CN106029093B - 脑信号蛋白-4d结合分子治疗神经变性疾病的用途 - Google Patents

脑信号蛋白-4d结合分子治疗神经变性疾病的用途 Download PDF

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CN106029093B
CN106029093B CN201480070232.2A CN201480070232A CN106029093B CN 106029093 B CN106029093 B CN 106029093B CN 201480070232 A CN201480070232 A CN 201480070232A CN 106029093 B CN106029093 B CN 106029093B
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antibody
sema4d
sema
antigen
disease
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CN106029093A (zh
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E·S·史密斯
M·左德勒
W·J·鲍尔斯
A·乔纳森
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Vaccinex Inc
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    • A—HUMAN NECESSITIES
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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CN201480070232.2A 2013-10-21 2014-10-21 脑信号蛋白-4d结合分子治疗神经变性疾病的用途 Active CN106029093B (zh)

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US201361893814P 2013-10-21 2013-10-21
US61/893,814 2013-10-21
US201461979384P 2014-04-14 2014-04-14
US61/979,384 2014-04-14
US201462012805P 2014-06-16 2014-06-16
US62/012,805 2014-06-16
PCT/US2014/061592 WO2015061330A1 (en) 2013-10-21 2014-10-21 Use of semaphorin-4d binding molecules for treating neurodegenerative disorders

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CN117597360A (zh) 2020-06-25 2024-02-23 瓦西尼斯公司 脑信号蛋白-4d结合分子在rett综合征治疗中的应用
JPWO2022137964A1 (2) * 2020-12-23 2022-06-30
JP2024535403A (ja) * 2021-09-27 2024-09-30 バクシネックス インコーポレーティッド 神経変性障害を処置するための抗セマフォリン４ｄ結合分子の使用に関する予測アウトカムプロファイリング
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