CL2015000332A1 - Forma cristalina a y racemato cristalino de 1-(5'-(5-(3,5-dicloro-4-fluorofenil)-5-(trifluorometil)-4,5-dihidroisoxazol-3-il)-3'h-espiro[azetidin-3,1'-isobenzofuran]-1-il)-2-(metilsulfonil)etanona; procedimiento de preparacion de la forma cristalina a; composicion que la comprende; y su uso para el tratamiento de una infeccion o infestacion parasitaria. - Google Patents

Forma cristalina a y racemato cristalino de 1-(5'-(5-(3,5-dicloro-4-fluorofenil)-5-(trifluorometil)-4,5-dihidroisoxazol-3-il)-3'h-espiro[azetidin-3,1'-isobenzofuran]-1-il)-2-(metilsulfonil)etanona; procedimiento de preparacion de la forma cristalina a; composicion que la comprende; y su uso para el tratamiento de una infeccion o infestacion parasitaria.

Info

Publication number: CL2015000332A1
Authority: CL; Chile
Prior art keywords: crystalline form; crystalline; dihydroisoxazol; isobenzofuran; azetidin
Prior art date: 2012-08-31

Application number

CL2015000332A

Other languages

English (en)

Inventor

Denis Billen

Matthew Joseph Birchmeier

Ronald J Vanderroest

Original Assignee

Zoetis Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-08-31

Filing date

2015-02-11

Publication date

2015-05-15

2015-02-11 Application filed by Zoetis Llc filed Critical Zoetis Llc

2015-05-15 Publication of CL2015000332A1 publication Critical patent/CL2015000332A1/es

Links

FLEFKKUZMDEUIP-UHFFFAOYSA-N 1-[6-[5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4h-1,2-oxazol-3-yl]spiro[1h-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone Chemical compound C1N(C(=O)CS(=O)(=O)C)CC21C1=CC=C(C=3CC(ON=3)(C=3C=C(Cl)C(F)=C(Cl)C=3)C(F)(F)F)C=C1CO2 FLEFKKUZMDEUIP-UHFFFAOYSA-N 0.000 title 1
206010061217 Infestation Diseases 0.000 title 1
208000015181 infectious disease Diseases 0.000 title 1
230000003071 parasitic effect Effects 0.000 title 1
238000002360 preparation method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CL2015000332A 2012-08-31 2015-02-11 Forma cristalina a y racemato cristalino de 1-(5'-(5-(3,5-dicloro-4-fluorofenil)-5-(trifluorometil)-4,5-dihidroisoxazol-3-il)-3'h-espiro[azetidin-3,1'-isobenzofuran]-1-il)-2-(metilsulfonil)etanona; procedimiento de preparacion de la forma cristalina a; composicion que la comprende; y su uso para el tratamiento de una infeccion o infestacion parasitaria. CL2015000332A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201261695410P	2012-08-31	2012-08-31

Publications (1)

Publication Number	Publication Date
CL2015000332A1 true CL2015000332A1 (es)	2015-05-15

Family

ID=49115603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2015000332A CL2015000332A1 (es)	2012-08-31	2015-02-11	Forma cristalina a y racemato cristalino de 1-(5'-(5-(3,5-dicloro-4-fluorofenil)-5-(trifluorometil)-4,5-dihidroisoxazol-3-il)-3'h-espiro[azetidin-3,1'-isobenzofuran]-1-il)-2-(metilsulfonil)etanona; procedimiento de preparacion de la forma cristalina a; composicion que la comprende; y su uso para el tratamiento de una infeccion o infestacion parasitaria.

Country Status (28)

Country	Link
US (1)	US9200003B2 (es)
EP (1)	EP2890699B1 (es)
JP (1)	JP6109942B2 (es)
KR (1)	KR101736643B1 (es)
CN (1)	CN104812758B (es)
AR (1)	AR092409A1 (es)
AU (1)	AU2013308887B2 (es)
BR (1)	BR112015004135B8 (es)
CA (1)	CA2881467C (es)
CL (1)	CL2015000332A1 (es)
CY (1)	CY1120611T1 (es)
DK (1)	DK2890699T3 (es)
ES (1)	ES2671271T3 (es)
HR (1)	HRP20180861T1 (es)
HU (1)	HUE037667T2 (es)
LT (1)	LT2890699T (es)
MX (1)	MX351463B (es)
NO (1)	NO2931268T3 (es)
NZ (1)	NZ704175A (es)
PH (1)	PH12015500441B1 (es)
PL (1)	PL2890699T3 (es)
PT (1)	PT2890699T (es)
RS (1)	RS57284B1 (es)
RU (1)	RU2614978C2 (es)
SI (1)	SI2890699T1 (es)
TR (1)	TR201807735T4 (es)
WO (1)	WO2014036056A1 (es)
ZA (1)	ZA201500728B (es)

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MX2019011785A (es)	2017-03-31	2019-11-18	Basf Se	Proceso para preparar compuestos de 2,3-dihidrotiazolo[3,2-a]pirim idin-4-io quirales.
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2013
- 2013-08-28 HR HRP20180861TT patent/HRP20180861T1/hr unknown
- 2013-08-28 AU AU2013308887A patent/AU2013308887B2/en active Active
- 2013-08-28 CN CN201380044821.9A patent/CN104812758B/zh active Active
- 2013-08-28 WO PCT/US2013/056945 patent/WO2014036056A1/en not_active Ceased
- 2013-08-28 RS RS20180636A patent/RS57284B1/sr unknown
- 2013-08-28 CA CA2881467A patent/CA2881467C/en active Active
- 2013-08-28 LT LTEP13756985.1T patent/LT2890699T/lt unknown
- 2013-08-28 SI SI201331062T patent/SI2890699T1/en unknown
- 2013-08-28 NZ NZ704175A patent/NZ704175A/en unknown
- 2013-08-28 MX MX2015002679A patent/MX351463B/es active IP Right Grant
- 2013-08-28 TR TR2018/07735T patent/TR201807735T4/tr unknown
- 2013-08-28 DK DK13756985.1T patent/DK2890699T3/en active
- 2013-08-28 EP EP13756985.1A patent/EP2890699B1/en active Active
- 2013-08-28 PL PL13756985T patent/PL2890699T3/pl unknown
- 2013-08-28 US US14/422,098 patent/US9200003B2/en active Active
- 2013-08-28 BR BR112015004135A patent/BR112015004135B8/pt active IP Right Grant
- 2013-08-28 PT PT137569851T patent/PT2890699T/pt unknown
- 2013-08-28 ES ES13756985.1T patent/ES2671271T3/es active Active
- 2013-08-28 RU RU2015107052A patent/RU2614978C2/ru active
- 2013-08-28 JP JP2015529970A patent/JP6109942B2/ja active Active
- 2013-08-28 KR KR1020157004953A patent/KR101736643B1/ko active Active
- 2013-08-28 HU HUE13756985A patent/HUE037667T2/hu unknown
- 2013-08-30 AR ARP130103110A patent/AR092409A1/es unknown
- 2013-12-13 NO NO13863231A patent/NO2931268T3/no unknown
2015
- 2015-01-30 ZA ZA2015/00728A patent/ZA201500728B/en unknown
- 2015-02-11 CL CL2015000332A patent/CL2015000332A1/es unknown
- 2015-02-27 PH PH12015500441A patent/PH12015500441B1/en unknown
2018
- 2018-06-13 CY CY181100619T patent/CY1120611T1/el unknown

Also Published As

Publication number	Publication date
ZA201500728B (en)	2016-08-31
BR112015004135B1 (pt)	2020-12-08
EP2890699A1 (en)	2015-07-08
AU2013308887A1 (en)	2015-02-19
NO2931268T3 (es)	2018-04-21
WO2014036056A1 (en)	2014-03-06
HUE037667T2 (hu)	2018-09-28
AR092409A1 (es)	2015-04-22
CY1120611T1 (el)	2019-12-11
JP2015526522A (ja)	2015-09-10
AU2013308887B2 (en)	2015-11-12
KR101736643B1 (ko)	2017-05-16
US20150183795A1 (en)	2015-07-02
JP6109942B2 (ja)	2017-04-05
BR112015004135A2 (pt)	2017-07-04
PT2890699T (pt)	2018-06-01
SI2890699T1 (en)	2018-07-31
CN104812758B (zh)	2017-05-03
PH12015500441A1 (en)	2015-04-20
MX2015002679A (es)	2015-05-12
RS57284B1 (sr)	2018-08-31
BR112015004135B8 (pt)	2022-11-22
RU2614978C2 (ru)	2017-03-31
EP2890699B1 (en)	2018-04-11
HRP20180861T1 (hr)	2018-07-13
PL2890699T3 (pl)	2018-10-31
US9200003B2 (en)	2015-12-01
PH12015500441B1 (en)	2015-04-20
LT2890699T (lt)	2018-06-25
HK1209125A1 (en)	2016-03-24
MX351463B (es)	2017-10-16
DK2890699T3 (en)	2018-06-14
NZ704175A (en)	2015-10-30
ES2671271T3 (es)	2018-06-05
CN104812758A (zh)	2015-07-29
TR201807735T4 (tr)	2018-06-21
RU2015107052A (ru)	2016-10-20
KR20150038366A (ko)	2015-04-08
CA2881467A1 (en)	2014-03-06
CA2881467C (en)	2017-08-29

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PE20141406A1 (es)	2014-10-25	4-(8-metoxi-1-((1-metoxipropan-2-il)-2-(tetrahidro-2h-piran-4-il)-1h-imidazo[4,5-c]quinolin-7-il)-3,5-dimetilisoxazol y su uso como inhibidor bromodominio
CL2013001723A1 (es)	2013-12-27	Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina; metodos de preparacion; composicion farmaceutica; y el uso en el tratamiento de los trastornos mediados por la cinasa de linfoma anaplasico.
CL2014000601A1 (es)	2014-10-10	Composición tópica veterinaria que comprende al menos un agente activo derivado de isoxazolina; y uso de la composición para el tratamiento o prevención de una infestación o infección por parásitos en un animal.
BRPI0813237A2 (pt)	2014-12-23	Composto, método para preparar o composto, composição, medicamento, e, uso do composto.
DOP2017000038A (es)	2018-04-15	2-(morfolin-4-il)-1,7-naftiridinas
BR112014010206A2 (pt)	2017-05-16	composto, composição farmacêutica, uso de composto, e, método para a profilaxia ou tratamento de um estado ou condição de doença
UY33397A (es)	2011-12-01	Forma sólida de un naftaleno carboxamida
CL2014002589A1 (es)	2015-01-30	Compuestos inhibidores de beta-lactamasas derivados de 7-oxo-1,6-diazabiciclo[3.2.1] octano; composicion farmaceutica que los comprende y uso para tratar una infeccion bacteriana.
CL2008000403A1 (es)	2008-08-18	Compuestos derivados de pentafluorotiobenzamido-acetonitrilo; composicion farmaceutica; y uso para tratar una infestacion por parasitos.
BR112014010179A8 (pt)	2018-01-09	composto, composição farmacêutica, uso de um composto, e, método para a profilaxia ou tratamento de um estado ou condição
LT3088401T (lt)	2019-07-25	(6s,9as)-n-benzil-6-((4-hidroksifenil)metil)-4,7-diokso-8-((6-(3-(piperazin-1-il)azetidin-1-il)piridin-2-il)metil)-2-(prop-2-en-1-il)-oktahidro-1h-pirazino(2,1-c)(1,2,4)triazin-1-karboksamido junginys
CL2013003287A1 (es)	2014-07-25	Compuestos derivados de 5-trifluorometil-4,5-dihidro-isoxazol; compuestos intermediarios; procedimiento de preparacion; composiciones farmaceuticas que los comprenden; y uso en el tratamiento de una infestacion de parasitos en animales.
BRPI0920598A2 (pt)	2015-12-29	formas sólidas de n-(4(7-azabiciclo[2.2.1]heptan-7-il)-2-(triflúor-metil)fenil)-4-oxo-5-(triflúor-metil)-1,4-di-hidroquinolina-3-carboxamida
BRPI0914147A2 (pt)	2015-10-20	composição herbicidas, uso das composições, método para controlar vegetação indesejável, e, formulação herbicida.
BRPI0922233A2 (pt)	2018-05-29	compostos, composições farmacêiticas e métodos para uso no tratamento de síndromes metabólicas.
BR112014014769A2 (pt)	2017-06-13	Composto, composição farmacêutica, e, uso de um composto ou sal.
BRPI0806531A2 (pt)	2014-04-22	Composto, composição farmacêutica, agente terapêutico, e, uso do composto.
BR112013030163A2 (pt)	2017-03-01	composto, uso cosmético de pelo menos um composto, composição farmacêutica ou cosmética e processo para preparar um composto.
DOP2012000105A (es)	2013-01-31	Compuestos de espiropiperidina y uso farmaceutico del mismo para tratar la diabetes
BRPI1015983A2 (pt)	2016-04-19	composto, uso do composto, método para tratar um paciente, e, composição farmacêutica.
CL2014000849A1 (es)	2014-08-29	Compuestos derivados de benzilindazoles sustituido, inhibidores de la quinasa bub1; procedimiento de fabricacion; composicion farmaceutica; combinacion farmaceutica; y su uso en el tratamiento de enfermedades hiperproliferativas.
CL2014000552A1 (es)	2014-09-12	Uso de 4,4´-[fluoro-(1h-1,2,4-triazol-1-il)metileno]bisbenzonitrilo para el tratamiento del hipogonadismo y composicion farmaceutica oral que comprende al compuesto y kit farmaceutico que comprende a la composicion.
CL2014001861A1 (es)	2014-11-07	Compuestos derivados de bencil sulfonamida, inhibidores de mogat-2; compuesto cristalino; composicion farmaceutica; y su uso en el tratamiento de la hipertrigliceridemia.
BRPI0818448A2 (pt)	2015-05-12	Composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento ou prevenção de um distúrbio madiano pelo receptor mglur5.