CL2020002891A1 - Nuevos derivados de quinolina - Google Patents

Nuevos derivados de quinolina

Info

Publication number
CL2020002891A1
CL2020002891A1 CL2020002891A CL2020002891A CL2020002891A1 CL 2020002891 A1 CL2020002891 A1 CL 2020002891A1 CL 2020002891 A CL2020002891 A CL 2020002891A CL 2020002891 A CL2020002891 A CL 2020002891A CL 2020002891 A1 CL2020002891 A1 CL 2020002891A1
Authority
CL
Chile
Prior art keywords
compounds
preparation
new quinoline
quinoline derivatives
pharmaceutical compositions
Prior art date
Application number
CL2020002891A
Other languages
English (en)
Inventor
Johannes Köbberling
Adeline Köhler
Thomas Ilg
Ulrich Görgens
Hans-Georg Schwarz
Claudia Welz
Kirsten Börngen
Daniel Kulke
Walter Hübsch
Maike Hink
Claudia Böhm
Niels Lindner
Wei Zhuang
Nils Griebenow
Iring Heisler
Bernd Alig
Original Assignee
Bayer Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh
Publication of CL2020002891A1 publication Critical patent/CL2020002891A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

La invención abarca nuevos compuestos de quinolina de la fórmula general (I): en la cual A, R1, R2, R3, R4, R5, R6 y Q son como se definen en el presente, procedimientos para la elaboración de dichos compuestos, compuestos intermedios útiles para la elaboración de dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para la elaboración de composiciones farmacéuticas para el tratamiento, control y/o prevención de enfermedades, en particular de infecciones con helmintos, como un único agente o en combinación con otros principios activos.
CL2020002891A 2018-05-09 2020-11-06 Nuevos derivados de quinolina CL2020002891A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18171490 2018-05-09

Publications (1)

Publication Number Publication Date
CL2020002891A1 true CL2020002891A1 (es) 2021-05-14

Family

ID=62148180

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020002891A CL2020002891A1 (es) 2018-05-09 2020-11-06 Nuevos derivados de quinolina

Country Status (20)

Country Link
US (2) US11572357B2 (es)
EP (1) EP3790874B1 (es)
JP (1) JP7403472B2 (es)
KR (1) KR102858945B1 (es)
CN (1) CN112074514B (es)
AU (1) AU2019266511B2 (es)
CA (1) CA3099610A1 (es)
CL (1) CL2020002891A1 (es)
CO (1) CO2020013876A2 (es)
DK (1) DK3790874T3 (es)
ES (1) ES2945559T3 (es)
IL (1) IL278472B2 (es)
MX (1) MX2020011873A (es)
PH (1) PH12020551891A1 (es)
PL (1) PL3790874T3 (es)
PT (1) PT3790874T (es)
SG (1) SG11202010024UA (es)
TW (1) TWI813680B (es)
UY (1) UY38226A (es)
WO (1) WO2019215182A1 (es)

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MX2021000293A (es) 2018-07-09 2021-07-15 Boehringer Ingelheim Animal Health Usa Inc Compuestos heterociclicos antihelminticos.
PL3897842T3 (pl) * 2018-12-18 2025-05-19 Elanco Tiergesundheit Ag Pochodne bicykliczne
BR112021018631A2 (pt) 2019-03-19 2021-11-23 Boehringer Ingelheim Animal Health Usa Inc Compostos anti-helmínticos de aza-benzotiofeno e aza-benzofurano
WO2021122911A1 (en) 2019-12-18 2021-06-24 Intervet International B.V. Anthelmintic compounds comprising a quinoline structure
BR112022020315A2 (pt) 2020-04-09 2022-12-13 Bayer Animal Health Gmbh Novos compostos anti-helmínticos
WO2021242581A1 (en) 2020-05-29 2021-12-02 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic heterocyclic compounds
AU2021395477A1 (en) 2020-12-11 2023-06-22 Intervet International B.V. Anthelmintic compounds comprising a thienopyridine structure
EP4148052A1 (en) 2021-09-09 2023-03-15 Bayer Animal Health GmbH New quinoline derivatives
UY39995A (es) 2021-11-01 2023-05-15 Boehringer Ingelheim Vetmedica GmbH Compuestos de pirrolopiridazina como antihelmínticos
WO2024213752A1 (en) 2023-04-14 2024-10-17 Elanco Animal Health Gmbh Long-term prevention and/or treatment of a disease by slo-1 inhibitors
CN121620507A (zh) 2023-08-02 2026-03-06 英特维特国际股份有限公司 具有驱虫活性的甲酰胺-4-喹啉化合物

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Also Published As

Publication number Publication date
AU2019266511A1 (en) 2020-10-22
US12559481B2 (en) 2026-02-24
EP3790874A1 (en) 2021-03-17
ES2945559T3 (es) 2023-07-04
EP3790874B1 (en) 2023-03-15
US20210139468A1 (en) 2021-05-13
PH12020551891A1 (en) 2021-05-31
CN112074514A (zh) 2020-12-11
PT3790874T (pt) 2023-05-31
IL278472A (es) 2020-12-31
TWI813680B (zh) 2023-09-01
MX2020011873A (es) 2021-01-20
CN112074514B (zh) 2024-10-29
TW202016100A (zh) 2020-05-01
AU2019266511B2 (en) 2022-12-08
CA3099610A1 (en) 2019-11-14
BR112020022619A2 (pt) 2021-02-02
CO2020013876A2 (es) 2020-11-20
SG11202010024UA (en) 2020-11-27
KR20210006401A (ko) 2021-01-18
PL3790874T3 (pl) 2023-06-19
JP2021523131A (ja) 2021-09-02
UY38226A (es) 2019-12-31
US20230141809A1 (en) 2023-05-11
IL278472B2 (en) 2023-08-01
DK3790874T3 (da) 2023-05-15
KR102858945B1 (ko) 2025-09-11
JP7403472B2 (ja) 2023-12-22
IL278472B1 (en) 2023-04-01
WO2019215182A1 (en) 2019-11-14
US11572357B2 (en) 2023-02-07

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