CO2020002500A2 - Análogos de insulina acilados novedosos y usos de estos - Google Patents
Análogos de insulina acilados novedosos y usos de estosInfo
- Publication number
- CO2020002500A2 CO2020002500A2 CONC2020/0002500A CO2020002500A CO2020002500A2 CO 2020002500 A2 CO2020002500 A2 CO 2020002500A2 CO 2020002500 A CO2020002500 A CO 2020002500A CO 2020002500 A2 CO2020002500 A2 CO 2020002500A2
- Authority
- CO
- Colombia
- Prior art keywords
- insulin analogs
- acylated insulin
- novel acylated
- novel
- analogs
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
- G01N2440/14—Post-translational modifications [PTMs] in chemical analysis of biological material phosphorylation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
Abstract
RESUMEN La presente invención se refiere a análogos de insulina novedosos y derivados de estos, tales como análogos de insulina acilados, y su uso farmacéutico, en particular en el tratamiento o prevención de afecciones médicas relacionadas con la diabetes, la obesidad y enfermedades cardiovasculares.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17186612 | 2017-08-17 | ||
| EP17204872 | 2017-12-01 | ||
| PCT/EP2018/072191 WO2019034726A1 (en) | 2017-08-17 | 2018-08-16 | NOVEL ACYLATED INSULIN ANALOGUES AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2020002500A2 true CO2020002500A2 (es) | 2020-06-09 |
Family
ID=63165388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2020/0002500A CO2020002500A2 (es) | 2017-08-17 | 2020-03-04 | Análogos de insulina acilados novedosos y usos de estos |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10919949B2 (es) |
| EP (1) | EP3668892A1 (es) |
| JP (2) | JP2020531451A (es) |
| KR (1) | KR20200038502A (es) |
| CN (1) | CN111032685A (es) |
| AU (1) | AU2018317810A1 (es) |
| BR (1) | BR112020002364A2 (es) |
| CA (1) | CA3071686A1 (es) |
| CL (1) | CL2020000310A1 (es) |
| CO (1) | CO2020002500A2 (es) |
| IL (1) | IL272394A (es) |
| MA (1) | MA49896A (es) |
| MX (1) | MX2020001434A (es) |
| PE (1) | PE20211264A1 (es) |
| PH (1) | PH12020550050A1 (es) |
| RU (1) | RU2020108281A (es) |
| SG (1) | SG11202001077UA (es) |
| TW (1) | TW201917134A (es) |
| WO (1) | WO2019034726A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4808785B2 (ja) | 2005-12-28 | 2011-11-02 | ノボ・ノルデイスク・エー／エス | インスリン組成物および組成物の製造方法 |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| US12343383B2 (en) | 2019-07-12 | 2025-07-01 | Novo Nordisk A/S | High concentration insulin formulation |
| WO2022159395A1 (en) | 2021-01-20 | 2022-07-28 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
| MX2024003236A (es) | 2021-09-15 | 2024-06-19 | Viking Therapeutics Inc | Composiciones y metodos para el tratamiento de trastornos metabolicos y hepaticos. |
| JPWO2024185897A1 (es) * | 2023-03-09 | 2024-09-12 |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE50892B1 (en) | 1980-02-11 | 1986-08-06 | Novo Industri As | Process for preparing insulin esters |
| DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| US5616729A (en) | 1986-07-17 | 1997-04-01 | Board Of Governors Of Wayne State University | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers |
| DK105489D0 (da) | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| DK155690D0 (da) | 1990-06-28 | 1990-06-28 | Novo Nordisk As | Nye peptider |
| DK10191D0 (da) | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
| DK33591D0 (es) | 1991-02-27 | 1991-02-27 | Novo Nordisk As | |
| ZA954983B (en) | 1994-06-17 | 1996-02-14 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
| US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| US6451970B1 (en) | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
| EP0946735B1 (en) | 1996-12-20 | 2006-02-08 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
| ES2180511T3 (es) | 1999-01-26 | 2003-02-16 | Lilly Co Eli | Formulaciones monodispersas de analogos de insulina acilados hexamericos. |
| WO2000069901A2 (en) * | 1999-05-19 | 2000-11-23 | Xencor, Inc. | Proteins with insulin-like activity useful in the treatment of diabetes |
| KR20030004317A (ko) | 1999-12-29 | 2003-01-14 | 노보 노르디스크 에이/에스 | 인슐린 선구물질 및 인슐린 선구물질 유사체의 제조 방법 |
| CN1902226A (zh) | 2003-12-03 | 2007-01-24 | 诺和诺德公司 | 单链胰岛素 |
| WO2006008238A1 (en) | 2004-07-16 | 2006-01-26 | Novo Nordisk A/S | Method for selective acylation |
| WO2006082204A1 (en) | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
| EP1991576B1 (en) * | 2006-02-27 | 2010-09-29 | Novo Nordisk A/S | Insulin derivatives |
| DK2074141T3 (en) | 2006-09-22 | 2016-11-28 | Novo Nordisk As | The protease resistant insulin analogues. |
| KR20100053561A (ko) | 2007-08-15 | 2010-05-20 | 노보 노르디스크 에이/에스 | 아실 및 알킬렌 글리콜 부분을 갖는 인슐린 유사체 |
| WO2009112583A2 (en) | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
| CN102037008B (zh) * | 2008-03-18 | 2016-08-31 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定化的、酰化胰岛素类似物 |
| CN102307584A (zh) | 2008-12-19 | 2012-01-04 | 印第安纳大学研究及科技有限公司 | 表现出对胰岛素受体的高活性的基于yl的胰岛素-样生长因子 |
| WO2010080609A1 (en) | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| WO2010080606A1 (en) | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Insulin analogs |
| WO2011003820A1 (de) | 2009-07-06 | 2011-01-13 | Sanofi-Aventis Deutschland Gmbh | Hitze- und schüttelstabile insulinzubereitungen |
| EP2582719B1 (en) | 2010-06-16 | 2016-08-10 | Indiana University Research and Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| WO2011159882A2 (en) | 2010-06-16 | 2011-12-22 | Indiana University Research And Technology Corporation | Novel stabilized insulin agonists |
| EP2585484A1 (en) | 2010-06-23 | 2013-05-01 | Novo Nordisk A/S | Insulin analogues containing additional disulfide bonds |
| JP5912112B2 (ja) | 2010-06-24 | 2016-04-27 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | アミド系インスリンプロドラッグ |
| WO2011163460A1 (en) | 2010-06-24 | 2011-12-29 | Indiana University Research And Technology Corporation | Yl-based insulin-like growth factors exhibiting high activity at the insulin receptor |
| WO2012015692A2 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinantly expressed insulin polypeptides and uses thereof |
| JP2013540771A (ja) | 2010-10-15 | 2013-11-07 | ノヴォ ノルディスク アー／エス | 新規ｎ末端修飾インスリン誘導体 |
| AR087433A1 (es) | 2011-08-08 | 2014-03-26 | Merck Sharp & Dohme | Analogos de insulina n-glicosilados |
| US9573987B2 (en) | 2011-12-20 | 2017-02-21 | Indiana University Research And Technology Corporation | CTP-based insulin analogs for treatment of diabetes |
| US20140357838A1 (en) | 2011-12-21 | 2014-12-04 | Novo Nordisk A/S | N-Terminally Modified Insulin Derivatives |
| AU2013323669B2 (en) | 2012-09-26 | 2018-03-01 | Indiana University Research And Technology Corporation | Insulin analog dimers |
| US9707276B2 (en) | 2012-12-03 | 2017-07-18 | Merck Sharp & Dohme Corp. | O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues |
| EP2931301B2 (en) | 2012-12-17 | 2021-09-15 | Merck Sharp & Dohme Corp. | Process for purifying insulin and analogues thereof |
| WO2014158900A1 (en) | 2013-03-14 | 2014-10-02 | Indiana University Research And Technology Corporation | Insulin-incretin conjugates |
| CN105392475A (zh) | 2013-07-24 | 2016-03-09 | 诺和诺德股份有限公司 | 包含片剂核和阴离子共聚物涂层的用于口服胰岛素给药的药学组合物 |
| TW201605470A (zh) | 2013-10-04 | 2016-02-16 | 默沙東藥廠 | 葡萄糖反應性胰島素結合物 |
| AR099569A1 (es) * | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| ES2822994T3 (es) | 2014-09-24 | 2021-05-05 | Univ Indiana Res & Tech Corp | Conjugados de incretina-insulina |
| WO2016049174A1 (en) | 2014-09-24 | 2016-03-31 | Indiana University Research And Technology Corporation | Lipidated amide-based insulin prodrugs |
| EA036714B1 (ru) | 2014-11-21 | 2020-12-10 | Мерк Шарп И Доум Корп. | Частичные агонисты инсулинового рецептора |
| US20180000742A1 (en) | 2015-01-29 | 2018-01-04 | Novo Nordisk A/S | Pharmaceutical Composition for Oral Insulin Administration Comprising a Tablet Core and a Polyvinyl Alcohol Coating |
| US10562951B2 (en) | 2015-03-10 | 2020-02-18 | Merck Sharp & Dohme Corp. | Process for preparing recombinant insulin using microfiltration |
| WO2016164288A1 (en) | 2015-04-08 | 2016-10-13 | Merck Sharp & Dohme Corp. | Glucose-responsive insulin conjugates |
| WO2016172269A2 (en) | 2015-04-20 | 2016-10-27 | University Of Utah Research Foundation | Insulin analogs having shortened b chain peptides and associated methods |
| EP3341401A1 (en) * | 2015-08-25 | 2018-07-04 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
| MX2018002223A (es) * | 2015-08-25 | 2018-03-23 | Novo Nordisk As | Derivados de insulina novedosos y usos medicos de los mismos. |
| JP2018531899A (ja) * | 2015-08-25 | 2018-11-01 | ノヴォ ノルディスク アー／エス | 新規インスリン誘導体及びその医学的使用 |
| US10745457B2 (en) | 2015-09-02 | 2020-08-18 | Merck Sharp & Dohme Corp. | Process for obtaining insulin with correctly formed disulfide bonds |
-
2018
- 2018-08-16 CN CN201880052683.1A patent/CN111032685A/zh not_active Withdrawn
- 2018-08-16 CA CA3071686A patent/CA3071686A1/en not_active Withdrawn
- 2018-08-16 TW TW107128618A patent/TW201917134A/zh unknown
- 2018-08-16 BR BR112020002364-7A patent/BR112020002364A2/pt not_active Application Discontinuation
- 2018-08-16 US US15/998,755 patent/US10919949B2/en active Active
- 2018-08-16 WO PCT/EP2018/072191 patent/WO2019034726A1/en not_active Ceased
- 2018-08-16 PE PE2020000179A patent/PE20211264A1/es unknown
- 2018-08-16 AU AU2018317810A patent/AU2018317810A1/en not_active Withdrawn
- 2018-08-16 RU RU2020108281A patent/RU2020108281A/ru unknown
- 2018-08-16 EP EP18752779.1A patent/EP3668892A1/en not_active Withdrawn
- 2018-08-16 JP JP2020508562A patent/JP2020531451A/ja not_active Withdrawn
- 2018-08-16 SG SG11202001077UA patent/SG11202001077UA/en unknown
- 2018-08-16 MX MX2020001434A patent/MX2020001434A/es unknown
- 2018-08-16 KR KR1020207006535A patent/KR20200038502A/ko not_active Withdrawn
- 2018-08-16 MA MA049896A patent/MA49896A/fr unknown
-
2020
- 2020-01-31 IL IL272394A patent/IL272394A/en unknown
- 2020-02-05 CL CL2020000310A patent/CL2020000310A1/es unknown
- 2020-02-07 PH PH12020550050A patent/PH12020550050A1/en unknown
- 2020-03-04 CO CONC2020/0002500A patent/CO2020002500A2/es unknown
- 2020-11-05 US US17/089,993 patent/US20210094999A1/en not_active Abandoned
-
2022
- 2022-04-25 JP JP2022071578A patent/JP2022105082A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018317810A1 (en) | 2020-03-19 |
| CN111032685A (zh) | 2020-04-17 |
| IL272394A (en) | 2020-03-31 |
| PH12020550050A1 (en) | 2020-10-19 |
| WO2019034726A1 (en) | 2019-02-21 |
| CA3071686A1 (en) | 2019-02-21 |
| US20190194285A1 (en) | 2019-06-27 |
| TW201917134A (zh) | 2019-05-01 |
| MX2020001434A (es) | 2020-03-20 |
| MA49896A (fr) | 2020-06-24 |
| US20210094999A1 (en) | 2021-04-01 |
| EP3668892A1 (en) | 2020-06-24 |
| US10919949B2 (en) | 2021-02-16 |
| RU2020108281A3 (es) | 2022-03-09 |
| BR112020002364A2 (pt) | 2020-09-01 |
| PE20211264A1 (es) | 2021-07-15 |
| SG11202001077UA (en) | 2020-03-30 |
| CL2020000310A1 (es) | 2020-07-10 |
| RU2020108281A (ru) | 2021-08-26 |
| JP2022105082A (ja) | 2022-07-12 |
| JP2020531451A (ja) | 2020-11-05 |
| KR20200038502A (ko) | 2020-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO2020002500A2 (es) | Análogos de insulina acilados novedosos y usos de estos | |
| AR099569A1 (es) | Derivados de insulina y los usos médicos de estos | |
| CR20110509A (es) | Composicion farmaceutica | |
| BR112019004534A2 (pt) | análogo de amilina, método para a síntese e composição farmacêutica | |
| UY34859A (es) | Análogos peptídicos de la exendina 4. | |
| MX2018002223A (es) | Derivados de insulina novedosos y usos medicos de los mismos. | |
| EA201591839A1 (ru) | Терапевтические пептиды | |
| CO2019006017A2 (es) | Composiciones farmacéuticas que contienen insulina | |
| ECSP16078782A (es) | Compuestos de isoindolinona como moduladores de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados | |
| MX2018000419A (es) | Derivados de amida sustituida que tienen actividad multimodal contra el dolor. | |
| MX2018002446A (es) | Compuestos heterociclicos fusionados como moduladores s1p. | |
| DOP2016000170A (es) | Compuestos derivados de hidroxiformamida y usos del mismo | |
| BR112017000898A2 (pt) | oritavancina de alta pureza e método de produção da mesma | |
| JOP20210201A1 (ar) | مركب لخفض جلوكوز الدم | |
| BR112017024908A2 (pt) | usos terapêuticos da 4-cloroquinurenina | |
| UY37622A (es) | Derivados de pirazol como inhibidores de bromodominio de la familia bet y su uso en aplicaciones terapéuticas | |
| MX2023000398A (es) | Analogos de insulina novedosos y usos de estos. | |
| CL2017002229A1 (es) | Inhibidores de bace1. | |
| MD4763B1 (ro) | Compoziţie farmaceutică | |
| ECSP16094286A (es) | Compuestos, composición farmacéutica y su uso en el tratamiento de enfermedades neurodegenerativas | |
| BR112017003227A2 (pt) | composto, composição farmacêutica e uso de um composto | |
| MX378539B (es) | Analagos de apelina ciclicos. | |
| MX374598B (es) | Complejo de tanato de sitagliptina. | |
| ITUB20169928A1 (it) | Formulazioni farmaceutiche per il trattamento del diabete | |
| EA201301340A1 (ru) | Фармацевтическая композиция, обладающая нейропротекторным действием, её применение и способы повышения жизнеспособности и профилактики или лечения цереброваскулярных и нейродегенеративных заболеваний |