CN1037235C - 6-（取代氨基）嘌呤促细胞分裂素在制备抗衰老组合物中的用途 - Google Patents

6-（取代氨基）嘌呤促细胞分裂素在制备抗衰老组合物中的用途 Download PDF

Info

Publication number: CN1037235C
Authority: CN; China
Prior art keywords: cells; kinetin; purine; substituted amino; skin
Prior art date: 1991-05-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CN91104472A

Other languages

English (en)

Chinese (zh)

Other versions

CN1068033A (zh

Inventor

苏雷叙·I·S·拉滕

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Senetek PLC

Original Assignee

Senetek PLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-16

Filing date

1991-06-28

Publication date

1998-02-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27508530&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1037235(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1991-05-16 Priority to AT91912579T priority Critical patent/ATE185272T1/de

1991-05-16 Priority to DK91912579T priority patent/DK0584068T4/da

1991-05-16 Priority to CA002108369A priority patent/CA2108369C/en

1991-05-16 Priority to DE69131692T priority patent/DE69131692T3/de

1991-05-16 Priority to AU81884/91A priority patent/AU666836B2/en

1991-05-16 Priority to KR1019930703452A priority patent/KR100196660B1/ko

1991-05-16 Priority to ES91912579T priority patent/ES2140392T5/es

1991-05-16 Priority to EP91912579A priority patent/EP0584068B2/en

1991-05-16 Priority to JP03512066A priority patent/JP3103375B2/ja

1991-05-16 Priority to PCT/US1991/003466 priority patent/WO1992020341A1/en

1991-05-16 Priority to BR9107307A priority patent/BR9107307A/pt

1991-05-21 Priority claimed from NZ238210A external-priority patent/NZ238210A/en

1991-05-21 Priority to IL9820491A priority patent/IL98204A/en

1991-05-21 Priority to NZ247836A priority patent/NZ247836A/en

1991-05-29 Priority to IN409/MAS/91A priority patent/IN172210B/en

1991-06-28 Priority to CN91104472A priority patent/CN1037235C/zh

1991-06-28 Application filed by Senetek PLC filed Critical Senetek PLC

1993-01-20 Publication of CN1068033A publication Critical patent/CN1068033A/zh

1993-11-15 Priority to NO934115A priority patent/NO304814B1/no

1993-11-15 Priority to FI935039A priority patent/FI111219B/fi

1998-02-04 Publication of CN1037235C publication Critical patent/CN1037235C/zh

1998-02-04 Application granted granted Critical

2000-01-07 Priority to GR20000400023T priority patent/GR3032325T3/el

2006-06-28 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

-1 6-(substituted amino)purine Chemical class 0.000 title claims abstract description 71
239000000203 mixture Substances 0.000 title claims abstract description 69
239000003226 mitogen Substances 0.000 title claims abstract description 46
230000003712 anti-aging effect Effects 0.000 title abstract 2
FAIXYKHYOGVFKA-UHFFFAOYSA-N Kinetin Natural products N=1C=NC=2N=CNC=2C=1N(C)C1=CC=CO1 FAIXYKHYOGVFKA-UHFFFAOYSA-N 0.000 claims abstract description 70
QANMHLXAZMSUEX-UHFFFAOYSA-N kinetin Chemical compound N=1C=NC=2N=CNC=2C=1NCC1=CC=CO1 QANMHLXAZMSUEX-UHFFFAOYSA-N 0.000 claims abstract description 70
229960001669 kinetin Drugs 0.000 claims abstract description 70
239000006210 lotion Substances 0.000 claims abstract description 14
239000006071 cream Substances 0.000 claims abstract description 11
230000010261 cell growth Effects 0.000 claims abstract description 8
239000002674 ointment Substances 0.000 claims abstract description 6
230000032677 cell aging Effects 0.000 claims abstract description 5
238000002360 preparation method Methods 0.000 claims abstract description 3
210000004027 cell Anatomy 0.000 claims description 184
210000002950 fibroblast Anatomy 0.000 claims description 44
230000000694 effects Effects 0.000 claims description 42
230000002411 adverse Effects 0.000 claims description 31
210000004962 mammalian cell Anatomy 0.000 claims description 20
239000001963 growth medium Substances 0.000 claims description 14
230000035755 proliferation Effects 0.000 claims description 14
125000004432 carbon atom Chemical group C* 0.000 claims description 13
210000005260 human cell Anatomy 0.000 claims description 11
238000004113 cell culture Methods 0.000 claims description 6
150000001875 compounds Chemical class 0.000 claims description 5
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
210000001626 skin fibroblast Anatomy 0.000 claims description 2
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
230000002062 proliferating effect Effects 0.000 abstract description 29
210000004748 cultured cell Anatomy 0.000 abstract description 11
230000004660 morphological change Effects 0.000 abstract description 5
230000036541 health Effects 0.000 abstract description 3
239000000463 material Substances 0.000 abstract 1
210000003491 skin Anatomy 0.000 description 47
230000012010 growth Effects 0.000 description 34
238000000034 method Methods 0.000 description 34
230000032683 aging Effects 0.000 description 31
239000004166 Lanolin Substances 0.000 description 20
239000000194 fatty acid Substances 0.000 description 20
235000019388 lanolin Nutrition 0.000 description 20
229940039717 lanolin Drugs 0.000 description 20
235000014113 dietary fatty acids Nutrition 0.000 description 18
229930195729 fatty acid Natural products 0.000 description 18
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 17
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 14
239000002609 medium Substances 0.000 description 14
210000002808 connective tissue Anatomy 0.000 description 13
210000001519 tissue Anatomy 0.000 description 12
239000003995 emulsifying agent Substances 0.000 description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
241000124008 Mammalia Species 0.000 description 9
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
239000000243 solution Substances 0.000 description 9
210000004207 dermis Anatomy 0.000 description 8
238000002474 experimental method Methods 0.000 description 8
210000001035 gastrointestinal tract Anatomy 0.000 description 8
239000002562 thickening agent Substances 0.000 description 8
238000011282 treatment Methods 0.000 description 8
230000006820 DNA synthesis Effects 0.000 description 7
239000002585 base Substances 0.000 description 7
230000032823 cell division Effects 0.000 description 7
150000004665 fatty acids Chemical class 0.000 description 7
150000002191 fatty alcohols Chemical class 0.000 description 7
239000004615 ingredient Substances 0.000 description 7
230000000877 morphologic effect Effects 0.000 description 7
239000000546 pharmaceutical excipient Substances 0.000 description 7
229920001451 polypropylene glycol Polymers 0.000 description 7
WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 6
UQHKFADEQIVWID-UHFFFAOYSA-N cytokinin Natural products C1=NC=2C(NCC=C(CO)C)=NC=NC=2N1C1CC(O)C(CO)O1 UQHKFADEQIVWID-UHFFFAOYSA-N 0.000 description 6
239000004062 cytokinin Substances 0.000 description 6
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 6
230000009758 senescence Effects 0.000 description 6
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 5
241000196324 Embryophyta Species 0.000 description 5
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 5
239000002202 Polyethylene glycol Substances 0.000 description 5
150000005018 aminopurines Chemical class 0.000 description 5
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 5
239000002537 cosmetic Substances 0.000 description 5
239000003974 emollient agent Substances 0.000 description 5
210000000981 epithelium Anatomy 0.000 description 5
239000000499 gel Substances 0.000 description 5
235000011187 glycerol Nutrition 0.000 description 5
238000001727 in vivo Methods 0.000 description 5
239000000314 lubricant Substances 0.000 description 5
229920001223 polyethylene glycol Polymers 0.000 description 5
238000001243 protein synthesis Methods 0.000 description 5
239000002904 solvent Substances 0.000 description 5
235000010356 sorbitol Nutrition 0.000 description 5
239000000126 substance Substances 0.000 description 5
230000014616 translation Effects 0.000 description 5
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
230000009286 beneficial effect Effects 0.000 description 4
230000007423 decrease Effects 0.000 description 4
239000007788 liquid Substances 0.000 description 4
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 4
239000003921 oil Substances 0.000 description 4
235000019198 oils Nutrition 0.000 description 4
229920005862 polyol Polymers 0.000 description 4
239000003380 propellant Substances 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
102000004169 proteins and genes Human genes 0.000 description 4
210000004927 skin cell Anatomy 0.000 description 4
239000007787 solid Substances 0.000 description 4
239000000600 sorbitol Substances 0.000 description 4
229940104230 thymidine Drugs 0.000 description 4
PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 3
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical class CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
241000282412 Homo Species 0.000 description 3
NWBJYWHLCVSVIJ-UHFFFAOYSA-N N-benzyladenine Chemical compound N=1C=NC=2NC=NC=2C=1NCC1=CC=CC=C1 NWBJYWHLCVSVIJ-UHFFFAOYSA-N 0.000 description 3
206010028980 Neoplasm Diseases 0.000 description 3
239000004264 Petrolatum Substances 0.000 description 3
229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
229920001214 Polysorbate 60 Polymers 0.000 description 3
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 3
230000003679 aging effect Effects 0.000 description 3
125000000129 anionic group Chemical group 0.000 description 3
238000000376 autoradiography Methods 0.000 description 3
235000013871 bee wax Nutrition 0.000 description 3
239000012166 beeswax Substances 0.000 description 3
230000008901 benefit Effects 0.000 description 3
201000011510 cancer Diseases 0.000 description 3
229960000541 cetyl alcohol Drugs 0.000 description 3
235000012000 cholesterol Nutrition 0.000 description 3
LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 3
230000002500 effect on skin Effects 0.000 description 3
239000003205 fragrance Substances 0.000 description 3
239000003102 growth factor Substances 0.000 description 3
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 3
238000002372 labelling Methods 0.000 description 3
230000007774 longterm Effects 0.000 description 3
238000002156 mixing Methods 0.000 description 3
229940066842 petrolatum Drugs 0.000 description 3
235000019271 petrolatum Nutrition 0.000 description 3
239000000047 product Substances 0.000 description 3
208000024891 symptom Diseases 0.000 description 3
230000000699 topical effect Effects 0.000 description 3
UZKQTCBAMSWPJD-UQCOIBPSSA-N trans-Zeatin Natural products OCC(/C)=C\CNC1=NC=NC2=C1N=CN2 UZKQTCBAMSWPJD-UQCOIBPSSA-N 0.000 description 3
UZKQTCBAMSWPJD-FARCUNLSSA-N trans-zeatin Chemical compound OCC(/C)=C/CNC1=NC=NC2=C1N=CN2 UZKQTCBAMSWPJD-FARCUNLSSA-N 0.000 description 3
239000001993 wax Substances 0.000 description 3
229940023877 zeatin Drugs 0.000 description 3
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 2
XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
RWLALWYNXFYRGW-UHFFFAOYSA-N 2-Ethyl-1,3-hexanediol Chemical compound CCCC(O)C(CC)CO RWLALWYNXFYRGW-UHFFFAOYSA-N 0.000 description 2
HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 2
102000008186 Collagen Human genes 0.000 description 2
108010035532 Collagen Proteins 0.000 description 2
239000006144 Dulbecco’s modiﬁed Eagle's medium Substances 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 2
ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
102000004142 Trypsin Human genes 0.000 description 2
108090000631 Trypsin Proteins 0.000 description 2
239000004164 Wax ester Substances 0.000 description 2
230000002159 abnormal effect Effects 0.000 description 2
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
239000002253 acid Substances 0.000 description 2
239000000443 aerosol Substances 0.000 description 2
125000000217 alkyl group Chemical group 0.000 description 2
238000013459 approach Methods 0.000 description 2
YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
229910002092 carbon dioxide Inorganic materials 0.000 description 2
125000002091 cationic group Chemical group 0.000 description 2
230000022131 cell cycle Effects 0.000 description 2
229920001436 collagen Polymers 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
230000001186 cumulative effect Effects 0.000 description 2
230000001351 cycling effect Effects 0.000 description 2
230000003247 decreasing effect Effects 0.000 description 2
238000011161 development Methods 0.000 description 2
230000018109 developmental process Effects 0.000 description 2
229940031578 diisopropyl adipate Drugs 0.000 description 2
NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
239000002552 dosage form Substances 0.000 description 2
239000003925 fat Substances 0.000 description 2
235000019197 fats Nutrition 0.000 description 2
125000005313 fatty acid group Chemical group 0.000 description 2
230000001605 fetal effect Effects 0.000 description 2
239000012530 fluid Substances 0.000 description 2
238000010353 genetic engineering Methods 0.000 description 2
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
229930195733 hydrocarbon Natural products 0.000 description 2
150000002430 hydrocarbons Chemical class 0.000 description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
230000001788 irregular Effects 0.000 description 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
210000002510 keratinocyte Anatomy 0.000 description 2
238000012423 maintenance Methods 0.000 description 2
230000007246 mechanism Effects 0.000 description 2
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 2
FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 2
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
229940055577 oleyl alcohol Drugs 0.000 description 2
XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
239000003375 plant hormone Substances 0.000 description 2
229920000740 poly(D-lysine) polymer Polymers 0.000 description 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
230000002441 reversible effect Effects 0.000 description 2
WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 2
229940066675 ricinoleate Drugs 0.000 description 2
239000000344 soap Substances 0.000 description 2
239000007909 solid dosage form Substances 0.000 description 2
239000012177 spermaceti Substances 0.000 description 2
229940084106 spermaceti Drugs 0.000 description 2
PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
235000000346 sugar Nutrition 0.000 description 2
HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
230000002588 toxic effect Effects 0.000 description 2
230000009466 transformation Effects 0.000 description 2
239000012588 trypsin Substances 0.000 description 2
210000003934 vacuole Anatomy 0.000 description 2
239000003981 vehicle Substances 0.000 description 2
235000019386 wax ester Nutrition 0.000 description 2
DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
ZWVMLYRJXORSEP-UHFFFAOYSA-N 1,2,6-Hexanetriol Chemical compound OCCCCC(O)CO ZWVMLYRJXORSEP-UHFFFAOYSA-N 0.000 description 1
JQJSFAJISYZPER-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-(2,3-dihydro-1h-inden-5-ylsulfonyl)urea Chemical compound C1=CC(Cl)=CC=C1NC(=O)NS(=O)(=O)C1=CC=C(CCC2)C2=C1 JQJSFAJISYZPER-UHFFFAOYSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 1
XFOQWQKDSMIPHT-UHFFFAOYSA-N 2,3-dichloro-6-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=C(Cl)C(Cl)=N1 XFOQWQKDSMIPHT-UHFFFAOYSA-N 0.000 description 1
KIHBGTRZFAVZRV-UHFFFAOYSA-N 2-Hydroxyoctadecanoic acid Natural products CCCCCCCCCCCCCCCCC(O)C(O)=O KIHBGTRZFAVZRV-UHFFFAOYSA-N 0.000 description 1
LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
XTQUSEDRZLDHRC-UHFFFAOYSA-N 3-octadecanoyloxybutyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCC(C)OC(=O)CCCCCCCCCCCCCCCCC XTQUSEDRZLDHRC-UHFFFAOYSA-N 0.000 description 1
NZXZINXFUSKTPH-UHFFFAOYSA-N 4-[4-(4-butylcyclohexyl)cyclohexyl]-1,2-difluorobenzene Chemical compound C1CC(CCCC)CCC1C1CCC(C=2C=C(F)C(F)=CC=2)CC1 NZXZINXFUSKTPH-UHFFFAOYSA-N 0.000 description 1
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
IBYCEACZVUOBIV-UHFFFAOYSA-N 4-methylpentyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCC(C)C IBYCEACZVUOBIV-UHFFFAOYSA-N 0.000 description 1
AUGIYYGVQDZOLU-UHFFFAOYSA-N 4-methylpentyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCC(C)C AUGIYYGVQDZOLU-UHFFFAOYSA-N 0.000 description 1
ORQVWBNUTLIVLY-UHFFFAOYSA-N 6-(furan-2-ylmethyl)purin-6-amine Chemical compound N1=CN=C2N=CN=C2C1(N)CC1=CC=CO1 ORQVWBNUTLIVLY-UHFFFAOYSA-N 0.000 description 1
150000005020 6-aminopurines Chemical class 0.000 description 1
XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
DKGXIVRSAKPDHF-UHFFFAOYSA-N 6-chloro-3-methyl-1-phenylpyrimidine-2,4-dione Chemical compound O=C1N(C)C(=O)C=C(Cl)N1C1=CC=CC=C1 DKGXIVRSAKPDHF-UHFFFAOYSA-N 0.000 description 1
ODMZDMMTKHXXKA-QXMHVHEDSA-N 8-methylnonyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCCCCCCC(C)C ODMZDMMTKHXXKA-QXMHVHEDSA-N 0.000 description 1
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
OYHQOLUKZRVURQ-HZJYTTRNSA-M 9-cis,12-cis-Octadecadienoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC([O-])=O OYHQOLUKZRVURQ-HZJYTTRNSA-M 0.000 description 1
GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
235000019489 Almond oil Nutrition 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
229930192334 Auxin Natural products 0.000 description 1
235000021357 Behenic acid Nutrition 0.000 description 1
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 description 1
239000004215 Carbon black (E152) Substances 0.000 description 1
102000016942 Elastin Human genes 0.000 description 1
108010014258 Elastin Proteins 0.000 description 1
URXZXNYJPAJJOQ-UHFFFAOYSA-N Erucic acid Natural products CCCCCCC=CCCCCCCCCCCCC(O)=O URXZXNYJPAJJOQ-UHFFFAOYSA-N 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
239000001856 Ethyl cellulose Substances 0.000 description 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
102000016359 Fibronectins Human genes 0.000 description 1
108010067306 Fibronectins Proteins 0.000 description 1
229930191978 Gibberellin Natural products 0.000 description 1
CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
238000012404 In vitro experiment Methods 0.000 description 1
102000004877 Insulin Human genes 0.000 description 1
108090001061 Insulin Proteins 0.000 description 1
102000010638 Kinesin Human genes 0.000 description 1
108010063296 Kinesin Proteins 0.000 description 1
239000005639 Lauric acid Substances 0.000 description 1
102000008072 Lymphokines Human genes 0.000 description 1
108010074338 Lymphokines Proteins 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
GWFGDXZQZYMSMJ-UHFFFAOYSA-N Octadecansaeure-heptadecylester Natural products CCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC GWFGDXZQZYMSMJ-UHFFFAOYSA-N 0.000 description 1
MHXBHWLGRWOABW-UHFFFAOYSA-N Octadecansaeure-tetradecylester Natural products CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC MHXBHWLGRWOABW-UHFFFAOYSA-N 0.000 description 1
239000005642 Oleic acid Substances 0.000 description 1
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
235000019482 Palm oil Nutrition 0.000 description 1
235000021314 Palmitic acid Nutrition 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
239000004721 Polyphenylene oxide Chemical class 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
CMCJFUXWBBHIIL-UHFFFAOYSA-N Propylene glycol stearate Chemical class CC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O CMCJFUXWBBHIIL-UHFFFAOYSA-N 0.000 description 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
102000044126 RNA-Binding Proteins Human genes 0.000 description 1
108700020471 RNA-Binding Proteins Proteins 0.000 description 1
108091028664 Ribonucleotide Proteins 0.000 description 1
230000018199 S phase Effects 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
235000019485 Safflower oil Nutrition 0.000 description 1
HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
240000001058 Sterculia urens Species 0.000 description 1
235000015125 Sterculia urens Nutrition 0.000 description 1
229930182558 Sterol Natural products 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
108020004566 Transfer RNA Proteins 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical group CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
244000098338 Triticum aestivum Species 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000009471 action Effects 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
125000002015 acyclic group Chemical group 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
150000001335 aliphatic alkanes Chemical class 0.000 description 1
229910052936 alkali metal sulfate Inorganic materials 0.000 description 1
239000008168 almond oil Substances 0.000 description 1
230000001668 ameliorated effect Effects 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
235000011130 ammonium sulphate Nutrition 0.000 description 1
210000004102 animal cell Anatomy 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229940114079 arachidonic acid Drugs 0.000 description 1
235000021342 arachidonic acid Nutrition 0.000 description 1
238000003556 assay Methods 0.000 description 1
239000012298 atmosphere Substances 0.000 description 1
238000000211 autoradiogram Methods 0.000 description 1
239000002363 auxin Substances 0.000 description 1
239000008163 avocado oil Substances 0.000 description 1
235000021302 avocado oil Nutrition 0.000 description 1
210000000270 basal cell Anatomy 0.000 description 1
229940116226 behenic acid Drugs 0.000 description 1
239000000440 bentonite Substances 0.000 description 1
229910000278 bentonite Inorganic materials 0.000 description 1
235000012216 bentonite Nutrition 0.000 description 1
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
238000001574 biopsy Methods 0.000 description 1
230000001851 biosynthetic effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
IUGNTDSUZLPSOK-UHFFFAOYSA-N bis(4-methylpentyl) hexanedioate Chemical compound CC(C)CCCOC(=O)CCCCC(=O)OCCCC(C)C IUGNTDSUZLPSOK-UHFFFAOYSA-N 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
239000001273 butane Substances 0.000 description 1
235000019437 butane-1,3-diol Nutrition 0.000 description 1
NZIKRHKSEITLPS-UHFFFAOYSA-N butane-1,3-diol;octadecanoic acid Chemical compound CC(O)CCO.CCCCCCCCCCCCCCCCCC(O)=O NZIKRHKSEITLPS-UHFFFAOYSA-N 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000004204 candelilla wax Substances 0.000 description 1
235000013868 candelilla wax Nutrition 0.000 description 1
229940073532 candelilla wax Drugs 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229940096529 carboxypolymethylene Drugs 0.000 description 1
239000004203 carnauba wax Substances 0.000 description 1
235000013869 carnauba wax Nutrition 0.000 description 1
239000004359 castor oil Substances 0.000 description 1
235000019438 castor oil Nutrition 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
230000010094 cellular senescence Effects 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
150000001841 cholesterols Chemical class 0.000 description 1
235000012716 cod liver oil Nutrition 0.000 description 1
239000003026 cod liver oil Substances 0.000 description 1
239000008294 cold cream Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
229940038226 comfrey root extract Drugs 0.000 description 1
235000005687 corn oil Nutrition 0.000 description 1
239000002285 corn oil Substances 0.000 description 1
235000012343 cottonseed oil Nutrition 0.000 description 1
239000002385 cottonseed oil Substances 0.000 description 1
239000006059 cover glass Substances 0.000 description 1
238000012136 culture method Methods 0.000 description 1
238000012258 culturing Methods 0.000 description 1
230000002354 daily effect Effects 0.000 description 1
KBODESQIOVVMAI-UHFFFAOYSA-N decyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCC KBODESQIOVVMAI-UHFFFAOYSA-N 0.000 description 1
SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
230000001934 delay Effects 0.000 description 1
230000002939 deleterious effect Effects 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
YSAVZVORKRDODB-WDSKDSINSA-N diethyl tartrate Chemical compound CCOC(=O)[C@@H](O)[C@H](O)C(=O)OCC YSAVZVORKRDODB-WDSKDSINSA-N 0.000 description 1
239000004205 dimethyl polysiloxane Substances 0.000 description 1
235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
230000003292 diminished effect Effects 0.000 description 1
SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
229960000735 docosanol Drugs 0.000 description 1
QQQMUBLXDAFBRH-UHFFFAOYSA-N dodecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)O QQQMUBLXDAFBRH-UHFFFAOYSA-N 0.000 description 1
239000000975 dye Substances 0.000 description 1
229920002549 elastin Polymers 0.000 description 1
230000001804 emulsifying effect Effects 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
239000003623 enhancer Substances 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
210000002919 epithelial cell Anatomy 0.000 description 1
DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
PLAQRFBMXJJBBQ-UHFFFAOYSA-N ethane-1,2-diol;2-methylpentane-2,4-diol Chemical compound OCCO.CC(O)CC(C)(C)O PLAQRFBMXJJBBQ-UHFFFAOYSA-N 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
WCHFOOKTKZYYAE-UHFFFAOYSA-N ethoxyperoxyethane Chemical compound CCOOOCC WCHFOOKTKZYYAE-UHFFFAOYSA-N 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
230000003203 everyday effect Effects 0.000 description 1
239000000284 extract Substances 0.000 description 1
230000001815 facial effect Effects 0.000 description 1
239000012894 fetal calf serum Substances 0.000 description 1
102000034240 fibrous proteins Human genes 0.000 description 1
108091005899 fibrous proteins Proteins 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000012737 fresh medium Substances 0.000 description 1
239000007789 gas Substances 0.000 description 1
230000014509 gene expression Effects 0.000 description 1
210000004602 germ cell Anatomy 0.000 description 1
IXORZMNAPKEEDV-UHFFFAOYSA-N gibberellic acid GA3 Natural products OC(=O)C1C2(C3)CC(=C)C3(O)CCC2C2(C=CC3O)C1C3(C)C(=O)O2 IXORZMNAPKEEDV-UHFFFAOYSA-N 0.000 description 1
239000003448 gibberellin Substances 0.000 description 1
235000020710 ginseng extract Nutrition 0.000 description 1
239000003862 glucocorticoid Substances 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
150000002314 glycerols Chemical class 0.000 description 1
IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
TZMQHOJDDMFGQX-UHFFFAOYSA-N hexane-1,1,1-triol Chemical class CCCCCC(O)(O)O TZMQHOJDDMFGQX-UHFFFAOYSA-N 0.000 description 1
229940100463 hexyl laurate Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
230000036571 hydration Effects 0.000 description 1
238000006703 hydration reaction Methods 0.000 description 1
238000007327 hydrogenolysis reaction Methods 0.000 description 1
239000008311 hydrophilic ointment Substances 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
238000002513 implantation Methods 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
229940093629 isopropyl isostearate Drugs 0.000 description 1
XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
229940049918 linoleate Drugs 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
238000009629 microbiological culture Methods 0.000 description 1
239000004200 microcrystalline wax Substances 0.000 description 1
235000019808 microcrystalline wax Nutrition 0.000 description 1
230000005012 migration Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
239000011707 mineral Substances 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
235000010935 mono and diglycerides of fatty acids Nutrition 0.000 description 1
150000002780 morpholines Chemical class 0.000 description 1
210000005088 multinucleated cell Anatomy 0.000 description 1
229940043348 myristyl alcohol Drugs 0.000 description 1
TWNYVXWYJQBLCA-UHFFFAOYSA-N n-(cyclohexylmethyl)-7h-purin-6-amine Chemical compound N=1C=NC=2N=CNC=2C=1NCC1CCCCC1 TWNYVXWYJQBLCA-UHFFFAOYSA-N 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
WCZNSRQVTJYMRQ-UHFFFAOYSA-N n-phenyl-7h-purin-6-amine Chemical compound N=1C=NC=2N=CNC=2C=1NC1=CC=CC=C1 WCZNSRQVTJYMRQ-UHFFFAOYSA-N 0.000 description 1
239000001272 nitrous oxide Substances 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
230000001777 nootropic effect Effects 0.000 description 1
KHLCTMQBMINUNT-UHFFFAOYSA-N octadecane-1,12-diol Chemical compound CCCCCCC(O)CCCCCCCCCCCO KHLCTMQBMINUNT-UHFFFAOYSA-N 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
NKBWPOSQERPBFI-UHFFFAOYSA-N octadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC NKBWPOSQERPBFI-UHFFFAOYSA-N 0.000 description 1
229940049964 oleate Drugs 0.000 description 1
229960002969 oleic acid Drugs 0.000 description 1
BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
125000000466 oxiranyl group Chemical group 0.000 description 1
239000002540 palm oil Substances 0.000 description 1
SSZBUIDZHHWXNJ-UHFFFAOYSA-N palmityl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCC SSZBUIDZHHWXNJ-UHFFFAOYSA-N 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
230000035515 penetration Effects 0.000 description 1
239000002304 perfume Substances 0.000 description 1
230000000737 periodic effect Effects 0.000 description 1
230000002085 persistent effect Effects 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
229930195732 phytohormone Natural products 0.000 description 1
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
229920001515 polyalkylene glycol Polymers 0.000 description 1
229920000570 polyether Chemical class 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920000223 polyglycerol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000008569 process Effects 0.000 description 1
NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 1
239000001294 propane Substances 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
239000000700 radioactive tracer Substances 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000004043 responsiveness Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
239000002336 ribonucleotide Substances 0.000 description 1
125000002652 ribonucleotide group Chemical group 0.000 description 1
WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 1
229960003656 ricinoleic acid Drugs 0.000 description 1
FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 1
235000005713 safflower oil Nutrition 0.000 description 1
239000003813 safflower oil Substances 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
235000014102 seafood Nutrition 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
239000010703 silicon Substances 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
229920002545 silicone oil Polymers 0.000 description 1
230000009759 skin aging Effects 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229940035044 sorbitan monolaurate Drugs 0.000 description 1
239000001587 sorbitan monostearate Substances 0.000 description 1
235000011076 sorbitan monostearate Nutrition 0.000 description 1
229940035048 sorbitan monostearate Drugs 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
241000894007 species Species 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000010186 staining Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
229940012831 stearyl alcohol Drugs 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
150000003432 sterols Chemical class 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
229940037128 systemic glucocorticoids Drugs 0.000 description 1
TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
239000003104 tissue culture media Substances 0.000 description 1
230000001256 tonic effect Effects 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
230000001131 transforming effect Effects 0.000 description 1
230000007704 transition Effects 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
239000012178 vegetable wax Substances 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Birds (AREA)
Molecular Biology (AREA)
Gerontology & Geriatric Medicine (AREA)
Cosmetics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Road Signs Or Road Markings (AREA)
Organic Insulating Materials (AREA)
Measuring Volume Flow (AREA)
Ink Jet (AREA)
Stroboscope Apparatuses (AREA)
Tea And Coffee (AREA)
Materials Applied To Surfaces To Minimize Adherence Of Mist Or Water (AREA)
Medicinal Preparation (AREA)

CN91104472A 1991-05-16 1991-06-28 6-（取代氨基）嘌呤促细胞分裂素在制备抗衰老组合物中的用途 Expired - Fee Related CN1037235C (zh)

Priority Applications (18)

Application Number	Priority Date	Filing Date	Title
DK91912579T DK0584068T4 (da)	1991-05-16	1991-05-16	Fremgangsmåde og præparat til forbedring af de uheldige virkninger af ældning
CA002108369A CA2108369C (en)	1991-05-16	1991-05-16	Method and composition for ameliorating the adverse effects of aging
DE69131692T DE69131692T3 (de)	1991-05-16	1991-05-16	Verfahren und zusammensetzung zur verbesserung der ungünstigen auswirkungen des alterns
AU81884/91A AU666836B2 (en)	1991-05-16	1991-05-16	Method and composition for ameliorating the adverse effects of aging
KR1019930703452A KR100196660B1 (ko)	1991-05-16	1991-05-16	노화의 악영향을 개선하기 위한 조성물
ES91912579T ES2140392T5 (es)	1991-05-16	1991-05-16	Metodo y composicion para mejorar los efectos adversos del envejecimiento.
EP91912579A EP0584068B2 (en)	1991-05-16	1991-05-16	Method and composition for ameliorating the adverse effects of aging
JP03512066A JP3103375B2 (ja)	1991-05-16	1991-05-16	老化の不都合な影響を改善するための方法および組成物
PCT/US1991/003466 WO1992020341A1 (en)	1991-05-16	1991-05-16	Method and composition for ameliorating the adverse effects of aging
BR9107307A BR9107307A (pt)	1991-05-16	1991-05-16	Processo e composiçao para atenuar os efeitos adversos do envelhecimento em células de mamiferos
AT91912579T ATE185272T1 (de)	1991-05-16	1991-05-16	Verfahren und zusammensetzung zur verbesserung der ungünstigen auswirkungen des alterns
NZ247836A NZ247836A (en)	1991-05-16	1991-05-21	Countering the adverse effects of aging on mammalian cells using 6-(substituted amino) purine cytokinins
IL9820491A IL98204A (en)	1991-05-16	1991-05-21	Cosmetic method and compositions for ameliorating the adverse effects of aging using 6-(substituted amino) purine cytokinins
IN409/MAS/91A IN172210B (2)	1991-05-16	1991-05-29
CN91104472A CN1037235C (zh)	1991-05-16	1991-06-28	6-（取代氨基）嘌呤促细胞分裂素在制备抗衰老组合物中的用途
NO934115A NO304814B1 (no)	1991-05-16	1993-11-15	Kosmetisk preparat samt fremgangsmÕte for behandling av en kultur av pattedyrceller
FI935039A FI111219B (fi)	1991-05-16	1993-11-15	Menetelmä ja koostumus nisäkkään ihon kosmeettisen ulkonäön parantamiseksi
GR20000400023T GR3032325T3 (en)	1991-05-16	2000-01-07	Method and composition for ameliorating the adverse effects of aging

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
PCT/US1991/003466 WO1992020341A1 (en)	1991-05-16	1991-05-16	Method and composition for ameliorating the adverse effects of aging
CA002108369A CA2108369C (en)	1991-05-16	1991-05-16	Method and composition for ameliorating the adverse effects of aging
NZ238210A NZ238210A (en)	1991-05-21	1991-05-21	Use of 6-(substituted amino) purine cytokinins for inhibiting effects of ageing on mammalian cells
IL9820491A IL98204A (en)	1991-05-16	1991-05-21	Cosmetic method and compositions for ameliorating the adverse effects of aging using 6-(substituted amino) purine cytokinins
CN91104472A CN1037235C (zh)	1991-05-16	1991-06-28	6-（取代氨基）嘌呤促细胞分裂素在制备抗衰老组合物中的用途

Publications (2)

Publication Number	Publication Date
CN1068033A CN1068033A (zh)	1993-01-20
CN1037235C true CN1037235C (zh)	1998-02-04

Family

ID=27508530

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CN91104472A Expired - Fee Related CN1037235C (zh)	1991-05-16	1991-06-28	6-（取代氨基）嘌呤促细胞分裂素在制备抗衰老组合物中的用途

Country Status (18)

Country	Link
EP (1)	EP0584068B2 (2)
JP (1)	JP3103375B2 (2)
KR (1)	KR100196660B1 (2)
CN (1)	CN1037235C (2)
AT (1)	ATE185272T1 (2)
AU (1)	AU666836B2 (2)
BR (1)	BR9107307A (2)
CA (1)	CA2108369C (2)
DE (1)	DE69131692T3 (2)
DK (1)	DK0584068T4 (2)
ES (1)	ES2140392T5 (2)
FI (1)	FI111219B (2)
GR (1)	GR3032325T3 (2)
IL (1)	IL98204A (2)
IN (1)	IN172210B (2)
NO (1)	NO304814B1 (2)
NZ (1)	NZ247836A (2)
WO (1)	WO1992020341A1 (2)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2001031549A (ja) *	1999-07-14	2001-02-06	Pola Chem Ind Inc	真皮コラーゲン線維束再構築剤及びそれを含有する化粧料
WO2002042440A2 (en) *	2000-11-25	2002-05-30	University Of Leeds	Regulation of plant growth by modifying the expression of a putative trna-isope ntenyl transferase
DE10100122A1 (de) *	2001-01-03	2002-07-11	Henkel Kgaa	Verfahren zur Bestimmung der Hautalterung in vitro
JP2002212052A (ja) *	2001-01-15	2002-07-31	Hajime Ito	外用組成物
KR20080070782A (ko) *	2001-04-13	2008-07-30	오츠카 세이야쿠 가부시키가이샤	당 흡수 촉진제
CZ294535B6 (cs) *	2001-08-02	2005-01-12	Ústav Experimentální Botaniky Avčr	Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
JP4567307B2 (ja) *	2003-08-25	2010-10-20	株式会社ノエビア	皮膚外用剤
CN100493509C (zh) *	2007-06-04	2009-06-03	西北农林科技大学	化合物6-糠基氨基嘌呤用于制备抗睾丸衰老药物的应用
CN100493507C (zh) *	2007-06-04	2009-06-03	西北农林科技大学	化合物6-糠基氨基嘌呤制备抗雌性生殖器官损伤药物应用
CN100493510C (zh) *	2007-06-04	2009-06-03	西北农林科技大学	6-糠氨基嘌呤用于制备治疗心肌组织氧化损伤药物的应用
CN100493508C (zh) *	2007-06-04	2009-06-03	西北农林科技大学	化合物6-糠氨基嘌呤用于制备抗心肌缺血损伤药物的应用
CN100493506C (zh) *	2007-06-04	2009-06-03	西北农林科技大学	化合物6-糠基氨基嘌呤在制备抗脑组织氧化损伤药物应用
CZ302225B6 (cs) *	2007-07-04	2010-12-29	Univerzita Palackého v Olomouci	Substituované 6-anilinopurinové deriváty jako inhibitory cytokinin oxidasy a prípravky obsahující tyto slouceniny

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4853386A (en) *	1985-08-17	1989-08-01	Boehringer Mannheim Gmbh	N6 -disubstituted purine derivatives, and pharmaceutical compositions containing them, useful for treating allergic diseases, bronchospastic and bronchoconstrictory conditions
US5021422A (en) *	1989-06-08	1991-06-04	Senetek Plc	Method and composition for treating hyperproliferative skin diseases using 6-aminopurine cytokinins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1587633A (2) †	1968-07-04	1970-03-27
DD148889A3 (de) *	1974-08-19	1981-06-17	Forsch Die Gaerungsindustrie E	Verfahren zur herstellung eiweissreicher hefen
JPS6019709A (ja) *	1983-07-14	1985-01-31	Tsunetaka Yokoyama	皮膚の老化防止及細胞分裂促進の化粧品の製造方法
JPH0619709A (ja) *	1992-04-29	1994-01-28	Sun Microsyst Inc	パイプラインプロセッサを有するコンピュータシステム

1991
- 1991-05-16 DK DK91912579T patent/DK0584068T4/da active
- 1991-05-16 DE DE69131692T patent/DE69131692T3/de not_active Expired - Fee Related
- 1991-05-16 JP JP03512066A patent/JP3103375B2/ja not_active Expired - Fee Related
- 1991-05-16 CA CA002108369A patent/CA2108369C/en not_active Expired - Lifetime
- 1991-05-16 ES ES91912579T patent/ES2140392T5/es not_active Expired - Lifetime
- 1991-05-16 AU AU81884/91A patent/AU666836B2/en not_active Ceased
- 1991-05-16 BR BR9107307A patent/BR9107307A/pt not_active IP Right Cessation
- 1991-05-16 AT AT91912579T patent/ATE185272T1/de not_active IP Right Cessation
- 1991-05-16 EP EP91912579A patent/EP0584068B2/en not_active Expired - Lifetime
- 1991-05-16 KR KR1019930703452A patent/KR100196660B1/ko not_active Expired - Fee Related
- 1991-05-16 WO PCT/US1991/003466 patent/WO1992020341A1/en not_active Ceased
- 1991-05-21 NZ NZ247836A patent/NZ247836A/en not_active IP Right Cessation
- 1991-05-21 IL IL9820491A patent/IL98204A/en not_active IP Right Cessation
- 1991-05-29 IN IN409/MAS/91A patent/IN172210B/en unknown
- 1991-06-28 CN CN91104472A patent/CN1037235C/zh not_active Expired - Fee Related
1993
- 1993-11-15 FI FI935039A patent/FI111219B/fi active
- 1993-11-15 NO NO934115A patent/NO304814B1/no not_active IP Right Cessation
2000
- 2000-01-07 GR GR20000400023T patent/GR3032325T3/el not_active IP Right Cessation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4853386A (en) *	1985-08-17	1989-08-01	Boehringer Mannheim Gmbh	N6 -disubstituted purine derivatives, and pharmaceutical compositions containing them, useful for treating allergic diseases, bronchospastic and bronchoconstrictory conditions
US5021422A (en) *	1989-06-08	1991-06-04	Senetek Plc	Method and composition for treating hyperproliferative skin diseases using 6-aminopurine cytokinins

Also Published As

Publication number	Publication date
DE69131692T2 (de)	2000-03-16
ES2140392T5 (es)	2004-10-16
EP0584068A1 (en)	1994-03-02
DE69131692T3 (de)	2004-09-23
FI111219B (fi)	2003-06-30
EP0584068A4 (2)	1994-04-06
NO304814B1 (no)	1999-02-22
AU666836B2 (en)	1996-02-29
DK0584068T4 (da)	2004-06-14
EP0584068B2 (en)	2004-04-28
IL98204A (en)	1994-11-11
DK0584068T3 (da)	2000-04-10
BR9107307A (pt)	1994-06-14
ES2140392T3 (es)	2000-03-01
GR3032325T3 (en)	2000-04-27
FI935039L (fi)	1993-11-15
NO934115L (no)	1994-01-17
WO1992020341A1 (en)	1992-11-26
JPH10510240A (ja)	1998-10-06
DE69131692D1 (de)	1999-11-11
ATE185272T1 (de)	1999-10-15
FI935039A0 (fi)	1993-11-15
AU8188491A (en)	1992-12-30
CN1068033A (zh)	1993-01-20
NO934115D0 (no)	1993-11-15
IN172210B (2)	1993-05-01
JP3103375B2 (ja)	2000-10-30
KR100196660B1 (ko)	1999-06-15
CA2108369A1 (en)	1992-11-17
EP0584068B1 (en)	1999-10-06
NZ247836A (en)	1997-03-24
CA2108369C (en)	2003-01-28

Legal Events

Date	Code	Title	Description
1993-01-20	C06	Publication
1993-01-20	PB01	Publication
1994-10-05	C10	Entry into substantive examination
1994-10-05	SE01	Entry into force of request for substantive examination
1998-02-04	C14	Grant of patent or utility model
1998-02-04	GR01	Patent grant
2002-06-12	C15	Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
2002-06-12	OR01	Other related matters
2011-09-07	C17	Cessation of patent right
2011-09-07	CF01	Termination of patent right due to non-payment of annual fee	Granted publication date: 19980204 Termination date: 20100628

Publication	Publication Date	Title
CN1037235C (zh)	1998-02-04	6-（取代氨基）嘌呤促细胞分裂素在制备抗衰老组合物中的用途
US5614407A (en)	1997-03-25	Methods for ameliorating the adverse effects of aging
CN1160996A (zh)	1997-10-01	把物质释放至皮肤的方法及其中所用到的组合物
CN116440049B (zh)	2023-12-22	一种适用于敏感肌和具有修复皮肤屏障功效的美白组合物及其应用
CN1878530A (zh)	2006-12-13	用于毛发增粗的方法和组合物
CN118236326B (zh)	2025-01-21	一种米诺地尔泡沫剂及其制备方法
CN1655800A (zh)	2005-08-17	用于改善黑斑病的组合物以及用于减轻肌肤黯淡的组合物
KR20070122315A (ko)	2007-12-31	자가 진피 세포 및 히알루론산을 함유하는 주사용 인체연조직 충전제 조성물
CN110812306B (zh)	2021-08-06	皮肤保养及修复组合物
CN115851598A (zh)	2023-03-28	β-羟基丁酸在促进神经干细胞增殖中的用途
JP3486600B2 (ja)	2004-01-13	哺乳動物細胞の処置方法
JP6656890B2 (ja)	2020-03-04	フィラグリン産生促進剤
CN1720019A (zh)	2006-01-11	黑素细胞的树突伸长抑制剂以及含有该抑制剂的皮肤外用剂
CN114129565A (zh)	2022-03-04	组蛋白甲基转移酶ezh2抑制剂在促使骨代谢进入高转换以修复骨缺损产品中的应用
JP2000319184A (ja)	2000-11-21	皮膚の美的外観を改善するための方法
JPH06128141A (ja)	1994-05-10	皮膚外用剤
US12274686B2 (en)	2025-04-15	Specialized pro-resolving mediators (SPMs) as melanocyte growth promoter and pro-survival factors and uses thereof
IE911715A1 (en)	1992-12-02	Method and composition for ameliorating the adverse effects¹of aging
CA2525670A1 (en)	2005-02-24	Hair regenerator
JP2001026546A (ja)	2001-01-30	発がん抑制剤
NZ238210A (en)	1993-10-26	Use of 6-(substituted amino) purine cytokinins for inhibiting effects of ageing on mammalian cells
CN1157178C (zh)	2004-07-14	改善皮肤或毛发的组合物
JP2026031381A (ja)	2026-02-24	線維芽細胞増殖因子－５産生抑制剤
JP2006124399A (ja)	2006-05-18	皮膚又は毛髪の増進用組成物
KR20020063841A (ko)	2002-08-05	심미적 교정을 위한 콜로이드성 조성물