MA34465B1 - Inhibiteurs de tyrosine kinase de bruton - Google Patents

Inhibiteurs de tyrosine kinase de bruton

Info

Publication number
MA34465B1
MA34465B1 MA35658A MA35658A MA34465B1 MA 34465 B1 MA34465 B1 MA 34465B1 MA 35658 A MA35658 A MA 35658A MA 35658 A MA35658 A MA 35658A MA 34465 B1 MA34465 B1 MA 34465B1
Authority
MA
Morocco
Prior art keywords
tyrosine kinase
kinase inhibitors
compounds
useful
diseases associated
Prior art date
Application number
MA35658A
Other languages
English (en)
Inventor
Steven Joseph Berthel
Roland J Billedeau
Christine E Brotherton-Pleiss
Fariborz Firooznia
Stephen Deems Gabriel
Xiaochun Han
Ramona Hilgenkamp
Saul Jaime-Figueroa
Buelent Kocer
Francisco Javier Lopez-Tapia
Yan Lou
Lucja Orzechowski
Timothy D Owens
Jenny Tan
Peter Michael Wovkulich
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45565273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34465(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA34465B1 publication Critical patent/MA34465B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DES DÉRIVÉS DE 6-(2-HYDROXYMÉTHYL-PHÉNYL)-2-MÉTHYL-2H-PYRIDAZIN-3-ONE SELON LA FORMULE GÉNÉRIQUE (I) : DANS LAQUELLE LES VARIABLES X, R, ET Y4, SONT DÉFINIS COMME PRÉSENTEMENT DÉCRIT, QUI INHIBENT BTK. LES COMPOSÉS PRÉSENTEMENT DÉCRITS SONT UTILES POUR MODULER L'ACTIVITÉ DE BTK ET TRAITER DES MALADIES ASSOCIÉES À UNE ACTIVITÉ BTK EXCESSIVE. LES COMPOSÉS SONT ÉGALEMENT UTILES POUR TRAITER DES MALADIES INFLAMMATOIRES ET AUTO-IMMUNES ASSOCIÉES À UNE PROLIFÉRATION ABERRANTE DE LYMPHOCYTES B, TELLE QUE LA POLYARTHRITE RHUMATOÏDE. LA PRÉSENTE INVENTION CONCERNE EN OUTRE DES COMPOSITIONS CONTENANT DES COMPOSÉS DE FORMULE I ET AU MOINS UN VÉHICULE, DILUANT OU EXCIPIENT.
MA35658A 2010-08-12 2011-08-09 Inhibiteurs de tyrosine kinase de bruton MA34465B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37288710P 2010-08-12 2010-08-12
US201161497093P 2011-06-15 2011-06-15
PCT/EP2011/063657 WO2012020008A1 (fr) 2010-08-12 2011-08-09 Inhibiteurs de tyrosine kinase de bruton

Publications (1)

Publication Number Publication Date
MA34465B1 true MA34465B1 (fr) 2013-08-01

Family

ID=45565273

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35658A MA34465B1 (fr) 2010-08-12 2011-08-09 Inhibiteurs de tyrosine kinase de bruton

Country Status (20)

Country Link
US (2) US8481540B2 (fr)
EP (1) EP2603500B1 (fr)
JP (1) JP5823518B2 (fr)
KR (1) KR101546167B1 (fr)
CN (1) CN103153984B (fr)
AR (1) AR082590A1 (fr)
AU (1) AU2011288489A1 (fr)
BR (1) BR112013003114A2 (fr)
CA (1) CA2807634A1 (fr)
CL (1) CL2013000391A1 (fr)
CO (1) CO6620025A2 (fr)
EA (1) EA201390207A1 (fr)
EC (1) ECSP13012437A (fr)
ES (1) ES2528371T3 (fr)
MA (1) MA34465B1 (fr)
MX (1) MX2013001715A (fr)
PE (1) PE20131153A1 (fr)
SG (1) SG187747A1 (fr)
WO (1) WO2012020008A1 (fr)
ZA (1) ZA201300705B (fr)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102007038957A1 (de) * 2007-08-17 2009-02-19 Merck Patent Gmbh 6-Thioxo-pyridazinderivate
DE102007061963A1 (de) * 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
DE102008019907A1 (de) * 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) * 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
DE102008037790A1 (de) * 2008-08-14 2010-02-18 Merck Patent Gmbh Bicyclische Triazolderivate
US8586599B2 (en) 2008-12-22 2013-11-19 Merck Patent Gmbh Polymorphic forms of 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof
CA2834077A1 (fr) 2011-05-17 2012-11-22 F. Hoffmann-La Roche Ag Inhibiteurs de tyrosine kinase de bruton
BR112014003582A2 (pt) * 2011-08-17 2017-03-14 Hoffmann La Roche inibidores da tirosina quinase de bruton
BR112014010439A2 (pt) 2011-11-03 2017-04-18 F Hoffmann - La Roche Ag compostos, composição farmacêutica, processo de produção, método de tratamento de uma doença ou distúrbio, métodos, kit e uso de uma composição farmacêutica
RU2622391C2 (ru) * 2011-11-03 2017-06-15 Ф. Хоффманн-Ля Рош Аг Соединения 8-фторфталазин-1(2н)-она в качестве ингибиторов тирозинкиназы брутона
KR20140096100A (ko) 2011-11-03 2014-08-04 에프. 호프만-라 로슈 아게 이환 피페라진 화합물
UA111756C2 (uk) 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
HRP20161774T1 (hr) * 2012-06-13 2017-02-24 F. Hoffmann - La Roche Ag Novi diazaspirocikloalkan i azaspirocikloalkan
CA2879570A1 (fr) 2012-07-24 2014-01-30 Pharmacyclics, Inc. Mutations associees a la resistance a des inhibiteurs de la tyrosine kinase de bruton (btk)
JP6348492B2 (ja) 2012-08-10 2018-06-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ブルトン型チロシンキナーゼ（ｂｔｋ）阻害剤としてのヘテロ芳香族化合物
RU2015111133A (ru) * 2012-09-13 2016-11-10 Ф. Хоффманн-Ля Рош Аг Ингибиторы тирозинкиназы брутона
BR112015004111A2 (pt) 2012-09-25 2017-07-04 Hoffmann La Roche novos derivados bicíclicos
MX2015006162A (es) * 2012-11-16 2015-08-14 Hoffmann La Roche Inhibidores de la tirosina-cinasa de bruton.
CN104968346B (zh) * 2012-11-30 2017-06-27 弗·哈夫曼-拉罗切有限公司 酪氨酸蛋白激酶抑制剂
HK1218416A1 (zh) * 2013-03-05 2017-02-17 F. Hoffmann-La Roche Ag 布鲁顿氏酪氨酸激酶抑制剂
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
SG11201506764WA (en) 2013-04-25 2015-09-29 Beigene Ltd Fused heterocyclic compounds as protein kinase inhibitors
CN104177338B (zh) * 2013-05-22 2018-04-03 南京勇山生物科技有限公司 一类布鲁顿激酶抑制剂
WO2015000949A1 (fr) * 2013-07-03 2015-01-08 F. Hoffmann-La Roche Ag Composés hétéroaryl pyridone et aza-pyridone amide
JP6623353B2 (ja) 2013-09-13 2019-12-25 ベイジーン スウィッツァーランド ゲーエムベーハー 抗ｐｄ−１抗体並びにその治療及び診断のための使用
EP3077384B1 (fr) * 2013-12-05 2017-09-06 F. Hoffmann-La Roche AG Composés de pyridone hétéroarylique et d'aza-pyridone à fonctionnalité électrophile
RU2653500C2 (ru) 2013-12-13 2018-05-10 Ф. Хоффманн-Ля Рош Аг Ингибиторы тирозинкиназы брутона
KR20160127754A (ko) 2014-03-12 2016-11-04 노파르티스 아게 Btk 억제제 및 akt 억제제를 포함하는 조합물
SI3122750T1 (sl) 2014-03-26 2019-12-31 F. Hoffmann-La Roche Ag Biciklične spojine kot zaviralci proizvodnje avtotaksina (ATX) in lizofosfatidne kisline (LPA)
KR20160128428A (ko) 2014-03-26 2016-11-07 에프. 호프만-라 로슈 아게 오토탁신(atx) 및 리소포스파티드산(lpa) 생성 억제제로서의 축합형 [1,4]다이아제핀 화합물
WO2015149056A1 (fr) * 2014-03-28 2015-10-01 Board Of Regents, The University Of Texas System Inhibition de tyrosine kinase de bruton (btk) dans le poumon pour traiter de l'inflammation pulmonaire grave et des blessures pulmonaires graves
KR102003754B1 (ko) 2014-07-03 2019-07-25 베이진 엘티디 Pd-l1 항체와 이를 이용한 치료 및 진단
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
WO2016209996A1 (fr) 2015-06-23 2016-12-29 University Of Oregon Hétérocycles contenant du phosphore et procédé de production et d'utilisation
JP6886967B2 (ja) 2015-09-04 2021-06-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ フェノキシメチル誘導体
JP6877413B2 (ja) 2015-09-24 2021-05-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 二重ａｔｘ／ｃａ阻害剤としての新規な二環式化合物
AU2016328365B2 (en) 2015-09-24 2020-04-23 F. Hoffmann-La Roche Ag New bicyclic compounds as dual ATX/CA inhibitors
RU2018112230A (ru) 2015-09-24 2019-10-30 Ф. Хоффманн-Ля Рош Аг Бициклические соединения в качестве ингибиторов atx
CN107635995B (zh) 2015-09-24 2022-08-19 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
NZ749997A (en) 2016-07-05 2022-11-25 Beigene Ltd Combination of a pd-l antagonist and a raf inhibitor for treating cancer
KR102604975B1 (ko) 2016-08-16 2023-11-24 베이진 스위찰랜드 게엠베하 (s)-7-(1-아크릴로일피페리딘-4-일)-2-(4-페녹시페닐)-4,5,6,7-테트라-하이드로피라졸로 [1,5-a] 피리미딘-3-카르복스아미드의 제조 및 그 용도
EP3500299B1 (fr) 2016-08-19 2023-12-13 BeiGene Switzerland GmbH Combinaison de zanubrutinib avec un anticorps anti-cd20 ou anti-pd-1 pour l'utilisation dans le traitement du cancer
JP2019529419A (ja) 2016-09-19 2019-10-17 エムイーアイ ファーマ，インク． 併用療法
WO2018137681A1 (fr) 2017-01-25 2018-08-02 Beigene, Ltd. Formes cristallines de (s) -7- (1- (but-2-ynoyl) pipéridin-4-yl) -2- (4-phénoxyphényl) -4, 5, 6, 7-tétrahy dropyrazolo [1, 5-a] pyrimidine-3-carboxamide, préparation et utilisations associées
WO2018167113A1 (fr) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag Nouveaux composés bicycliques utilisés en tant qu'inhibiteurs d'atx
EP3596059B1 (fr) 2017-03-16 2024-04-24 F. Hoffmann-La Roche AG Composés hétérocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca
KR102757960B1 (ko) 2017-06-26 2025-01-22 베이진 엘티디 간세포암(hepatocellular carcinoma: HCC)에 대한 면역 치료
CN110997677A (zh) 2017-08-12 2020-04-10 百济神州有限公司 具有改进的双重选择性的Btk抑制剂
TWI694995B (zh) * 2017-11-06 2020-06-01 美商美國禮來大藥廠 Btk抑制劑化合物
WO2019108795A1 (fr) 2017-11-29 2019-06-06 Beigene Switzerland Gmbh Traitement de lymphomes à cellules b indolentes ou agressives au moyen d'une combinaison comprenant des inhibiteurs de btk
BR112021007115A2 (pt) 2018-10-15 2021-07-20 Nurix Therapeutics, Inc. compostos bifuncionais para dedradação de btk por meio da via de proteossoma de ubiquitina
CN109438377B (zh) * 2018-12-13 2020-06-09 天津利安隆新材料股份有限公司 一种低温法制备含有醚键的长碳链三嗪类紫外线吸收剂的方法
MX2021012285A (es) 2019-04-09 2021-12-15 Nurix Therapeutics Inc Compuestos de piperidina 3-sustituidos para inhibicion del protooncogen-b de linfoma de linea b de casitas (cbl-b) y uso de un inhibidor de cbl-b en combinacion con una vacuna contra el cancer y/o con un virus oncolitico.
AU2020278592B2 (en) 2019-05-17 2024-10-10 Nurix Therapeutics, Inc. Cyano cyclobutyl compounds for Cbl-b inhibition and uses thereof
US20220249491A1 (en) 2019-06-10 2022-08-11 Beigene Switzerland Gmbh Oral solid tablet comprising bruton's tyrosine kinase inhibitor and preparation method therefor
MX2021015675A (es) 2019-06-26 2022-02-03 Nurix Therapeutics Inc Compuestos de bencil-triazol sustituidos para la inhibicion de cbl-b y otros usos de los mismos.
US20230024442A1 (en) * 2019-11-08 2023-01-26 Nurix Therapeutics, Inc. Bifunctional compounds for grading btk via ubiquitin proteosome pathway
CA3160713A1 (fr) 2019-12-04 2021-06-10 Nurix Therapeutics, Inc. Composes bifonctionnels pour la degradation de la btk par l'intermediaire de la voie de l'ubiquitine-proteosome
WO2021110142A1 (fr) 2019-12-04 2021-06-10 Henan Normal University Imidazolecarboxamide substitué utilisé comme inhibiteurs de la tyrosine kinase de bruton
AU2022254104A1 (en) 2021-04-08 2023-10-26 Nurix Therapeutics, Inc. Combination therapies with cbl-b inhibitor compounds
KR20240090898A (ko) 2021-10-26 2024-06-21 누릭스 테라퓨틱스 인코포레이티드 암을 치료 및 예방하고 btk를 분해하기 위한 피페리디닐피라진-카복스아미드 화합물
US11786531B1 (en) 2022-06-08 2023-10-17 Beigene Switzerland Gmbh Methods of treating B-cell proliferative disorder

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004022562A1 (fr) 2002-09-09 2004-03-18 Cellular Genomics, Inc. 6-arykl-imidazo[1,2-a]pyrazin-8-ylamines, procede de preparation et procede d'utilisation correspondants
US7132425B2 (en) 2002-12-12 2006-11-07 Hoffmann-La Roche Inc. 5-substituted-six-membered heteroaromatic glucokinase activators
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
MX2007011041A (es) 2005-03-10 2008-02-22 Cgi Pharmaceuticals Inc Ciertas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas.
WO2006124731A2 (fr) 2005-05-12 2006-11-23 Irm Llc Composes et compositions utilise(e)s en tant qu'inhibiteurs de proteines-kinases
ES2351939T3 (es) 2005-08-09 2011-02-14 Irm Llc Compuestos y composiciones como inhibidores de proteínas cinasas.
ATE548363T1 (de) 2005-08-29 2012-03-15 Vertex Pharma 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen
JP2009506123A (ja) 2005-08-29 2009-02-12 バーテックス ファーマシューティカルズ インコーポレイテッド 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン
DE602006020293D1 (de) 2005-08-29 2011-04-07 Vertex Pharma 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin-kinasen nützlich sind
MX2008014618A (es) 2006-05-15 2008-11-28 Irm Llc Composiciones y metodos para inhibidores de cinasas del receptor fgf.
CA2657566A1 (fr) 2006-07-24 2008-01-31 F. Hoffmann-La Roche Ag Pyrazoles comme activateurs de glucokinase
AR063707A1 (es) 2006-09-11 2009-02-11 Cgi Pharmaceuticals Inc Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmacéuticas que las comprenden.
US7838523B2 (en) 2006-09-11 2010-11-23 Cgi Pharmaceuticals, Inc. Certain substituted amides, method of making, and method of use thereof
AR063706A1 (es) 2006-09-11 2009-02-11 Cgi Pharmaceuticals Inc Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
EP2270200A3 (fr) 2006-09-11 2011-07-13 CGI Pharmaceuticals, Inc. Inhibiteurs de la kinase et procédés pour les utiliser et les identifier
EP2205564B1 (fr) * 2007-10-23 2014-07-30 F. Hoffmann-La Roche AG Nouveaux inhibiteurs de kinase
JP5643105B2 (ja) 2007-12-14 2014-12-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規イミダゾ［１，２−ａ］ピリジン及びイミダゾ［１，２−ｂ］ピリダジン誘導体
US7683064B2 (en) * 2008-02-05 2010-03-23 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
WO2009098144A1 (fr) * 2008-02-05 2009-08-13 F. Hoffmann-La Roche Ag Nouvelles pyridinones et pyridazinones
US7741327B2 (en) 2008-04-16 2010-06-22 Hoffmann-La Roche Inc. Pyrrolidinone glucokinase activators
WO2009156284A1 (fr) * 2008-06-24 2009-12-30 F. Hoffmann-La Roche Ag Nouvelles pyridine-2-ones et pyridazine-3-ones substituées
AU2009265813B2 (en) * 2008-07-02 2014-04-10 F. Hoffmann-La Roche Ag Novel phenylpyrazinones as kinase inhibitors
US8299077B2 (en) * 2009-03-02 2012-10-30 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
CA2748414A1 (fr) * 2009-04-24 2010-10-28 F. Hoffmann-La Roche Ag Inhibiteurs de la tyrosine kinase de bruton
JP5842004B2 (ja) * 2010-09-01 2016-01-13 ジーアイリード コネチカット インコーポレーテッドＧｉｌｅａｄ Ｃｏｎｎｅｃｔｉｃｕｔ，Ｉｎｃ． ピリダジノン、その製造方法及びその使用方法
CA2834077A1 (fr) * 2011-05-17 2012-11-22 F. Hoffmann-La Roche Ag Inhibiteurs de tyrosine kinase de bruton

Also Published As

Publication number Publication date
CN103153984B (zh) 2015-04-22
CO6620025A2 (es) 2013-02-15
EP2603500A1 (fr) 2013-06-19
KR101546167B1 (ko) 2015-08-20
AU2011288489A1 (en) 2013-02-07
MX2013001715A (es) 2013-03-22
PE20131153A1 (es) 2013-10-05
CN103153984A (zh) 2013-06-12
US20120040949A1 (en) 2012-02-16
ECSP13012437A (es) 2013-03-28
SG187747A1 (en) 2013-03-28
EP2603500B1 (fr) 2014-11-19
KR20130038420A (ko) 2013-04-17
ES2528371T3 (es) 2015-02-09
US8940741B2 (en) 2015-01-27
CA2807634A1 (fr) 2012-02-16
ZA201300705B (en) 2014-06-25
WO2012020008A1 (fr) 2012-02-16
US20130178461A1 (en) 2013-07-11
BR112013003114A2 (pt) 2016-06-28
JP5823518B2 (ja) 2015-11-25
HK1186186A1 (en) 2014-03-07
JP2013533300A (ja) 2013-08-22
AR082590A1 (es) 2012-12-19
US8481540B2 (en) 2013-07-09
CL2013000391A1 (es) 2013-09-23
EA201390207A1 (ru) 2013-08-30

Similar Documents

Publication Publication Date Title
MA34465B1 (fr) Inhibiteurs de tyrosine kinase de bruton
MA35419B1 (fr) Inhibiteurs de la tyrosine kinase de bruton
MA35112B1 (fr) Inhibiteurs de tyrosine kinase de bruton
MA32487B1 (fr) Nouvelles pyridine-2-ones et pyridazine-3-ones substituees
MA32064B1 (fr) Nouvelles pyridinones et pyridazinones
EP1796669A4 (fr) Aminopiperidines utilisees comme inhibiteurs de la dipeptidyle peptidase-iv pour le traitement ou la prevention du diabete
MA49809A1 (fr) Composés utilisés comme inhibiteurs de kinase
MA27556A1 (fr) Derives de phenylalanine comme inhibiteurs de la dipeptidyl peptidase pour le traitement ou la prevention du diabete
MA31521B1 (fr) Dérivés de 2,3-dihydrobenzo[1,4] dioxin-2-ylméthyle utilisés en tant qu'antagonistes des alpha2c pour traiter des maladies des systèmes nerveux périphérique et central
EP1490335A4 (fr) Inhibiteurs de la dipeptidyl peptidase beta-amino heterocycliques pour le traitement ou la prevention du diabete
MA34300B1 (fr) Composés azotés hétérocycliques convenant comme inhibiteurs de la pde10
MA31075B1 (fr) Dérivés d'isoquinolone substitués par une cycloalkylamine.
MA33053B1 (fr) Inhibiteurs de la poly(adp-ribose) polymerase (parp)
MA29140B1 (fr) Dérivés de quinoléine hétéroaromatiques et leur utilisation comme inhibiteurs de PDE10
MA27548A1 (fr) Inhibiteurs heterocycliques beta-amines de la dipeptidyl peptidase pour le traitement ou la prevention du diabete.
EP1888066A4 (fr) Aminocyclohexanes en tant qu'inhibiteurs de dipeptidyle peptidase-iv pour le traitement ou la prevention du diabete
EP1819674A4 (fr) Aminopiperidines fusionnees utilisees comme inhibiteurs de la dipeptidyle peptidase-iv permettant de traiter ou de prevenir le diabete
MA47447A (fr) 2-hétéroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides pour le traitement du cancer
MA30232B1 (fr) Inhibiteurs de kinase bases sur l'hydantoine
MA31952B1 (fr) Pyrrolopyrimidines et pyrrolopyridines
EP1921917A4 (fr) Aminopiperidines fusionnees utilisees comme inhibiteurs de dipeptidyl-peptidase-iv pour le traitement ou la prevention du diabete
MA31683B1 (fr) Composes et procedes pour moduler fxr
MA27561A1 (fr) Derives d'aminoindazoles et leur utilisation comme inhibiteurs de kinases
TW200505903A (en) CGRP receptor antagonists
MA30911B1 (fr) Nouveaux derives de sulfonamide en tant qu'antagonistes de bradykinine