CL2019001077A1 - Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f] isoquinolina útiles en el tratamiento del cáncer. - Google Patents

Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f] isoquinolina útiles en el tratamiento del cáncer.

Info

Publication number
CL2019001077A1
CL2019001077A1 CL2019001077A CL2019001077A CL2019001077A1 CL 2019001077 A1 CL2019001077 A1 CL 2019001077A1 CL 2019001077 A CL2019001077 A CL 2019001077A CL 2019001077 A CL2019001077 A CL 2019001077A CL 2019001077 A1 CL2019001077 A1 CL 2019001077A1
Authority
CL
Chile
Prior art keywords
pyrazolo
tetrahydro
cancer
treatment
derivatives useful
Prior art date
Application number
CL2019001077A
Other languages
English (en)
Spanish (es)
Inventor
Bernard Christophe Barlaam
Johannes Wilhelmus Maria Nissink
James Stewart Scott
Bin Yang
Thomas Andrew MOSS
Samantha Jayne HUGHES
Daniel Hillebrand O'DONOVAN
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CL2019001077A1 publication Critical patent/CL2019001077A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CL2019001077A 2016-10-24 2019-04-18 Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f] isoquinolina útiles en el tratamiento del cáncer. CL2019001077A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662411799P 2016-10-24 2016-10-24
US201662435159P 2016-12-16 2016-12-16

Publications (1)

Publication Number Publication Date
CL2019001077A1 true CL2019001077A1 (es) 2019-06-21

Family

ID=60083331

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019001077A CL2019001077A1 (es) 2016-10-24 2019-04-18 Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f] isoquinolina útiles en el tratamiento del cáncer.

Country Status (36)

Country Link
US (5) US10131663B2 (pl)
EP (2) EP3433256B1 (pl)
JP (2) JP6744489B2 (pl)
KR (1) KR102178692B1 (pl)
CN (2) CN114656464B (pl)
AU (1) AU2017349797B2 (pl)
CL (1) CL2019001077A1 (pl)
CO (1) CO2019003950A2 (pl)
CR (1) CR20190204A (pl)
CY (2) CY1122566T1 (pl)
DK (2) DK3640251T3 (pl)
DO (1) DOP2019000104A (pl)
EC (1) ECSP19028657A (pl)
ES (2) ES2751902T3 (pl)
HR (1) HRP20220255T1 (pl)
HU (2) HUE057524T2 (pl)
IL (1) IL266245B (pl)
JO (1) JOP20190090B1 (pl)
LT (2) LT3640251T (pl)
ME (1) ME03547B (pl)
MX (1) MX382331B (pl)
MY (1) MY205300A (pl)
NI (1) NI201900039A (pl)
NZ (1) NZ753459A (pl)
PE (1) PE20191078A1 (pl)
PH (1) PH12019500830A1 (pl)
PL (2) PL3433256T3 (pl)
PT (2) PT3640251T (pl)
RS (1) RS59445B1 (pl)
SG (1) SG11201903182XA (pl)
SI (2) SI3640251T1 (pl)
SM (2) SMT202200098T1 (pl)
TW (1) TWI735681B (pl)
UA (1) UA125824C2 (pl)
WO (1) WO2018077630A1 (pl)
ZA (1) ZA201900694B (pl)

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US10981911B2 (en) 2016-12-16 2021-04-20 Janssen Pharmaceutica Nv Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
US11059823B2 (en) 2016-12-16 2021-07-13 Janssen Pharmaceutica Nv Small molecule inhibitors of the JAK family of kinases
US11066406B2 (en) 2018-06-15 2021-07-20 Janssen Pharmaceutica Nv Small molecule inhibitors of the JAK family of kinases
US12390451B2 (en) 2021-03-11 2025-08-19 Janssen Pharmaceutica Nv Small molecule inhibitor of the JAK family of kinases

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Cited By (7)

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Publication number Priority date Publication date Assignee Title
US10981911B2 (en) 2016-12-16 2021-04-20 Janssen Pharmaceutica Nv Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
US11059823B2 (en) 2016-12-16 2021-07-13 Janssen Pharmaceutica Nv Small molecule inhibitors of the JAK family of kinases
US11827638B2 (en) 2016-12-16 2023-11-28 Janssen Pharmaceutica Nv Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
US12202831B2 (en) 2016-12-16 2025-01-21 Janssen Pharmaceutica Nv Small molecule inhibitors of the JAK family of kinases
US11066406B2 (en) 2018-06-15 2021-07-20 Janssen Pharmaceutica Nv Small molecule inhibitors of the JAK family of kinases
US11787807B2 (en) 2018-06-15 2023-10-17 Janssen Pharmaceutica Nv Small molecule inhibitors of the JAK family of kinases
US12390451B2 (en) 2021-03-11 2025-08-19 Janssen Pharmaceutica Nv Small molecule inhibitor of the JAK family of kinases

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NI201900039A (es) 2020-05-15
JP6744489B2 (ja) 2020-08-19
DOP2019000104A (es) 2019-05-15
IL266245A (en) 2019-06-30
HUE057524T2 (hu) 2022-05-28
NZ753459A (en) 2023-01-27
PT3640251T (pt) 2022-02-22
PH12019500830A1 (en) 2019-07-24
US10961241B2 (en) 2021-03-30
US20240383895A1 (en) 2024-11-21
CN114656464A (zh) 2022-06-24
LT3433256T (lt) 2019-11-11
DK3640251T3 (da) 2022-03-07
SG11201903182XA (en) 2019-05-30
DK3433256T3 (da) 2019-10-28
HUE045714T2 (hu) 2020-01-28
SMT202200098T1 (it) 2022-03-21
EP3640251A1 (en) 2020-04-22
WO2018077630A1 (en) 2018-05-03
PL3433256T3 (pl) 2020-01-31
RS59445B1 (sr) 2019-11-29
SI3640251T1 (sl) 2022-04-29
PE20191078A1 (es) 2019-08-20
US20180111931A1 (en) 2018-04-26
ME03547B (me) 2020-07-20
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