CO2022008092A2 - N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos - Google Patents

N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos

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Publication number
CO2022008092A2
CO2022008092A2 CONC2022/0008092A CO2022008092A CO2022008092A2 CO 2022008092 A2 CO2022008092 A2 CO 2022008092A2 CO 2022008092 A CO2022008092 A CO 2022008092A CO 2022008092 A2 CO2022008092 A2 CO 2022008092A2
Authority
CO
Colombia
Prior art keywords
hydroxycytidine
derivatives
uses related
antiviral uses
antiviral
Prior art date
Application number
CONC2022/0008092A
Other languages
English (en)
Inventor
Michael G Natchus
George R Painter
Gregory R Bluemling
Shuli Mao
Jose Marengo
Michael W Hager
David Perryman
Original Assignee
Univ Emory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory filed Critical Univ Emory
Publication of CO2022008092A2 publication Critical patent/CO2022008092A2/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/52—Purines, e.g. adenine
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    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
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Abstract

Esta divulgación se relaciona con ciertos derivados de N4-hidroxicitidina, composiciones farmacéuticas y métodos relacionados con los mismos. En ciertas realizaciones, la divulgación se relaciona con el tratamiento o la profilaxis del coronavirus humano 2019-nCoV.
CONC2022/0008092A 2020-02-07 2022-06-07 N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos CO2022008092A2 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062971559P 2020-02-07 2020-02-07
US202062988133P 2020-03-11 2020-03-11
US202062994604P 2020-03-25 2020-03-25
US202063006625P 2020-04-07 2020-04-07
PCT/US2021/016984 WO2021159044A1 (en) 2020-02-07 2021-02-07 N4-hydroxycytidine and derivatives and anti-viral uses related thereto

Publications (1)

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CO2022008092A2 true CO2022008092A2 (es) 2022-07-08

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US (2) US20210252033A1 (es)
EP (1) EP4017501A4 (es)
JP (2) JP7745892B2 (es)
KR (1) KR20220139914A (es)
CN (2) CN120284995A (es)
AR (1) AR127030A2 (es)
AU (1) AU2021216049A1 (es)
BR (1) BR112022015479A2 (es)
CA (1) CA3167054A1 (es)
CL (1) CL2022000423A1 (es)
CO (1) CO2022008092A2 (es)
CR (1) CR20220082A (es)
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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3939985B1 (en) 2014-12-26 2024-05-08 Emory University Pharmaceutical compositions comprising n4-hydroxycytidine derivatives for the treatment or prevention of influenza or coronavirus infections
SG11202004403QA (en) 2017-12-07 2020-06-29 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
US12280096B2 (en) 2021-07-12 2025-04-22 Penland Foundation Treatments of cancer using nitrous oxide and botulinum toxin
EP4157448A4 (en) * 2020-06-02 2024-09-04 Model Medicines, Inc. METHODS AND COMPOSITIONS FOR TREATING RNA VIRAL INFECTIONS
US20230270669A1 (en) * 2020-09-04 2023-08-31 Mexichem Fluor S.A. De C.V. Pharmaceutical composition
EP4333887A4 (en) * 2021-05-05 2025-05-21 Inovio Pharmaceuticals, Inc. Vaccines against coronavirus and methods of use
WO2022262845A1 (en) * 2021-06-18 2022-12-22 Suzhou Spring-Sea Bio-Pharmaceuticals Co., Ltd. Ester derivatives of n4-hydroxycytidine and use thereof
WO2023025319A1 (zh) * 2021-08-27 2023-03-02 南京知和医药科技有限公司 一种新型的胞苷衍生物及其药物组合物和用途
CN115737665A (zh) * 2021-09-02 2023-03-07 广州谷森制药有限公司 胞苷衍生物和与其相关的抗病毒用途
WO2023070058A1 (en) * 2021-10-20 2023-04-27 Merck Sharp & Dohme Llc Treatment of viruses with antiviral nucleosides
WO2023067623A1 (en) * 2021-10-20 2023-04-27 Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) A short and cost effective synthetic route towards anti viral eidd-1931 and its hydrate polymorphs
CN114306254B (zh) * 2021-11-30 2023-11-03 南京正济医药研究有限公司 一种Molnupiravir口服固体制剂及其制备方法
US11541071B1 (en) 2021-12-16 2023-01-03 Ascletis BioScience Co., Ltd Nucleoside derivatives and methods of use thereof
CN116496334A (zh) * 2022-01-25 2023-07-28 上海和誉生物医药科技有限公司 一种抗病毒抑制剂及其在药学上的应用
CN114948982A (zh) * 2022-02-14 2022-08-30 广州谷森制药有限公司 一种具有协同增效效应的药物组合物及其其抗病毒用途
WO2024123207A1 (ru) * 2022-12-08 2024-06-13 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации 5'-о-(3-фенилпропионил)-n4-гидроксицитидин и его применение
WO2024123206A1 (ru) * 2022-12-08 2024-06-13 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Способ получения 5',-о-(3-фенилпропионил)-n4-гидроксицитидина
WO2024125604A1 (en) * 2022-12-16 2024-06-20 Suzhou Spring-Sea Bio-Pharmaceuticals Co. Ltd. Diester derivatives of n4-hydroxycytidine and use thereof
CN116217644B (zh) * 2023-04-24 2023-08-08 南京颐媛生物医学研究院有限公司 抗冠状病毒核糖核苷类化合物及其制备方法和应用

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EP3939985B1 (en) 2014-12-26 2024-05-08 Emory University Pharmaceutical compositions comprising n4-hydroxycytidine derivatives for the treatment or prevention of influenza or coronavirus infections
WO2017106710A1 (en) * 2015-12-17 2017-06-22 Emory University Nucleotide and nucleoside therapeutic compositions and uses related thereto
US10874683B2 (en) * 2016-03-10 2020-12-29 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
SG11202004403QA (en) * 2017-12-07 2020-06-29 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto

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