ES3063301T3 - Use of semaphorin-4d binding molecules for treating neurodegenerative disorders - Google Patents

Use of semaphorin-4d binding molecules for treating neurodegenerative disorders

Info

Publication number
ES3063301T3
ES3063301T3 ES19208515T ES19208515T ES3063301T3 ES 3063301 T3 ES3063301 T3 ES 3063301T3 ES 19208515 T ES19208515 T ES 19208515T ES 19208515 T ES19208515 T ES 19208515T ES 3063301 T3 ES3063301 T3 ES 3063301T3
Authority
ES
Spain
Prior art keywords
semaphorin
binding molecules
neurodegenerative disorders
treating neurodegenerative
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES19208515T
Other languages
English (en)
Spanish (es)
Inventor
Ernest S Smith
Maurice Zauderer
William J Bowers
Alan Jonason
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vaccinex Inc
Original Assignee
Vaccinex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Application granted granted Critical
Publication of ES3063301T3 publication Critical patent/ES3063301T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES19208515T 2013-10-21 2014-10-21 Use of semaphorin-4d binding molecules for treating neurodegenerative disorders Active ES3063301T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361893814P 2013-10-21 2013-10-21
US201461979384P 2014-04-14 2014-04-14
US201462012805P 2014-06-16 2014-06-16

Publications (1)

Publication Number Publication Date
ES3063301T3 true ES3063301T3 (en) 2026-04-16

Family

ID=52826380

Family Applications (2)

Application Number Title Priority Date Filing Date
ES19208515T Active ES3063301T3 (en) 2013-10-21 2014-10-21 Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
ES14855074T Active ES2773961T3 (es) 2013-10-21 2014-10-21 Uso de moléculas de unión a semaforina-4D para el tratamiento de trastornos neurodegenerativos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES14855074T Active ES2773961T3 (es) 2013-10-21 2014-10-21 Uso de moléculas de unión a semaforina-4D para el tratamiento de trastornos neurodegenerativos

Country Status (19)

Country Link
US (4) US9598495B2 (2)
EP (3) EP3639853B1 (2)
JP (2) JP6461944B2 (2)
KR (4) KR102308493B1 (2)
CN (2) CN106029093B (2)
AU (3) AU2014340210B2 (2)
BR (1) BR112016009047B1 (2)
CA (2) CA2927841C (2)
DK (1) DK3060252T3 (2)
EA (1) EA033072B1 (2)
ES (2) ES3063301T3 (2)
IL (3) IL275720B (2)
MX (2) MX374708B (2)
NZ (1) NZ630892A (2)
PL (1) PL3060252T3 (2)
PT (1) PT3060252T (2)
SG (2) SG10201707786QA (2)
WO (1) WO2015061330A1 (2)
ZA (1) ZA201602686B (2)

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US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
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EP3585435A4 (en) * 2017-02-22 2020-12-16 Vaccinex, Inc. EARLY DETECTION OF GLIAL CELL ACTIVATION IN NEURODEGENERATIVE OR NEURO-INFLAMMATORY DISEASES
ES2963046T3 (es) 2017-03-20 2024-03-25 Vaccinex Inc Tratamiento del cáncer con un anticuerpo contra la semaforina-4d combinado con un agente modulador epigenético
CA3061963A1 (en) 2017-05-05 2018-11-08 Vaccinex, Inc. Human anti-semaphorin 4d antibody
CN109410218B (zh) * 2018-10-08 2020-08-11 百度在线网络技术（北京）有限公司 用于生成车辆损伤信息的方法和装置
EP3693380A1 (en) * 2019-02-11 2020-08-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Dual inhibition of plexin-b1 and plexin-b2
CN117597360A (zh) 2020-06-25 2024-02-23 瓦西尼斯公司 脑信号蛋白-4d结合分子在rett综合征治疗中的应用
JPWO2022137964A1 (2) * 2020-12-23 2022-06-30
JP2024535403A (ja) * 2021-09-27 2024-09-30 バクシネックス インコーポレーティッド 神経変性障害を処置するための抗セマフォリン４ｄ結合分子の使用に関する予測アウトカムプロファイリング
US20230101618A1 (en) * 2021-09-27 2023-03-30 Vaccinex, Inc. Predictive outcome profiling for use of an anti-semaphorin-4d binding molecule to treat neurodegenerative disorders
US20230331863A1 (en) 2022-02-13 2023-10-19 Vaccinex, Inc. Combination therapy with semaphorin-4d blockade and htt-lowering agent for treatment of huntington's disease
AU2024243083A1 (en) * 2023-04-03 2025-11-20 Sialbio Co., Ltd. Pharmaceutical composition for preventing or treating sjogren's syndrome, containing recombinant anti-semaphorin 4d antibody as active ingredient
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WO2026030311A1 (en) * 2024-07-29 2026-02-05 Vaccinex, Inc. Use of semaphorin-4d inhibitory molecules to treat cognitive impairment

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Also Published As

Publication number Publication date
US20190322757A1 (en) 2019-10-24
CA3193983A1 (en) 2015-04-30
ES2773961T3 (es) 2020-07-15
AU2021202095A1 (en) 2021-05-06
MX2016005050A (es) 2016-08-17
KR20160065981A (ko) 2016-06-09
MX2020009260A (es) 2020-10-01
KR20210118246A (ko) 2021-09-29
EP3060252A1 (en) 2016-08-31
CN106029093A (zh) 2016-10-12
EP4717270A2 (en) 2026-04-01
IL245089B (en) 2020-10-29
PT3060252T (pt) 2020-03-04
BR112016009047B1 (pt) 2024-02-06
JP6461944B2 (ja) 2019-01-30
CA2927841A1 (en) 2015-04-30
AU2014340210A1 (en) 2016-05-05
US9249227B2 (en) 2016-02-02
ZA201602686B (en) 2020-11-25
EP3060252A4 (en) 2017-06-07
EP3639853C0 (en) 2026-01-21
CN106029093B (zh) 2023-03-28
AU2021202095B2 (en) 2023-11-02
AU2021202095B9 (en) 2023-11-09
EP3060252B1 (en) 2019-12-11
KR102602502B1 (ko) 2023-11-14
EA033072B1 (ru) 2019-08-30
IL275720A (en) 2020-08-31
WO2015061330A1 (en) 2015-04-30
CN116966293A (zh) 2023-10-31
US9598495B2 (en) 2017-03-21
PL3060252T3 (pl) 2020-05-18
SG11201603167YA (en) 2016-05-30
AU2014340210B2 (en) 2019-08-08
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IL295045B2 (en) 2024-04-01
JP2019059786A (ja) 2019-04-18
AU2019257379B2 (en) 2021-04-01
EP3639853A1 (en) 2020-04-22
JP6875363B2 (ja) 2021-05-26
AU2019257379A1 (en) 2019-11-14
KR20230159633A (ko) 2023-11-21
BR112016009047A2 (pt) 2017-09-19
IL275720B (en) 2022-09-01
NZ630892A (en) 2016-03-31
KR20220110853A (ko) 2022-08-09
IL295045A (en) 2022-09-01
JP2017502920A (ja) 2017-01-26
DK3060252T3 (da) 2020-03-16
US20150110800A1 (en) 2015-04-23
US10385136B2 (en) 2019-08-20
US20170198053A1 (en) 2017-07-13
IL245089A0 (en) 2016-06-30
EA201690813A1 (ru) 2016-08-31
US20150353641A1 (en) 2015-12-10
MX374708B (es) 2025-03-06
SG10201707786QA (en) 2017-10-30
CA2927841C (en) 2023-05-23
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IL295045B1 (en) 2023-12-01
KR102308493B1 (ko) 2021-10-07

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