CL2008003825A1 - Compuestos derivados de 4-pirrolidinbenzonitrilo, moduladores selectivos de receptores de androgeno; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento de una enfermedad o trastorno seleccionada de piel envejecida, enfermedad de alzheimer, anemia, artritis, gota, arterosclerosis, enfermedad osea, entre otras. - Google Patents

Compuestos derivados de 4-pirrolidinbenzonitrilo, moduladores selectivos de receptores de androgeno; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento de una enfermedad o trastorno seleccionada de piel envejecida, enfermedad de alzheimer, anemia, artritis, gota, arterosclerosis, enfermedad osea, entre otras.

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Publication number
CL2008003825A1
CL2008003825A1 CL2008003825A CL2008003825A CL2008003825A1 CL 2008003825 A1 CL2008003825 A1 CL 2008003825A1 CL 2008003825 A CL2008003825 A CL 2008003825A CL 2008003825 A CL2008003825 A CL 2008003825A CL 2008003825 A1 CL2008003825 A1 CL 2008003825A1
Authority
CL
Chile
Prior art keywords
disease
gout
anemia
atherosclerosis
alzheimer
Prior art date
Application number
CL2008003825A
Other languages
English (en)
Inventor
Lin Zhi
Original Assignee
Ligand Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharm Inc filed Critical Ligand Pharm Inc
Publication of CL2008003825A1 publication Critical patent/CL2008003825A1/es

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Abstract

Compuestos moduladores selectivos de receptores de andrógeno derivados de pirrolidin u oxazinoquinolina composición farmacéutica, útil para tratar una enfermedad o trastorno seleccionada de entre piel envejecida, enfermedad de Alzheimer, anemia, anorexia, artritis, gota, arterosclerosis, enfermedad ósea, caquexia, cáncer de mama, disfunción cardiaca.
CL2008003825A 2007-12-21 2008-12-19 Compuestos derivados de 4-pirrolidinbenzonitrilo, moduladores selectivos de receptores de androgeno; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento de una enfermedad o trastorno seleccionada de piel envejecida, enfermedad de alzheimer, anemia, artritis, gota, arterosclerosis, enfermedad osea, entre otras. CL2008003825A1 (es)

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PCT/US2008/013657 WO2009082437A2 (en) 2007-12-21 2008-12-12 Selective androgen receptor modulators (sarms) and uses thereof

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