CN1166597C - 含氮基团的转化方法 - Google Patents

含氮基团的转化方法 Download PDF

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Publication number: CN1166597C
Authority: CN; China
Prior art keywords: dox; cytotoxic; doxorubicin; μmol; aldehyde
Prior art date: 1995-11-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CNB021439192A

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English (en)

Chinese (zh)

Other versions

CN1405127A (zh

Inventor

A��V��ɳ��

A·V·沙利

ɼ��

A·A·纳吉

R－Z·凯

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

TURINY EDUCTATION FOUNDATION ADMINISTRATION

Original Assignee

Tulaini Education Fund Management Office

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-27

Filing date

1996-11-14

Publication date

2004-09-15

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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24247176&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1166597(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-11-14 Application filed by Tulaini Education Fund Management Office filed Critical Tulaini Education Fund Management Office

2003-03-26 Publication of CN1405127A publication Critical patent/CN1405127A/zh

2004-09-15 Application granted granted Critical

2004-09-15 Publication of CN1166597C publication Critical patent/CN1166597C/zh

2016-11-14 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

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GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 description 1
125000005270 trialkylamine group Chemical group 0.000 description 1
125000004205 trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 description 1
VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
230000002476 tumorcidal effect Effects 0.000 description 1
206010046766 uterine cancer Diseases 0.000 description 1
229940070710 valerate Drugs 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
239000003039 volatile agent Substances 0.000 description 1

Images

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)

CNB021439192A 1995-11-27 1996-11-14 含氮基团的转化方法 Expired - Lifetime CN1166597C (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/562,652		1995-11-27
US08/562,652 US5843903A (en)	1995-11-27	1995-11-27	Targeted cytotoxic anthracycline analogs

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
CNB961986050A Division CN1137136C (zh)	1995-11-27	1996-11-14	定向细胞毒性蒽环型类似物

Publications (2)

Publication Number	Publication Date
CN1405127A CN1405127A (zh)	2003-03-26
CN1166597C true CN1166597C (zh)	2004-09-15

Family

ID=24247176

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CNB021439192A Expired - Lifetime CN1166597C (zh)	1995-11-27	1996-11-14	含氮基团的转化方法
CNB961986050A Expired - Lifetime CN1137136C (zh)	1995-11-27	1996-11-14	定向细胞毒性蒽环型类似物

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CNB961986050A Expired - Lifetime CN1137136C (zh)	1995-11-27	1996-11-14	定向细胞毒性蒽环型类似物

Country Status (27)

Country	Link
US (2)	US5843903A (2)
EP (2)	EP0863917B1 (2)
JP (2)	JP3987575B2 (2)
KR (2)	KR100467899B1 (2)
CN (2)	CN1166597C (2)
AT (2)	ATE401305T1 (2)
AU (1)	AU709539B2 (2)
BR (1)	BR9611647B1 (2)
CA (2)	CA2238574C (2)
CZ (1)	CZ297297B6 (2)
DE (2)	DE69630233T2 (2)
DK (2)	DK1384710T3 (2)
EA (1)	EA001372B1 (2)
ES (2)	ES2310222T3 (2)
HK (1)	HK1052920B (2)
HU (1)	HU229870B1 (2)
IL (3)	IL119691A (2)
IS (2)	IS2178B (2)
MX (1)	MX9804119A (2)
NO (2)	NO324035B1 (2)
NZ (1)	NZ322054A (2)
PL (3)	PL191781B1 (2)
PT (2)	PT863917E (2)
SK (2)	SK284672B6 (2)
UA (1)	UA67722C2 (2)
WO (1)	WO1997019954A1 (2)
ZA (1)	ZA969709B (2)

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1995
- 1995-11-27 US US08/562,652 patent/US5843903A/en not_active Expired - Lifetime
1996
- 1996-11-14 AT AT03010988T patent/ATE401305T1/de active
- 1996-11-14 CN CNB021439192A patent/CN1166597C/zh not_active Expired - Lifetime
- 1996-11-14 CA CA002238574A patent/CA2238574C/en not_active Expired - Lifetime
- 1996-11-14 PL PL358737A patent/PL191781B1/pl unknown
- 1996-11-14 SK SK341-2004A patent/SK284672B6/sk not_active IP Right Cessation
- 1996-11-14 ES ES03010988T patent/ES2310222T3/es not_active Expired - Lifetime
- 1996-11-14 DK DK03010988T patent/DK1384710T3/da active
- 1996-11-14 NZ NZ322054A patent/NZ322054A/en not_active IP Right Cessation
- 1996-11-14 CZ CZ0135798A patent/CZ297297B6/cs not_active IP Right Cessation
- 1996-11-14 BR BRPI9611647-1A patent/BR9611647B1/pt not_active IP Right Cessation
- 1996-11-14 WO PCT/EP1996/005029 patent/WO1997019954A1/en not_active Ceased
- 1996-11-14 HU HU9903771A patent/HU229870B1/hu unknown
- 1996-11-14 KR KR10-2004-7004548A patent/KR100467899B1/ko not_active Expired - Lifetime
- 1996-11-14 CA CA002471775A patent/CA2471775C/en not_active Expired - Lifetime
- 1996-11-14 AT AT96938216T patent/ATE251179T1/de active
- 1996-11-14 EA EA199800492A patent/EA001372B1/ru not_active IP Right Cessation
- 1996-11-14 UA UA98063318A patent/UA67722C2/uk unknown
- 1996-11-14 AU AU75722/96A patent/AU709539B2/en not_active Expired
- 1996-11-14 PT PT96938216T patent/PT863917E/pt unknown
- 1996-11-14 EP EP96938216A patent/EP0863917B1/en not_active Expired - Lifetime
- 1996-11-14 DK DK96938216T patent/DK0863917T3/da active
- 1996-11-14 PT PT03010988T patent/PT1384710E/pt unknown
- 1996-11-14 PL PL96358646A patent/PL188786B1/pl unknown
- 1996-11-14 JP JP52012397A patent/JP3987575B2/ja not_active Expired - Lifetime
- 1996-11-14 EP EP03010988A patent/EP1384710B1/en not_active Expired - Lifetime
- 1996-11-14 PL PL96326865A patent/PL187230B1/pl unknown
- 1996-11-14 DE DE69630233T patent/DE69630233T2/de not_active Expired - Lifetime
- 1996-11-14 SK SK628-98A patent/SK284392B6/sk unknown
- 1996-11-14 DE DE69637604T patent/DE69637604D1/de not_active Expired - Lifetime
- 1996-11-14 CN CNB961986050A patent/CN1137136C/zh not_active Expired - Lifetime
- 1996-11-14 ES ES96938216T patent/ES2205067T3/es not_active Expired - Lifetime
- 1996-11-14 KR KR10-1998-0703948A patent/KR100445754B1/ko not_active Expired - Lifetime
- 1996-11-20 ZA ZA9609709A patent/ZA969709B/xx unknown
- 1996-11-26 IL IL11969196A patent/IL119691A/en not_active IP Right Cessation
- 1996-11-26 IL IL13468596A patent/IL134685A/en not_active IP Right Cessation
1998
- 1998-05-05 IS IS4734A patent/IS2178B/is unknown
- 1998-05-15 NO NO19982252A patent/NO324035B1/no not_active IP Right Cessation
- 1998-05-25 MX MX9804119A patent/MX9804119A/es unknown
- 1998-07-15 US US09/116,125 patent/US6184374B1/en not_active Expired - Lifetime
2000
- 2000-02-23 IL IL13468500A patent/IL134685A0/xx unknown
2003
- 2003-07-09 HK HK03104934.8A patent/HK1052920B/zh not_active IP Right Cessation
2005
- 2005-03-01 NO NO20051111A patent/NO20051111L/no not_active Application Discontinuation
2006
- 2006-11-09 IS IS8567A patent/IS2634B/is unknown
- 2006-11-15 JP JP2006309698A patent/JP4778405B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EA199800492A1 (ru)	1998-12-24
BR9611647A (pt)	1999-02-23
CA2471775C (en)	2008-01-29
US5843903A (en)	1998-12-01
ZA969709B (en)	1997-08-25
PT863917E (pt)	2004-02-27
CA2238574A1 (en)	1997-06-05
EA001372B1 (ru)	2001-02-26
NO20051111L (no)	2005-03-01
ATE401305T1 (de)	2008-08-15
KR100445754B1 (ko)	2004-12-08
NO982252L (no)	1998-05-15
EP1384710B1 (en)	2008-07-16
SK284392B6 (sk)	2005-03-04
EP0863917A1 (en)	1998-09-16
IL134685A (en)	2002-12-01
DE69637604D1 (de)	2008-08-28
PL187230B1 (pl)	2004-06-30
JP2007045845A (ja)	2007-02-22
IS2178B (is)	2006-12-15
HK1017363A1 (en)	1999-11-19
CA2238574C (en)	2004-10-19
PL191781B1 (pl)	2006-07-31
CA2471775A1 (en)	1997-06-05
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