CN1286821C - 用作细胞周期蛋白依赖性激酶抑制剂的2－苯氨基－嘧啶衍生物 - Google Patents

用作细胞周期蛋白依赖性激酶抑制剂的2－苯氨基－嘧啶衍生物 Download PDF

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Publication number
CN1286821C
CN1286821C CNB028149637A CN02814963A CN1286821C CN 1286821 C CN1286821 C CN 1286821C CN B028149637 A CNB028149637 A CN B028149637A CN 02814963 A CN02814963 A CN 02814963A CN 1286821 C CN1286821 C CN 1286821C
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China
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formula
compound
alkyl
sulfamoyl
acceptable salt
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Expired - Fee Related
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CNB028149637A
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English (en)
Chinese (zh)
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CN1541208A (zh
Inventor
N·J·纽科姆
A·P·托马斯
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB028149637A 2001-05-30 2002-05-24 用作细胞周期蛋白依赖性激酶抑制剂的2－苯氨基－嘧啶衍生物 Expired - Fee Related CN1286821C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0113041.8 2001-05-30
GBGB0113041.8A GB0113041D0 (en) 2001-05-30 2001-05-30 Chemical compounds

Publications (2)

Publication Number Publication Date
CN1541208A CN1541208A (zh) 2004-10-27
CN1286821C true CN1286821C (zh) 2006-11-29

Family

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Family Applications (1)

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CNB028149637A Expired - Fee Related CN1286821C (zh) 2001-05-30 2002-05-24 用作细胞周期蛋白依赖性激酶抑制剂的2－苯氨基－嘧啶衍生物

Country Status (19)

Country Link
US (1) US6939872B2 (de)
EP (1) EP1406876B1 (de)
JP (1) JP2004533458A (de)
KR (1) KR20040030644A (de)
CN (1) CN1286821C (de)
AT (1) ATE349432T1 (de)
BR (1) BR0210071A (de)
CA (1) CA2448305A1 (de)
DE (1) DE60217118T2 (de)
DK (1) DK1406876T3 (de)
ES (1) ES2278023T3 (de)
GB (1) GB0113041D0 (de)
IL (1) IL158975A0 (de)
MX (1) MXPA03010877A (de)
NO (1) NO20035210L (de)
NZ (1) NZ529763A (de)
PT (1) PT1406876E (de)
WO (1) WO2002096887A1 (de)
ZA (1) ZA200309165B (de)

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Also Published As

Publication number Publication date
NO20035210L (no) 2003-11-27
CA2448305A1 (en) 2002-12-05
DK1406876T3 (da) 2007-04-02
NO20035210D0 (no) 2003-11-24
JP2004533458A (ja) 2004-11-04
EP1406876A1 (de) 2004-04-14
ATE349432T1 (de) 2007-01-15
US6939872B2 (en) 2005-09-06
GB0113041D0 (en) 2001-07-18
NZ529763A (en) 2006-01-27
DE60217118T2 (de) 2007-06-28
DE60217118D1 (de) 2007-02-08
CN1541208A (zh) 2004-10-27
US20040198757A1 (en) 2004-10-07
ZA200309165B (en) 2005-03-10
IL158975A0 (en) 2004-05-12
MXPA03010877A (es) 2004-02-17
EP1406876B1 (de) 2006-12-27
BR0210071A (pt) 2004-06-22
KR20040030644A (ko) 2004-04-09
WO2002096887A1 (en) 2002-12-05
PT1406876E (pt) 2007-02-28
ES2278023T3 (es) 2007-08-01

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