CN1805926A - 二苯基氮杂环丁酮衍生物的反式异构体的制备方法 - Google Patents

二苯基氮杂环丁酮衍生物的反式异构体的制备方法 Download PDF

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Publication number
CN1805926A
CN1805926A CNA2004800162566A CN200480016256A CN1805926A CN 1805926 A CN1805926 A CN 1805926A CN A2004800162566 A CNA2004800162566 A CN A2004800162566A CN 200480016256 A CN200480016256 A CN 200480016256A CN 1805926 A CN1805926 A CN 1805926A
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CN
China
Prior art keywords
general formula
ether
chiral
acid
thf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800162566A
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English (en)
Chinese (zh)
Inventor
K·K·G·S·卡鲁提
P·D·拉瑟德
R·C·阿里扬
Y·库马
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of CN1805926A publication Critical patent/CN1805926A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNA2004800162566A 2003-05-05 2004-05-05 二苯基氮杂环丁酮衍生物的反式异构体的制备方法 Pending CN1805926A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN668/DEL/2003 2003-05-05
IN668DE2003 2003-05-05

Publications (1)

Publication Number Publication Date
CN1805926A true CN1805926A (zh) 2006-07-19

Family

ID=33428285

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800162566A Pending CN1805926A (zh) 2003-05-05 2004-05-05 二苯基氮杂环丁酮衍生物的反式异构体的制备方法

Country Status (4)

Country Link
EP (1) EP1626954A2 (de)
CN (1) CN1805926A (de)
AR (1) AR044177A1 (de)
WO (1) WO2004099132A2 (de)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103086938A (zh) * 2011-10-28 2013-05-08 沈阳药科大学 依泽替米贝的合成方法
CN103121966A (zh) * 2011-11-17 2013-05-29 重庆华邦胜凯制药有限公司 定向合成(4-氯苯基)-(吡啶-2-基)-甲醇的方法
CN103204795A (zh) * 2012-01-11 2013-07-17 重庆华邦胜凯制药有限公司 一种手性氮杂环丁酮类化合物的制备方法
CN104744331A (zh) * 2013-12-31 2015-07-01 浙江九洲药业股份有限公司 一种依泽替米贝中间体的合成工艺
CN107176920A (zh) * 2017-04-19 2017-09-19 上海恒晟药业有限公司 一种依泽麦布的合成新工艺
CN110818606A (zh) * 2018-08-08 2020-02-21 上海博志研新药物技术有限公司 依折麦布及其中间体的制备方法

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
CA2550215A1 (en) 2003-12-23 2005-07-07 Astrazeneca Ab Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
JP2007526251A (ja) * 2004-12-03 2007-09-13 テバ ファーマシューティカル インダストリーズ リミティド エゼチミベ多形体
TW200726746A (en) 2005-05-06 2007-07-16 Microbia Inc Processes for production of 4-biphenylylazetidin-2-ones
JP2008540557A (ja) * 2005-05-11 2008-11-20 マイクロビア インコーポレーテッド フェノール型４−ビフェニリルアゼチジン−２−オンの製造方法
AU2006249905A1 (en) * 2005-05-25 2006-11-30 Microbia, Inc. Processes for production of 4-(biphenylyl)azetidin-2-one phosphonic acids
UY29607A1 (es) 2005-06-20 2007-01-31 Astrazeneca Ab Compuestos quimicos
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
MY148538A (en) 2005-06-22 2013-04-30 Astrazeneca Ab Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions
WO2007017705A1 (en) * 2005-08-09 2007-02-15 Glenmark Pharmaceuticals Limited Process for the preparation of azetidinones
WO2008061238A2 (en) * 2006-11-16 2008-05-22 Ironwood Pharmaceuticals, Inc. Processes for production of 4-biphenylyazetidin-2-ones
EP2128133A1 (de) 2008-05-26 2009-12-02 Lek Pharmaceuticals D.D. Ezetiminverfahren und -zusammensetzung
KR20110015449A (ko) * 2008-06-02 2011-02-15 시플라 리미티드 아르포르모테롤의 합성방법
EP2414529A2 (de) 2009-04-01 2012-02-08 Matrix Laboratories Ltd Enzymatisches verfahren zur herstellung von (s)-5-(4-fluorphenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-on, einer zwischenstufe von ezetimib, und weitere umwandlung zu ezetimib
PL231215B1 (pl) 2011-06-15 2019-02-28 Inst Chemii Organicznej Polskiej Akademii Nauk Sposób wytwarzania podstawionych azetydynonów oraz związków pośrednich do ich syntezy
ES2641993T3 (es) 2012-06-22 2017-11-14 Henkel Ag & Co. Kgaa Sustancias de reserva de aroma fotolábiles
CN108586373A (zh) * 2018-06-22 2018-09-28 苏州市贝克生物科技有限公司 依折麦布中间体的合成方法
WO2025238768A1 (ja) * 2024-05-15 2025-11-20 Ｎｔｔ株式会社 リチウム二次電池
WO2025238757A1 (ja) * 2024-05-15 2025-11-20 Ｎｔｔ株式会社 二次電池

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103086938A (zh) * 2011-10-28 2013-05-08 沈阳药科大学 依泽替米贝的合成方法
CN103121966A (zh) * 2011-11-17 2013-05-29 重庆华邦胜凯制药有限公司 定向合成(4-氯苯基)-(吡啶-2-基)-甲醇的方法
CN103204795A (zh) * 2012-01-11 2013-07-17 重庆华邦胜凯制药有限公司 一种手性氮杂环丁酮类化合物的制备方法
CN103204795B (zh) * 2012-01-11 2016-12-14 重庆华邦胜凯制药有限公司 一种手性氮杂环丁酮类化合物的制备方法
CN104744331A (zh) * 2013-12-31 2015-07-01 浙江九洲药业股份有限公司 一种依泽替米贝中间体的合成工艺
CN104744331B (zh) * 2013-12-31 2018-05-15 浙江九洲药业股份有限公司 一种依泽替米贝中间体的合成工艺
CN107176920A (zh) * 2017-04-19 2017-09-19 上海恒晟药业有限公司 一种依泽麦布的合成新工艺
CN107176920B (zh) * 2017-04-19 2019-09-20 江苏恒盛药业有限公司 一种依泽麦布的合成新工艺
CN110818606A (zh) * 2018-08-08 2020-02-21 上海博志研新药物技术有限公司 依折麦布及其中间体的制备方法
CN110818606B (zh) * 2018-08-08 2021-06-29 上海博志研新药物技术有限公司 依折麦布及其中间体的制备方法

Also Published As

Publication number Publication date
WO2004099132A3 (en) 2005-03-24
AR044177A1 (es) 2005-08-24
EP1626954A2 (de) 2006-02-22
WO2004099132A2 (en) 2004-11-18

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