GB9923968D0 (en) * 1999-10-11 1999-12-15 Pfizer Ltd Therapeutic agents
GB0126417D0 (en) * 2001-11-02 2002-01-02 Pfizer Ltd Crystal structure

Also Published As

Publication number Publication date
WO2004097010A1 (en) 2004-11-11
CA2522472A1 (en) 2004-11-11
BRPI0409931A (pt) 2006-04-25
EP1623026A1 (en) 2006-02-08
TW200510540A (en) 2005-03-16
JP2006525801A (ja) 2006-11-16
RU2005133628A (ru) 2007-05-10
MXPA05011769A (es) 2006-01-26
AR044133A1 (es) 2005-08-24

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