CL2011000838A1 - Compuestos heterociclicos derivados de tetraciclos ortocondensados con un grupo pirimidina 2,4,6-triona espirocondensado, inhibidores de la adn girasa bacteriana; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una infeccion bacteriana. - Google Patents

Compuestos heterociclicos derivados de tetraciclos ortocondensados con un grupo pirimidina 2,4,6-triona espirocondensado, inhibidores de la adn girasa bacteriana; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una infeccion bacteriana.

Info

Publication number
CL2011000838A1
CL2011000838A1 CL2011000838A CL2011000838A CL2011000838A1 CL 2011000838 A1 CL2011000838 A1 CL 2011000838A1 CL 2011000838 A CL2011000838 A CL 2011000838A CL 2011000838 A CL2011000838 A CL 2011000838A CL 2011000838 A1 CL2011000838 A1 CL 2011000838A1
Authority
CL
Chile
Prior art keywords
spirocondensate
trione
ortho
pyrimidine
condensed
Prior art date
Application number
CL2011000838A
Other languages
English (en)
Inventor
Sheila Irene Hauck
Kevin Barvian
Gregory Stevan Basara
Madhusudhanreddy Gowravaram
Fei Zhou
Original Assignee
Astrazeneca Ab Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab Astrazeneca Uk Ltd filed Critical Astrazeneca Ab Astrazeneca Uk Ltd
Publication of CL2011000838A1 publication Critical patent/CL2011000838A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

Compuestos heterocíclicos derivados de tetracíclos ortocondensados con un grupo pirimidina 2,4,6-triona espirocondensado, inhibidores de la ADN girasa bacteriana; proceso de preparación; composición farmacéutica; y su uso para el tratamiento de una infección bacteriana.
CL2011000838A 2008-10-14 2011-04-14 Compuestos heterociclicos derivados de tetraciclos ortocondensados con un grupo pirimidina 2,4,6-triona espirocondensado, inhibidores de la adn girasa bacteriana; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una infeccion bacteriana. CL2011000838A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10518908P 2008-10-14 2008-10-14

Publications (1)

Publication Number Publication Date
CL2011000838A1 true CL2011000838A1 (es) 2011-10-21

Family

ID=41668347

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011000838A CL2011000838A1 (es) 2008-10-14 2011-04-14 Compuestos heterociclicos derivados de tetraciclos ortocondensados con un grupo pirimidina 2,4,6-triona espirocondensado, inhibidores de la adn girasa bacteriana; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una infeccion bacteriana.

Country Status (24)

Country Link
US (1) US8658641B2 (es)
EP (1) EP2350077B1 (es)
JP (2) JP5749169B2 (es)
KR (1) KR101676886B1 (es)
CN (2) CN104086565A (es)
AR (1) AR073862A1 (es)
AU (1) AU2009305203B2 (es)
BR (1) BRPI0920180B1 (es)
CA (1) CA2736335C (es)
CL (1) CL2011000838A1 (es)
CO (1) CO6382126A2 (es)
CR (1) CR20110195A (es)
CU (1) CU20110083A7 (es)
DO (1) DOP2011000102A (es)
EA (1) EA201100613A1 (es)
EC (1) ECSP11010980A (es)
ES (1) ES2565611T3 (es)
HK (1) HK1203483A1 (es)
IL (1) IL211728A0 (es)
MX (1) MX2011003598A (es)
TW (1) TW201020258A (es)
UY (1) UY32174A (es)
WO (1) WO2010043893A1 (es)
ZA (1) ZA201103533B (es)

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WO2016073889A1 (en) 2014-11-06 2016-05-12 Lysosomal Therapeutics Inc. Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
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TW201629026A (zh) 2015-02-02 2016-08-16 佛瑪治療公司 作為ｈｄａｃ抑制劑的３－烷基雙環［４，５，０］異羥肟酸
WO2016168660A1 (en) 2015-04-17 2016-10-20 Forma Therapeutics, Inc. 3-spiro-7-hydroxamic acid tetralins as hdac inhibitors
WO2017024455A1 (zh) * 2015-08-07 2017-02-16 苏州大学张家港工业技术研究院 一种螺环羟吲哚咪唑啉并氧氮杂卓化合物及其合成方法
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JP6949025B2 (ja) 2015-12-17 2021-10-13 ヤンセン ファーマシューティカ エヌ．ベー． リスペリドンに対する抗体及びその使用
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Also Published As

Publication number Publication date
UY32174A (es) 2010-05-31
CN104086565A (zh) 2014-10-08
WO2010043893A1 (en) 2010-04-22
DOP2011000102A (es) 2011-05-15
CR20110195A (es) 2011-06-08
CA2736335C (en) 2017-05-09
US8658641B2 (en) 2014-02-25
MX2011003598A (es) 2011-04-27
TW201020258A (en) 2010-06-01
CA2736335A1 (en) 2010-04-22
AU2009305203A1 (en) 2010-04-22
AR073862A1 (es) 2010-12-09
ZA201103533B (en) 2012-01-25
CO6382126A2 (es) 2012-02-15
EA201100613A1 (ru) 2011-12-30
EP2350077B1 (en) 2016-01-27
ECSP11010980A (es) 2011-05-31
IL211728A0 (en) 2011-06-30
JP2012505261A (ja) 2012-03-01
BRPI0920180A2 (pt) 2020-12-29
US20110245224A1 (en) 2011-10-06
KR101676886B1 (ko) 2016-11-16
EP2350077A1 (en) 2011-08-03
KR20110090895A (ko) 2011-08-10
BRPI0920180B1 (pt) 2021-10-26
CN102245605A (zh) 2011-11-16
JP5749169B2 (ja) 2015-07-15
HK1160127A1 (zh) 2012-08-10
CU20110083A7 (es) 2013-05-31
ES2565611T3 (es) 2016-04-05
AU2009305203B2 (en) 2013-03-07
CN102245605B (zh) 2016-01-27
HK1203483A1 (en) 2015-10-30
JP2015178510A (ja) 2015-10-08

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