CN1080263C - 合成β－构型二氧戊环核苷的方法及中间体 - Google Patents

合成β－构型二氧戊环核苷的方法及中间体 Download PDF

Info

Publication number
CN1080263C
CN1080263C CN96199879A CN96199879A CN1080263C CN 1080263 C CN1080263 C CN 1080263C CN 96199879 A CN96199879 A CN 96199879A CN 96199879 A CN96199879 A CN 96199879A CN 1080263 C CN1080263 C CN 1080263C
Authority
CN
China
Prior art keywords
formula
alkyl
hydrogen
group
iodine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN96199879A
Other languages
English (en)
Chinese (zh)
Other versions
CN1208414A (zh
Inventor
T·曼索尔
A·斯姆波伊尔
K·贝德纳斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Canada Inc
Original Assignee
Biochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochem Pharma Inc filed Critical Biochem Pharma Inc
Publication of CN1208414A publication Critical patent/CN1208414A/zh
Application granted granted Critical
Publication of CN1080263C publication Critical patent/CN1080263C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN96199879A 1995-12-14 1996-12-13 合成β－构型二氧戊环核苷的方法及中间体 Expired - Lifetime CN1080263C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9525606.1A GB9525606D0 (en) 1995-12-14 1995-12-14 Method and compositions for the synthesis of dioxolane nucleosides with › - configuration
GB9525606.1 1995-12-14

Publications (2)

Publication Number Publication Date
CN1208414A CN1208414A (zh) 1999-02-17
CN1080263C true CN1080263C (zh) 2002-03-06

Family

ID=10785435

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96199879A Expired - Lifetime CN1080263C (zh) 1995-12-14 1996-12-13 合成β－构型二氧戊环核苷的方法及中间体

Country Status (27)

Country Link
US (4) US5922867A (2)
EP (1) EP0970074B1 (2)
JP (1) JP3229990B2 (2)
KR (1) KR100406159B1 (2)
CN (1) CN1080263C (2)
AP (1) AP879A (2)
AT (1) ATE214699T1 (2)
AU (1) AU706328B2 (2)
BR (1) BR9612351A (2)
CA (1) CA2237730C (2)
DE (1) DE69620042T2 (2)
DK (1) DK0970074T3 (2)
EA (1) EA000844B1 (2)
ES (1) ES2172697T3 (2)
GB (1) GB9525606D0 (2)
HU (1) HU224076B1 (2)
IL (3) IL144155A (2)
IN (1) IN187349B (2)
MX (1) MX9804701A (2)
NO (1) NO309901B1 (2)
NZ (1) NZ323855A (2)
OA (1) OA11094A (2)
PL (1) PL188447B1 (2)
PT (1) PT970074E (2)
TW (1) TW341574B (2)
WO (1) WO1997021706A1 (2)
ZA (1) ZA9610544B (2)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0986375A2 (en) 1997-04-07 2000-03-22 Triangle Pharmaceuticals Inc. Use of mkc-442 in combination with other antiviral agents
CA2340214C (en) 1998-08-12 2007-10-30 Triangle Pharmaceuticals, Inc. Method of manufacture of 1,3-oxathiolane nucleosides
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
PT1140937E (pt) 1998-12-23 2004-04-30 Shire Biochem Inc Analogos de nucleosidos antivirais
AU2653200A (en) * 1999-02-11 2000-08-29 Biochem Pharma Inc. Stereoselective synthesis of nucleoside analogues
DE60011637T2 (de) * 1999-09-24 2004-11-11 Shire Biochem Inc., Laval Dioxolan nukleosidanalogen zur behandlung und vorbeugung von viralen infektionen
US6566365B1 (en) * 1999-11-04 2003-05-20 Biochem Pharma Inc. Method for the treatment of Flaviviridea viral infection using nucleoside analogues
WO2001058920A2 (en) * 2000-02-10 2001-08-16 Mitsui Chemicals, Inc. Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside
EP1265890B1 (en) 2000-02-11 2007-04-18 Shire BioChem Inc. Stereoselective synthesis of nucleoside analogues
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
KR101150250B1 (ko) * 2001-03-01 2012-06-12 아보트 래버러토리즈 시스-ｆｔｃ의 다형 및 기타 결정형
AU2002329970A1 (en) * 2001-09-04 2003-03-18 Isis Pharmaceuticals, Inc. Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase
CA2465682A1 (en) * 2001-11-02 2003-05-08 Shire Biochem Inc. Methods of treating leukemia
EP1569652A4 (en) * 2001-12-14 2008-07-02 Pharmasset Inc NUCLEOSIDES N SP 4 / SP-ACYLCYTOSINES FOR THE TREATMENT OF VIRAL INFECTIONS
CA2473736C (en) 2002-01-25 2011-10-11 Shire Biochem Inc. Process for producing dioxolane nucleoside analogues
EP1534255B1 (en) 2002-08-06 2011-01-19 Pharmasset, Inc. Processes for preparing 1,3-dioxolane nucleosides
ES2394304T3 (es) 2002-10-15 2013-01-30 Exxonmobil Chemical Patents, Inc. Sistema de múltiples catalizadores para la polimerización de olefinas y polímeros producidos a partir de éstos
DE10335061B4 (de) 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
BRPI0507363A (pt) 2004-02-03 2007-07-03 Univ Emory métodos para manufatura de 1,3-dioxolano nucleosìdeos
US7749531B2 (en) * 2005-06-08 2010-07-06 Indicator Systems International Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) * 2007-07-30 2017-10-24 Rfs Pharma Llc processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) * 2009-04-17 2012-01-25 中国石油化工股份有限公司 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
WO2018022263A1 (en) 2016-07-29 2018-02-01 Exxonmobil Chemical Patents Inc. Polymerization processes using high molecular weight polyhydric quenching agents
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy
JP7337539B2 (ja) 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014729A1 (en) * 1991-02-22 1992-09-03 Emory University Antiviral 1,3-dioxolane nucleosides and synthesis thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0673086A (ja) * 1992-06-22 1994-03-15 Eli Lilly & Co 立体選択的な陰イオングリコシル化法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014729A1 (en) * 1991-02-22 1992-09-03 Emory University Antiviral 1,3-dioxolane nucleosides and synthesis thereof

Also Published As

Publication number Publication date
GB9525606D0 (en) 1996-02-14
MX9804701A (es) 1998-10-31
CA2237730C (en) 2001-12-04
EP0970074A1 (en) 2000-01-12
EA000844B1 (ru) 2000-06-26
PT970074E (pt) 2002-09-30
NO982716D0 (no) 1998-06-12
AU1089397A (en) 1997-07-03
AU706328B2 (en) 1999-06-17
IL144155A (en) 2003-07-06
IL124663A (en) 2001-10-31
HUP9901050A3 (en) 2001-05-28
OA11094A (en) 2003-03-13
IL124663A0 (en) 1998-12-06
ZA9610544B (en) 1997-07-29
DE69620042T2 (de) 2002-10-17
HK1017886A1 (en) 1999-12-03
NO309901B1 (no) 2001-04-17
CN1208414A (zh) 1999-02-17
ATE214699T1 (de) 2002-04-15
PL327443A1 (en) 1998-12-07
KR100406159B1 (ko) 2004-11-16
US20020058670A1 (en) 2002-05-16
IL144155A0 (en) 2002-05-23
ES2172697T3 (es) 2002-10-01
EA199800555A1 (ru) 1999-02-25
US6069250A (en) 2000-05-30
JP2000501714A (ja) 2000-02-15
DE69620042D1 (de) 2002-04-25
IN187349B (2) 2002-03-30
AP9801252A0 (en) 1998-06-30
PL188447B1 (pl) 2005-02-28
KR19990072141A (ko) 1999-09-27
AP879A (en) 2000-10-02
NO982716L (no) 1998-06-12
WO1997021706A1 (en) 1997-06-19
EP0970074B1 (en) 2002-03-20
JP3229990B2 (ja) 2001-11-19
TW341574B (en) 1998-10-01
US5922867A (en) 1999-07-13
BR9612351A (pt) 1999-07-13
CA2237730A1 (en) 1997-06-19
HU224076B1 (hu) 2005-05-30
DK0970074T3 (da) 2002-07-15
NZ323855A (en) 1999-11-29
US20030060476A1 (en) 2003-03-27
HUP9901050A2 (hu) 2001-04-28

Similar Documents

Publication Publication Date Title
CN1080263C (zh) 合成β－构型二氧戊环核苷的方法及中间体
KR100381705B1 (ko) 비씨에이취-189와 그 관련 화합물의 입체선택적 합성방법및 비씨에이취-189의 신규한 유도체
KR0160144B1 (ko) 뉴클레오시드의 부분 입체 이성체를 선택적으로 합성하는 방법
Fleet et al. Methyl 5-0-tert-butyldiphenylsilyl-2-deoxy-α β-d-threo-pentofuranoside as a divergent intermediate for the synthesis of 3'-substituted-2', 3'-dideoxynucleosides: synthesis of 3'-azido-3'-deoxythymidine, 3'-deoxy-3'-fluorothymidine and 3'-cyano-3'-deoxythymidine.
CN1149871A (zh) 核苷类似物的非对映选择合成方法
JP2009161553A (ja) 新規なピラジン誘導体またはその塩、それらを含有する医薬組成物並びにそれらの製造中間体
CN1049435C (zh) 含苯基和杂环基的青蒿素衍生物及其制备方法
WO1993018051A1 (fr) Procede de production de derive de nucleosides
HK1017886B (en) METHOD AND INTERMEDIATE FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDE WITH β-CONFIGURATION
CN1041167C (zh) 免疫抑制剂
CN101076536A (zh) β－核苷的立体选择性合成
EA020552B1 (ru) Способ получения производных дезоксирибофуранозы
US5153337A (en) Stereo and enantioselective synthesis of tetrahydro-5-substituted-3-methylene-2-furanmethanols
JPH06263793A (ja) ピラノース型ヌクレオシド誘導体
CN1222157A (zh) 高收率非对映选择性合成二脱氧核苷的方法
KR20200022257A (ko) Sglt-2 억제제인 다파글리플로진 전구체의 제조방법
WO2003040139A1 (en) Diastereoselective process for the preparation of the antiviral agent4-amino-1-(2r-hydroxymethyl-[1,3]oxathiolan-5s-yl)-1h-pyrimidin-2-one
CN1629176A (zh) 含羟胺的l－核苷类似物、其制备方法及其应用
JPWO1993018051A1 (ja) ヌクレオシド誘導体の製造方法
HK1020969A (en) Processes for high-yield diastereoselective synthesis of dideoxynucleosides
CN1177593A (zh) 新的n－取代的环胺、其制备方法以及含有它们的药物组合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term

Granted publication date: 20020306

EXPY Termination of patent right or utility model