CL2020002796A1 - Derivados de gip y usos de estos - Google Patents

Derivados de gip y usos de estos

Info

Publication number
CL2020002796A1
CL2020002796A1 CL2020002796A CL2020002796A CL2020002796A1 CL 2020002796 A1 CL2020002796 A1 CL 2020002796A1 CL 2020002796 A CL2020002796 A CL 2020002796A CL 2020002796 A CL2020002796 A CL 2020002796A CL 2020002796 A1 CL2020002796 A1 CL 2020002796A1
Authority
CL
Chile
Prior art keywords
gip
relates
peptides
derivatives
nash
Prior art date
Application number
CL2020002796A
Other languages
English (en)
Inventor
Reedtz-Runge Steffen
Frederik Johan Hogendorf Wouter
Thøgersen Henning
Raymond Cox Nicholas
J Knerr Patrick
Dimarchi Richard
Finan Brian
F Lau Jesper
Liu Fa
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of CL2020002796A1 publication Critical patent/CL2020002796A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/645—Secretins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2235—Secretins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a péptidos novedosos que son derivados de análogos del polipéptido insulinotrópico dependiente de la glucosa (GIP) que tienen una estabilidad física mejorada en solución y un perfil de acción prolongado. Más en particular, la invención se refiere a dichos péptidos que son agonistas del receptor de GIP y a su uso en el control del peso o para el tratamiento de enfermedades tales como la obesidad, la diabetes o la esteatohepatitis no alcohólica (NASH).
CL2020002796A 2018-05-04 2020-10-28 Derivados de gip y usos de estos CL2020002796A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862666916P 2018-05-04 2018-05-04
EP18172827 2018-05-17

Publications (1)

Publication Number Publication Date
CL2020002796A1 true CL2020002796A1 (es) 2021-02-19

Family

ID=66440040

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020002796A CL2020002796A1 (es) 2018-05-04 2020-10-28 Derivados de gip y usos de estos

Country Status (20)

Country Link
US (3) US11633459B2 (es)
EP (1) EP3788063B1 (es)
JP (2) JP6818940B2 (es)
KR (1) KR102379958B1 (es)
CN (1) CN112074531B (es)
AU (1) AU2019263674B2 (es)
BR (1) BR112020022027A2 (es)
CA (1) CA3097939A1 (es)
CL (1) CL2020002796A1 (es)
CO (1) CO2020014180A2 (es)
ES (1) ES2961384T3 (es)
IL (1) IL278171A (es)
MA (1) MA52483A (es)
MX (1) MX2020011427A (es)
PE (1) PE20210473A1 (es)
PH (1) PH12020551742A1 (es)
RU (1) RU2020136305A (es)
SG (1) SG11202010297UA (es)
TW (1) TWI707865B (es)
WO (1) WO2019211451A1 (es)

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WO2018049214A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
US10800761B2 (en) 2018-02-20 2020-10-13 Incyte Corporation Carboxamide compounds and uses thereof
WO2019164847A1 (en) 2018-02-20 2019-08-29 Incyte Corporation Indazole compounds and uses thereof
TWI707865B (zh) * 2018-05-04 2020-10-21 丹麥商諾佛 儂迪克股份有限公司 Gip衍生物及其用途
US10899755B2 (en) 2018-08-08 2021-01-26 Incyte Corporation Benzothiazole compounds and uses thereof
PE20221419A1 (es) 2019-08-06 2022-09-20 Incyte Corp Formas solidas de un inhibidor de hpk1
JP7415022B2 (ja) * 2020-02-05 2024-01-16 イーライ リリー アンド カンパニー 三連樹脂反応器ペプチド合成機
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CA3230915A1 (en) 2021-09-06 2023-03-09 Thomas Boehme New peptides as potent and selective gip receptor agonists
WO2023118263A1 (en) * 2021-12-21 2023-06-29 Embark Biotech Aps Agonists for treatment of eating disorder
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CN120659805A (zh) * 2023-10-31 2025-09-16 深圳信立泰药业股份有限公司 Glp-1化合物及其制备方法与应用
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Also Published As

Publication number Publication date
CO2020014180A2 (es) 2021-01-29
KR20210005700A (ko) 2021-01-14
RU2020136305A (ru) 2022-05-05
BR112020022027A2 (pt) 2021-02-02
KR102379958B1 (ko) 2022-04-01
ES2961384T3 (es) 2024-03-11
US11633459B2 (en) 2023-04-25
EP3788063A1 (en) 2021-03-10
AU2019263674A1 (en) 2020-11-26
SG11202010297UA (en) 2020-11-27
CN112074531A (zh) 2020-12-11
JP6818940B2 (ja) 2021-01-27
MA52483A (fr) 2021-03-10
PE20210473A1 (es) 2021-03-08
TWI707865B (zh) 2020-10-21
US10604555B2 (en) 2020-03-31
TW202003550A (zh) 2020-01-16
EP3788063C0 (en) 2023-08-09
IL278171A (en) 2020-11-30
JP2020528925A (ja) 2020-10-01
JP2020125311A (ja) 2020-08-20
WO2019211451A1 (en) 2019-11-07
PH12020551742A1 (en) 2021-06-28
MX2020011427A (es) 2020-12-07
US20220000982A1 (en) 2022-01-06
AU2019263674B2 (en) 2023-03-02
EP3788063B1 (en) 2023-08-09
CA3097939A1 (en) 2019-11-07
US20190367578A1 (en) 2019-12-05
CN112074531B (zh) 2025-04-15
US20240190938A1 (en) 2024-06-13

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