PL3129392T3 - Triterpenoidy o aktywności hamującej dojrzewanie hiv, podstawione w pozycji 3 niearomatycznym pierścieniem zawierającym podstawnik fluorowcoalkilowy - Google Patents

Triterpenoidy o aktywności hamującej dojrzewanie hiv, podstawione w pozycji 3 niearomatycznym pierścieniem zawierającym podstawnik fluorowcoalkilowy

Info

Publication number: PL3129392T3
Authority: PL; Poland
Prior art keywords: triterpenoids; substituted; aromatic ring; inhibitory activity; ring carrying
Prior art date: 2014-04-11

Application number

PL15718402T

Other languages

English (en)

Inventor

Sing-Yuen Sit

Yan Chen

Jie Chen

Jacob Swidorski

Brian Lee Venables

Ny Sin

Nicholas A. Meanwell

Alicia Regueiro-Ren

Richard A. Hartz

Li Xu

Zheng Liu

Original Assignee

VIIV Healthcare UK(No.4) Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-04-11

Filing date

2015-04-09

Publication date

2021-04-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53002809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3129392(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2015-04-09 Application filed by VIIV Healthcare UK(No.4) Limited filed Critical VIIV Healthcare UK(No.4) Limited

2021-04-06 Publication of PL3129392T3 publication Critical patent/PL3129392T3/pl

Links

230000002401 inhibitory effect Effects 0.000 title 1
230000035800 maturation Effects 0.000 title 1
125000006574 non-aromatic ring group Chemical group 0.000 title 1
150000003648 triterpenes Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL15718402T 2014-04-11 2015-04-09 Triterpenoidy o aktywności hamującej dojrzewanie hiv, podstawione w pozycji 3 niearomatycznym pierścieniem zawierającym podstawnik fluorowcoalkilowy PL3129392T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201461978306P	2014-04-11	2014-04-11
PCT/US2015/025029 WO2015157483A1 (en)	2014-04-11	2015-04-09	Triterpenoids with hiv maturation inhibitory activity, substituted in position 3 by a non-aromatic ring carrying a haloalkyl substituent
EP15718402.9A EP3129392B1 (en)	2014-04-11	2015-04-09	Triterpenoids with hiv maturation inhibitory activity, substituted in position 3 by a non-aromatic ring carrying a haloalkyl substituent

Publications (1)

Publication Number	Publication Date
PL3129392T3 true PL3129392T3 (pl)	2021-04-06

Family

ID=53002809

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL15718402T PL3129392T3 (pl)	2014-04-11	2015-04-09	Triterpenoidy o aktywności hamującej dojrzewanie hiv, podstawione w pozycji 3 niearomatycznym pierścieniem zawierającym podstawnik fluorowcoalkilowy

Country Status (36)

Country	Link
US (5)	US9527882B2 (pl)
EP (2)	EP3750910A1 (pl)
JP (1)	JP6568202B2 (pl)
KR (1)	KR102411082B1 (pl)
CN (1)	CN106604909B (pl)
AR (1)	AR101077A1 (pl)
AU (1)	AU2015243500B2 (pl)
BR (1)	BR112016023414B1 (pl)
CA (1)	CA2944778C (pl)
CL (1)	CL2016002528A1 (pl)
CR (1)	CR20160472A (pl)
CY (1)	CY1123742T1 (pl)
DK (1)	DK3129392T3 (pl)
DO (1)	DOP2016000277A (pl)
EA (1)	EA030178B1 (pl)
ES (1)	ES2828705T3 (pl)
HR (1)	HRP20201645T1 (pl)
HU (1)	HUE051719T2 (pl)
IL (1)	IL248053B (pl)
LT (1)	LT3129392T (pl)
MA (1)	MA39374A1 (pl)
MX (1)	MX374543B (pl)
NZ (1)	NZ724644A (pl)
PE (1)	PE20161391A1 (pl)
PH (1)	PH12016501951B1 (pl)
PL (1)	PL3129392T3 (pl)
PT (1)	PT3129392T (pl)
RS (1)	RS60959B1 (pl)
SG (2)	SG11201608041QA (pl)
SI (1)	SI3129392T1 (pl)
SM (1)	SMT202000581T1 (pl)
TW (1)	TWI659964B (pl)
UA (1)	UA120927C2 (pl)
UY (1)	UY36070A (pl)
WO (1)	WO2015157483A1 (pl)
ZA (1)	ZA201606748B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI3129392T1 (sl)	2014-04-11	2020-11-30	VIIV Healthcare UK(No.4) Limited	Triterpenoidi z inhibitorno aktivnostjo maturacije HIV-a, substituirani na položaju 3 z nearomatskim obročem, ki nosi haloalkilni substituent
WO2017085677A2 (en) *	2015-11-20	2017-05-26	ViiV Healthcare UK (No.4) Limited	Hiv maturation inhibitor formulations
AR107512A1 (es) *	2016-02-04	2018-05-09	VIIV HEALTHCARE UK Nº 5 LTD	Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
EP3506902A4 (en) *	2016-08-31	2020-04-22	VIIV Healthcare Company	COMBINATIONS AND USES AND TREATMENTS THEREOF
ES2970042T3 (es) *	2018-04-24	2024-05-24	Viiv Healthcare Uk No 5 Ltd	Compuestos con actividad inhibidora de la maduración del VIH
SMT202300049T1 (it) *	2018-12-10	2023-03-17	Viiv Healthcare Uk No 4 Ltd	Sale mesilato di un composto di ammino-lupano con attivita’ di inibizione della maturazione dell’hiv
CN109705189B (zh) *	2018-12-29	2020-06-05	中国医学科学院药用植物研究所	具有式i所示结构的三萜衍生物及其制备方法和应用
CN110981765A (zh) *	2019-11-07	2020-04-10	肇庆巨元生化有限公司	一种25-羟基维生素d3中间体的制备方法
UY38982A (es) *	2019-12-09	2021-06-30	Viiv Healthcare Co	Composiciones farmacéuticas

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AR035311A1 (es)	1999-01-27	2004-05-12	Wyeth Corp	Derivados de acido hidroxamico que contienen alquinilo, como inhibidores de las metalloproteinasas de matriz y de la tace, composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento
US20040110785A1 (en)	2001-02-02	2004-06-10	Tao Wang	Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
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EP1730163A4 (en)	2004-03-17	2009-12-30	Panacos Pharmaceuticals Inc	Pharmaceutical salts of 3-O- (3,3-dimethylsuccinyl) betulinic acid
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CN103038245B (zh) *	2010-06-04	2015-03-25	百时美施贵宝公司	作为hiv成熟抑制剂的c-3经修饰的桦木酸衍生物
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KR101886467B1 (ko)	2011-01-31	2018-08-07	비브 헬스케어 유케이 (넘버4) 리미티드	Hiv 성숙 억제 활성을 갖는 c-17 및 c-3 변형 트리테르페노이드
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SI3129392T1 (sl)	2014-04-11	2020-11-30	VIIV Healthcare UK(No.4) Limited	Triterpenoidi z inhibitorno aktivnostjo maturacije HIV-a, substituirani na položaju 3 z nearomatskim obročem, ki nosi haloalkilni substituent

2015
- 2015-04-09 SI SI201531396T patent/SI3129392T1/sl unknown
- 2015-04-09 SG SG11201608041QA patent/SG11201608041QA/en unknown
- 2015-04-09 NZ NZ724644A patent/NZ724644A/en unknown
- 2015-04-09 UA UAA201609970A patent/UA120927C2/uk unknown
- 2015-04-09 ES ES15718402T patent/ES2828705T3/es active Active
- 2015-04-09 HR HRP20201645TT patent/HRP20201645T1/hr unknown
- 2015-04-09 BR BR112016023414-6A patent/BR112016023414B1/pt active IP Right Grant
- 2015-04-09 CN CN201580031487.2A patent/CN106604909B/zh active Active
- 2015-04-09 TW TW104111466A patent/TWI659964B/zh active
- 2015-04-09 SG SG10201709017PA patent/SG10201709017PA/en unknown
- 2015-04-09 CR CR20160472A patent/CR20160472A/es unknown
- 2015-04-09 EA EA201691760A patent/EA030178B1/ru unknown
- 2015-04-09 EP EP20187878.2A patent/EP3750910A1/en not_active Withdrawn
- 2015-04-09 EP EP15718402.9A patent/EP3129392B1/en active Active
- 2015-04-09 SM SM20200581T patent/SMT202000581T1/it unknown
- 2015-04-09 LT LTEP15718402.9T patent/LT3129392T/lt unknown
- 2015-04-09 PL PL15718402T patent/PL3129392T3/pl unknown
- 2015-04-09 CA CA2944778A patent/CA2944778C/en active Active
- 2015-04-09 RS RS20201276A patent/RS60959B1/sr unknown
- 2015-04-09 PE PE2016001948A patent/PE20161391A1/es unknown
- 2015-04-09 WO PCT/US2015/025029 patent/WO2015157483A1/en not_active Ceased
- 2015-04-09 DK DK15718402.9T patent/DK3129392T3/da active
- 2015-04-09 PT PT157184029T patent/PT3129392T/pt unknown
- 2015-04-09 UY UY0001036070A patent/UY36070A/es not_active Application Discontinuation
- 2015-04-09 US US14/682,179 patent/US9527882B2/en active Active
- 2015-04-09 JP JP2017504607A patent/JP6568202B2/ja active Active
- 2015-04-09 MA MA39374A patent/MA39374A1/fr unknown
- 2015-04-09 MX MX2016013425A patent/MX374543B/es active IP Right Grant
- 2015-04-09 HU HUE15718402A patent/HUE051719T2/hu unknown
- 2015-04-09 AU AU2015243500A patent/AU2015243500B2/en active Active
- 2015-04-09 KR KR1020167031312A patent/KR102411082B1/ko not_active Expired - Fee Related
- 2015-04-09 AR ARP150101078A patent/AR101077A1/es unknown
2016
- 2016-09-26 IL IL248053A patent/IL248053B/en active IP Right Grant
- 2016-09-29 ZA ZA2016/06748A patent/ZA201606748B/en unknown
- 2016-10-03 PH PH12016501951A patent/PH12016501951B1/en unknown
- 2016-10-05 CL CL2016002528A patent/CL2016002528A1/es unknown
- 2016-10-11 DO DO2016000277A patent/DOP2016000277A/es unknown
- 2016-11-07 US US15/344,756 patent/US20170056420A1/en not_active Abandoned
2017
- 2017-08-16 US US15/678,381 patent/US10245275B2/en active Active
2019
- 2019-01-22 US US16/253,393 patent/US10780102B2/en active Active
2020
- 2020-08-03 US US16/983,052 patent/US11464790B2/en active Active
- 2020-10-27 CY CY20201101017T patent/CY1123742T1/el unknown

Also Published As

Publication number	Publication date
BR112016023414B1 (pt)	2022-09-13
MX2016013425A (es)	2017-05-02
BR112016023414A2 (pl)	2017-08-15
LT3129392T (lt)	2020-11-10
PH12016501951B1 (en)	2021-02-19
CN106604909B (zh)	2019-02-15
JP2017510659A (ja)	2017-04-13
KR102411082B1 (ko)	2022-06-17
ZA201606748B (en)	2018-05-30
KR20160147809A (ko)	2016-12-23
AR101077A1 (es)	2016-11-23
PE20161391A1 (es)	2017-01-10
EP3129392A1 (en)	2017-02-15
DOP2016000277A (es)	2017-02-28
IL248053B (en)	2020-04-30
CA2944778C (en)	2022-06-14
MA39374A1 (fr)	2018-06-29
CL2016002528A1 (es)	2017-06-23
UA120927C2 (uk)	2020-03-10
TW201623324A (zh)	2016-07-01
EP3750910A1 (en)	2020-12-16
DK3129392T3 (da)	2020-10-19
AU2015243500A1 (en)	2016-10-27
US10780102B2 (en)	2020-09-22
SMT202000581T1 (it)	2020-11-10
US20170340650A1 (en)	2017-11-30
CN106604909A (zh)	2017-04-26
SG10201709017PA (en)	2017-11-29
AU2015243500B2 (en)	2017-03-30
RS60959B1 (sr)	2020-11-30
MX374543B (es)	2025-03-06
PT3129392T (pt)	2020-10-30
WO2015157483A1 (en)	2015-10-15
US20190151336A1 (en)	2019-05-23
NZ724644A (en)	2023-07-28
IL248053A0 (en)	2016-11-30
EP3129392B1 (en)	2020-08-05
ES2828705T3 (es)	2021-05-27
US10245275B2 (en)	2019-04-02
US9527882B2 (en)	2016-12-27
CA2944778A1 (en)	2015-10-15
US20170056420A1 (en)	2017-03-02
EA201691760A1 (ru)	2017-02-28
HUE051719T2 (hu)	2021-03-29
UY36070A (es)	2015-10-30
JP6568202B2 (ja)	2019-08-28
SI3129392T1 (sl)	2020-11-30
SG11201608041QA (en)	2016-10-28
US11464790B2 (en)	2022-10-11
US20200360404A1 (en)	2020-11-19
TWI659964B (zh)	2019-05-21
PH12016501951A1 (en)	2017-01-09
CR20160472A (es)	2017-03-10
HRP20201645T1 (hr)	2020-12-25
EA030178B1 (ru)	2018-06-29
CY1123742T1 (el)	2022-03-24
US20150291655A1 (en)	2015-10-15

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AU359973S (en)	2015-01-16	A flask
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PL3230481T3 (pl)	2019-08-30	Stop ferrytyczny
IT201600122159A1 (it)	2018-06-01	Cursore per una cerniera lampo.
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