MA39374A1 - Triterpénoïdes présentant une activité d'inhibition de la maturation du vih, substitués en 3ème position par un cycle non aromatique portant un substituant halogénoalkyle - Google Patents
Triterpénoïdes présentant une activité d'inhibition de la maturation du vih, substitués en 3ème position par un cycle non aromatique portant un substituant halogénoalkyleInfo
- Publication number
- MA39374A1 MA39374A1 MA39374A MA39374A MA39374A1 MA 39374 A1 MA39374 A1 MA 39374A1 MA 39374 A MA39374 A MA 39374A MA 39374 A MA39374 A MA 39374A MA 39374 A1 MA39374 A1 MA 39374A1
- Authority
- MA
- Morocco
- Prior art keywords
- triterpenoids
- substituted
- aromatic ring
- inhibition activity
- ring bearing
- Prior art date
Links
- 150000003648 triterpenes Chemical class 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title 1
- 230000001747 exhibiting effect Effects 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000035800 maturation Effects 0.000 title 1
- 125000006574 non-aromatic ring group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La présente invention concerne des composés dotés de propriétés pharmaceutiques et bioactives, leurs compositions pharmaceutiques et des procédés d'utilisation. En particulier, des triterpénoïdes qui présentent une activité antivirale unique sont utilisés comme inhibiteurs de maturation du vih, tels que représentés par des composés de formule i : avec x choisi parmi un cycle c
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461978306P | 2014-04-11 | 2014-04-11 | |
| PCT/US2015/025029 WO2015157483A1 (fr) | 2014-04-11 | 2015-04-09 | Triterpénoïdes présentant une activité d'inhibition de la maturation du vih, substitués en 3ème position par un cycle non aromatique portant un substituant halogénoalkyle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA39374A1 true MA39374A1 (fr) | 2018-06-29 |
Family
ID=53002809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA39374A MA39374A1 (fr) | 2014-04-11 | 2015-04-09 | Triterpénoïdes présentant une activité d'inhibition de la maturation du vih, substitués en 3ème position par un cycle non aromatique portant un substituant halogénoalkyle |
Country Status (36)
| Country | Link |
|---|---|
| US (5) | US9527882B2 (fr) |
| EP (2) | EP3750910A1 (fr) |
| JP (1) | JP6568202B2 (fr) |
| KR (1) | KR102411082B1 (fr) |
| CN (1) | CN106604909B (fr) |
| AR (1) | AR101077A1 (fr) |
| AU (1) | AU2015243500B2 (fr) |
| BR (1) | BR112016023414B1 (fr) |
| CA (1) | CA2944778C (fr) |
| CL (1) | CL2016002528A1 (fr) |
| CR (1) | CR20160472A (fr) |
| CY (1) | CY1123742T1 (fr) |
| DK (1) | DK3129392T3 (fr) |
| DO (1) | DOP2016000277A (fr) |
| EA (1) | EA030178B1 (fr) |
| ES (1) | ES2828705T3 (fr) |
| HR (1) | HRP20201645T1 (fr) |
| HU (1) | HUE051719T2 (fr) |
| IL (1) | IL248053B (fr) |
| LT (1) | LT3129392T (fr) |
| MA (1) | MA39374A1 (fr) |
| MX (1) | MX374543B (fr) |
| NZ (1) | NZ724644A (fr) |
| PE (1) | PE20161391A1 (fr) |
| PH (1) | PH12016501951B1 (fr) |
| PL (1) | PL3129392T3 (fr) |
| PT (1) | PT3129392T (fr) |
| RS (1) | RS60959B1 (fr) |
| SG (2) | SG10201709017PA (fr) |
| SI (1) | SI3129392T1 (fr) |
| SM (1) | SMT202000581T1 (fr) |
| TW (1) | TWI659964B (fr) |
| UA (1) | UA120927C2 (fr) |
| UY (1) | UY36070A (fr) |
| WO (1) | WO2015157483A1 (fr) |
| ZA (1) | ZA201606748B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY36070A (es) | 2014-04-11 | 2015-10-30 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Triterpenoides con actividad inhibidora de la maduración de hiv |
| EP3377177A2 (fr) * | 2015-11-20 | 2018-09-26 | VIIV Healthcare UK(No.4) Limited | Formulations d'inhibiteurs de maturation du vih |
| AR107512A1 (es) * | 2016-02-04 | 2018-05-09 | VIIV HEALTHCARE UK Nº 5 LTD | Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1 |
| EP3506902A4 (fr) * | 2016-08-31 | 2020-04-22 | VIIV Healthcare Company | Combinaisons, utilisations et traitements correspondants |
| ES2970042T3 (es) * | 2018-04-24 | 2024-05-24 | Viiv Healthcare Uk No 5 Ltd | Compuestos con actividad inhibidora de la maduración del VIH |
| ES2938486T3 (es) * | 2018-12-10 | 2023-04-11 | Viiv Healthcare Uk No 4 Ltd | Sal de mesilato de un compuesto de amino-lupano con actividad inhibidora de maduración del VIH |
| CN109705189B (zh) * | 2018-12-29 | 2020-06-05 | 中国医学科学院药用植物研究所 | 具有式i所示结构的三萜衍生物及其制备方法和应用 |
| CN110981765A (zh) * | 2019-11-07 | 2020-04-10 | 肇庆巨元生化有限公司 | 一种25-羟基维生素d3中间体的制备方法 |
| JP7703538B2 (ja) * | 2019-12-09 | 2025-07-07 | ヴィーブ、ヘルスケア、カンパニー | カボテグラビルを含んでなる医薬組成物 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4906661A (en) | 1981-11-12 | 1990-03-06 | E. I. Du Pont De Nemours And Company | Esters of aryloxypropanolamine derivatives |
| US5413999A (en) | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| US5679828A (en) | 1995-06-05 | 1997-10-21 | Biotech Research Labs, Inc. | Betulinic acid and dihydrobetulinic acid derivatives and uses therefor |
| AR035311A1 (es) | 1999-01-27 | 2004-05-12 | Wyeth Corp | Derivados de acido hidroxamico que contienen alquinilo, como inhibidores de las metalloproteinasas de matriz y de la tace, composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US7365221B2 (en) | 2002-09-26 | 2008-04-29 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
| US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| BRPI0508854A (pt) | 2004-03-17 | 2007-08-28 | Panacos Pharmaceuticals Inc | sais farmacêuticos de ácido-3-o-(3',3'-dimetilsuccinil) betulìnico |
| TW200628161A (en) | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
| WO2008115281A2 (fr) | 2006-10-16 | 2008-09-25 | Myriad Genetics, Inc. | Composés de traitement d'infections virales |
| WO2009020732A1 (fr) * | 2007-08-03 | 2009-02-12 | Advanced Life Sciences, Inc. | Triterpénoïdes de type lupane modifiés en position 30 et leurs analogues |
| CA2714049A1 (fr) | 2008-02-14 | 2009-08-20 | Virochem Pharma Inc. | Nouveaux derives de 17ss-lupane |
| US9067966B2 (en) | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
| RS54239B1 (sr) | 2010-06-04 | 2015-12-31 | Bristol-Myers Squibb Company | C-28 amidi modifikovanih derivata c-3 betulinske kiseline kao inhibitori sazrevanja hiv-a |
| US8754068B2 (en) | 2010-06-04 | 2014-06-17 | Bristol-Myers Squibb Company | Modified C-3 betulinic acid derivatives as HIV maturation inhibitors |
| US8846647B2 (en) | 2011-01-31 | 2014-09-30 | Bristol-Myers Squibb Company | C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity |
| HUE026371T2 (en) | 2011-01-31 | 2016-05-30 | Bristol Myers Squibb Co | C-28 amines from modified C-3 betulinic acid derivatives as anti-HIV matrices |
| US8906889B2 (en) | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
| US8889854B2 (en) * | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
| UY36070A (es) | 2014-04-11 | 2015-10-30 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Triterpenoides con actividad inhibidora de la maduración de hiv |
-
2015
- 2015-04-09 UY UY0001036070A patent/UY36070A/es not_active Application Discontinuation
- 2015-04-09 TW TW104111466A patent/TWI659964B/zh active
- 2015-04-09 SI SI201531396T patent/SI3129392T1/sl unknown
- 2015-04-09 SG SG10201709017PA patent/SG10201709017PA/en unknown
- 2015-04-09 CR CR20160472A patent/CR20160472A/es unknown
- 2015-04-09 EP EP20187878.2A patent/EP3750910A1/fr not_active Withdrawn
- 2015-04-09 US US14/682,179 patent/US9527882B2/en active Active
- 2015-04-09 HR HRP20201645TT patent/HRP20201645T1/hr unknown
- 2015-04-09 ES ES15718402T patent/ES2828705T3/es active Active
- 2015-04-09 NZ NZ724644A patent/NZ724644A/en unknown
- 2015-04-09 CN CN201580031487.2A patent/CN106604909B/zh active Active
- 2015-04-09 UA UAA201609970A patent/UA120927C2/uk unknown
- 2015-04-09 MX MX2016013425A patent/MX374543B/es active IP Right Grant
- 2015-04-09 WO PCT/US2015/025029 patent/WO2015157483A1/fr not_active Ceased
- 2015-04-09 EP EP15718402.9A patent/EP3129392B1/fr active Active
- 2015-04-09 CA CA2944778A patent/CA2944778C/fr active Active
- 2015-04-09 KR KR1020167031312A patent/KR102411082B1/ko not_active Expired - Fee Related
- 2015-04-09 DK DK15718402.9T patent/DK3129392T3/da active
- 2015-04-09 AU AU2015243500A patent/AU2015243500B2/en active Active
- 2015-04-09 HU HUE15718402A patent/HUE051719T2/hu unknown
- 2015-04-09 PL PL15718402T patent/PL3129392T3/pl unknown
- 2015-04-09 AR ARP150101078A patent/AR101077A1/es unknown
- 2015-04-09 RS RS20201276A patent/RS60959B1/sr unknown
- 2015-04-09 BR BR112016023414-6A patent/BR112016023414B1/pt active IP Right Grant
- 2015-04-09 PE PE2016001948A patent/PE20161391A1/es unknown
- 2015-04-09 JP JP2017504607A patent/JP6568202B2/ja active Active
- 2015-04-09 SG SG11201608041QA patent/SG11201608041QA/en unknown
- 2015-04-09 EA EA201691760A patent/EA030178B1/ru unknown
- 2015-04-09 LT LTEP15718402.9T patent/LT3129392T/lt unknown
- 2015-04-09 PT PT157184029T patent/PT3129392T/pt unknown
- 2015-04-09 MA MA39374A patent/MA39374A1/fr unknown
- 2015-04-09 SM SM20200581T patent/SMT202000581T1/it unknown
-
2016
- 2016-09-26 IL IL248053A patent/IL248053B/en active IP Right Grant
- 2016-09-29 ZA ZA2016/06748A patent/ZA201606748B/en unknown
- 2016-10-03 PH PH12016501951A patent/PH12016501951B1/en unknown
- 2016-10-05 CL CL2016002528A patent/CL2016002528A1/es unknown
- 2016-10-11 DO DO2016000277A patent/DOP2016000277A/es unknown
- 2016-11-07 US US15/344,756 patent/US20170056420A1/en not_active Abandoned
-
2017
- 2017-08-16 US US15/678,381 patent/US10245275B2/en active Active
-
2019
- 2019-01-22 US US16/253,393 patent/US10780102B2/en active Active
-
2020
- 2020-08-03 US US16/983,052 patent/US11464790B2/en active Active
- 2020-10-27 CY CY20201101017T patent/CY1123742T1/el unknown
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