CL2013000352A1 - Compuesto derivado de isoxazolina como agentes antiparasitarios; composicion farmaceutica o veterinaria que comprende el compuesto; uso del compuesto para preparar un medicamento. - Google Patents
Compuesto derivado de isoxazolina como agentes antiparasitarios; composicion farmaceutica o veterinaria que comprende el compuesto; uso del compuesto para preparar un medicamento.Info
- Publication number
- CL2013000352A1 CL2013000352A1 CL2013000352A CL2013000352A CL2013000352A1 CL 2013000352 A1 CL2013000352 A1 CL 2013000352A1 CL 2013000352 A CL2013000352 A CL 2013000352A CL 2013000352 A CL2013000352 A CL 2013000352A CL 2013000352 A1 CL2013000352 A1 CL 2013000352A1
- Authority
- CL
- Chile
- Prior art keywords
- compound
- isoxazoline
- medicine
- pharmaceutical
- prepare
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 3
- WEQPBCSPRXFQQS-UHFFFAOYSA-N 4,5-dihydro-1,2-oxazole Chemical compound C1CC=NO1 WEQPBCSPRXFQQS-UHFFFAOYSA-N 0.000 title 1
- 239000003096 antiparasitic agent Substances 0.000 title 1
- 229940125687 antiparasitic agent Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37101410P | 2010-08-05 | 2010-08-05 | |
| US201161445221P | 2011-02-22 | 2011-02-22 | |
| US201161451888P | 2011-03-11 | 2011-03-11 | |
| US201161486831P | 2011-05-17 | 2011-05-17 | |
| US201161490811P | 2011-05-27 | 2011-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013000352A1 true CL2013000352A1 (es) | 2013-09-23 |
Family
ID=45556573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013000352A CL2013000352A1 (es) | 2010-08-05 | 2013-02-04 | Compuesto derivado de isoxazolina como agentes antiparasitarios; composicion farmaceutica o veterinaria que comprende el compuesto; uso del compuesto para preparar un medicamento. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8415310B2 (es) |
| EP (1) | EP2601190B1 (es) |
| JP (1) | JP5409968B2 (es) |
| KR (1) | KR101508862B1 (es) |
| CN (1) | CN103270036B (es) |
| AR (1) | AR082562A1 (es) |
| AU (1) | AU2011287323B2 (es) |
| BR (1) | BR112013002871B1 (es) |
| CA (1) | CA2807005C (es) |
| CL (1) | CL2013000352A1 (es) |
| CO (1) | CO6680631A2 (es) |
| ES (1) | ES2682303T3 (es) |
| MX (1) | MX2013001437A (es) |
| NZ (1) | NZ606194A (es) |
| PH (1) | PH12013500164A1 (es) |
| RU (1) | RU2551354C2 (es) |
| UY (1) | UY33545A (es) |
| WO (1) | WO2012017359A1 (es) |
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| TWI487486B (zh) | 2009-12-01 | 2015-06-11 | Syngenta Participations Ag | 以異唑啉衍生物為主之殺蟲化合物 |
| CN103562190A (zh) * | 2011-03-22 | 2014-02-05 | 佐蒂斯有限责任公司 | 作为抗寄生虫药的异噁唑啉衍生物 |
| WO2012155352A1 (en) | 2011-05-19 | 2012-11-22 | Eli Lilly And Company | Dihydroisoxazole compounds, parasiticidal uses and formulations thereof |
| PL3172964T3 (pl) | 2011-09-12 | 2021-03-08 | Boehringer Ingelheim Animal Health USA Inc. | Kompozycje przeciwpasożytniczne zawierające izoksazolinową substancję czynną, sposób i ich zastosowania |
| WO2013116230A1 (en) | 2012-02-03 | 2013-08-08 | Zoetis Llc | Dihydrofuran azetidine derivatives as antiparasitic agents |
| JP2015505560A (ja) * | 2012-02-03 | 2015-02-23 | ゾエティス・エルエルシー | 抗寄生虫薬としてのキラルイソオキサゾリンアゼチジン誘導体の製造法 |
| LT2811998T (lt) | 2012-02-06 | 2019-02-25 | Merial, Inc. | Paraziticidinės peroralinės veterinarinės kompozicijos, apimančios sistemiškai veikiančius aktyviuosius agentus, būdai ir jų panaudojimas |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| EP2833866B2 (en) | 2012-04-04 | 2024-11-27 | Intervet International B.V. | Soft chewable pharmaceutical products |
| MX336431B (es) * | 2012-05-09 | 2016-01-18 | Zoetis Services Llc | Derivados de azetidina como agentes antiparasitarios. |
| BR112015004135B8 (pt) * | 2012-08-31 | 2022-11-22 | Zoetis Services Llc | Formas cristalinas de 1-(5'-(5-(3,5-dicloro-4-fluorofenil)-5-(trifluorometil)-4,5-di-hidroisoxazol-3-il)-3'h-espiro[azetidina-3,1'-isobenzofuran]-1-il)-2-(metilsulfonil)etanona, sua composição, seu uso e seu processo de preparação |
| CA2882199A1 (en) * | 2012-09-04 | 2014-03-13 | Zoetis Llc | Spirocyclic isoxazoline derivatives for treatment of sea lice |
| BR112015004826A2 (pt) | 2012-09-07 | 2017-07-04 | Zoetis Llc | derivados espirocíclicos como agentes antiparasíticos |
| EP2892901A1 (en) * | 2012-09-07 | 2015-07-15 | Zoetis LLC | Spirocyclic isoxazolines as antiparasitic agents |
| ES2748631T3 (es) | 2012-09-07 | 2020-03-17 | Zoetis Services Llc | Combinaciones parasiticidas de isoxazolina espirocíclica |
| AU2013245478A1 (en) | 2012-11-01 | 2014-05-15 | Sumitomo Chemical Company, Limited | Method for administering agent for controlling ectoparasite to dog |
| MX368078B (es) * | 2012-11-21 | 2019-09-17 | Zoetis Llc | Sintesis de derivados de isoxazolina espirociclicos. |
| AR094112A1 (es) * | 2012-12-20 | 2015-07-08 | Novartis Tiergesundheit Ag | (hetero)arilacrilamidas utiles para controlar ectoparasitos |
| PL2953942T3 (pl) | 2013-02-06 | 2018-03-30 | Bayer Cropscience Aktiengesellschaft | Podstawione halogenem pochodne pirazolu jako środki do zwalczania szkodników |
| AR094882A1 (es) * | 2013-02-26 | 2015-09-02 | Zoetis Llc | Selamectina para el tratamiento de las infestaciones por piojos de mar, composición |
| RU2545891C2 (ru) * | 2013-04-30 | 2015-04-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ставропольский государственный аграрный университет" | Способ лечения собак при бабезиозе и получения препарата из личинок трутней пчел и сока свеклы для их лечения |
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| BR112016023898A8 (pt) | 2014-04-17 | 2021-03-30 | Basf Se | uso de compostos malononitrila para proteger animais de parasitas |
| JP2017521441A (ja) | 2014-07-15 | 2017-08-03 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ａｎｉｍａｌ Ｈｅａｌｔｈ Ｇｍｂｈ | 有害生物防除剤としてのアリール−トリアゾリルピリジン類 |
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| RS58961B1 (sr) | 2015-01-22 | 2019-08-30 | Sanofi Aventis Deutschland | Proces proizvodnje 2-[4-(ciklopropankarbonil)fenil]-2-metil-propannitrila |
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| CN107835818B (zh) | 2015-05-20 | 2022-04-29 | 勃林格殷格翰动物保健美国公司 | 驱虫缩酚酸肽化合物 |
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| EP3541789A1 (en) | 2016-11-16 | 2019-09-25 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
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| MX2020001724A (es) | 2017-08-14 | 2020-07-29 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas. |
| KR101789736B1 (ko) | 2017-08-30 | 2017-10-25 | 대한민국 | 이버멕틴을 함유하는 조피볼락의 클라비네마 마리에 감염 구제용 조성물 |
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| DE69716925T2 (de) * | 1996-08-21 | 2003-09-11 | Pharmacia & Upjohn Co., Kalamazoo | Isoxazoline derivate und ihre verwendung als antimikroben |
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| TW200803740A (en) * | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| BRPI0707091B8 (pt) * | 2006-03-10 | 2018-02-14 | Nissan Chemical Ind Ltd | composto de isoxalina e benzaldoxima substituído ou um sal do mesmo; pesticida, agroquímico, endo- ou ecto-parasiticidapara mamíferos ou pássaros, inseticida e acaricida contendo como um ou mais ingredientes ativos selecionados a partir do composto de isoxalina substituído e o sal do mesmo |
| JP2008044880A (ja) | 2006-08-15 | 2008-02-28 | Bayer Cropscience Ag | 殺虫性イソオキサゾリン類 |
| JP2008260691A (ja) * | 2007-04-10 | 2008-10-30 | Bayer Cropscience Ag | 殺虫性アリールイソオキサゾリン誘導体 |
| US8372867B2 (en) | 2007-04-10 | 2013-02-12 | Bayer Cropscience Ag | Insecticidal aryl isoxazoline derivatives |
| WO2009005015A1 (ja) | 2007-06-29 | 2009-01-08 | Nissan Chemical Industries, Ltd. | 置換イソキサゾリン又はエノンオキシム化合物および有害生物防除剤 |
| CN101801940B (zh) | 2007-09-10 | 2013-04-10 | 日产化学工业株式会社 | 取代异*唑啉化合物和有害生物防除剂 |
| WO2009051956A2 (en) | 2007-10-16 | 2009-04-23 | E. I. Du Pont De Nemours And Company | Pyrazole-substituted isoxazoline insecticides |
| TWI411395B (zh) * | 2007-12-24 | 2013-10-11 | Syngenta Participations Ag | 殺蟲化合物 |
| EP2331536B1 (en) * | 2008-08-22 | 2013-08-21 | Syngenta Participations AG | Insecticidal compounds |
| CN102131789A (zh) * | 2008-08-22 | 2011-07-20 | 先正达参股股份有限公司 | 杀虫化合物 |
| ES2442342T3 (es) | 2008-12-18 | 2014-02-11 | Novartis Ag | Derivados de las isoxazolinas y su uso como pesticida |
| CA2747354C (en) * | 2008-12-19 | 2016-12-06 | Novartis Ag | Isoxazoline derivatives and their use as pesticide |
| CA2747986A1 (en) | 2008-12-23 | 2010-07-01 | Basf Se | Substituted amidine compounds for combating animal pests |
-
2011
- 2011-07-27 ES ES11757416.0T patent/ES2682303T3/es active Active
- 2011-07-27 JP JP2013522329A patent/JP5409968B2/ja active Active
- 2011-07-27 NZ NZ606194A patent/NZ606194A/en unknown
- 2011-07-27 KR KR20137005502A patent/KR101508862B1/ko active Active
- 2011-07-27 CA CA2807005A patent/CA2807005C/en active Active
- 2011-07-27 WO PCT/IB2011/053355 patent/WO2012017359A1/en not_active Ceased
- 2011-07-27 PH PH1/2013/500164A patent/PH12013500164A1/en unknown
- 2011-07-27 AU AU2011287323A patent/AU2011287323B2/en active Active
- 2011-07-27 CN CN201180048341.0A patent/CN103270036B/zh active Active
- 2011-07-27 RU RU2013104027/04A patent/RU2551354C2/ru active
- 2011-07-27 EP EP11757416.0A patent/EP2601190B1/en active Active
- 2011-07-27 BR BR112013002871-8A patent/BR112013002871B1/pt active IP Right Grant
- 2011-07-27 MX MX2013001437A patent/MX2013001437A/es unknown
- 2011-08-03 UY UY0001033545A patent/UY33545A/es not_active Application Discontinuation
- 2011-08-04 US US13/197,826 patent/US8415310B2/en active Active
- 2011-08-04 AR ARP110102823A patent/AR082562A1/es active IP Right Grant
-
2013
- 2013-02-04 CL CL2013000352A patent/CL2013000352A1/es unknown
- 2013-02-04 CO CO13020595A patent/CO6680631A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011287323A1 (en) | 2013-03-07 |
| HK1184780A1 (en) | 2014-01-30 |
| MX2013001437A (es) | 2013-06-05 |
| WO2012017359A1 (en) | 2012-02-09 |
| EP2601190B1 (en) | 2018-07-04 |
| KR20130062333A (ko) | 2013-06-12 |
| RU2551354C2 (ru) | 2015-05-20 |
| BR112013002871B1 (pt) | 2018-11-21 |
| UY33545A (es) | 2012-02-29 |
| CN103270036A (zh) | 2013-08-28 |
| AU2011287323B2 (en) | 2015-12-17 |
| AR082562A1 (es) | 2012-12-19 |
| CA2807005C (en) | 2015-04-07 |
| PH12013500164A1 (en) | 2015-07-08 |
| NZ606194A (en) | 2013-12-20 |
| RU2013104027A (ru) | 2014-09-10 |
| JP2013532719A (ja) | 2013-08-19 |
| US20120035122A1 (en) | 2012-02-09 |
| KR101508862B1 (ko) | 2015-04-07 |
| CN103270036B (zh) | 2015-11-25 |
| JP5409968B2 (ja) | 2014-02-05 |
| BR112013002871A2 (pt) | 2017-04-04 |
| CO6680631A2 (es) | 2013-05-31 |
| ES2682303T3 (es) | 2018-09-19 |
| CA2807005A1 (en) | 2012-02-09 |
| US8415310B2 (en) | 2013-04-09 |
| EP2601190A1 (en) | 2013-06-12 |
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