PL191781B1 - Nowe związki antracyklinowe, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie do wytwarzania leku - Google Patents

Nowe związki antracyklinowe, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie do wytwarzania leku

Info

Publication number: PL191781B1
Authority: PL; Poland
Prior art keywords: compound; trp; cys; formula; lys
Prior art date: 1995-11-27

Application number

PL358737A

Other languages

English (en)

Polish (pl)

Inventor

Andrew Schally

Attila Nagy

Ren-Zhi Cai

Original Assignee

Univ Tulane

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-27

Filing date

1996-11-14

Publication date

2006-07-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24247176&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL191781(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-11-14 Application filed by Univ Tulane filed Critical Univ Tulane

2006-07-31 Publication of PL191781B1 publication Critical patent/PL191781B1/pl

Links

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150000002576 ketones Chemical class 0.000 description 1
231100000518 lethal Toxicity 0.000 description 1
230000001665 lethal effect Effects 0.000 description 1
125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
239000003446 ligand Substances 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
201000005202 lung cancer Diseases 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
229940049920 malate Drugs 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-L malate(2-) Chemical compound [O-]C(=O)C(O)CC([O-])=O BJEPYKJPYRNKOW-UHFFFAOYSA-L 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
230000001394 metastastic effect Effects 0.000 description 1
206010061289 metastatic neoplasm Diseases 0.000 description 1
230000000394 mitotic effect Effects 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
125000002757 morpholinyl group Chemical group 0.000 description 1
230000017066 negative regulation of growth Effects 0.000 description 1
210000005170 neoplastic cell Anatomy 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000011368 organic material Substances 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000000863 peptide conjugate Substances 0.000 description 1
230000010412 perfusion Effects 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
125000006239 protecting group Chemical group 0.000 description 1
XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 description 1
238000011002 quantification Methods 0.000 description 1
239000002994 raw material Substances 0.000 description 1
238000005932 reductive alkylation reaction Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
230000007017 scission Effects 0.000 description 1
150000003335 secondary amines Chemical group 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
229960001153 serine Drugs 0.000 description 1
JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
241000894007 species Species 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000010186 staining Methods 0.000 description 1
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201000011549 stomach cancer Diseases 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
DZLNHFMRPBPULJ-UHFFFAOYSA-N thioproline Chemical compound OC(=O)C1CSCN1 DZLNHFMRPBPULJ-UHFFFAOYSA-N 0.000 description 1
229940034199 thyrotropin-releasing hormone Drugs 0.000 description 1
231100000816 toxic dose Toxicity 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
125000005270 trialkylamine group Chemical group 0.000 description 1
VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
230000005748 tumor development Effects 0.000 description 1
229940070710 valerate Drugs 0.000 description 1
239000003039 volatile agent Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
230000004580 weight loss Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)

PL358737A 1995-11-27 1996-11-14 Nowe związki antracyklinowe, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie do wytwarzania leku PL191781B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/562,652 US5843903A (en)	1995-11-27	1995-11-27	Targeted cytotoxic anthracycline analogs
PCT/EP1996/005029 WO1997019954A1 (en)	1995-11-27	1996-11-14	Targeted cytotoxic anthracycline analogs

Publications (1)

Publication Number	Publication Date
PL191781B1 true PL191781B1 (pl)	2006-07-31

Family

ID=24247176

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PL358737A PL191781B1 (pl)	1995-11-27	1996-11-14	Nowe związki antracyklinowe, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie do wytwarzania leku
PL96358646A PL188786B1 (pl)	1995-11-27	1996-11-14	Sposób przekształcania azotu pierwszorzędowej grupy aminowej
PL96326865A PL187230B1 (pl)	1995-11-27	1996-11-14	Nowe związki antracyklinowe, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie do wytwarzania leku

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
PL96358646A PL188786B1 (pl)	1995-11-27	1996-11-14	Sposób przekształcania azotu pierwszorzędowej grupy aminowej
PL96326865A PL187230B1 (pl)	1995-11-27	1996-11-14	Nowe związki antracyklinowe, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie do wytwarzania leku

Country Status (27)

Country	Link
US (2)	US5843903A (2)
EP (2)	EP0863917B1 (2)
JP (2)	JP3987575B2 (2)
KR (2)	KR100467899B1 (2)
CN (2)	CN1166597C (2)
AT (2)	ATE401305T1 (2)
AU (1)	AU709539B2 (2)
BR (1)	BR9611647B1 (2)
CA (2)	CA2238574C (2)
CZ (1)	CZ297297B6 (2)
DE (2)	DE69630233T2 (2)
DK (2)	DK1384710T3 (2)
EA (1)	EA001372B1 (2)
ES (2)	ES2310222T3 (2)
HK (1)	HK1052920B (2)
HU (1)	HU229870B1 (2)
IL (3)	IL119691A (2)
IS (2)	IS2178B (2)
MX (1)	MX9804119A (2)
NO (2)	NO324035B1 (2)
NZ (1)	NZ322054A (2)
PL (3)	PL191781B1 (2)
PT (2)	PT863917E (2)
SK (2)	SK284672B6 (2)
UA (1)	UA67722C2 (2)
WO (1)	WO1997019954A1 (2)
ZA (1)	ZA969709B (2)

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1995
- 1995-11-27 US US08/562,652 patent/US5843903A/en not_active Expired - Lifetime
1996
- 1996-11-14 AT AT03010988T patent/ATE401305T1/de active
- 1996-11-14 CN CNB021439192A patent/CN1166597C/zh not_active Expired - Lifetime
- 1996-11-14 CA CA002238574A patent/CA2238574C/en not_active Expired - Lifetime
- 1996-11-14 PL PL358737A patent/PL191781B1/pl unknown
- 1996-11-14 SK SK341-2004A patent/SK284672B6/sk not_active IP Right Cessation
- 1996-11-14 ES ES03010988T patent/ES2310222T3/es not_active Expired - Lifetime
- 1996-11-14 DK DK03010988T patent/DK1384710T3/da active
- 1996-11-14 NZ NZ322054A patent/NZ322054A/en not_active IP Right Cessation
- 1996-11-14 CZ CZ0135798A patent/CZ297297B6/cs not_active IP Right Cessation
- 1996-11-14 BR BRPI9611647-1A patent/BR9611647B1/pt not_active IP Right Cessation
- 1996-11-14 WO PCT/EP1996/005029 patent/WO1997019954A1/en not_active Ceased
- 1996-11-14 HU HU9903771A patent/HU229870B1/hu unknown
- 1996-11-14 KR KR10-2004-7004548A patent/KR100467899B1/ko not_active Expired - Lifetime
- 1996-11-14 CA CA002471775A patent/CA2471775C/en not_active Expired - Lifetime
- 1996-11-14 AT AT96938216T patent/ATE251179T1/de active
- 1996-11-14 EA EA199800492A patent/EA001372B1/ru not_active IP Right Cessation
- 1996-11-14 UA UA98063318A patent/UA67722C2/uk unknown
- 1996-11-14 AU AU75722/96A patent/AU709539B2/en not_active Expired
- 1996-11-14 PT PT96938216T patent/PT863917E/pt unknown
- 1996-11-14 EP EP96938216A patent/EP0863917B1/en not_active Expired - Lifetime
- 1996-11-14 DK DK96938216T patent/DK0863917T3/da active
- 1996-11-14 PT PT03010988T patent/PT1384710E/pt unknown
- 1996-11-14 PL PL96358646A patent/PL188786B1/pl unknown
- 1996-11-14 JP JP52012397A patent/JP3987575B2/ja not_active Expired - Lifetime
- 1996-11-14 EP EP03010988A patent/EP1384710B1/en not_active Expired - Lifetime
- 1996-11-14 PL PL96326865A patent/PL187230B1/pl unknown
- 1996-11-14 DE DE69630233T patent/DE69630233T2/de not_active Expired - Lifetime
- 1996-11-14 SK SK628-98A patent/SK284392B6/sk unknown
- 1996-11-14 DE DE69637604T patent/DE69637604D1/de not_active Expired - Lifetime
- 1996-11-14 CN CNB961986050A patent/CN1137136C/zh not_active Expired - Lifetime
- 1996-11-14 ES ES96938216T patent/ES2205067T3/es not_active Expired - Lifetime
- 1996-11-14 KR KR10-1998-0703948A patent/KR100445754B1/ko not_active Expired - Lifetime
- 1996-11-20 ZA ZA9609709A patent/ZA969709B/xx unknown
- 1996-11-26 IL IL11969196A patent/IL119691A/en not_active IP Right Cessation
- 1996-11-26 IL IL13468596A patent/IL134685A/en not_active IP Right Cessation
1998
- 1998-05-05 IS IS4734A patent/IS2178B/is unknown
- 1998-05-15 NO NO19982252A patent/NO324035B1/no not_active IP Right Cessation
- 1998-05-25 MX MX9804119A patent/MX9804119A/es unknown
- 1998-07-15 US US09/116,125 patent/US6184374B1/en not_active Expired - Lifetime
2000
- 2000-02-23 IL IL13468500A patent/IL134685A0/xx unknown
2003
- 2003-07-09 HK HK03104934.8A patent/HK1052920B/zh not_active IP Right Cessation
2005
- 2005-03-01 NO NO20051111A patent/NO20051111L/no not_active Application Discontinuation
2006
- 2006-11-09 IS IS8567A patent/IS2634B/is unknown
- 2006-11-15 JP JP2006309698A patent/JP4778405B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EA199800492A1 (ru)	1998-12-24
BR9611647A (pt)	1999-02-23
CA2471775C (en)	2008-01-29
US5843903A (en)	1998-12-01
ZA969709B (en)	1997-08-25
PT863917E (pt)	2004-02-27
CA2238574A1 (en)	1997-06-05
EA001372B1 (ru)	2001-02-26
NO20051111L (no)	2005-03-01
ATE401305T1 (de)	2008-08-15
KR100445754B1 (ko)	2004-12-08
NO982252L (no)	1998-05-15
EP1384710B1 (en)	2008-07-16
SK284392B6 (sk)	2005-03-04
EP0863917A1 (en)	1998-09-16
IL134685A (en)	2002-12-01
DE69637604D1 (de)	2008-08-28
PL187230B1 (pl)	2004-06-30
JP2007045845A (ja)	2007-02-22
IS2178B (is)	2006-12-15
HK1017363A1 (en)	1999-11-19
CA2238574C (en)	2004-10-19
CA2471775A1 (en)	1997-06-05
WO1997019954A1 (en)	1997-06-05
DK0863917T3 (da)	2004-01-19
IL134685A0 (en)	2001-04-30
ES2310222T3 (es)	2009-01-01
PL326865A1 (en)	1998-10-26
JP2000502055A (ja)	2000-02-22
DE69630233D1 (de)	2003-11-06
HK1052920B (zh)	2005-03-04
HUP9903771A3 (en)	2000-07-28
AU709539B2 (en)	1999-09-02
KR19990071672A (ko)	1999-09-27
PT1384710E (pt)	2008-10-08
NO982252D0 (no)	1998-05-15
EP1384710A1 (en)	2004-01-28
IL119691A0 (en)	1997-02-18
CZ297297B6 (cs)	2006-11-15
CN1137136C (zh)	2004-02-04
IL119691A (en)	2002-02-10
IS2634B (is)	2010-06-15
IS4734A (is)	1998-05-05
KR20040037176A (ko)	2004-05-04
US6184374B1 (en)	2001-02-06
ES2205067T3 (es)	2004-05-01
HU229870B1 (en)	2014-10-28
CN1166597C (zh)	2004-09-15
CN1202903A (zh)	1998-12-23
ATE251179T1 (de)	2003-10-15
CZ135798A3 (cs)	1998-10-14
CN1405127A (zh)	2003-03-26
PL188786B1 (pl)	2005-04-29
HUP9903771A2 (hu)	2000-02-28
HK1052920A1 (en)	2003-10-03
BR9611647B1 (pt)	2010-03-09
SK284672B6 (sk)	2005-08-04
JP4778405B2 (ja)	2011-09-21
NO324035B1 (no)	2007-07-30
SK62898A3 (en)	1999-06-11
JP3987575B2 (ja)	2007-10-10
EP0863917B1 (en)	2003-10-01
KR100467899B1 (ko)	2005-01-24
MX9804119A (es)	1998-09-30
UA67722C2 (en)	2004-07-15
DK1384710T3 (da)	2008-11-17
NZ322054A (en)	1999-04-29
DE69630233T2 (de)	2004-08-05
IS8567A (is)	2006-11-09
AU7572296A (en)	1997-06-19

Publication	Publication Date	Title
PL191781B1 (pl)	2006-07-31	Nowe związki antracyklinowe, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie do wytwarzania leku
Nagy et al.	1996	Cytotoxic analogs of luteinizing hormone-releasing hormone containing doxorubicin or 2-pyrrolinodoxorubicin, a derivative 500-1000 times more potent.
JPH05505630A (ja)	1993-08-19	Ｌｈｒｈ拮抗薬
JPH04224600A (ja)	1992-08-13	細胞毒性成分を有する黄体形成ホルモン放出ホルモン類似体
AU748507B2 (en)	2002-06-06	Novel synthetic reaction and targeted cytotoxic anthracycline analogs obtained thereby
EP0737691B1 (en)	1998-09-09	Bombesin analogs
UA76474C2 (en)	2006-08-15	Method for conversion of nitrogen of primary aminogroup - or --hydroxy of primary amine into nitrogen of monounsaturated compound
CA2144264A1 (en)	1996-09-10	Bombesin analogs
HK1016416B (en)	2000-07-21	Bombesin analogs
HK1017363B (en)	2004-10-29	Targeted cytotoxic anthracycline analogs