CN1642525A - 无水化合物的hfa混悬剂 - Google Patents

无水化合物的hfa混悬剂 Download PDF

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Publication number
CN1642525A
CN1642525A CNA038072475A CN03807247A CN1642525A CN 1642525 A CN1642525 A CN 1642525A CN A038072475 A CNA038072475 A CN A038072475A CN 03807247 A CN03807247 A CN 03807247A CN 1642525 A CN1642525 A CN 1642525A
Authority
CN
China
Prior art keywords
suspensoid
acid
tiotropium
hfa
impelling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA038072475A
Other languages
English (en)
Chinese (zh)
Inventor
克里斯特尔·施梅尔泽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Publication of CN1642525A publication Critical patent/CN1642525A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CNA038072475A 2002-03-28 2003-03-20 无水化合物的hfa混悬剂 Pending CN1642525A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10214264.5 2002-03-28
DE10214264A DE10214264A1 (de) 2002-03-28 2002-03-28 HFA-Suspensionsformulierungen eines Anhydrats

Publications (1)

Publication Number Publication Date
CN1642525A true CN1642525A (zh) 2005-07-20

Family

ID=28050990

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038072475A Pending CN1642525A (zh) 2002-03-28 2003-03-20 无水化合物的hfa混悬剂

Country Status (21)

Country Link
EP (1) EP1492498A2 (sr)
JP (1) JP5147158B2 (sr)
KR (1) KR101005717B1 (sr)
CN (1) CN1642525A (sr)
AU (1) AU2003221509B2 (sr)
BR (1) BR0308709A (sr)
CA (1) CA2479638C (sr)
DE (1) DE10214264A1 (sr)
EA (1) EA008610B1 (sr)
EC (1) ECSP045322A (sr)
HR (1) HRP20040890A2 (sr)
IL (1) IL163696A0 (sr)
ME (1) ME00246B (sr)
MX (1) MXPA04009338A (sr)
NO (1) NO20044004L (sr)
NZ (1) NZ536030A (sr)
PL (1) PL371295A1 (sr)
RS (1) RS52481B (sr)
UA (1) UA79776C2 (sr)
WO (1) WO2003082244A2 (sr)
ZA (1) ZA200405637B (sr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102753152A (zh) * 2009-05-29 2012-10-24 珍珠治疗公司 活性剂的呼吸递送
CN115252552A (zh) * 2016-09-19 2022-11-01 墨西哥氟石股份公司 药物组合物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0609295A2 (pt) * 2005-05-02 2010-03-23 Boehringer Ingelheim Int formas cristalinas de brometo de tiotràpio, composiÇço farmacÊutica, uso e mÉtodo para preparar as mesmas
JP2008540367A (ja) * 2005-05-02 2008-11-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規結晶性臭化チオトロピウム
AU2015201037C1 (en) * 2009-05-29 2017-07-27 Pearl Therapeutics, Inc. Respiratory delivery of active agents
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
KR102391332B1 (ko) 2013-03-15 2022-04-26 펄 테라퓨틱스 인코포레이티드 미립자 결정질 재료를 컨디셔닝하는 방법 및 시스템

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
CN1150890C (zh) * 1998-08-04 2004-05-26 杰格研究股份公司 药用气溶胶制剂
GB0009606D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Therapeutic combinations
GB0009605D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Medicaments
GB0009592D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory combinations
GB0009583D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory formulations
ATE452639T1 (de) * 2000-10-31 2010-01-15 Boehringer Ingelheim Pharma Arzneimittelkompositionen aus tiotropiumsalzen und epinastin zur therapie von atemswegserkrankungen
DE10111058A1 (de) * 2001-03-08 2002-09-12 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und NK¶1¶-Rezeptor-Antagonisten
DE10113366A1 (de) * 2001-03-20 2002-09-26 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Endothelinantagonisten

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102753152A (zh) * 2009-05-29 2012-10-24 珍珠治疗公司 活性剂的呼吸递送
CN102753152B (zh) * 2009-05-29 2015-09-23 珍珠治疗公司 活性剂的呼吸递送
CN115252552A (zh) * 2016-09-19 2022-11-01 墨西哥氟石股份公司 药物组合物

Also Published As

Publication number Publication date
EA200401159A1 (ru) 2005-04-28
ME00246B (me) 2011-05-10
MXPA04009338A (es) 2005-01-25
JP5147158B2 (ja) 2013-02-20
KR20040098022A (ko) 2004-11-18
MEP47308A (en) 2011-02-10
KR101005717B1 (ko) 2011-01-05
AU2003221509B2 (en) 2008-01-24
HRP20040890A2 (en) 2005-06-30
ECSP045322A (es) 2005-01-28
EA008610B1 (ru) 2007-06-29
YU86004A (sh) 2006-08-17
BR0308709A (pt) 2005-01-04
UA79776C2 (en) 2007-07-25
AU2003221509A1 (en) 2003-10-13
CA2479638A1 (en) 2003-10-09
WO2003082244A3 (de) 2004-02-05
JP2005527550A (ja) 2005-09-15
IL163696A0 (en) 2005-12-18
RS52481B (sr) 2013-02-28
WO2003082244A2 (de) 2003-10-09
ZA200405637B (en) 2005-07-27
PL371295A1 (en) 2005-06-13
NZ536030A (en) 2006-07-28
EP1492498A2 (de) 2005-01-05
NO20044004L (no) 2004-10-05
CA2479638C (en) 2011-01-04
DE10214264A1 (de) 2003-10-16

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