CN1107677C - 喜树碱衍生物和制备方法及其作为抗肿瘤剂的应用 - Google Patents

喜树碱衍生物和制备方法及其作为抗肿瘤剂的应用 Download PDF

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Publication number
CN1107677C
CN1107677C CN97192493A CN97192493A CN1107677C CN 1107677 C CN1107677 C CN 1107677C CN 97192493 A CN97192493 A CN 97192493A CN 97192493 A CN97192493 A CN 97192493A CN 1107677 C CN1107677 C CN 1107677C
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China
Prior art keywords
compound
formula
hydrogen
compounds
alkyl
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Expired - Fee Related
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CN97192493A
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English (en)
Chinese (zh)
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CN1211987A (zh
Inventor
L·默里尼
S·潘科
F·尊尼诺
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Istituto Nazionale per lo Studio e la Cura die Tumori
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Istituto Nazionale per lo Studio e la Cura die Tumori
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Application filed by Istituto Nazionale per lo Studio e la Cura die Tumori filed Critical Istituto Nazionale per lo Studio e la Cura die Tumori
Publication of CN1211987A publication Critical patent/CN1211987A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
CN97192493A 1996-02-23 1997-02-19 喜树碱衍生物和制备方法及其作为抗肿瘤剂的应用 Expired - Fee Related CN1107677C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI96A000338 1996-02-23
IT96MI000338A IT1282673B1 (it) 1996-02-23 1996-02-23 Derivati della camptotecina e loro uso come agenti antitumorali

Publications (2)

Publication Number Publication Date
CN1211987A CN1211987A (zh) 1999-03-24
CN1107677C true CN1107677C (zh) 2003-05-07

Family

ID=11373368

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97192493A Expired - Fee Related CN1107677C (zh) 1996-02-23 1997-02-19 喜树碱衍生物和制备方法及其作为抗肿瘤剂的应用

Country Status (22)

Country Link
US (2) US6130227A (2)
EP (1) EP0885230B1 (2)
JP (1) JP4171527B2 (2)
KR (1) KR100497906B1 (2)
CN (1) CN1107677C (2)
AT (1) ATE221071T1 (2)
AU (1) AU718361B2 (2)
BR (1) BR9707622B1 (2)
CZ (1) CZ289268B6 (2)
DE (1) DE69714220T2 (2)
DK (1) DK0885230T3 (2)
EE (1) EE03529B1 (2)
ES (1) ES2180932T3 (2)
HU (1) HUP9900987A3 (2)
IL (1) IL125856A (2)
IT (1) IT1282673B1 (2)
NZ (1) NZ331126A (2)
PT (1) PT885230E (2)
RU (1) RU2165935C2 (2)
SK (1) SK283217B6 (2)
UA (1) UA49005C2 (2)
WO (1) WO1997031003A1 (2)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002519335A (ja) * 1998-06-26 2002-07-02 クアナム メディカル コーポレイション 再狭窄の予防のためのトポイソメラーゼインヒビター
ATE216998T1 (de) * 1999-03-09 2002-05-15 Sigma Tau Ind Farmaceuti Camptothecin-derivate mit antitumor-wirkung
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
AR025587A1 (es) 1999-09-13 2002-12-04 Hoffmann La Roche Formulaciones en dispersion que contienen inhibidores de lipasa
US6950757B2 (en) * 2001-04-11 2005-09-27 Emerald Biostructures, Inc. Screening methods for identifying ligands
RU2319482C2 (ru) * 2001-11-23 2008-03-20 Чугаи Сейяку Кабусики Кайся Способ идентификации противоопухолевых целевых ферментов
RU2300535C2 (ru) * 2002-03-01 2007-06-10 Фармация Италия С.П.А. Полиморфная форма кристаллического гидрохлорида иринотекана, способ ее получения и фармацевтическая композиция на ее основе
TW200306314A (en) * 2002-04-16 2003-11-16 Tanabe Seiyaku Co Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation
US7067666B2 (en) * 2003-06-27 2006-06-27 Research Triangle Institute 7-substituted camptothecin and camptothecin analogs and methods for producing the same
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
AR046579A1 (es) * 2003-11-12 2005-12-14 Smithkline Beecham Corp Compuesto cristalino de topotecan, composicion farmaceutica que lo comprende, procedimiento para prepararlo y su uso para preparar dicha composicion farmaceutica
PT1962850E (pt) * 2005-12-21 2012-05-21 Sigma Tau Ind Farmaceuti Tratamento de tumores resistentes a drogas
WO2007095389A2 (en) * 2006-02-17 2007-08-23 Novacea, Inc. Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs
CN101033230B (zh) * 2006-03-10 2010-12-08 中国科学院上海药物研究所 一类喜树碱衍生物及其应用
ITMI20061474A1 (it) * 2006-07-26 2008-01-27 Indena Spa Derivati della camptotecina ad attivita antitumorale
CN102731516B (zh) * 2011-04-07 2014-07-02 宁波天衡药业股份有限公司 一类具有抗肿瘤活性的喜树碱衍生物
CN104774209B (zh) * 2014-01-15 2018-06-19 上海海和药物研究开发有限公司 一种9-烯丙基喜树碱衍生物的合成方法
CN117940432B (zh) * 2021-09-01 2025-12-23 上海弼领生物技术有限公司 一种喜树碱类化合物、其制备方法和用途
CN120554369A (zh) * 2024-05-24 2025-08-29 深圳微芯生物科技股份有限公司 喜树碱类似物及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088642A2 (en) * 1982-03-10 1983-09-14 Kabushiki Kaisha Yakult Honsha New camptothecin derivatives and process for their preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
US5459269A (en) * 1992-06-18 1995-10-17 North Carolina State University 14-halo-camptothecins
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
IL127800A (en) * 1996-08-19 2005-11-20 Bionumerik Pharmaceuticals Inc Highly lipophilic 7-substituted camptothecin derivatives and pharmaceutical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088642A2 (en) * 1982-03-10 1983-09-14 Kabushiki Kaisha Yakult Honsha New camptothecin derivatives and process for their preparation

Also Published As

Publication number Publication date
BR9707622A (pt) 1999-07-27
EP0885230B1 (en) 2002-07-24
ITMI960338A0 (2) 1996-02-23
SK112798A3 (en) 1999-01-11
CN1211987A (zh) 1999-03-24
RU2165935C2 (ru) 2001-04-27
ITMI960338A1 (it) 1997-08-23
EP0885230A1 (en) 1998-12-23
JP2000505448A (ja) 2000-05-09
PT885230E (pt) 2002-12-31
ES2180932T3 (es) 2003-02-16
HUP9900987A2 (hu) 1999-08-30
CZ265298A3 (cs) 1999-01-13
US6130227A (en) 2000-10-10
DE69714220D1 (de) 2002-08-29
UA49005C2 (uk) 2002-09-16
AU718361B2 (en) 2000-04-13
SK283217B6 (sk) 2003-03-04
EE9800259A (et) 1999-02-15
KR100497906B1 (ko) 2006-03-09
DK0885230T3 (da) 2002-11-18
BR9707622B1 (pt) 2010-08-10
US6306868B1 (en) 2001-10-23
KR19990087110A (ko) 1999-12-15
JP4171527B2 (ja) 2008-10-22
NZ331126A (en) 2000-02-28
IT1282673B1 (it) 1998-03-31
HUP9900987A3 (en) 2000-01-28
WO1997031003A1 (en) 1997-08-28
CZ289268B6 (cs) 2001-12-12
IL125856A0 (en) 1999-04-11
ATE221071T1 (de) 2002-08-15
AU1875397A (en) 1997-09-10
IL125856A (en) 2001-08-26
EE03529B1 (et) 2001-10-15
DE69714220T2 (de) 2002-11-14

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Granted publication date: 20030507

Termination date: 20110219