ECSP088620A - 1h-indoles sustituidos por sulfonilo como ligandos para los receptores 5-hidroxitriptamina - Google Patents

1h-indoles sustituidos por sulfonilo como ligandos para los receptores 5-hidroxitriptamina

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Publication number
ECSP088620A
ECSP088620A EC2008008620A ECSP088620A ECSP088620A EC SP088620 A ECSP088620 A EC SP088620A EC 2008008620 A EC2008008620 A EC 2008008620A EC SP088620 A ECSP088620 A EC SP088620A EC SP088620 A ECSP088620 A EC SP088620A
Authority
EC
Ecuador
Prior art keywords
receptors
hydroxitriptamine
ligandos
sulfonyl
hydroxytryptamine
Prior art date
Application number
EC2008008620A
Other languages
English (en)
Inventor
Robert Emmett Mcdevitt
Ronald Charles Bernotas
Albert Jean Robichaud
Richard Dale Coghlan
Gavin David Heffernan
Yanfang Li
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP088620A publication Critical patent/ECSP088620A/es

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

La presente invención se dirige a compuestos de Fórmula I: que son moduladores de los receptores 5-hidroxitriptamina-6 y 5-hidroxitriptamina-2A y que son inhibidores de retoma de norepinefrina. Los compuestos de la invención, y la composición farmacéutica de estos, son útiles en el tratamiento de trastornos relacionados con o asociados con los receptores 5-hidroxitriptamina-6 y 5-hidroxtriptamina-2A o con la inhibición de retoma de norepinefrina.
EC2008008620A 2006-01-13 2008-07-11 1h-indoles sustituidos por sulfonilo como ligandos para los receptores 5-hidroxitriptamina ECSP088620A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75883306P 2006-01-13 2006-01-13

Publications (1)

Publication Number Publication Date
ECSP088620A true ECSP088620A (es) 2008-08-29

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ID=38179679

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Application Number Title Priority Date Filing Date
EC2008008620A ECSP088620A (es) 2006-01-13 2008-07-11 1h-indoles sustituidos por sulfonilo como ligandos para los receptores 5-hidroxitriptamina

Country Status (16)

Country Link
US (1) US7645752B2 (es)
EP (1) EP1973876A2 (es)
JP (1) JP2009523734A (es)
KR (1) KR20080114688A (es)
CN (1) CN101370775A (es)
AU (1) AU2007206016A1 (es)
BR (1) BRPI0706523A2 (es)
CA (1) CA2636007A1 (es)
CR (1) CR10138A (es)
EC (1) ECSP088620A (es)
IL (1) IL192695A0 (es)
MX (1) MX2008009022A (es)
NO (1) NO20083057L (es)
RU (1) RU2008127501A (es)
WO (1) WO2007084841A2 (es)
ZA (1) ZA200806071B (es)

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NO20083057L (no) 2008-10-03
EP1973876A2 (en) 2008-10-01
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CA2636007A1 (en) 2007-07-26
ZA200806071B (en) 2009-04-29
WO2007084841A2 (en) 2007-07-26
IL192695A0 (en) 2009-02-11
US20070203120A1 (en) 2007-08-30
JP2009523734A (ja) 2009-06-25
WO2007084841A3 (en) 2007-09-13
CR10138A (es) 2008-10-03
CN101370775A (zh) 2009-02-18
US7645752B2 (en) 2010-01-12

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