CL2015002157A1 - Una composición inmunogenica que comprende: un sacárido capsular pneumococico conjugado, incluyendo sacarido depolimerizado de serotipo 18c; y antígeno de proteína de unión a factor h (fhbp) menincocócico, pero sin incluir vesículas de membrana meningocócica; metodo de preparación de la composición - Google Patents
Una composición inmunogenica que comprende: un sacárido capsular pneumococico conjugado, incluyendo sacarido depolimerizado de serotipo 18c; y antígeno de proteína de unión a factor h (fhbp) menincocócico, pero sin incluir vesículas de membrana meningocócica; metodo de preparación de la composiciónInfo
- Publication number
- CL2015002157A1 CL2015002157A1 CL2015002157A CL2015002157A CL2015002157A1 CL 2015002157 A1 CL2015002157 A1 CL 2015002157A1 CL 2015002157 A CL2015002157 A CL 2015002157A CL 2015002157 A CL2015002157 A CL 2015002157A CL 2015002157 A1 CL2015002157 A1 CL 2015002157A1
- Authority
- CL
- Chile
- Prior art keywords
- composition
- saccharide
- fhbp
- factor
- preparation
- Prior art date
Links
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000001720 carbohydrates Chemical class 0.000 title 2
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 239000000427 antigen Substances 0.000 title 1
- 108091008324 binding proteins Proteins 0.000 title 1
- 239000012528 membrane Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
COMPOSICIÓN INMUNOGÉNICA QUE COMPRENDE UN SACÁRIDO CAPSULAR PNEUMOCOCICO CONJUGADO, INCLUYENDO SACÁRIDO DEPOLIMERIZADO DE SEROTIPO 18C, Y ANTÍGENO DE PROTEÍNA DE UNIÓN A FACTOR H (FHBP) MENINCOCÓCICO, PERO SIN INCLUIR VESÍCULAS DE MEMBRANA EXTERNA MENINGOCÓCICA; Y MÉTODO DE PREPARACIÓN DE LA COMPOSICIÓN
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16300509P | 2009-03-24 | 2009-03-24 | |
| US27040709P | 2009-07-07 | 2009-07-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2015002157A1 true CL2015002157A1 (es) | 2016-01-15 |
Family
ID=42470802
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011002369A CL2011002369A1 (es) | 2009-03-24 | 2011-09-23 | Una composicion inmunogenica que comprende: un sacarido capsular neumococico conjugado, incluyendo sacarido depolimerizado de serotipo 18c; y antigeno de proteina de union a factor h (fhbp) meningococico, pero sin incluir vesiculas de membrana meningococida. y metodo de preparacion de la composicion. |
| CL2015002157A CL2015002157A1 (es) | 2009-03-24 | 2015-07-31 | Una composición inmunogenica que comprende: un sacárido capsular pneumococico conjugado, incluyendo sacarido depolimerizado de serotipo 18c; y antígeno de proteína de unión a factor h (fhbp) menincocócico, pero sin incluir vesículas de membrana meningocócica; metodo de preparación de la composición |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011002369A CL2011002369A1 (es) | 2009-03-24 | 2011-09-23 | Una composicion inmunogenica que comprende: un sacarido capsular neumococico conjugado, incluyendo sacarido depolimerizado de serotipo 18c; y antigeno de proteina de union a factor h (fhbp) meningococico, pero sin incluir vesiculas de membrana meningococida. y metodo de preparacion de la composicion. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20120064103A1 (es) |
| EP (2) | EP3017826A1 (es) |
| JP (2) | JP5668049B2 (es) |
| CN (1) | CN102438649A (es) |
| AU (1) | AU2010227220B2 (es) |
| BR (1) | BRPI1009829A2 (es) |
| CA (1) | CA2756533A1 (es) |
| CL (2) | CL2011002369A1 (es) |
| NZ (1) | NZ595291A (es) |
| RU (1) | RU2555757C2 (es) |
| WO (1) | WO2010109324A1 (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| PL2411048T3 (pl) | 2009-03-24 | 2020-11-16 | Glaxosmithkline Biologicals Sa | Adjuwantowe meningokokowe białko wiążące czynnik h |
| CA2803239A1 (en) * | 2010-06-25 | 2011-12-29 | Novartis Ag | Combinations of meningococcal factor h binding proteins |
| RU2580620C2 (ru) | 2010-08-23 | 2016-04-10 | ВАЙЕТ ЭлЭлСи | СТАБИЛЬНЫЕ КОМПОЗИЦИИ АНТИГЕНОВ Neisseria meningitidis rLP2086 |
| WO2012032489A1 (en) | 2010-09-10 | 2012-03-15 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| CA2865745C (en) | 2012-03-09 | 2018-01-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| RU2014151567A (ru) * | 2012-05-22 | 2016-07-10 | Новартис Аг | Конъюгат менингококка серогруппы х |
| WO2013177397A1 (en) | 2012-05-24 | 2013-11-28 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Multivalent meningococcal conjugates and methods for preparing cojugates |
| HK1205138A1 (en) | 2012-07-27 | 2015-12-11 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia |
| US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| US11160855B2 (en) * | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| AU2016221318B2 (en) | 2015-02-19 | 2020-06-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CN104844712B (zh) * | 2015-04-03 | 2019-06-28 | 长春百克生物科技股份公司 | 肺炎链球菌蛋白抗原及其制备方法和应用 |
| US20180360943A1 (en) | 2015-12-10 | 2018-12-20 | National Research Council Of Canada | Lipidated streptococcus pneumoniae antigen compositions, methods of preparation and use |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| MX2019007910A (es) | 2016-12-30 | 2019-12-05 | Sutrovax Inc | Conjugados de polipeptido-antigeno con aminoacidos no naturales. |
| MX392525B (es) | 2017-01-20 | 2025-03-12 | Pfizer | Composiciones inmunogenicas para su uso en vacunas neumococicas |
| US10183070B2 (en) | 2017-01-31 | 2019-01-22 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| CN107151270B (zh) * | 2017-03-22 | 2018-07-31 | 武汉博沃生物科技有限公司 | 重组ΔfHbp-NadA融合蛋白载体及其制备方法和应用 |
| DK3817775T3 (da) * | 2018-07-04 | 2024-09-16 | Vaxcyte Inc | Forbedringer i immunogene konjugater |
| EP4034157A1 (en) | 2019-09-27 | 2022-08-03 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CN118702827B (zh) * | 2024-08-27 | 2025-03-07 | 南京澄实生物医药科技有限公司 | 一种预防肺炎链球菌感染的融合蛋白及其应用 |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4057685A (en) | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
| US4673574A (en) | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
| US4459286A (en) | 1983-01-31 | 1984-07-10 | Merck & Co., Inc. | Coupled H. influenzae type B vaccine |
| US4663160A (en) | 1983-03-14 | 1987-05-05 | Miles Laboratories, Inc. | Vaccines for gram-negative bacteria |
| US4761283A (en) | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
| US4808700A (en) | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
| IT1187753B (it) | 1985-07-05 | 1987-12-23 | Sclavo Spa | Coniugati glicoproteici ad attivita' immunogenica trivalente |
| US5204098A (en) | 1988-02-16 | 1993-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Polysaccharide-protein conjugates |
| NL8802046A (nl) | 1988-08-18 | 1990-03-16 | Gen Electric | Polymeermengsel met polyester en alkaansulfonaat, daaruit gevormde voorwerpen. |
| US6716432B1 (en) | 1988-12-16 | 2004-04-06 | James Cleland Paton | Pneumolysin mutants and pneumococcal vaccines made therefrom |
| MC2178A1 (fr) | 1988-12-16 | 1992-05-22 | Nederlanden Staat | Mutants de la pneumolysine et vaccins a base de pneumocoque prepares a partir de ces mutants |
| DE68907045T2 (de) | 1989-01-17 | 1993-12-02 | Eniricerche Spa | Synthetische Peptide und deren Verwendung als allgemeine Träger für die Herstellung von immunogenischen Konjugaten, die für die Entwicklung von synthetischen Impfstoffen geeignet sind. |
| WO1990014837A1 (en) | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
| JPH04506662A (ja) | 1989-07-14 | 1992-11-19 | アメリカン・サイアナミド・カンパニー | 接合体ワクチンのためのサイトカイニンおよびホルモンのキヤリヤー |
| IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| DE69113564T2 (de) | 1990-08-13 | 1996-05-30 | American Cyanamid Co | Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff. |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| US5425946A (en) | 1992-08-31 | 1995-06-20 | North American Vaccine, Inc. | Vaccines against group C Neisseria meningitidis |
| JP4097691B2 (ja) | 1992-08-31 | 2008-06-11 | バクスター、ヘルスケア、ソシエテ、アノニム | C群髄膜炎菌に対するワクチン |
| NL9201716A (nl) | 1992-10-02 | 1994-05-02 | Nederlanden Staat | Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat. |
| AU5543294A (en) | 1993-10-29 | 1995-05-22 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
| US5698438A (en) | 1994-10-18 | 1997-12-16 | Oregon Health Sciences University | Bacterial hemoglobin receptor gene |
| IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
| CA2271720A1 (en) | 1996-10-31 | 1998-05-07 | Human Genome Sciences, Inc. | Streptococcus pneumoniae polynucleotides and sequences |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| WO1998053851A1 (en) | 1997-05-28 | 1998-12-03 | University Of Iowa Research Foundation | Laft mutants of pathogenic gram-negative bacteria |
| GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| AU740956B2 (en) | 1997-07-21 | 2001-11-15 | Baxter Healthcare Sa | Modified immunogenic pneumolysin compositions as vaccines |
| US6645503B1 (en) | 1998-03-10 | 2003-11-11 | Wyeth Holdings Corporation | Antigenic conjugates of conserved lipopolysaccharides of gram negative bacteria |
| DE19814925C2 (de) * | 1998-04-03 | 2000-10-05 | Thomas Harrer | Arzneimittel zur Induktion zytotoxischer T-Zellen |
| AU770378B2 (en) | 1998-04-23 | 2004-02-19 | Uab Research Foundation | Pneumococcal surface protein C(PspC), epitopic regions and strain selection thereof, and uses therefor |
| EP2261347A3 (en) | 1998-05-01 | 2012-01-11 | Novartis Vaccines and Diagnostics, Inc. | Neisseria meningitidis antigens and compositions |
| CN1263510C (zh) | 1998-08-19 | 2006-07-12 | 巴克斯特健康护理股份有限公司 | 多糖-蛋白质缀合物或寡糖-蛋白质缀合物、其制备方法及其应用 |
| CA2347849C (en) | 1998-10-22 | 2013-06-25 | The University Of Montana | Omp85 proteins of neisseria gonorrhoeae and neisseria meningitidis, compositions containing same and methods of use thereof |
| PT1127137E (pt) | 1998-11-03 | 2007-12-28 | Staat Nl Verteg Door Min Welzi | Lps com toxicidade reduzida a partir de bactérias gramnegativas modificadas geneticamente |
| AU1626199A (en) | 1998-12-04 | 2000-06-26 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | A vi-repa conjugate vaccine for immunization against salmonella typhi |
| DE69940439D1 (de) | 1998-12-21 | 2009-04-02 | Medimmune Inc | Streptococcus pneumoniae proteine und immunogene fragmente für impstoffe |
| JP2002539273A (ja) | 1999-03-19 | 2002-11-19 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | ワクチン |
| CA2365914A1 (en) | 1999-04-09 | 2000-10-19 | Techlab, Inc. | Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines |
| CA2372235A1 (en) | 1999-04-30 | 2000-11-09 | Rino Rappuoli | Conserved neisserial antigens |
| US6531131B1 (en) | 1999-08-10 | 2003-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for Neisseria meningitidis |
| GB9925559D0 (en) | 1999-10-28 | 1999-12-29 | Smithkline Beecham Biolog | Novel method |
| EP1234039A2 (en) | 1999-11-29 | 2002-08-28 | Chiron Spa | 85kDa NEISSERIAL ANTIGEN |
| MXPA02007184A (es) | 2000-01-25 | 2004-02-26 | Univ Queensland | Proteinas que comprenden regiones conservadas de antigenos de superficie nhha de neisseria meningitidis. |
| GB0007432D0 (en) | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
| WO2002008426A2 (en) | 2000-07-20 | 2002-01-31 | Hansa Medical Ab | Fh-binding protein of streptococcus pneumoniae |
| GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| US20030035806A1 (en) | 2001-05-11 | 2003-02-20 | D'ambra Anello J. | Novel meningitis conjugate vaccine |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| ES2320334T3 (es) | 2002-02-22 | 2009-05-21 | National Research Council Of Canada | Uso de analogos de acidos grasos para el tratamiento y/o prevencion de enfermedades proliferativas de la piel. |
| DK1777236T3 (en) | 2002-03-26 | 2017-02-27 | Glaxosmithkline Biologicals Sa | MODIFIED SUCCARIDES WHICH IMPROVED WATER STABILITY FOR USE AS A MEDICINE |
| DK1511768T3 (da) | 2002-06-11 | 2007-08-20 | Glaxosmithkline Biolog Sa | Immunogene sammensætninger |
| CA2493124C (en) | 2002-08-02 | 2014-04-29 | Glaxosmithkline Biologicals S.A. | Vaccine |
| CN1809380B (zh) | 2002-10-11 | 2010-05-12 | 启龙有限公司 | 广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗 |
| CN100443116C (zh) | 2002-11-07 | 2008-12-17 | 新纳几美国公司 | 治疗或预防肺炎球菌感染的组合物及其用途 |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| EP2333114A1 (en) | 2003-04-15 | 2011-06-15 | Intercell AG | S. pneumoniae antigens |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| US7556814B2 (en) * | 2003-10-23 | 2009-07-07 | Karp Nelson M | Immunogenic compositions comprising UV-irradiated, psoralen-inactivated, desialated human immunodeficiency virus (HIV) devoid of CD55 and CD59 in the viral membrane |
| JP5393978B2 (ja) | 2004-04-05 | 2014-01-22 | ゾエティス・ピー・エルエルシー | マイクロ流動化された水中油型乳剤及びワクチン組成物 |
| GB0408977D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB0410220D0 (en) | 2004-05-07 | 2004-06-09 | Kirkham Lea Ann | Mutant pneumolysin proteins |
| GB0419408D0 (en) * | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
| LT2682126T (lt) * | 2005-01-27 | 2017-02-27 | Children`s Hospital & Research Center at Oakland | Gna1870 pagrindu gaminamos pūslelių pavidalo vakcinos, skirtos plataus spektro apsaugai nuo neisseria meningitidis sukeltų ligų |
| US7955605B2 (en) | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| DK3466982T3 (da) | 2005-04-08 | 2020-08-03 | Wyeth Llc | Separation af forurenende kontaminanter fra streptococcus pneumoniae-polysaccharid ved ph-manipulation |
| EP2425853A1 (en) | 2005-04-08 | 2012-03-07 | Wyeth LLC | Multivalent Pneumococcal Polysaccharide-Protein Conjugate Composition |
| US7691368B2 (en) | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
| LT2351578T (lt) | 2005-06-27 | 2017-04-10 | Glaxosmithkline Biologicals S.A. | Vakcinų gavimo būdas |
| US8703095B2 (en) | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
| GB0524066D0 (en) * | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| BRPI0620460B8 (pt) * | 2005-12-22 | 2021-05-25 | Glaxosmithkline Biologicals Sa | uso de composição imunogênica para bebês, e, processo para produzir uma vacina |
| ES2383209T3 (es) * | 2006-03-22 | 2012-06-19 | Novartis Ag | Regímenes para la inmunización con conjugados meningococicos |
| TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| DE602007003596D1 (de) | 2006-06-12 | 2010-01-14 | Glaxosmithkline Biolog Sa | Impfstoff |
| KR101467002B1 (ko) | 2006-10-10 | 2014-12-01 | 와이어쓰 엘엘씨 | 스트렙토코쿠스 뉴모니애 제3형 다당류의 정제 방법 |
| ES2397714T3 (es) | 2006-10-12 | 2013-03-08 | Glaxosmithkline Biologicals S.A. | Vacuna que comprende un adyuvante de emulsión de aceite en agua |
| EP1923069A1 (en) | 2006-11-20 | 2008-05-21 | Intercell AG | Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto |
| JP5637848B2 (ja) * | 2007-06-04 | 2014-12-10 | ノバルティス アーゲー | 髄膜炎ワクチンの製剤化 |
| EP2185576A4 (en) * | 2007-08-02 | 2011-01-12 | Childrens Hosp & Res Ct Oak | FHBP- AND LPXL1-BASED VESICIUM VACCINES FOR BROADBAND PROTECTION AGAINST NEISSERIA MENINGITIDIS-RELATED DISEASES |
| PL2411048T3 (pl) * | 2009-03-24 | 2020-11-16 | Glaxosmithkline Biologicals Sa | Adjuwantowe meningokokowe białko wiążące czynnik h |
-
2010
- 2010-03-24 US US13/260,548 patent/US20120064103A1/en not_active Abandoned
- 2010-03-24 BR BRPI1009829A patent/BRPI1009829A2/pt not_active Application Discontinuation
- 2010-03-24 CN CN2010800235863A patent/CN102438649A/zh active Pending
- 2010-03-24 EP EP15194612.6A patent/EP3017826A1/en not_active Withdrawn
- 2010-03-24 CA CA2756533A patent/CA2756533A1/en not_active Abandoned
- 2010-03-24 JP JP2012501409A patent/JP5668049B2/ja not_active Expired - Fee Related
- 2010-03-24 AU AU2010227220A patent/AU2010227220B2/en not_active Ceased
- 2010-03-24 EP EP20100716044 patent/EP2411045A1/en not_active Withdrawn
- 2010-03-24 NZ NZ595291A patent/NZ595291A/xx not_active IP Right Cessation
- 2010-03-24 WO PCT/IB2010/000734 patent/WO2010109324A1/en not_active Ceased
- 2010-03-24 RU RU2011142774/10A patent/RU2555757C2/ru not_active IP Right Cessation
-
2011
- 2011-09-23 CL CL2011002369A patent/CL2011002369A1/es unknown
-
2014
- 2014-10-28 JP JP2014219043A patent/JP2015028081A/ja not_active Withdrawn
-
2015
- 2015-07-31 CL CL2015002157A patent/CL2015002157A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2011142774A (ru) | 2013-04-27 |
| EP2411045A1 (en) | 2012-02-01 |
| JP2015028081A (ja) | 2015-02-12 |
| WO2010109324A9 (en) | 2010-12-29 |
| AU2010227220A1 (en) | 2011-10-13 |
| RU2555757C2 (ru) | 2015-07-10 |
| CN102438649A (zh) | 2012-05-02 |
| US20120064103A1 (en) | 2012-03-15 |
| JP2012521403A (ja) | 2012-09-13 |
| BRPI1009829A2 (pt) | 2016-11-16 |
| EP3017826A1 (en) | 2016-05-11 |
| AU2010227220B2 (en) | 2014-11-13 |
| WO2010109324A1 (en) | 2010-09-30 |
| JP5668049B2 (ja) | 2015-02-12 |
| NZ595291A (en) | 2013-08-30 |
| CL2011002369A1 (es) | 2012-02-17 |
| CA2756533A1 (en) | 2010-09-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2011002369A1 (es) | Una composicion inmunogenica que comprende: un sacarido capsular neumococico conjugado, incluyendo sacarido depolimerizado de serotipo 18c; y antigeno de proteina de union a factor h (fhbp) meningococico, pero sin incluir vesiculas de membrana meningococida. y metodo de preparacion de la composicion. | |
| CL2010001360A1 (es) | Composicion inmunogenica que comprende un componente antigenico y una formulacion de adyuvante la que comprende una saponina, un esterol, un compuesto de amonio cuaternario y un polimero; procedimiento de preparacion; y sus usos. | |
| EP4056198A3 (en) | Outer membrane vesicles | |
| WO2010070453A3 (en) | Meningococcal vaccines including hemoglobin receptor | |
| MX2009008928A (es) | Composiciones que comprenden conjugados de polisacaridos y su uso como vacunas. | |
| MX2009001412A (es) | Vacunas de matriz de proteinas y metodos de hacer y administrar tales vacunas. | |
| PE20142115A1 (es) | Composiciones de neisseria meningitidis y metodos de las mismas | |
| AR093712A1 (es) | Composicion inmunogena, vacuna, uso y procedimiento de prevencion o tratamiento | |
| GB201101665D0 (en) | Immunogenic compositions | |
| MX2010012999A (es) | Vacuna de vesícula de membrana externa nativa multivalente del meningococo, método para su fabricación y uso. | |
| EP4434550A3 (en) | Human antibody drug conjugates against tissue culture | |
| MX2009013112A (es) | Formulacion de vacunas para meningitis. | |
| MX363307B (es) | Plataformas para suministro de antigenos. | |
| EA201291105A1 (ru) | Пероральная вакцина, содержащая антиген и агонист toll-подобного рецептора | |
| BRPI1013780B8 (pt) | Composição imunogênica útil para imunização contra staphylococcus aureus, seu método de preparação e composição farmacêutica | |
| MX2014014576A (es) | Vacunas para meningococo de serogrupo x. | |
| CO6480954A2 (es) | Método para producir una preparación altamente concentrada de inmunoglobulina de uso subcutaneo | |
| WO2011024072A3 (en) | Hybrid polypeptides including meningococcal fhbp sequences | |
| TR201802380T4 (tr) | Benzonaftiridin içeren aşılar. | |
| CY1123814T1 (el) | ΣΥΖΕΥΓΜΑΤΑ nOMV-ΑΝΤΙΓΟΝΟΥ ΚΑΙ ΧΡΗΣΗ ΑΥΤΩΝ | |
| MX2015002482A (es) | Composicion inmunogenica. | |
| EA201291437A1 (ru) | Концентрация вакцинных антигенов без лиофилизации | |
| WO2013022808A3 (en) | Immunogenic protein conjugates and methods for making and using the same | |
| BR112019010227A2 (pt) | conjugado imunogênico, processo para preparação de conjugado imunogênico, composição imunogênica, vacina, e, uso de nomv | |
| CO2023010612A2 (es) | Vacuna recombinante meningocócica b |