CL2016002528A1 - Triterpenos con actividad inhibidora de la maduración de vih, substituido en posición 3 por un anillo sin aroma que lleva un sustituyente haloalkyl. - Google Patents

Triterpenos con actividad inhibidora de la maduración de vih, substituido en posición 3 por un anillo sin aroma que lleva un sustituyente haloalkyl.

Info

Publication number
CL2016002528A1
CL2016002528A1 CL2016002528A CL2016002528A CL2016002528A1 CL 2016002528 A1 CL2016002528 A1 CL 2016002528A1 CL 2016002528 A CL2016002528 A CL 2016002528A CL 2016002528 A CL2016002528 A CL 2016002528A CL 2016002528 A1 CL2016002528 A1 CL 2016002528A1
Authority
CL
Chile
Prior art keywords
triterpenes
unscented
replaced
inhibitory activity
ring bearing
Prior art date
Application number
CL2016002528A
Other languages
English (en)
Inventor
Sing-Yuen Sit
Yan Chen
Jie Chen
Jacob Swidorski
Brian Lee Venables
Ny Sin
Nicholas A Meanwell
Alicia Regueiro-Ren
Richard A Hartz
Li Xu
Zheng Liu
Original Assignee
Viiv Healthcare Uk (No 4) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53002809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016002528(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Viiv Healthcare Uk (No 4) Ltd filed Critical Viiv Healthcare Uk (No 4) Ltd
Publication of CL2016002528A1 publication Critical patent/CL2016002528A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

<p>COMPUESTOS DERIVADOS DE TRITERPENOS CON ACTIVIVIDAD INHIBIDORA DE LA MADURACION DE VIH, SUBSTITUIDOS EN POSICION 3 POR UN ANILLO NO AROMATICO QUE LLEVA UN SUSTITUYENTE HALOALQUILO; COMPUESTO INTERMEDIARIO; COMPOSICIÓN FARAMCEUTICA; Y PROCEDIMIENTO PARA TRATAR UN MAMIFERO INFECTADO CON VIH. </p>
CL2016002528A 2014-04-11 2016-10-05 Triterpenos con actividad inhibidora de la maduración de vih, substituido en posición 3 por un anillo sin aroma que lleva un sustituyente haloalkyl. CL2016002528A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461978306P 2014-04-11 2014-04-11

Publications (1)

Publication Number Publication Date
CL2016002528A1 true CL2016002528A1 (es) 2017-06-23

Family

ID=53002809

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016002528A CL2016002528A1 (es) 2014-04-11 2016-10-05 Triterpenos con actividad inhibidora de la maduración de vih, substituido en posición 3 por un anillo sin aroma que lleva un sustituyente haloalkyl.

Country Status (36)

Country Link
US (5) US9527882B2 (es)
EP (2) EP3750910A1 (es)
JP (1) JP6568202B2 (es)
KR (1) KR102411082B1 (es)
CN (1) CN106604909B (es)
AR (1) AR101077A1 (es)
AU (1) AU2015243500B2 (es)
BR (1) BR112016023414B1 (es)
CA (1) CA2944778C (es)
CL (1) CL2016002528A1 (es)
CR (1) CR20160472A (es)
CY (1) CY1123742T1 (es)
DK (1) DK3129392T3 (es)
DO (1) DOP2016000277A (es)
EA (1) EA030178B1 (es)
ES (1) ES2828705T3 (es)
HR (1) HRP20201645T1 (es)
HU (1) HUE051719T2 (es)
IL (1) IL248053B (es)
LT (1) LT3129392T (es)
MA (1) MA39374A1 (es)
MX (1) MX374543B (es)
NZ (1) NZ724644A (es)
PE (1) PE20161391A1 (es)
PH (1) PH12016501951B1 (es)
PL (1) PL3129392T3 (es)
PT (1) PT3129392T (es)
RS (1) RS60959B1 (es)
SG (2) SG11201608041QA (es)
SI (1) SI3129392T1 (es)
SM (1) SMT202000581T1 (es)
TW (1) TWI659964B (es)
UA (1) UA120927C2 (es)
UY (1) UY36070A (es)
WO (1) WO2015157483A1 (es)
ZA (1) ZA201606748B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3129392T1 (sl) 2014-04-11 2020-11-30 VIIV Healthcare UK(No.4) Limited Triterpenoidi z inhibitorno aktivnostjo maturacije HIV-a, substituirani na položaju 3 z nearomatskim obročem, ki nosi haloalkilni substituent
WO2017085677A2 (en) * 2015-11-20 2017-05-26 ViiV Healthcare UK (No.4) Limited Hiv maturation inhibitor formulations
AR107512A1 (es) * 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
EP3506902A4 (en) * 2016-08-31 2020-04-22 VIIV Healthcare Company COMBINATIONS AND USES AND TREATMENTS THEREOF
ES2970042T3 (es) * 2018-04-24 2024-05-24 Viiv Healthcare Uk No 5 Ltd Compuestos con actividad inhibidora de la maduración del VIH
SMT202300049T1 (it) * 2018-12-10 2023-03-17 Viiv Healthcare Uk No 4 Ltd Sale mesilato di un composto di ammino-lupano con attivita’ di inibizione della maturazione dell’hiv
CN109705189B (zh) * 2018-12-29 2020-06-05 中国医学科学院药用植物研究所 具有式i所示结构的三萜衍生物及其制备方法和应用
CN110981765A (zh) * 2019-11-07 2020-04-10 肇庆巨元生化有限公司 一种25-羟基维生素d3中间体的制备方法
UY38982A (es) * 2019-12-09 2021-06-30 Viiv Healthcare Co Composiciones farmacéuticas

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AR035311A1 (es) 1999-01-27 2004-05-12 Wyeth Corp Derivados de acido hidroxamico que contienen alquinilo, como inhibidores de las metalloproteinasas de matriz y de la tace, composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento
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CN103038245B (zh) * 2010-06-04 2015-03-25 百时美施贵宝公司 作为hiv成熟抑制剂的c-3经修饰的桦木酸衍生物
PL2670764T3 (pl) 2011-01-31 2016-02-29 Bristol Myers Squibb Co C-28 aminy zmodyfikowanych C-3 pochodnych kwasu betulinowego jako inhibitory dojrzewania HIV
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Also Published As

Publication number Publication date
BR112016023414B1 (pt) 2022-09-13
MX2016013425A (es) 2017-05-02
PL3129392T3 (pl) 2021-04-06
BR112016023414A2 (es) 2017-08-15
LT3129392T (lt) 2020-11-10
PH12016501951B1 (en) 2021-02-19
CN106604909B (zh) 2019-02-15
JP2017510659A (ja) 2017-04-13
KR102411082B1 (ko) 2022-06-17
ZA201606748B (en) 2018-05-30
KR20160147809A (ko) 2016-12-23
AR101077A1 (es) 2016-11-23
PE20161391A1 (es) 2017-01-10
EP3129392A1 (en) 2017-02-15
DOP2016000277A (es) 2017-02-28
IL248053B (en) 2020-04-30
CA2944778C (en) 2022-06-14
MA39374A1 (fr) 2018-06-29
UA120927C2 (uk) 2020-03-10
TW201623324A (zh) 2016-07-01
EP3750910A1 (en) 2020-12-16
DK3129392T3 (da) 2020-10-19
AU2015243500A1 (en) 2016-10-27
US10780102B2 (en) 2020-09-22
SMT202000581T1 (it) 2020-11-10
US20170340650A1 (en) 2017-11-30
CN106604909A (zh) 2017-04-26
SG10201709017PA (en) 2017-11-29
AU2015243500B2 (en) 2017-03-30
RS60959B1 (sr) 2020-11-30
MX374543B (es) 2025-03-06
PT3129392T (pt) 2020-10-30
WO2015157483A1 (en) 2015-10-15
US20190151336A1 (en) 2019-05-23
NZ724644A (en) 2023-07-28
IL248053A0 (en) 2016-11-30
EP3129392B1 (en) 2020-08-05
ES2828705T3 (es) 2021-05-27
US10245275B2 (en) 2019-04-02
US9527882B2 (en) 2016-12-27
CA2944778A1 (en) 2015-10-15
US20170056420A1 (en) 2017-03-02
EA201691760A1 (ru) 2017-02-28
HUE051719T2 (hu) 2021-03-29
UY36070A (es) 2015-10-30
JP6568202B2 (ja) 2019-08-28
SI3129392T1 (sl) 2020-11-30
SG11201608041QA (en) 2016-10-28
US11464790B2 (en) 2022-10-11
US20200360404A1 (en) 2020-11-19
TWI659964B (zh) 2019-05-21
PH12016501951A1 (en) 2017-01-09
CR20160472A (es) 2017-03-10
HRP20201645T1 (hr) 2020-12-25
EA030178B1 (ru) 2018-06-29
CY1123742T1 (el) 2022-03-24
US20150291655A1 (en) 2015-10-15

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