NO20051111L - Fremgangsmate for omdanning av nitrogen i en primaer aminogruppe til nitrogen i en monoumettet, nitrogenholdig, heterocyklisk forbindelse - Google Patents

Fremgangsmate for omdanning av nitrogen i en primaer aminogruppe til nitrogen i en monoumettet, nitrogenholdig, heterocyklisk forbindelse

Info

Publication number
NO20051111L
NO20051111L NO20051111A NO20051111A NO20051111L NO 20051111 L NO20051111 L NO 20051111L NO 20051111 A NO20051111 A NO 20051111A NO 20051111 A NO20051111 A NO 20051111A NO 20051111 L NO20051111 L NO 20051111L
Authority
NO
Norway
Prior art keywords
nitrogen
monounsaturated
amino group
heterocyclic compound
containing heterocyclic
Prior art date
Application number
NO20051111A
Other languages
English (en)
Inventor
Andrew V Schally
Attila A Nagy
Ren-Zhi Cai
Original Assignee
Tulane Educat Fund Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24247176&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20051111(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tulane Educat Fund Inc filed Critical Tulane Educat Fund Inc
Publication of NO20051111L publication Critical patent/NO20051111L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Fremgangsmåte for omdanning av nitrogenet i en primær aminogruppe i et primært <x,p eller a,y-hydroksyamin til nitrogenet i en mono-umettet, nitrogenholdig heterocyklisk forbindelse med mellom 5 og 6 atomer i ringen, der fremgangsmåten omfatter trinnene: a) behandling av hydroksyaminet med et overskudd av et halogenaldehyd med et aldehydkarbon,et halogen-bærende karbon og med 2 eller 3 deler mellom aldehydkarbonet og det halogen-bærende karbon valgt blant CH, CHCHog OCHb) tilsetning av et overskudd, beregnet på hydroksyaminet, av en organisk base c) nøytralisering av basen med en svak syre, og d) behandling med en fortynnet, vandig syre.
NO20051111A 1995-11-27 2005-03-01 Fremgangsmate for omdanning av nitrogen i en primaer aminogruppe til nitrogen i en monoumettet, nitrogenholdig, heterocyklisk forbindelse NO20051111L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/562,652 US5843903A (en) 1995-11-27 1995-11-27 Targeted cytotoxic anthracycline analogs
PCT/EP1996/005029 WO1997019954A1 (en) 1995-11-27 1996-11-14 Targeted cytotoxic anthracycline analogs

Publications (1)

Publication Number Publication Date
NO20051111L true NO20051111L (no) 2005-03-01

Family

ID=24247176

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19982252A NO324035B1 (no) 1995-11-27 1998-05-15 Antracyklin-analoger samt blandinger og anvendelser derav
NO20051111A NO20051111L (no) 1995-11-27 2005-03-01 Fremgangsmate for omdanning av nitrogen i en primaer aminogruppe til nitrogen i en monoumettet, nitrogenholdig, heterocyklisk forbindelse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO19982252A NO324035B1 (no) 1995-11-27 1998-05-15 Antracyklin-analoger samt blandinger og anvendelser derav

Country Status (27)

Country Link
US (2) US5843903A (no)
EP (2) EP0863917B1 (no)
JP (2) JP3987575B2 (no)
KR (2) KR100467899B1 (no)
CN (2) CN1166597C (no)
AT (2) ATE401305T1 (no)
AU (1) AU709539B2 (no)
BR (1) BR9611647B1 (no)
CA (2) CA2238574C (no)
CZ (1) CZ297297B6 (no)
DE (2) DE69630233T2 (no)
DK (2) DK1384710T3 (no)
EA (1) EA001372B1 (no)
ES (2) ES2310222T3 (no)
HK (1) HK1052920B (no)
HU (1) HU229870B1 (no)
IL (3) IL119691A (no)
IS (2) IS2178B (no)
MX (1) MX9804119A (no)
NO (2) NO324035B1 (no)
NZ (1) NZ322054A (no)
PL (3) PL191781B1 (no)
PT (2) PT863917E (no)
SK (2) SK284672B6 (no)
UA (1) UA67722C2 (no)
WO (1) WO1997019954A1 (no)
ZA (1) ZA969709B (no)

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Also Published As

Publication number Publication date
EA199800492A1 (ru) 1998-12-24
BR9611647A (pt) 1999-02-23
CA2471775C (en) 2008-01-29
US5843903A (en) 1998-12-01
ZA969709B (en) 1997-08-25
PT863917E (pt) 2004-02-27
CA2238574A1 (en) 1997-06-05
EA001372B1 (ru) 2001-02-26
ATE401305T1 (de) 2008-08-15
KR100445754B1 (ko) 2004-12-08
NO982252L (no) 1998-05-15
EP1384710B1 (en) 2008-07-16
SK284392B6 (sk) 2005-03-04
EP0863917A1 (en) 1998-09-16
IL134685A (en) 2002-12-01
DE69637604D1 (de) 2008-08-28
PL187230B1 (pl) 2004-06-30
JP2007045845A (ja) 2007-02-22
IS2178B (is) 2006-12-15
HK1017363A1 (en) 1999-11-19
CA2238574C (en) 2004-10-19
PL191781B1 (pl) 2006-07-31
CA2471775A1 (en) 1997-06-05
WO1997019954A1 (en) 1997-06-05
DK0863917T3 (da) 2004-01-19
IL134685A0 (en) 2001-04-30
ES2310222T3 (es) 2009-01-01
PL326865A1 (en) 1998-10-26
JP2000502055A (ja) 2000-02-22
DE69630233D1 (de) 2003-11-06
HK1052920B (zh) 2005-03-04
HUP9903771A3 (en) 2000-07-28
AU709539B2 (en) 1999-09-02
KR19990071672A (ko) 1999-09-27
PT1384710E (pt) 2008-10-08
NO982252D0 (no) 1998-05-15
EP1384710A1 (en) 2004-01-28
IL119691A0 (en) 1997-02-18
CZ297297B6 (cs) 2006-11-15
CN1137136C (zh) 2004-02-04
IL119691A (en) 2002-02-10
IS2634B (is) 2010-06-15
IS4734A (is) 1998-05-05
KR20040037176A (ko) 2004-05-04
US6184374B1 (en) 2001-02-06
ES2205067T3 (es) 2004-05-01
HU229870B1 (en) 2014-10-28
CN1166597C (zh) 2004-09-15
CN1202903A (zh) 1998-12-23
ATE251179T1 (de) 2003-10-15
CZ135798A3 (cs) 1998-10-14
CN1405127A (zh) 2003-03-26
PL188786B1 (pl) 2005-04-29
HUP9903771A2 (hu) 2000-02-28
HK1052920A1 (en) 2003-10-03
BR9611647B1 (pt) 2010-03-09
SK284672B6 (sk) 2005-08-04
JP4778405B2 (ja) 2011-09-21
NO324035B1 (no) 2007-07-30
SK62898A3 (en) 1999-06-11
JP3987575B2 (ja) 2007-10-10
EP0863917B1 (en) 2003-10-01
KR100467899B1 (ko) 2005-01-24
MX9804119A (es) 1998-09-30
UA67722C2 (en) 2004-07-15
DK1384710T3 (da) 2008-11-17
NZ322054A (en) 1999-04-29
DE69630233T2 (de) 2004-08-05
IS8567A (is) 2006-11-09
AU7572296A (en) 1997-06-19

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