CL2013000391A1 - Compuestos derivados de 6-(2-hidroximetil-fenil)-2-metil-2h-piridazin-3-ona, inhibidores de la tirosina-quinasa de bruton (btk); composicion farmaceutica; metodo para tratar una condicion inflamatoria y/o autoinmune, artritis reumatoidea o asma; y su uso para tratar una condicion inflamatoria y/o autoinmune. - Google Patents
Compuestos derivados de 6-(2-hidroximetil-fenil)-2-metil-2h-piridazin-3-ona, inhibidores de la tirosina-quinasa de bruton (btk); composicion farmaceutica; metodo para tratar una condicion inflamatoria y/o autoinmune, artritis reumatoidea o asma; y su uso para tratar una condicion inflamatoria y/o autoinmune.Info
- Publication number
- CL2013000391A1 CL2013000391A1 CL2013000391A CL2013000391A CL2013000391A1 CL 2013000391 A1 CL2013000391 A1 CL 2013000391A1 CL 2013000391 A CL2013000391 A CL 2013000391A CL 2013000391 A CL2013000391 A CL 2013000391A CL 2013000391 A1 CL2013000391 A1 CL 2013000391A1
- Authority
- CL
- Chile
- Prior art keywords
- inflammatory
- treat
- autoimmune condition
- btk
- pyridazin
- Prior art date
Links
- 230000001363 autoimmune Effects 0.000 title 2
- 230000002757 inflammatory effect Effects 0.000 title 2
- GQGMIWXIWCELQB-UHFFFAOYSA-N 6-[2-(hydroxymethyl)phenyl]-2-methylpyridazin-3-one Chemical compound C1=CC(=O)N(C)N=C1C1=CC=CC=C1CO GQGMIWXIWCELQB-UHFFFAOYSA-N 0.000 title 1
- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 title 1
- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 title 1
- 208000006673 asthma Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 206010039073 rheumatoid arthritis Diseases 0.000 title 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 title 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37288710P | 2010-08-12 | 2010-08-12 | |
| US201161497093P | 2011-06-15 | 2011-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013000391A1 true CL2013000391A1 (es) | 2013-09-23 |
Family
ID=45565273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013000391A CL2013000391A1 (es) | 2010-08-12 | 2013-02-08 | Compuestos derivados de 6-(2-hidroximetil-fenil)-2-metil-2h-piridazin-3-ona, inhibidores de la tirosina-quinasa de bruton (btk); composicion farmaceutica; metodo para tratar una condicion inflamatoria y/o autoinmune, artritis reumatoidea o asma; y su uso para tratar una condicion inflamatoria y/o autoinmune. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8481540B2 (es) |
| EP (1) | EP2603500B1 (es) |
| JP (1) | JP5823518B2 (es) |
| KR (1) | KR101546167B1 (es) |
| CN (1) | CN103153984B (es) |
| AR (1) | AR082590A1 (es) |
| AU (1) | AU2011288489A1 (es) |
| BR (1) | BR112013003114A2 (es) |
| CA (1) | CA2807634A1 (es) |
| CL (1) | CL2013000391A1 (es) |
| CO (1) | CO6620025A2 (es) |
| EA (1) | EA201390207A1 (es) |
| EC (1) | ECSP13012437A (es) |
| ES (1) | ES2528371T3 (es) |
| MA (1) | MA34465B1 (es) |
| MX (1) | MX2013001715A (es) |
| PE (1) | PE20131153A1 (es) |
| SG (1) | SG187747A1 (es) |
| WO (1) | WO2012020008A1 (es) |
| ZA (1) | ZA201300705B (es) |
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| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007038957A1 (de) * | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-Thioxo-pyridazinderivate |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008019907A1 (de) * | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008028905A1 (de) * | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
| MX2011006682A (es) | 2008-12-22 | 2011-07-13 | Merck Patent Gmbh | Nuevas formas polimorficas de dihidrogeno-fosfato de 6-(1-metil-1h-pirazol-4-il)-2-{3-[5-(2-morfolin-4-il-etoxi)-pirim idin-2-il]-bencil}-2h-piridazin-3-ona y procesos para su preparacion. |
| JP5859640B2 (ja) | 2011-05-17 | 2016-02-10 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ブルトンチロシンキナーゼ阻害剤 |
| HK1197060A1 (en) * | 2011-08-17 | 2015-01-02 | F. Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
| EA027561B1 (ru) | 2011-11-03 | 2017-08-31 | Ф.Хоффманн-Ля Рош Аг | Алкилированные соединения пиперазина в качестве ингибиторов тирозинкиназы брутона |
| UA111756C2 (uk) | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
| US8669251B2 (en) | 2011-11-03 | 2014-03-11 | Genentech, Inc. | 8-fluorophthalazin-1(2H)-one compounds |
| KR20140096100A (ko) | 2011-11-03 | 2014-08-04 | 에프. 호프만-라 로슈 아게 | 이환 피페라진 화합물 |
| TWI633087B (zh) * | 2012-06-13 | 2018-08-21 | 赫孚孟拉羅股份公司 | 新穎二氮雜螺環烷及氮雜螺環烷 |
| AU2013293087B2 (en) | 2012-07-24 | 2017-08-31 | Pharmacyclics Llc | Mutations associated with resistance to inhibitors of Bruton's tyrosine kinase (BTK) |
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| CA2881761A1 (en) * | 2012-09-13 | 2014-03-20 | Christine E. Brotherton-Pleiss | Inhibitors of bruton's tyrosine kinase |
| EP3590940B1 (en) | 2012-09-25 | 2021-06-09 | F. Hoffmann-La Roche AG | Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases |
| US9458105B2 (en) * | 2012-11-16 | 2016-10-04 | Hoffmann-La Roche Inc. | Inhibitors of Bruton's tyrosine kinase |
| EP2925323B1 (en) * | 2012-11-30 | 2017-05-17 | F. Hoffmann-La Roche AG | An inhibitor of bruton's tyrosine kinase |
| EP2964642B1 (en) * | 2013-03-05 | 2017-11-15 | F. Hoffmann-La Roche AG | Inhibitors of bruton's tyrosine kinase |
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| WO2015149056A1 (en) * | 2014-03-28 | 2015-10-01 | Board Of Regents, The University Of Texas System | Inhibition of bruton's tyrosine kinase (btk) in the lung to treat severe lung inflammation and lung injury |
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| PE20180451A1 (es) | 2015-09-24 | 2018-03-05 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores de atx |
| MX2017015034A (es) | 2015-09-24 | 2018-04-13 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca). |
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| EP4509183A3 (en) | 2016-08-16 | 2025-05-21 | BeiGene Switzerland GmbH | Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof |
| AU2017313085B2 (en) | 2016-08-19 | 2024-06-20 | Beone Medicines I Gmbh | Use of a combination comprising a Btk inhibitor for treating cancers |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004022562A1 (en) | 2002-09-09 | 2004-03-18 | Cellular Genomics, Inc. | 6-ARYL-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF |
| MY141521A (en) | 2002-12-12 | 2010-05-14 | Hoffmann La Roche | 5-substituted-six-membered heteroaromatic glucokinase activators |
| WO2005014599A1 (en) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
| WO2006099075A2 (en) | 2005-03-10 | 2006-09-21 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
| WO2006124731A2 (en) | 2005-05-12 | 2006-11-23 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| AU2006279992A1 (en) | 2005-08-09 | 2007-02-22 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| ATE548363T1 (de) | 2005-08-29 | 2012-03-15 | Vertex Pharma | 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen |
| DE602006020293D1 (de) | 2005-08-29 | 2011-04-07 | Vertex Pharma | 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin-kinasen nützlich sind |
| ATE528302T1 (de) | 2005-08-29 | 2011-10-15 | Vertex Pharma | 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind |
| MX2008014618A (es) | 2006-05-15 | 2008-11-28 | Irm Llc | Composiciones y metodos para inhibidores de cinasas del receptor fgf. |
| MX2009000688A (es) | 2006-07-24 | 2009-01-30 | Hoffmann La Roche | Pirazoles como activadores de glucocinasa. |
| JP2010502751A (ja) | 2006-09-11 | 2010-01-28 | シージーアイ ファーマシューティカルズ，インコーポレイティド | キナーゼ阻害物質、およびキナーゼ阻害物質の使用および同定方法 |
| US7838523B2 (en) | 2006-09-11 | 2010-11-23 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
| PE20080839A1 (es) | 2006-09-11 | 2008-08-23 | Cgi Pharmaceuticals Inc | Determinadas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas |
| PE20081370A1 (es) | 2006-09-11 | 2008-11-28 | Cgi Pharmaceuticals Inc | Determinadas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas |
| JP5587193B2 (ja) * | 2007-10-23 | 2014-09-10 | エフ．ホフマン−ラ ロシュ アーゲー | 新規なキナーゼ阻害剤 |
| CN101952283B (zh) | 2007-12-14 | 2013-04-17 | 霍夫曼-拉罗奇有限公司 | 咪唑并[1，2-a]吡啶和咪唑并[1，2-b]哒嗪衍生物 |
| DK2242749T3 (da) * | 2008-02-05 | 2013-06-17 | Hoffmann La Roche | Nye pyridinoner og pyridazinoner |
| US7683064B2 (en) * | 2008-02-05 | 2010-03-23 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
| EP2297142B1 (en) * | 2008-06-24 | 2015-10-14 | F. Hoffmann-La Roche AG | Novel substituted pyridin-2-ones and pyridazin-3-ones |
| CA2728683C (en) * | 2008-07-02 | 2017-05-02 | F.Hoffmann-La Roche Ag | Novel phenylpyrazinones as kinase inhibitors |
| US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| EP2421854B1 (en) * | 2009-04-24 | 2014-07-23 | F.Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
| WO2012030990A1 (en) * | 2010-09-01 | 2012-03-08 | Gilead Connecticut, Inc. | Pyridazinones, method of making, and method of use thereof |
| JP5859640B2 (ja) * | 2011-05-17 | 2016-02-10 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ブルトンチロシンキナーゼ阻害剤 |
-
2011
- 2011-08-08 AR ARP110102870A patent/AR082590A1/es unknown
- 2011-08-09 AU AU2011288489A patent/AU2011288489A1/en not_active Abandoned
- 2011-08-09 JP JP2013523591A patent/JP5823518B2/ja not_active Expired - Fee Related
- 2011-08-09 CN CN201180048444.7A patent/CN103153984B/zh not_active Expired - Fee Related
- 2011-08-09 EP EP11746518.7A patent/EP2603500B1/en not_active Not-in-force
- 2011-08-09 WO PCT/EP2011/063657 patent/WO2012020008A1/en not_active Ceased
- 2011-08-09 MX MX2013001715A patent/MX2013001715A/es unknown
- 2011-08-09 ES ES11746518.7T patent/ES2528371T3/es active Active
- 2011-08-09 KR KR1020137006162A patent/KR101546167B1/ko not_active Expired - Fee Related
- 2011-08-09 BR BR112013003114A patent/BR112013003114A2/pt active Search and Examination
- 2011-08-09 PE PE2013000232A patent/PE20131153A1/es not_active Application Discontinuation
- 2011-08-09 SG SG2013009246A patent/SG187747A1/en unknown
- 2011-08-09 MA MA35658A patent/MA34465B1/fr unknown
- 2011-08-09 EA EA201390207A patent/EA201390207A1/ru unknown
- 2011-08-09 CA CA2807634A patent/CA2807634A1/en not_active Abandoned
- 2011-08-11 US US13/207,481 patent/US8481540B2/en not_active Expired - Fee Related
-
2013
- 2013-01-25 ZA ZA2013/00705A patent/ZA201300705B/en unknown
- 2013-01-31 CO CO13018558A patent/CO6620025A2/es not_active Application Discontinuation
- 2013-02-08 EC ECSP13012437 patent/ECSP13012437A/es unknown
- 2013-02-08 CL CL2013000391A patent/CL2013000391A1/es unknown
- 2013-03-01 US US13/781,815 patent/US8940741B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201300705B (en) | 2014-06-25 |
| EP2603500B1 (en) | 2014-11-19 |
| KR20130038420A (ko) | 2013-04-17 |
| ECSP13012437A (es) | 2013-03-28 |
| AU2011288489A1 (en) | 2013-02-07 |
| WO2012020008A1 (en) | 2012-02-16 |
| EA201390207A1 (ru) | 2013-08-30 |
| US20120040949A1 (en) | 2012-02-16 |
| CN103153984B (zh) | 2015-04-22 |
| US20130178461A1 (en) | 2013-07-11 |
| CO6620025A2 (es) | 2013-02-15 |
| US8481540B2 (en) | 2013-07-09 |
| PE20131153A1 (es) | 2013-10-05 |
| US8940741B2 (en) | 2015-01-27 |
| JP5823518B2 (ja) | 2015-11-25 |
| CA2807634A1 (en) | 2012-02-16 |
| BR112013003114A2 (pt) | 2016-06-28 |
| JP2013533300A (ja) | 2013-08-22 |
| HK1186186A1 (en) | 2014-03-07 |
| EP2603500A1 (en) | 2013-06-19 |
| CN103153984A (zh) | 2013-06-12 |
| ES2528371T3 (es) | 2015-02-09 |
| KR101546167B1 (ko) | 2015-08-20 |
| AR082590A1 (es) | 2012-12-19 |
| MA34465B1 (fr) | 2013-08-01 |
| SG187747A1 (en) | 2013-03-28 |
| MX2013001715A (es) | 2013-03-22 |
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