CL2019000726A1 - Anticuerpos anti-muc16-cd3 biespecíficos y conjugados antimuc16-fármacos. - Google Patents

Anticuerpos anti-muc16-cd3 biespecíficos y conjugados antimuc16-fármacos.

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Publication number
CL2019000726A1
CL2019000726A1 CL2019000726A CL2019000726A CL2019000726A1 CL 2019000726 A1 CL2019000726 A1 CL 2019000726A1 CL 2019000726 A CL2019000726 A CL 2019000726A CL 2019000726 A CL2019000726 A CL 2019000726A CL 2019000726 A1 CL2019000726 A1 CL 2019000726A1
Authority
CL
Chile
Prior art keywords
muc16
antibodies
human
cancer
useful
Prior art date
Application number
CL2019000726A
Other languages
English (en)
Inventor
Marcus Kelly
Thomas Nittoli
Lauric Haber
Eric Smith
Jessica R Kirshner
Sandra Coetzee
Alison Crawford
Yashu Liu
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of CL2019000726A1 publication Critical patent/CL2019000726A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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Abstract

LA MUCINA 16 (MUC16) SE EXPRESA EN NIVELES ALTOS EN EL CÁNCER DE OVARIO Y SE MUESTRA QUE LA EXPRESIÓN EN CÉLULAS CANCEROSAS PROTEGE A LAS CÉLULAS TUMORALES DEL SISTEMA INMUNOLÓGICO. LA PRESENTE INVENCIÓN PROPORCIONA ANTICUERPOS CONTRA IGG HUMANA DE LONGITUD COMPLETA NOVEDOSOS QUE SE FIJAN A ANTI-MUC16 HUMANO (ANTICUERPOS MONOESPECÍFICOS). LA PRESENTE INVENCIÓN TAMBIÉN PROPORCIONA ANTICUERPOS BIESPECÍFICOS (BSABS) NOVEDOSOS QUE SE FIJAN A MUC16 Y CD3, Y ACTIVAN LOS LINFOCITOS T A TRAVÉS DEL COMPLEJO CD3 EN PRESENCIA DE TUMORES QUE EXPRESAN MUC16. DE ACUERDO CON DETERMINADAS FORMAS DE REALIZACIÓN, LA PRESENTE INVENCIÓN PROPORCIONA MOLÉCULAS DE FIJACIÓN AL ANTÍGENO BIESPECÍFICAS QUE COMPRENDEN UN PRIMER DOMINIO DE FIJACIÓN AL ANTÍGENO QUE SE FIJA ESPECÍFICAMENTE A CD3 HUMANO Y DE MONO, Y UNA SEGUNDA MOLÉCULA DE FIJACIÓN AL ANTÍGENO QUE SE FIJA ESPECÍFICAMENTE A MUC16 HUMANA Y DE MONO. EN DETERMINADAS FORMAS DE REALIZACIÓN, LAS MOLÉCULAS DE FIJACIÓN AL ANTÍGENO BIESPECÍFICAS DE LA PRESENTE INVENCIÓN PUEDEN INHIBIR EL CRECIMIENTO DE TUMORES QUE EXPRESAN MUC16. LAS MOLÉCULAS DE FIJACIÓN AL ANTÍGENO BIESPECÍFICAS DE LA INVENCIÓN SON ÚTILES PARA EL TRATAMIENTO DE ENFERMEDADES Y TRASTORNOS EN LOS QUE SE DESEA Y/O ES TERAPÉUTICAMENTE BENEFICIOSA UNA RESPUESTA INMUNITARIA DIRIGIDA A MUC16 INDUCIDA O REGULADA DE MANERA ASCENDENTE. POR EJEMPLO, LOS ANTICUERPOS BIESPECÍFICOS DE LA INVENCIÓN SON ÚTILES PARA EL TRATAMIENTO DE DIVERSOS TIPOS DE CÁNCER, QUE INCLUYEN EL CÁNCER DE OVARIO. LA PRESENTE INVENCIÓN TAMBIÉN INCLUYE CONJUGADOS ANTICUERPO-FÁRMACO ANTI-MUC16 QUE INHIBEN EL CRECIMIENTO DE TUMORES IN VIVO. EN ALGUNAS FORMAS DE REALIZACIÓN, LOS ANTICUERPOS ANTI-MUC16 SON ÚTILES EN MÉTODOS DE DIAGNÓSTICO PARA IDENTIFICAR LA PRESENCIA DE MUC16 EN MUESTRAS DE TEJIDO Y/O PLASMA.
CL2019000726A 2016-09-23 2019-03-20 Anticuerpos anti-muc16-cd3 biespecíficos y conjugados antimuc16-fármacos. CL2019000726A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662399249P 2016-09-23 2016-09-23
US201762558711P 2017-09-14 2017-09-14

Publications (1)

Publication Number Publication Date
CL2019000726A1 true CL2019000726A1 (es) 2019-05-31

Family

ID=60083442

Family Applications (4)

Application Number Title Priority Date Filing Date
CL2019000712A CL2019000712A1 (es) 2016-09-23 2019-03-19 Anticuerpos anti-muc16 (mucina 16).
CL2019000726A CL2019000726A1 (es) 2016-09-23 2019-03-20 Anticuerpos anti-muc16-cd3 biespecíficos y conjugados antimuc16-fármacos.
CL2021002645A CL2021002645A1 (es) 2016-09-23 2021-10-08 Anticuerpos anti-muc16-cd3 biespecíficos y conjugados anti-muc16-fármacos. (divisional de solicitud 201900726)
CL2023002690A CL2023002690A1 (es) 2016-09-23 2023-09-08 Anticuerpos anti-muc16-cd3 biespecíficos y conjugados anti-muc16-fármacos (divisional de 202102645)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2019000712A CL2019000712A1 (es) 2016-09-23 2019-03-19 Anticuerpos anti-muc16 (mucina 16).

Family Applications After (2)

Application Number Title Priority Date Filing Date
CL2021002645A CL2021002645A1 (es) 2016-09-23 2021-10-08 Anticuerpos anti-muc16-cd3 biespecíficos y conjugados anti-muc16-fármacos. (divisional de solicitud 201900726)
CL2023002690A CL2023002690A1 (es) 2016-09-23 2023-09-08 Anticuerpos anti-muc16-cd3 biespecíficos y conjugados anti-muc16-fármacos (divisional de 202102645)

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US (4) US10738130B2 (es)
EP (3) EP4273172A3 (es)
JP (2) JP7066691B2 (es)
KR (2) KR102418667B1 (es)
CN (2) CN110214026B (es)
AU (2) AU2017339711B2 (es)
BR (2) BR112019005670A2 (es)
CA (3) CA3037536C (es)
CL (4) CL2019000712A1 (es)
CO (1) CO2019003967A2 (es)
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DK (2) DK3515946T5 (es)
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SMT202300308T1 (it) 2023-11-13
IL265369A (en) 2019-05-30
RS63660B1 (sr) 2022-11-30
JP2019536740A (ja) 2019-12-19
IL265369B2 (en) 2024-03-01
CL2019000712A1 (es) 2019-05-31
AU2017331363B2 (en) 2024-06-13
CL2021002645A1 (es) 2022-04-29
AU2017331363A1 (en) 2019-04-11
CA3287248A1 (en) 2026-03-02
MY194596A (en) 2022-12-06
US12570764B2 (en) 2026-03-10
US20180118848A1 (en) 2018-05-03
CN110036032B (zh) 2023-09-05
SMT202200359T1 (it) 2022-11-18
IL265369B1 (en) 2023-11-01
HUE063020T2 (hu) 2023-12-28
CL2023002690A1 (es) 2024-02-02
NZ751903A (en) 2025-09-26
PT3515487T (pt) 2023-08-24
ZA201901557B (en) 2024-08-28
RS64691B1 (sr) 2023-11-30
DK3515946T3 (en) 2022-08-01
LT3515946T (lt) 2022-08-10
NZ751907A (en) 2025-09-26
AU2017339711B2 (en) 2024-06-06
HUE059761T2 (hu) 2022-12-28
ZA201901591B (en) 2024-05-30
CN110214026B (zh) 2023-12-05
CN110036032A (zh) 2019-07-19
JP7066690B2 (ja) 2022-05-13
DK3515946T5 (da) 2024-09-02
HRP20221202T1 (hr) 2022-12-09
BR112019005670A2 (pt) 2019-06-04
WO2018058003A1 (en) 2018-03-29
PH12019500550A1 (en) 2019-05-27
SI3515487T1 (sl) 2023-09-29
KR102418667B1 (ko) 2022-07-12
DK3515487T5 (da) 2024-09-02
HRP20231281T1 (hr) 2024-02-02
AU2017339711A1 (en) 2019-04-11
US10738130B2 (en) 2020-08-11
EP4273172A3 (en) 2024-02-28
US20200317810A1 (en) 2020-10-08
MD3515487T2 (ro) 2023-11-30
KR20190073377A (ko) 2019-06-26
PT3515946T (pt) 2022-08-04
WO2018067331A9 (en) 2018-06-07

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