CR20130152A - Proteínas de la unión a il-12/p40 (divisional 9599) - Google Patents

Proteínas de la unión a il-12/p40 (divisional 9599)

Info

Publication number
CR20130152A
CR20130152A CR20130152A CR20130152A CR20130152A CR 20130152 A CR20130152 A CR 20130152A CR 20130152 A CR20130152 A CR 20130152A CR 20130152 A CR20130152 A CR 20130152A CR 20130152 A CR20130152 A CR 20130152A
Authority
CR
Costa Rica
Prior art keywords
hil
antibodies
proteins
divisional
union
Prior art date
Application number
CR20130152A
Other languages
English (en)
Inventor
Susan E Lacy
Emma Fung
Jonathan P Belk
Richard W Dixon
Michael Roguska
Paul R Hinton
Shankar Kumar
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of CR20130152A publication Critical patent/CR20130152A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

Proteínas de unión a IL-12 p40, en particular anticuerpos que se unen a la interleuquina-12 humana (hIL-12) y/o IL-23 humana (hIL-23). Específicamente, la invención se relaciona con anticuerpos que son quiméricos, con injertos de CDR y anticuerpos humanizados. Los anticuerpos preferidos tienen gran afinidad por hIL-12 y/o hIL-23 y neutralizan la actividad de hIL-12 y/o hIL-23 in vitro y in vivo. Un anticuerpo de la invención puede ser un anticuerpo de longitud completa o una porción de unión al antígeno del mismo.
CR20130152A 2005-06-30 2013-04-03 Proteínas de la unión a il-12/p40 (divisional 9599) CR20130152A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69567905P 2005-06-30 2005-06-30

Publications (1)

Publication Number Publication Date
CR20130152A true CR20130152A (es) 2013-05-23

Family

ID=37605037

Family Applications (10)

Application Number Title Priority Date Filing Date
CR9599A CR9599A (es) 2005-06-30 2007-12-18 Proteinas de union a il-12/p40
CR20130156A CR20130156A (es) 2005-06-30 2013-04-03 Proteínas de la unión a il-12/p40 (divisional 9599)
CR20130153A CR20130153A (es) 2005-06-30 2013-04-03 PROTEÍNAS DE LA UNIÓN A IL-12/P40 (Divisional 9599)
CR20130154A CR20130154A (es) 2005-06-30 2013-04-03 Proteínas de la unión a il-12/p40 (divisional exp. 9599)
CR20130157A CR20130157A (es) 2005-06-30 2013-04-03 PROTEÍNAS DE LA UNIÓN A IL-12/P40 (Divisional 9599)
CR20130155A CR20130155A (es) 2005-06-30 2013-04-03 PROTEÍNAS DE LA UNIÓN A IL-12/P40 (Divisional 9599)
CR20130151A CR20130151A (es) 2005-06-30 2013-04-03 PROTEÍNAS DE LA UNIÓN A IL-12/P40 (Divisional 9599)
CR20130149A CR20130149A (es) 2005-06-30 2013-04-03 Proteínas de la unión a il-12/p40 (divisional 9599)
CR20130152A CR20130152A (es) 2005-06-30 2013-04-03 Proteínas de la unión a il-12/p40 (divisional 9599)
CR20130150A CR20130150A (es) 2005-06-30 2013-04-03 Proteínas de la unión a il-12/p40 (divisional exp. 9599)

Family Applications Before (8)

Application Number Title Priority Date Filing Date
CR9599A CR9599A (es) 2005-06-30 2007-12-18 Proteinas de union a il-12/p40
CR20130156A CR20130156A (es) 2005-06-30 2013-04-03 Proteínas de la unión a il-12/p40 (divisional 9599)
CR20130153A CR20130153A (es) 2005-06-30 2013-04-03 PROTEÍNAS DE LA UNIÓN A IL-12/P40 (Divisional 9599)
CR20130154A CR20130154A (es) 2005-06-30 2013-04-03 Proteínas de la unión a il-12/p40 (divisional exp. 9599)
CR20130157A CR20130157A (es) 2005-06-30 2013-04-03 PROTEÍNAS DE LA UNIÓN A IL-12/P40 (Divisional 9599)
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