MA52967A - Composés antagonistes du pcsk9 - Google Patents

Composés antagonistes du pcsk9

Info

Publication number
MA52967A
MA52967A MA052967A MA52967A MA52967A MA 52967 A MA52967 A MA 52967A MA 052967 A MA052967 A MA 052967A MA 52967 A MA52967 A MA 52967A MA 52967 A MA52967 A MA 52967A
Authority
MA
Morocco
Prior art keywords
antagonist compounds
pcsk9 antagonist
pcsk9
compounds
antagonist
Prior art date
Application number
MA052967A
Other languages
English (en)
Other versions
MA52967B1 (fr
Inventor
Elisabetta Bianchi
Sobhana Babu Boga
Danila Branca
Fa-Xiang Ding
Sookhee Nicole Ha
Hubert B Josien
Angela Dawn Kerekes
Jian Liu
Anilkumar G Nair
Ling Tong
Thomas Joseph Tucker
Abbas M Walji
Harold B Wood
Chengwei Wu
Yusheng Xiong
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA52967A publication Critical patent/MA52967A/fr
Publication of MA52967B1 publication Critical patent/MA52967B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21061—Kexin (3.4.21.61), i.e. proprotein convertase subtilisin/kexin type 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
MA52967A 2018-06-21 2019-06-20 Composés antagonistes du pcsk9 MA52967B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862687913P 2018-06-21 2018-06-21
PCT/US2019/038155 WO2019246349A1 (fr) 2018-06-21 2019-06-20 Composés antagonistes du pcsk9
EP19739801.9A EP3810626B1 (fr) 2018-06-21 2019-06-20 Composés antagonistes du pcsk9

Publications (2)

Publication Number Publication Date
MA52967A true MA52967A (fr) 2021-04-28
MA52967B1 MA52967B1 (fr) 2025-09-30

Family

ID=67263083

Family Applications (1)

Application Number Title Priority Date Filing Date
MA52967A MA52967B1 (fr) 2018-06-21 2019-06-20 Composés antagonistes du pcsk9

Country Status (38)

Country Link
US (3) US11427616B2 (fr)
EP (2) EP3810626B1 (fr)
JP (3) JP7112531B2 (fr)
KR (2) KR20250161677A (fr)
CN (2) CN121130044A (fr)
AR (1) AR115597A1 (fr)
AU (2) AU2019290163C1 (fr)
BR (1) BR112020025274A8 (fr)
CA (1) CA3102629A1 (fr)
CL (2) CL2020003257A1 (fr)
CO (1) CO2021000456A2 (fr)
CR (1) CR20210031A (fr)
DK (1) DK3810626T3 (fr)
DO (1) DOP2020000250A (fr)
EA (1) EA202190086A1 (fr)
EC (1) ECSP21003643A (fr)
ES (1) ES3047399T3 (fr)
FI (1) FI3810626T3 (fr)
GE (2) GEP20237506B (fr)
HR (1) HRP20251302T1 (fr)
HU (1) HUE073367T2 (fr)
IL (2) IL321719A (fr)
JO (1) JOP20190150A1 (fr)
LT (1) LT3810626T (fr)
MA (1) MA52967B1 (fr)
MD (1) MD3810626T2 (fr)
MX (1) MX2020013726A (fr)
NI (1) NI202000101A (fr)
PE (1) PE20211584A1 (fr)
PH (1) PH12020552187A1 (fr)
PL (1) PL3810626T3 (fr)
PT (1) PT3810626T (fr)
RS (1) RS67338B1 (fr)
SG (1) SG11202012451WA (fr)
SI (1) SI3810626T1 (fr)
TW (1) TWI840376B (fr)
UA (1) UA129467C2 (fr)
WO (1) WO2019246349A1 (fr)

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WO2019246352A1 (fr) 2018-06-21 2019-12-26 Merck Sharp & Dohme Corp. Composés bicycliques antagonistes de pcsk9
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EP3810177B1 (fr) 2018-06-21 2024-12-04 Ra Pharmaceuticals, Inc. Peptides cycliques pour l'inhibition de la pcsk9
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US12577259B2 (en) 2019-12-20 2026-03-17 Merck Sharp & Dohme Llc PCSK9 antagonist compounds
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EP4727552A2 (fr) * 2023-06-15 2026-04-22 Merck Sharp & Dohme LLC Composés antagonistes de pcsk9 perméables passifs
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WO2025128805A1 (fr) 2023-12-15 2025-06-19 Merck Sharp & Dohme Llc Piège à il-1 bêta à peptide cyclique pour le traitement de l'athérosclérose et de troubles inflammatoires
WO2025242221A1 (fr) * 2024-05-24 2025-11-27 上海翰森生物医药科技有限公司 Nouvelle chaîne latérale modifiée, son procédé de préparation et son utilisation
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CN119930471A (zh) * 2024-12-31 2025-05-06 苏州默迪夫生物科技有限公司 Mk-a的制备方法、所用的中间体及其合成方法

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IL321719A (en) 2018-06-21 2025-08-01 Merck Sharp ַ& Dohme Llc Pcsk9 antagonist compounds
WO2021041770A1 (fr) 2019-08-30 2021-03-04 Merck Sharp & Dohme Corp. Composés antagonistes du pcsk9
US12577259B2 (en) 2019-12-20 2026-03-17 Merck Sharp & Dohme Llc PCSK9 antagonist compounds

Also Published As

Publication number Publication date
JP7112531B2 (ja) 2022-08-03
SI3810626T1 (sl) 2025-12-31
BR112020025274A8 (pt) 2023-02-14
JP2022141879A (ja) 2022-09-29
DOP2020000250A (es) 2021-02-28
US20230159592A1 (en) 2023-05-25
AU2022259744B2 (en) 2024-07-11
MD3810626T2 (ro) 2025-12-31
GEAP202215540A (en) 2022-12-12
JP7855670B2 (ja) 2026-05-08
NI202000101A (es) 2021-05-28
FI3810626T3 (fi) 2025-10-21
US20190389909A1 (en) 2019-12-26
US20250206781A1 (en) 2025-06-26
EP3810626B1 (fr) 2025-07-23
SG11202012451WA (en) 2021-01-28
CL2020003257A1 (es) 2021-07-23
AR115597A1 (es) 2021-02-03
IL321719A (en) 2025-08-01
KR102884527B1 (ko) 2025-11-13
ECSP21003643A (es) 2021-02-26
TW202019950A (zh) 2020-06-01
BR112020025274A2 (pt) 2021-03-09
HRP20251302T1 (hr) 2025-12-19
LT3810626T (lt) 2025-11-10
AU2019290163C1 (en) 2022-11-03
KR20210024035A (ko) 2021-03-04
JP2025041712A (ja) 2025-03-26
PE20211584A1 (es) 2021-08-18
US11427616B2 (en) 2022-08-30
MA52967B1 (fr) 2025-09-30
US12209145B2 (en) 2025-01-28
GEP20237506B (en) 2023-05-25
EA202190086A1 (ru) 2021-05-18
JOP20190150A1 (ar) 2019-12-21
UA129467C2 (uk) 2025-05-07
MX2020013726A (es) 2021-03-02
AU2022259744A1 (en) 2022-12-01
AU2019290163B2 (en) 2022-08-04
RS67338B1 (sr) 2025-11-28
EP3810626A1 (fr) 2021-04-28
EP4660303A3 (fr) 2026-02-25
CN112313243B (zh) 2025-09-02
IL279363B1 (en) 2025-08-01
EP4660303A2 (fr) 2025-12-10
DK3810626T3 (da) 2025-08-18
PH12020552187A1 (en) 2021-07-26
PT3810626T (pt) 2025-10-15
PL3810626T3 (pl) 2025-12-22
TWI840376B (zh) 2024-05-01
CN112313243A (zh) 2021-02-02
CO2021000456A2 (es) 2021-01-29
ES3047399T3 (en) 2025-12-03
WO2019246349A8 (fr) 2021-02-04
CR20210031A (es) 2021-02-11
JP7607615B2 (ja) 2024-12-27
CL2022000027A1 (es) 2022-08-19
JP2021522311A (ja) 2021-08-30
AU2019290163A1 (en) 2021-01-07
HUE073367T2 (hu) 2026-01-28
WO2019246349A1 (fr) 2019-12-26
CA3102629A1 (fr) 2019-12-26
IL279363A (en) 2021-01-31
IL279363B2 (en) 2025-12-01
KR20250161677A (ko) 2025-11-17
CN121130044A (zh) 2025-12-16

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