CN1101806C - 苯乙酰胺和苯乙酸的新偕二氟衍生物及其药物学应用 - Google Patents

苯乙酰胺和苯乙酸的新偕二氟衍生物及其药物学应用 Download PDF

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Publication number
CN1101806C
CN1101806C CN96108142A CN96108142A CN1101806C CN 1101806 C CN1101806 C CN 1101806C CN 96108142 A CN96108142 A CN 96108142A CN 96108142 A CN96108142 A CN 96108142A CN 1101806 C CN1101806 C CN 1101806C
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CN
China
Prior art keywords
substituted
hydrogen
alkyl
fluoro
compound
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Expired - Fee Related
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CN96108142A
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English (en)
Chinese (zh)
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CN1159443A (zh
Inventor
N·伯切特
A·D·C·皮多
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Fundacao Oswaldo Cruz
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Fundacao Oswaldo Cruz
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Publication of CN1159443A publication Critical patent/CN1159443A/zh
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Publication of CN1101806C publication Critical patent/CN1101806C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN96108142A 1996-03-11 1996-06-10 苯乙酰胺和苯乙酸的新偕二氟衍生物及其药物学应用 Expired - Fee Related CN1101806C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BRPI96009756 1996-03-11
BR9600975A BR9600975A (pt) 1996-03-11 1996-03-11 Derivados do ácido gem-difluorfenilacético e de gem-difluorfenilacetamida processo de sua preparação e suas aplicações farmacêuticas
BRPI9600975-6 1996-03-11

Publications (2)

Publication Number Publication Date
CN1159443A CN1159443A (zh) 1997-09-17
CN1101806C true CN1101806C (zh) 2003-02-19

Family

ID=38353109

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96108142A Expired - Fee Related CN1101806C (zh) 1996-03-11 1996-06-10 苯乙酰胺和苯乙酸的新偕二氟衍生物及其药物学应用

Country Status (10)

Country Link
JP (1) JP3947242B2 (2)
CN (1) CN1101806C (2)
BE (1) BE1010031A5 (2)
BR (1) BR9600975A (2)
CH (1) CH690722A5 (2)
DE (1) DE19610357C2 (2)
ES (1) ES2130923B1 (2)
FR (1) FR2745810B1 (2)
GB (1) GB2311066B (2)
IT (1) IT1283256B1 (2)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9922830D0 (en) * 1999-09-27 1999-11-24 Novartis Ag Processes
JP5685384B2 (ja) * 2010-03-29 2015-03-18 公益財団法人相模中央化学研究所 ３，３−ジフルオロ−２，３−ジヒドロインドール−２−オン誘導体の製造方法
CN108299137B (zh) * 2018-04-09 2020-04-14 中南大学 一种靛红腙类化合物选择性氟化方法
GB201916600D0 (en) * 2019-11-14 2020-01-01 Syngenta Crop Protection Ag 81991-gb-reg-org-nat-1
CN113698308B (zh) * 2021-08-25 2024-06-21 山东辰龙药业有限公司 一种溴芬酸钠合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5220064A (en) * 1986-11-26 1993-06-15 Warner-Lambert Company Substituted 4'-hydroxyphenylacetic acid derivatives having antiinflammatory and analgesic activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3895063A (en) * 1965-04-08 1975-07-15 Ciba Geigy Corp Substituted Anilino Benzyl Alcohols
US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
IL64724A0 (en) * 1981-02-17 1982-03-31 Robins Co Inc A H 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5220064A (en) * 1986-11-26 1993-06-15 Warner-Lambert Company Substituted 4'-hydroxyphenylacetic acid derivatives having antiinflammatory and analgesic activity

Also Published As

Publication number Publication date
CN1159443A (zh) 1997-09-17
GB2311066A (en) 1997-09-17
ES2130923A1 (es) 1999-07-01
JPH09323962A (ja) 1997-12-16
ITMI960505A1 (it) 1997-09-15
BE1010031A5 (fr) 1997-11-04
BR9600975A (pt) 1997-12-30
GB2311066B (en) 1999-12-08
DE19610357A1 (de) 1997-09-18
GB9605407D0 (en) 1996-05-15
JP3947242B2 (ja) 2007-07-18
ITMI960505A0 (2) 1996-03-15
DE19610357C2 (de) 1998-08-13
FR2745810A1 (fr) 1997-09-12
IT1283256B1 (it) 1998-04-16
CH690722A5 (fr) 2000-12-29
FR2745810B1 (fr) 1998-06-19
ES2130923B1 (es) 2000-01-16

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