CL2012000959A1 - Método para preparar éster aril-2-tetrazolil etílico de ácido carbámico que comprende una reducción enzimática enantioselectiva de una arilcetona para formar un compuesto de alcohol de configuración (r) y carbamatar el alcohol; método enzimático para preparar un compuesto de alcohol mediante una reducción por una oxidoreductasa. - Google Patents

Método para preparar éster aril-2-tetrazolil etílico de ácido carbámico que comprende una reducción enzimática enantioselectiva de una arilcetona para formar un compuesto de alcohol de configuración (r) y carbamatar el alcohol; método enzimático para preparar un compuesto de alcohol mediante una reducción por una oxidoreductasa.

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Publication number
CL2012000959A1
CL2012000959A1 CL2012000959A CL2012000959A CL2012000959A1 CL 2012000959 A1 CL2012000959 A1 CL 2012000959A1 CL 2012000959 A CL2012000959 A CL 2012000959A CL 2012000959 A CL2012000959 A CL 2012000959A CL 2012000959 A1 CL2012000959 A1 CL 2012000959A1
Authority
CL
Chile
Prior art keywords
reduction
alcohol
preparing
alcohol compound
enzymatic
Prior art date
Application number
CL2012000959A
Other languages
English (en)
Inventor
Sang Chul Lim
Moo Yong Uhm
Dae Won Lee
Hui Ho Kim
Dong Ho Lee
Hyun Seok Lee
Original Assignee
Sk Biopharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Sk Biopharmaceuticals Co Ltd filed Critical Sk Biopharmaceuticals Co Ltd
Publication of CL2012000959A1 publication Critical patent/CL2012000959A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DIVULGA UN MÉTODO PARA LA PREPARACIÓN DE ÉSTER (R)-1-ARIL-2-TETRAIOLIL-ETÍLICO DE ÁCIDO CARBÁMICO, QUE COMPRENDE LA REDUCCIÓN DE ENZIMÁTICA ENANLIOSELECTIVA DE LA ARILCETONA PARA 1IRMAR UN COMPUESTO DE ALCOHOL DE CONFIGURACIÓN (R) Y CARBAMATAR EL ALCOHOL; RESULTANTE. SE DIVULGA TAMBIÉN UN MÉTODO ENZIMÁTICO PARA PREPARAR UN COMPUESTO DE ALCOHOL MEDIANTE UNA REDUCCIÓN POR UNA OXIDOREDUCTASA.
CL2012000959A 2009-10-15 2012-04-13 Método para preparar éster aril-2-tetrazolil etílico de ácido carbámico que comprende una reducción enzimática enantioselectiva de una arilcetona para formar un compuesto de alcohol de configuración (r) y carbamatar el alcohol; método enzimático para preparar un compuesto de alcohol mediante una reducción por una oxidoreductasa. CL2012000959A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25186709P 2009-10-15 2009-10-15

Publications (1)

Publication Number Publication Date
CL2012000959A1 true CL2012000959A1 (es) 2012-10-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012000959A CL2012000959A1 (es) 2009-10-15 2012-04-13 Método para preparar éster aril-2-tetrazolil etílico de ácido carbámico que comprende una reducción enzimática enantioselectiva de una arilcetona para formar un compuesto de alcohol de configuración (r) y carbamatar el alcohol; método enzimático para preparar un compuesto de alcohol mediante una reducción por una oxidoreductasa.

Country Status (18)

Country Link
US (3) US8404461B2 (es)
EP (1) EP2488505B1 (es)
JP (1) JP5797656B2 (es)
KR (1) KR101708437B1 (es)
CN (1) CN102574821B (es)
AU (1) AU2010307466B2 (es)
BR (1) BR112012008858B1 (es)
CA (1) CA2776743C (es)
CL (1) CL2012000959A1 (es)
ES (1) ES2536488T3 (es)
HU (1) HUE025816T2 (es)
IL (1) IL218787A0 (es)
MX (1) MX2012004055A (es)
MY (1) MY162997A (es)
PL (1) PL2488505T3 (es)
RU (1) RU2539983C2 (es)
WO (1) WO2011046380A2 (es)
ZA (1) ZA201202629B (es)

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KR102421006B1 (ko) * 2016-05-19 2022-07-14 에스케이바이오팜 주식회사 두통의 예방학적 치료를 위한 카바메이트 화합물의 용도
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KR102635941B1 (ko) * 2016-12-14 2024-02-13 에스케이바이오팜 주식회사 진전 또는 진전 증후군의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도
CN110290788A (zh) 2016-12-14 2019-09-27 爱思开生物制药株式会社 氨基甲酸酯化合物用于预防、缓解或治疗双相障碍的用途
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CN111432812A (zh) * 2017-11-14 2020-07-17 爱思开生物制药株式会社 用于预防、减轻或治疗失神发作或显示失神发作的癫痫的氨基甲酸酯化合物的用途
KR102900174B1 (ko) 2017-11-14 2025-12-16 에스케이바이오팜 주식회사 근긴장증의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도
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