ZA9610544B - Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration - Google Patents

Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration

Info

Publication number: ZA9610544B
Authority: ZA; South Africa
Prior art keywords: beta; synthesis; compositions; configuration; dioxolane nucleosides
Prior art date: 1995-12-14

Application number

ZA9610544A

Other languages

English (en)

Inventor

Tarek Mansour

Alex Cimpoia

Krzystof Bednarski

Original Assignee

Iaf Biochem Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-14

Filing date

1996-12-13

Publication date

1997-07-29

1996-12-13 Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int

1997-07-29 Publication of ZA9610544B publication Critical patent/ZA9610544B/xx

Links

230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
239000002777 nucleoside Substances 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA9610544A 1995-12-14 1996-12-13 Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration ZA9610544B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9525606.1A GB9525606D0 (en)	1995-12-14	1995-12-14	Method and compositions for the synthesis of dioxolane nucleosides with - configuration

Publications (1)

Publication Number	Publication Date
ZA9610544B true ZA9610544B (en)	1997-07-29

Family

ID=10785435

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9610544A ZA9610544B (en)	1995-12-14	1996-12-13	Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration

Country Status (27)

Country	Link
US (4)	US5922867A (2)
EP (1)	EP0970074B1 (2)
JP (1)	JP3229990B2 (2)
KR (1)	KR100406159B1 (2)
CN (1)	CN1080263C (2)
AP (1)	AP879A (2)
AT (1)	ATE214699T1 (2)
AU (1)	AU706328B2 (2)
BR (1)	BR9612351A (2)
CA (1)	CA2237730C (2)
DE (1)	DE69620042T2 (2)
DK (1)	DK0970074T3 (2)
EA (1)	EA000844B1 (2)
ES (1)	ES2172697T3 (2)
GB (1)	GB9525606D0 (2)
HU (1)	HU224076B1 (2)
IL (3)	IL144155A (2)
IN (1)	IN187349B (2)
MX (1)	MX9804701A (2)
NO (1)	NO309901B1 (2)
NZ (1)	NZ323855A (2)
OA (1)	OA11094A (2)
PL (1)	PL188447B1 (2)
PT (1)	PT970074E (2)
TW (1)	TW341574B (2)
WO (1)	WO1997021706A1 (2)
ZA (1)	ZA9610544B (2)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0986375A2 (en)	1997-04-07	2000-03-22	Triangle Pharmaceuticals Inc.	Use of mkc-442 in combination with other antiviral agents
CA2340214C (en)	1998-08-12	2007-10-30	Triangle Pharmaceuticals, Inc.	Method of manufacture of 1,3-oxathiolane nucleosides
US6979561B1 (en)	1998-10-09	2005-12-27	Gilead Sciences, Inc.	Non-homogeneous systems for the resolution of enantiomeric mixtures
PT1140937E (pt)	1998-12-23	2004-04-30	Shire Biochem Inc	Analogos de nucleosidos antivirais
AU2653200A (en) *	1999-02-11	2000-08-29	Biochem Pharma Inc.	Stereoselective synthesis of nucleoside analogues
DE60011637T2 (de) *	1999-09-24	2004-11-11	Shire Biochem Inc., Laval	Dioxolan nukleosidanalogen zur behandlung und vorbeugung von viralen infektionen
US6566365B1 (en) *	1999-11-04	2003-05-20	Biochem Pharma Inc.	Method for the treatment of Flaviviridea viral infection using nucleoside analogues
WO2001058920A2 (en) *	2000-02-10	2001-08-16	Mitsui Chemicals, Inc.	Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside
EP1265890B1 (en)	2000-02-11	2007-04-18	Shire BioChem Inc.	Stereoselective synthesis of nucleoside analogues
WO2002051852A1 (fr) *	2000-12-27	2002-07-04	Mitsui Chemicals, Inc.	Procede de production d'un derive de saccharide non naturel
KR101150250B1 (ko) *	2001-03-01	2012-06-12	아보트 래버러토리즈	시스-ｆｔｃ의 다형 및 기타 결정형
AU2002329970A1 (en) *	2001-09-04	2003-03-18	Isis Pharmaceuticals, Inc.	Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase
CA2465682A1 (en) *	2001-11-02	2003-05-08	Shire Biochem Inc.	Methods of treating leukemia
EP1569652A4 (en) *	2001-12-14	2008-07-02	Pharmasset Inc	NUCLEOSIDES N SP 4 / SP-ACYLCYTOSINES FOR THE TREATMENT OF VIRAL INFECTIONS
CA2473736C (en)	2002-01-25	2011-10-11	Shire Biochem Inc.	Process for producing dioxolane nucleoside analogues
EP1534255B1 (en)	2002-08-06	2011-01-19	Pharmasset, Inc.	Processes for preparing 1,3-dioxolane nucleosides
ES2394304T3 (es)	2002-10-15	2013-01-30	Exxonmobil Chemical Patents, Inc.	Sistema de múltiples catalizadores para la polimerización de olefinas y polímeros producidos a partir de éstos
DE10335061B4 (de)	2003-07-31	2005-11-17	Wacker-Chemie Gmbh	Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
BRPI0507363A (pt)	2004-02-03	2007-07-03	Univ Emory	métodos para manufatura de 1,3-dioxolano nucleosìdeos
US7749531B2 (en) *	2005-06-08	2010-07-06	Indicator Systems International	Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) *	2007-07-30	2017-10-24	Rfs Pharma Llc	processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) *	2009-04-17	2012-01-25	中国石油化工股份有限公司	大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) *	2013-07-02	2013-09-11	山东大学	一种曲沙他滨的合成方法
WO2018022263A1 (en)	2016-07-29	2018-02-01	Exxonmobil Chemical Patents Inc.	Polymerization processes using high molecular weight polyhydric quenching agents
WO2019245444A1 (en)	2018-06-21	2019-12-26	Medivir Ab	Base-modified cytidine nucleotides for leukemia therapy
JP7337539B2 (ja)	2018-06-21	2023-09-04	メディヴィル・アクチエボラーグ	白血病療法のための塩基修飾シチジンヌクレオチド

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5276151A (en) *	1990-02-01	1994-01-04	Emory University	Method of synthesis of 1,3-dioxolane nucleosides
JPH0673086A (ja) *	1992-06-22	1994-03-15	Eli Lilly & Co	立体選択的な陰イオングリコシル化法

1995
- 1995-12-14 GB GBGB9525606.1A patent/GB9525606D0/en active Pending
1996
- 1996-12-13 BR BR9612351A patent/BR9612351A/pt not_active Application Discontinuation
- 1996-12-13 ZA ZA9610544A patent/ZA9610544B/xx unknown
- 1996-12-13 TW TW085115392A patent/TW341574B/zh active
- 1996-12-13 EA EA199800555A patent/EA000844B1/ru not_active IP Right Cessation
- 1996-12-13 PT PT96941539T patent/PT970074E/pt unknown
- 1996-12-13 IL IL14415596A patent/IL144155A/xx not_active IP Right Cessation
- 1996-12-13 AU AU10893/97A patent/AU706328B2/en not_active Expired
- 1996-12-13 CN CN96199879A patent/CN1080263C/zh not_active Expired - Lifetime
- 1996-12-13 AP APAP/P/1998/001252A patent/AP879A/en active
- 1996-12-13 WO PCT/CA1996/000845 patent/WO1997021706A1/en not_active Ceased
- 1996-12-13 DK DK96941539T patent/DK0970074T3/da active
- 1996-12-13 PL PL96327443A patent/PL188447B1/pl not_active IP Right Cessation
- 1996-12-13 HU HU9901050A patent/HU224076B1/hu active IP Right Grant
- 1996-12-13 AT AT96941539T patent/ATE214699T1/de not_active IP Right Cessation
- 1996-12-13 ES ES96941539T patent/ES2172697T3/es not_active Expired - Lifetime
- 1996-12-13 KR KR10-1998-0704473A patent/KR100406159B1/ko not_active Expired - Fee Related
- 1996-12-13 IL IL12466396A patent/IL124663A/en not_active IP Right Cessation
- 1996-12-13 DE DE69620042T patent/DE69620042T2/de not_active Expired - Lifetime
- 1996-12-13 US US08/849,722 patent/US5922867A/en not_active Expired - Lifetime
- 1996-12-13 CA CA002237730A patent/CA2237730C/en not_active Expired - Lifetime
- 1996-12-13 NZ NZ323855A patent/NZ323855A/xx unknown
- 1996-12-13 IN IN2810DE1996 patent/IN187349B/en unknown
- 1996-12-13 EP EP96941539A patent/EP0970074B1/en not_active Expired - Lifetime
- 1996-12-13 JP JP52157397A patent/JP3229990B2/ja not_active Expired - Lifetime
1998
- 1998-06-09 OA OA9800077A patent/OA11094A/en unknown
- 1998-06-11 MX MX9804701A patent/MX9804701A/es unknown
- 1998-06-12 NO NO982716A patent/NO309901B1/no unknown
1999
- 1999-02-17 US US09/251,431 patent/US6069250A/en not_active Expired - Lifetime
2001
- 2001-07-05 IL IL14415501A patent/IL144155A0/xx unknown
- 2001-11-16 US US09/987,845 patent/US20020058670A1/en not_active Abandoned
2002
- 2002-10-02 US US10/262,107 patent/US20030060476A1/en not_active Abandoned

Also Published As

Publication number	Publication date
GB9525606D0 (en)	1996-02-14
MX9804701A (es)	1998-10-31
CA2237730C (en)	2001-12-04
EP0970074A1 (en)	2000-01-12
EA000844B1 (ru)	2000-06-26
PT970074E (pt)	2002-09-30
NO982716D0 (no)	1998-06-12
AU1089397A (en)	1997-07-03
AU706328B2 (en)	1999-06-17
IL144155A (en)	2003-07-06
IL124663A (en)	2001-10-31
HUP9901050A3 (en)	2001-05-28
OA11094A (en)	2003-03-13
IL124663A0 (en)	1998-12-06
DE69620042T2 (de)	2002-10-17
HK1017886A1 (en)	1999-12-03
NO309901B1 (no)	2001-04-17
CN1208414A (zh)	1999-02-17
ATE214699T1 (de)	2002-04-15
PL327443A1 (en)	1998-12-07
KR100406159B1 (ko)	2004-11-16
US20020058670A1 (en)	2002-05-16
IL144155A0 (en)	2002-05-23
ES2172697T3 (es)	2002-10-01
EA199800555A1 (ru)	1999-02-25
US6069250A (en)	2000-05-30
JP2000501714A (ja)	2000-02-15
DE69620042D1 (de)	2002-04-25
IN187349B (2)	2002-03-30
AP9801252A0 (en)	1998-06-30
PL188447B1 (pl)	2005-02-28
KR19990072141A (ko)	1999-09-27
AP879A (en)	2000-10-02
NO982716L (no)	1998-06-12
WO1997021706A1 (en)	1997-06-19
EP0970074B1 (en)	2002-03-20
JP3229990B2 (ja)	2001-11-19
TW341574B (en)	1998-10-01
US5922867A (en)	1999-07-13
BR9612351A (pt)	1999-07-13
CA2237730A1 (en)	1997-06-19
HU224076B1 (hu)	2005-05-30
DK0970074T3 (da)	2002-07-15
NZ323855A (en)	1999-11-29
US20030060476A1 (en)	2003-03-27
HUP9901050A2 (hu)	2001-04-28
CN1080263C (zh)	2002-03-06

Publication	Publication Date	Title
IL124663A0 (en)	1998-12-06	Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration
AU2447195A (en)	1995-11-16	Process for the diastereoselective synthesis of nucleoside analogues
AU4237896A (en)	1996-06-06	Method and intermediates for the synthesis of korupensamines
EP0481038A4 (en)	1993-03-03	Saccharide compositions, methods and apparatus for their synthesis
TW352042U (en)	1999-02-01	High speed fastening apparatus
HUP9603377A3 (en)	1999-05-28	Crystalline maltitol composition and method for preparing the same
GB9225030D0 (en)	1993-01-20	Solvent based enzymatic synthesis
GB9503066D0 (en)	1995-04-05	Gas generating composition
EP0861817A4 (en)	1999-03-10	GAS GENERATING COMPOSITION
IL129868A0 (en)	2000-02-29	Process for the synthesis of benzothiopenes
PL316985A1 (en)	1997-03-03	Derivatives of adenosine
AU4980097A (en)	1998-05-15	Efficient synthesis of nucleosides
AU7706191A (en)	1991-11-28	Synthesis of nucleotide and nucleoside derivatives
GB9400987D0 (en)	1994-03-16	Production of nucleoside analogues
IL118238A0 (en)	1996-09-12	Synthesis of benzoquinolinones
IL113555A0 (en)	1995-08-31	Process for the synthesis of haloalkylferrocenes
SI0817784T1 (en)	2003-10-31	Process for the synthesis of nucleoside analogues
EG21037A (en)	2000-09-30	Process for the synthesis of benzathiophenes
GB9319985D0 (en)	1993-11-17	Method of making nucleosides
HU9501956D0 (en)	1995-09-28	Antiviral compositions and process for producing them
ZA953235B (en)	1995-12-21	Process for the diastereoselective synthesis of nucleoside analogues
SI0757684T1 (en)	1999-12-31	Process for the diastereoselective synthesis of nucleoside analogues
RU1833505C (ru)	1993-08-07	Cпocoб пoлучehия 2-tpet-буtил-4-metилфehoлa
AU6905394A (en)	1994-11-21	Method of reducing hcn in synthesis gas
AU131679S (en)	1997-10-08	Shield clock