CN1805943A - 作为PPAR调节剂的α取代羧酸 - Google Patents

作为PPAR调节剂的α取代羧酸 Download PDF

Info

Publication number: CN1805943A
Authority: CN; China
Prior art keywords: methyl; phenyl; oxazol; ethoxy; acid
Prior art date: 2003-04-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CNA2004800167362A

Other languages

English (en)

Chinese (zh)

Inventor

西蒙·贝利

保罗·S·汉弗莱斯

唐纳德·J·斯卡利茨基

苏慰国

卢克·R·曾德

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Inc

Original Assignee

Pfizer Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-15

Filing date

2004-04-01

Publication date

2006-07-19

2004-04-01 Application filed by Pfizer Inc filed Critical Pfizer Inc

2006-07-19 Publication of CN1805943A publication Critical patent/CN1805943A/zh

Status Pending legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/14—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Furan Compounds (AREA)
Pyridine Compounds (AREA)

CNA2004800167362A 2003-04-15 2004-04-01 作为PPAR调节剂的α取代羧酸 Pending CN1805943A (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US46321303P	2003-04-15	2003-04-15
US60/463,213		2003-04-15

Publications (1)

Publication Number	Publication Date
CN1805943A true CN1805943A (zh)	2006-07-19

Family

ID=33300053

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CNA2004800167362A Pending CN1805943A (zh)	2003-04-15	2004-04-01	作为PPAR调节剂的α取代羧酸

Country Status (25)

Country	Link
EP (1)	EP1615899A1 (is)
JP (1)	JP2006523671A (is)
KR (1)	KR20060009846A (is)
CN (1)	CN1805943A (is)
AP (1)	AP2005003418A0 (is)
AR (1)	AR044514A1 (is)
AU (1)	AU2004230316A1 (is)
BR (1)	BRPI0409429A (is)
CA (1)	CA2521915A1 (is)
CL (1)	CL2004000800A1 (is)
EA (1)	EA200501462A1 (is)
EC (1)	ECSP056105A (is)
IS (1)	IS8033A (is)
MA (1)	MA27764A1 (is)
MX (1)	MXPA05010967A (is)
NL (1)	NL1025946C2 (is)
NO (1)	NO20055370L (is)
OA (1)	OA13157A (is)
PA (1)	PA8600201A1 (is)
PE (1)	PE20050415A1 (is)
TN (1)	TNSN05262A1 (is)
TW (1)	TW200510353A (is)
UY (1)	UY28266A1 (is)
WO (1)	WO2004092145A1 (is)
ZA (1)	ZA200508362B (is)

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RU2006145872A (ru) *	2004-05-25	2008-06-27	Метаболекс, Инк. (Us)	Замещенные триазолы в качестве модуляторов ppar и способы их получения
AU2006244203B2 (en)	2005-05-09	2012-05-03	Achillion Pharmaceuticals, Inc.	Thiazole compounds and methods of use
CA2668070A1 (en)	2006-10-30	2008-05-08	Chroma Therapeutics Ltd.	Hydroxamates as inhibitors of histone deacetylase
AU2008221673B2 (en)	2007-03-08	2013-03-28	Albireo Ab	2 -substituted- 3 -phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease
EA200901573A1 (ru)	2007-05-22	2010-04-30	Ачиллион Фармасьютикалз, Инк.	Гетероарилзамещенные тиазолы
US8106209B2 (en)	2008-06-06	2012-01-31	Achillion Pharmaceuticals, Inc.	Substituted aminothiazole prodrugs of compounds with anti-HCV activity
EP2303841A1 (en)	2008-07-14	2011-04-06	Gilead Sciences, Inc.	Oxindolyl inhibitor compounds
EP2303881A2 (en)	2008-07-14	2011-04-06	Gilead Sciences, Inc.	Fused heterocyclyc inhibitors of histone deacetylase and/or cyclin-dependent kinases
JP5640005B2 (ja)	2008-07-14	2014-12-10	ギリアードサイエンシーズ，インコーポレイテッド	Ｈｄａｃおよび／またはｃｄｋ阻害剤としてのイミダゾシルピリジン化合物
KR20110038159A (ko)	2008-07-28	2011-04-13	길리애드 사이언시즈, 인코포레이티드	사이클로알킬리덴 및 헤테로사이클로알킬리덴 히스톤 데아세틸라아제 억제제 화합물
ES2463826T3 (es)	2009-06-08	2014-05-29	Gilead Sciences, Inc.	Compuestos inhibidores de HDAC de cicloalquilcarbamato benzamida anilina
CA2763786C (en)	2009-06-08	2014-09-30	Gilead Sciences, Inc.	Alkanoylamino benzamide aniline hdac inihibitor compounds
DE102010055499A1 (de) *	2010-12-22	2011-06-16	W.C. Heraeus Gmbh	Prozess zur Herstellung von Bendamustinalkylester, Bendarmustin sowie Derivaten davon
MX2014005304A (es)	2011-10-31	2015-03-20	Xenon Pharmaceuticals Inc	Biaril eter sulfonamidas y su uso como agentes terapeuticos.
ES2586213T3 (es)	2011-10-31	2016-10-13	Xenon Pharmaceuticals Inc.	Compuestos de bencenosulfonamida y su uso como agentes terapéuticos
FR2982858B1 (fr) *	2011-11-18	2013-11-29	Rhodia Operations	Procede de fabrication de composes comprenant des fonctions nitriles
FR2984322B1 (fr) *	2011-12-16	2013-12-20	Rhodia Operations	Procede de fabrication de composes comprenant des fonctions nitriles
CA2874621A1 (en)	2012-05-22	2013-11-28	Genentech, Inc.	N-substituted benzamides and their use in the treatment of pain
US10071957B2 (en)	2012-07-06	2018-09-11	Genentech, Inc.	N-substituted benzamides and methods of use thereof
CN105263490B (zh)	2013-03-14	2018-05-22	基因泰克公司	取代的三唑并吡啶及其使用方法
CA2898680A1 (en)	2013-03-15	2014-09-18	Genentech,Inc.	Substituted benzoxazoles and methods of use thereof
JP6383418B2 (ja)	2013-11-27	2018-08-29	ジェネンテック，インコーポレイテッド	置換ベンズアミド及びその使用方法
CN106715418A (zh)	2014-07-07	2017-05-24	基因泰克公司	治疗化合物及其使用方法
MA42118A (fr)	2015-05-22	2018-03-28	Genentech Inc	Benzamides substitués et leurs méthodes d'utilisation
WO2017035271A1 (en)	2015-08-27	2017-03-02	Genentech, Inc.	Therapeutic compounds and methods of use thereof
JP6987746B2 (ja)	2015-09-28	2022-01-05	ジェネンテック，インコーポレイテッド	治療用化合物及びその使用方法
US10899732B2 (en)	2015-11-25	2021-01-26	Genentech, Inc.	Substituted benzamides useful as sodium channel blockers
US10766858B2 (en)	2016-03-30	2020-09-08	Genentech, Inc.	Substituted benzamides and methods of use thereof
BR112019007763A2 (pt)	2016-10-17	2019-07-02	Genentech Inc	composto de fórmula, composição farmacêutica, métodos para tratar uma doença ou condição, para tratar dores, para diminuir o fluxo de íons e para tratar prurido, uso de um composto e invenção
EP3601273B1 (en)	2017-03-24	2021-12-01	Genentech, Inc.	4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
AR114263A1 (es)	2018-02-26	2020-08-12	Genentech Inc	Compuestos terapéuticos y métodos para utilizarlos
WO2019191702A1 (en)	2018-03-30	2019-10-03	F. Hoffmann-La Roche Ag	Substituted hydro-pyrido-azines as sodium channel inhibitors
TW202003490A (zh)	2018-05-22	2020-01-16	瑞士商赫孚孟拉羅股份公司	治療性化合物及其使用方法

Family Cites Families (2)

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Publication number	Priority date	Publication date	Assignee	Title
PT1088824E (pt) *	1999-09-30	2004-04-30	Pfizer Prod Inc	Pirrolil-amidas biciclicas como inibidores de glicogenio-fosforilase
EP1372632A1 (en) *	2001-02-15	2004-01-02	Pfizer Products Inc.	Proliferative activator receptor (ppar) compounds

2004
- 2004-04-01 CA CA002521915A patent/CA2521915A1/en not_active Abandoned
- 2004-04-01 MX MXPA05010967A patent/MXPA05010967A/es not_active Application Discontinuation
- 2004-04-01 EP EP04725121A patent/EP1615899A1/en not_active Withdrawn
- 2004-04-01 AP AP2005003418A patent/AP2005003418A0/xx unknown
- 2004-04-01 KR KR1020057019591A patent/KR20060009846A/ko not_active Ceased
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- 2004-04-01 CN CNA2004800167362A patent/CN1805943A/zh active Pending
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- 2004-04-13 AR ARP040101236A patent/AR044514A1/es unknown
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2005
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Publication number	Publication date
IS8033A (is)	2005-09-15
AP2005003418A0 (en)	2005-12-31
PA8600201A1 (es)	2005-02-04
NO20055370L (no)	2006-01-12
UY28266A1 (es)	2004-11-30
NL1025946A1 (nl)	2004-10-18
MXPA05010967A (es)	2005-11-28
AR044514A1 (es)	2005-09-14
CL2004000800A1 (es)	2005-03-04
NO20055370D0 (no)	2005-11-14
ZA200508362B (en)	2006-11-29
TW200510353A (en)	2005-03-16
NL1025946C2 (nl)	2005-02-01
EP1615899A1 (en)	2006-01-18
MA27764A1 (fr)	2006-02-01
AU2004230316A1 (en)	2004-10-28
WO2004092145A1 (en)	2004-10-28
PE20050415A1 (es)	2005-06-13
JP2006523671A (ja)	2006-10-19
CA2521915A1 (en)	2004-10-28
OA13157A (en)	2006-12-13
EA200501462A1 (ru)	2006-04-28
WO2004092145A8 (en)	2005-05-12
BRPI0409429A (pt)	2006-04-18
KR20060009846A (ko)	2006-02-01
ECSP056105A (es)	2006-03-01
TNSN05262A1 (fr)	2007-07-10

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